Diabetic nephropathy

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In medicine, diabetic nephropathies, also called Kimmelstiel-Wilson Disease and glomerulosclerosis, are "kidney injuries associated with diabetes mellitus and affecting kidney glomerulus; arterioles; kidney tubules; and the interstitium. Clinical signs include persistent proteinuria, from microalbuminuria progressing to albuminuria of greater than 300 mg/24 h, leading to reduced glomerular filtration rate and end-stage renal disease."[1]


Telmisartan, an angiotensin II type 1 receptor blocker, slows the increase in albuminuria but may worsen the serum creatinine and glomerular filtration rate.[2]


Diabetic nephropathy might be reversible after pancreas transplantation.[3]


  1. Anonymous (2023), Diabetic nephropathy (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. Mann JF, Schmieder RE, Dyal L, McQueen MJ, Schumacher H, Pogue J et al. (2009). "Effect of telmisartan on renal outcomes: a randomized trial.". Ann Intern Med 151 (1): 1-10, W1-2. PMID 19451556.
  3. Fioretto P, Steffes MW, Sutherland DE, Goetz FC, Mauer M (1998). "Reversal of lesions of diabetic nephropathy after pancreas transplantation.". N Engl J Med 339 (2): 69-75. PMID 9654536.