IgA nephropathy
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In medicine, IgA nephropathy, also called Berger's Disease, is a "chronic form of glomerulonephritis characterized by deposits of predominantly immunoglobulin A in the mesangial area (glomerular mesangium). Deposits of complement C3 and immunoglobulin G are also often found. Clinical features may progress from asymptomatic hematuria to end-stage kidney disease."[1]
Treatment
Treatment options include:
- Inhibitors of the renin angiotensin system according to a meta-analysis of randomized controlled trials.[2]
- Corticosteroids according to a meta-analysis of randomized controlled trials.[3]
- Corticosteroids combined with azathioprine may[4] or may not help[5].
- Oral calcitriol according to a single randomized controlled trial.[6]
References
- ↑ Anonymous (2024), IgA nephropathy (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Reid S, Cawthon PM, Craig JC, Samuels JA, Molony DA, Strippoli GF (2011). "Non-immunosuppressive treatment for IgA nephropathy.". Cochrane Database Syst Rev (3): CD003962. DOI:10.1002/14651858.CD003962.pub2. PMID 21412884. Research Blogging.
- ↑ Zhou YH, Tang LG, Guo SL, Jin ZC, Wu MJ, Zang JJ et al. (2011). "Steroids in the treatment of IgA nephropathy to the improvement of renal survival: a systematic review and meta-analysis.". PLoS One 6 (4): e18788. DOI:10.1371/journal.pone.0018788. PMID 21533280. PMC PMC3075273. Research Blogging.
- ↑ Stangou M, Ekonomidou D, Giamalis P, Liakou H, Tsiantoulas A, Pantzaki A et al. (2011). "Steroids and azathioprine in the treatment of IgA nephropathy.". Clin Exp Nephrol 15 (3): 373-80. DOI:10.1007/s10157-011-0415-3. PMID 21301920. Research Blogging.
- ↑ Pozzi C, Andrulli S, Pani A, Scaini P, Del Vecchio L, Fogazzi G et al. (2010). "Addition of azathioprine to corticosteroids does not benefit patients with IgA nephropathy.". J Am Soc Nephrol 21 (10): 1783-90. DOI:10.1681/ASN.2010010117. PMID 20634300. PMC PMC3013548. Research Blogging.
- ↑ Liu LJ, Lv JC, Shi SF, Chen YQ, Zhang H, Wang HY (2012). "Oral calcitriol for reduction of proteinuria in patients with IgA nephropathy: a randomized controlled trial.". Am J Kidney Dis 59 (1): 67-74. DOI:10.1053/j.ajkd.2011.09.014. PMID 22019331. Research Blogging.