Spironolactone

Spironolactone is an aldosterone antagonist used to treat edema associated with congestive heart failure, nephrotic syndrome or hepatic cirrhosis. Although it can also be used treat hirsutism and acne by effecting the endocrine system, such use can lead to adverse side effects. Its IUPAC name is S-[(7R,8R,9S,10R,13S,14S,17R)-10,13-dimethyl-3,5'-dioxospiro[2,6,7,8,9,11,12,14,15, 16-decahydro-1H-cyclopenta[a]phenanthrene-17,2'-oxolane]-7-yl] ethanethioate.

trade names

Abbolactone Acelat Aldace Aldactazide Aldactide Aldactone Aldactone A Alderon Aldopur Almatol Altex Aquareduct Deverol Diatensec Dira Duraspiron Espironolactona [INN-Spanish] Euteberol Lacalmin Lacdene Laractone Melarcon Nefurofan Osyrol SNL Sagisal Sincomen Spiresis Spiretic Spiridon Spiro-Tablinen Spiroctan Spiroctanie Spiroderm Spirolactone Spirolakton Spirolang Spirolone Spirone Spironocompren Spironolactone A Spironolactone [BAN:INN:JAN] Spironolactonum [INN-Latin] Spironolattone [DCIT] Sprioderm Supra-puren Suracton Uractone Urusonin Verospiron Verospirone Verospirone Opianin Xenalon

references

Material adapted from Drug Bank at (http://redpoll.pharmacy.ualberta.ca/drugbank/cgi-bin/getCard.cgi?CARD=APRD01234)