Talk:Melanocortins and appetite: Difference between revisions

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#[[User:Ruth Callaghan|Ruth Callaghan]] 13:14, 28 September 2010 (UTC)
#[[User:Ruth Callaghan|Ruth Callaghan]] 13:14, 28 September 2010 (UTC)
#[[User:Cadi M. J. Irvine|Cadi M. J. Irvine]] 13:16, 28 September 2010 (UTC)
#[[User:Cadi M. J. Irvine|Cadi M. J. Irvine]] 13:16, 28 September 2010 (UTC)
#[[User:Lisa L Hutchison|Lisa L Hutchison]] 16:21, 25 October 2010 (UTC)
===Figures and Diagrams===
{{Image|Adipocyte.png|right|300px|}}
You can also insert diagrams or photographs (to Upload files [[Cz:Upload]])). These '''must''' be your own original work - and you will therefore be the copyright holder; of course they may be based on or adapted from diagrams produced by others - in which case this must be declared clearly, and the source of the orinal idea must be cited. When you insert a figure or diagram into your article you will be asked to fill out a form in which you declare that you are the copyright holder and that you are willing to allow your work to be freely used by others - choose the "Release to the Public Domain" option when you come to that page of the form.
When you upload your file, give it a short descriptive name, like "Adipocyte.png". Then, if you type <nowiki> {{Image|Adipocyte.png|right|300px|}} </nowiki> in your article, the image will appear on the right hand side.
Begin your article with a brief overview of the scope of the article on interest group. Include the article name in '''bold''' in the first sentence.<ref>See the "Writing an Encyclopedia Article" handout for more details.</ref>
Remember you are writing an encyclopedia article; it is meant to be readable by a wide audience, and so you will need to explain some things clearly, without using unneccessary jargon. But you don't need to explain everything - you can '''link''' specialist terms to other articles about them - for example [[adipocyte]] or [[leptin]] simply by enclosing the word in double square brackets.
You can write your article directly onto the wiki- but at first you'll find it easier to write it in Word and copy and paste it onto the wiki.
Construct your article in sections and subsections, with headings and subheadings like this:
==References==
'''To insert references and/or footnotes in an article''', put the material you want in the reference or footnote between <nowiki> <ref> and </ref></nowiki>, like this:
<nowiki><ref>Person A ''et al.''(2010) The perfect reference for subpart 1 ''J Neuroendocrinol'' 36:36-52</ref> <ref>Author A, Author B (2009) Another perfect reference  ''J Neuroendocrinol'' 25:262-9</ref></nowiki>.
Look at the reference list below to see how this will look.<ref>Person A ''et al.'' (2010) The perfect reference for subpart 1 ''J Neuroendocrinol'' 36:36-52</ref> <ref>Author A, Author B (2009) Another perfect reference  ''J Neuroendocrinol'' 25:262-9</ref>
If there are more than two authors just put the first author followed by ''et al.'' (Person A ''at al.'' (2010) etc.)
Select your references carefully - make sure they are cited accurately, and pay attention to the precise formatting style of the references. Your references should be available on PubMed and so will have a PubMed number. (for example PMID: 17011504) Writing this without the colon, (i.e. just writing PMID 17011504) will automatically insert a link to the abstract on PubMed (see the reference to Johnsone ''et al.'' in the list.)
<ref>Johnstone LE ''et al.'' (2006)Neuronal activation in the hypothalamus and brainstem during feeding in rats ''Cell Metab'' 2006 4:313-21. PMID 17011504</ref>
Use references sparingly; there's no need to reference every single point, and often a good review will cover several points. However sometimes you will need to use the same reference more than once.
'''How to write the same reference twice:'''
Reference: Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. ''Psychopharmacology'' 191:391–431 PMID 17072591
First time:<nowiki>
<ref name=Berridge07>Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. ''Psychopharmacology'' 191:391–431 PMID 17072591
</ref></nowiki>
Second time:<nowiki><ref name=Berridge07/></nowiki>
This will appear like this the first time <ref name=Berridge07>Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. ''Psychopharmacology'' 191:391–431 PMID 17072591
</ref> and like this the second time <ref name=Berridge07/>
<references/>


