Talk:Schizophrenia

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The "references" section built incorrectly. You should list all the books used in this article at the bibliography subpage. & then list all the notes like <ref>Name, Year. page number.</ref> within the article. And name the section "Notes"

(Chunbum Park 11:20, 5 January 2008 (CST))

I'm not sure I understand. There are no books used in the article, only journal articles. The reference style I'm following seems fairly standard with other medical articles. If I've missed something here, let me know. Richard Pettitt 00:19, 7 January 2008 (CST)

Oh, books, or scholarly journal articles. 1) ppl want in which page you find the info within the article 2) it takes too much space & gets too complicated to copy-paste author date title chapter title isbn publisher copyright etc. So... all the author title date isbn publisher thing goes on the bibliography page. on the "notes section" within the mainspace article you just have "name, date. pp.x". See Japanese invasions of Korea (1592-1598). (Chunbum Park 15:16, 9 January 2008 (CST))

WHO study

I believe a WHO study showed that people who had less access to antipsychic meds had a higher quality of life than those who could afford the meds. I'm assuming this is the "in a glass jar" effect of being on meds. I'm not advocating no meds, but i think this data is something that should be mentioned and is significant.

I also believe I read that 2/3 of homeless in Los Angeles are schizophrenic. Tom Kelly 21:39, 14 January 2008 (CST)

Ok, 2/3 seems too high. Tom Kelly 22:14, 15 January 2008 (CST)

I'm not familiar with this WHO study. Could you dig it up? Also, I added a study on the prevalence of schizophrenia among the homeless.Richard Pettitt

effect of war on schizophrenia

I believe this would be an important section to the article.Tom Kelly 21:47, 14 January 2008 (CST)

percentage of schizophrenics who chain smoke

can you say self medicate? One of those 2,000+ chemicals in cigarette smoke must be doing something we have not yet discovered. Tom Kelly 21:47, 14 January 2008 (CST)

I added something on cigarettes under the treatment section.Richard Pettitt

I know that one hypothesis, theory, and some preliminary data predict that another chemical in cigarettes may be the chemical they self-medicate with (because nicotine alone doesn't explain the smoking. I will ask around for more info. Tom Kelly 22:10, 15 January 2008 (CST)

Yes, tobacco contains monoamine oxidase inhibitors (harman, or something like that), and clinical research suggested that they are at least in great part responsible for reinforcement of the urge to self-administer tobacco. OTOH, MAOI can cause schizophrenia-like symptoms. There's definitely something to dig here, IMO. The research I have in mind was done in France. Gotta go. Pierre-Alain Gouanvic 13:24, 16 January 2008 (CST)

Neuropharmacology. 2007 May;52(6):1415-25. Epub 2007 Feb 20.

Tranylcypromine enhancement of nicotine self-administration.

Moreover, an increase in extracellular dopamine in the nucleus accumbens was detected, using microdialysis, following nicotine (60 microg/kg) injection in tranylcypromine pre-treated rats. Depending on the time of tranylcypromine pretreatment (20 or 1 h), MAO activity was decreased by 72% and 99% and nicotine intake at day 5 was increased by 619 and 997%, respectively. Taken together, these results indicate that in a stringent self-administration acquisition test, MAO inhibition increases the rewarding effect of low doses of nicotine, possibly via a dopamine-dependent mechanism.

Schizophrenia is an hyperdopaminergic disorder, IMAOs cause dopamine elevations; high dopamine contributes to the reinforcement of tobacco addiction; schizophrenics require lower doses of the IMAO in tobacco to get the reinforcing effect. IMO. Pierre-Alain Gouanvic 19:20, 17 January 2008 (CST)

First person account, to fill the gap left by the DSM copyright restriction

Hello,

I wonder if we could use the moving story told by an investigator in the fields of paranoia and schizophrenia research, published in Schizophrenia Bulletin 2007 33(1):166-17: Peer-Professional First-Person Account: Schizophrenia From the Inside—Phenomenology and the Integration of Causes and Meanings, Peter K. Chadwick. See top of page for permissions. Pierre-Alain Gouanvic 19:06, 17 January 2008 (CST)