Hello. here is a link to an article- haven't read it yet but looks like a nice intro to the glamorous world of melanocortins:  
Hello. here is a link to an article- haven't read it yet but looks like a nice intro to the glamorous world of melanocortins:  
Line 10: Line 62:


[[User:Jessica Ivy|Jessica Ivy]] 13:49, 28 September 2010 (UTC)
[[User:Jessica Ivy|Jessica Ivy]] 13:49, 28 September 2010 (UTC)
:Jessica, remember to use the Bibliography page for references. Please write the whole ref with author names, year, title, journal, vol, and PubMed link if available.
[[User:Nancy Sabatier|Nancy Sabatier]] 17:02, 5 October 2010 (UTC)
==Related articles==
You'll see that on the Related articles subpage I've placed links to all the articles from the other groups this year - and also to last year's articles. Good luck with this.[[User:Gareth Leng|Gareth Leng]] 16:01, 9 October 2010 (UTC)
Hi guys, your reference list needs to be developped a bit more, have a look at what the other group have done, it'll give you an idea of how much they already put in. Also, you should start thinking about your introduction and plan for your main article. [[User:Nancy Sabatier|Nancy Sabatier]] 16:31, 14 October 2010 (UTC)
The plan looks sensible; you do need to keep a sharp eye out for key experimental studies; I'd suggest that you use the bibliography page to capture key details of experimental studies of particular significance; whether and how you incorporate those in the main article you can decide later. Without more detail and seeing what you're doing I can't give any better feedback at this stage.[[User:Gareth Leng|Gareth Leng]] 14:29, 25 October 2010 (UTC)
Cadi, if you look at the Mountjoy article (link to it in bibliog) there's quite an interesting bit about the fact that they've not developed specific melanocortin knock out mice. so there are some ideas for future directions etc there. [[User:Jessica Ivy|Jessica Ivy]] 20:29, 26 October 2010 (UTC)
This article is starting to take shape.  Good!  Though I agree with Nancy that the scope of reading should be increased to encompass original research papers.  Watch out for your spelling and make sure you are consistent with terms that might be unfamiliar to the lay reader; AGRP v. AgRP, for example.  The latter is more commonly used. [[User:John Menzies|John Menzies]] 12:41, 27 October 2010 (UTC)
==Detail==
One of the important things that you can learn from writing an encyclopedia article is strict attention to detail; you have to be sparing in what you write and strictly accurate. The same things count in exams. For example, look at the following
''"The melanocortin system is the name collectively given for; 
*''Neurons arising in the arcuate nucleus of the hypothalamus, and express AgRP,NPY or POMC.
*''POMC neurons that project to the brainstem
*''Melanocortin receptors, predominately MC3R and MC4R that respond to POMC peptides and AgRP." ''
Several things here almost right but not quite, or ambiguous so it's not clear that you've got it right or not.
#'collectively given': what does collectively mean here?
#NPY is not a melanocortin, although it co-exists with AgRP which is an inverse agonist at the MC4 receptor. It's just misleading to mention NPY here.
#''POMC neurons that project to the brainstem''; well actually the hypothalamus is part of the brainstem, so strictly you probably mean the caudal brainstem, but in fact I here you are talking about the POMC neurones that are ''in'' the caudal brainstem rather than those in the arcuate nucleus.
# '''All''' melanocortin receptors "respond" to some POMC products - I think here you're suggesting that MC3 and MC4 are the predominant melanocortin receptors in brain - needs a reference I think.
#melanocortin receptors only bind some POMC products - they do not bind opioids for example
# we wouldn't really say that receptors respond to anything - they bind, they are activated by etc
#you haven't actually mentioned alpha MSH here - the key melanocortin.
[[User:Gareth Leng|Gareth Leng]] 14:08, 2 November 2010 (UTC)
[[User:Cadi M. J. Irvine|Cadi M. J. Irvine]] 21:36, 16 November 2010 (UTC) I was wondering why some of my text isn't appearing on the page?
Well done to you all, there's a lot of good work here.
Cardi, I've corrected your text. The reason it didn't appear on the page is because your references weren't typed in correctly and that upset whole paragraphs. Maybe you should spend a couple of min checking again how to enter refs. Also, I've highlighted some refs in bold, these need to be entered using the wiki.
[[User:Nancy Sabatier|Nancy Sabatier]] 14:13, 17 November 2010 (UTC)
==Errors==
"NPY is not a melanocortin, yet it acts on the Melanocortin receptors to exert orexigenic effetcs"
No, NPY does '''not''' act on melanocortin receptors.[[User:Gareth Leng|Gareth Leng]] 13:56, 3 December 2010 (UTC)

Latest revision as of 11:47, 19 March 2024

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 Definition The regulation of food intake through neuropeptides related to adrenocorticotropic hormone. [d] [e]
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  1. Jessica Ivy 13:13, 28 September 2010 (UTC)
  2. Ruth Callaghan 13:14, 28 September 2010 (UTC)
  3. Cadi M. J. Irvine 13:16, 28 September 2010 (UTC)
  4. Lisa L Hutchison 16:21, 25 October 2010 (UTC)

Figures and Diagrams

Adipocyte.png

You can also insert diagrams or photographs (to Upload files Cz:Upload)). These must be your own original work - and you will therefore be the copyright holder; of course they may be based on or adapted from diagrams produced by others - in which case this must be declared clearly, and the source of the orinal idea must be cited. When you insert a figure or diagram into your article you will be asked to fill out a form in which you declare that you are the copyright holder and that you are willing to allow your work to be freely used by others - choose the "Release to the Public Domain" option when you come to that page of the form.


When you upload your file, give it a short descriptive name, like "Adipocyte.png". Then, if you type {{Image|Adipocyte.png|right|300px|}} in your article, the image will appear on the right hand side.

Begin your article with a brief overview of the scope of the article on interest group. Include the article name in bold in the first sentence.[1]

Remember you are writing an encyclopedia article; it is meant to be readable by a wide audience, and so you will need to explain some things clearly, without using unneccessary jargon. But you don't need to explain everything - you can link specialist terms to other articles about them - for example adipocyte or leptin simply by enclosing the word in double square brackets.

You can write your article directly onto the wiki- but at first you'll find it easier to write it in Word and copy and paste it onto the wiki.

Construct your article in sections and subsections, with headings and subheadings like this:



References

To insert references and/or footnotes in an article, put the material you want in the reference or footnote between <ref> and </ref>, like this:

<ref>Person A ''et al.''(2010) The perfect reference for subpart 1 ''J Neuroendocrinol'' 36:36-52</ref> <ref>Author A, Author B (2009) Another perfect reference ''J Neuroendocrinol'' 25:262-9</ref>.

Look at the reference list below to see how this will look.[2] [3]

If there are more than two authors just put the first author followed by et al. (Person A at al. (2010) etc.)


Select your references carefully - make sure they are cited accurately, and pay attention to the precise formatting style of the references. Your references should be available on PubMed and so will have a PubMed number. (for example PMID: 17011504) Writing this without the colon, (i.e. just writing PMID 17011504) will automatically insert a link to the abstract on PubMed (see the reference to Johnsone et al. in the list.) [4]

Use references sparingly; there's no need to reference every single point, and often a good review will cover several points. However sometimes you will need to use the same reference more than once.


How to write the same reference twice:

Reference: Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. Psychopharmacology 191:391–431 PMID 17072591

First time: <ref name=Berridge07>Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. ''Psychopharmacology'' 191:391–431 PMID 17072591 </ref>

Second time:<ref name=Berridge07/>

This will appear like this the first time [5] and like this the second time [5]


  1. See the "Writing an Encyclopedia Article" handout for more details.
  2. Person A et al. (2010) The perfect reference for subpart 1 J Neuroendocrinol 36:36-52
  3. Author A, Author B (2009) Another perfect reference J Neuroendocrinol 25:262-9
  4. Johnstone LE et al. (2006)Neuronal activation in the hypothalamus and brainstem during feeding in rats Cell Metab 2006 4:313-21. PMID 17011504
  5. 5.0 5.1 Berridge KC (2007) The debate over dopamine’s role in reward: the case for incentive salience. Psychopharmacology 191:391–431 PMID 17072591


Hello. here is a link to an article- haven't read it yet but looks like a nice intro to the glamorous world of melanocortins:

[1] article 1

Jessica Ivy 13:49, 28 September 2010 (UTC)


Jessica, remember to use the Bibliography page for references. Please write the whole ref with author names, year, title, journal, vol, and PubMed link if available.

Nancy Sabatier 17:02, 5 October 2010 (UTC)

Related articles

You'll see that on the Related articles subpage I've placed links to all the articles from the other groups this year - and also to last year's articles. Good luck with this.Gareth Leng 16:01, 9 October 2010 (UTC)


Hi guys, your reference list needs to be developped a bit more, have a look at what the other group have done, it'll give you an idea of how much they already put in. Also, you should start thinking about your introduction and plan for your main article. Nancy Sabatier 16:31, 14 October 2010 (UTC)

The plan looks sensible; you do need to keep a sharp eye out for key experimental studies; I'd suggest that you use the bibliography page to capture key details of experimental studies of particular significance; whether and how you incorporate those in the main article you can decide later. Without more detail and seeing what you're doing I can't give any better feedback at this stage.Gareth Leng 14:29, 25 October 2010 (UTC)


Cadi, if you look at the Mountjoy article (link to it in bibliog) there's quite an interesting bit about the fact that they've not developed specific melanocortin knock out mice. so there are some ideas for future directions etc there. Jessica Ivy 20:29, 26 October 2010 (UTC)

This article is starting to take shape. Good! Though I agree with Nancy that the scope of reading should be increased to encompass original research papers. Watch out for your spelling and make sure you are consistent with terms that might be unfamiliar to the lay reader; AGRP v. AgRP, for example. The latter is more commonly used. John Menzies 12:41, 27 October 2010 (UTC)


Detail

One of the important things that you can learn from writing an encyclopedia article is strict attention to detail; you have to be sparing in what you write and strictly accurate. The same things count in exams. For example, look at the following

"The melanocortin system is the name collectively given for;

  • Neurons arising in the arcuate nucleus of the hypothalamus, and express AgRP,NPY or POMC.
  • POMC neurons that project to the brainstem
  • Melanocortin receptors, predominately MC3R and MC4R that respond to POMC peptides and AgRP."

Several things here almost right but not quite, or ambiguous so it's not clear that you've got it right or not.

  1. 'collectively given': what does collectively mean here?
  2. NPY is not a melanocortin, although it co-exists with AgRP which is an inverse agonist at the MC4 receptor. It's just misleading to mention NPY here.
  3. POMC neurons that project to the brainstem; well actually the hypothalamus is part of the brainstem, so strictly you probably mean the caudal brainstem, but in fact I here you are talking about the POMC neurones that are in the caudal brainstem rather than those in the arcuate nucleus.
  4. All melanocortin receptors "respond" to some POMC products - I think here you're suggesting that MC3 and MC4 are the predominant melanocortin receptors in brain - needs a reference I think.
  5. melanocortin receptors only bind some POMC products - they do not bind opioids for example
  6. we wouldn't really say that receptors respond to anything - they bind, they are activated by etc
  7. you haven't actually mentioned alpha MSH here - the key melanocortin.

Gareth Leng 14:08, 2 November 2010 (UTC)

Cadi M. J. Irvine 21:36, 16 November 2010 (UTC) I was wondering why some of my text isn't appearing on the page?


Well done to you all, there's a lot of good work here. Cardi, I've corrected your text. The reason it didn't appear on the page is because your references weren't typed in correctly and that upset whole paragraphs. Maybe you should spend a couple of min checking again how to enter refs. Also, I've highlighted some refs in bold, these need to be entered using the wiki. Nancy Sabatier 14:13, 17 November 2010 (UTC)

Errors

"NPY is not a melanocortin, yet it acts on the Melanocortin receptors to exert orexigenic effetcs"

No, NPY does not act on melanocortin receptors.Gareth Leng 13:56, 3 December 2010 (UTC)