Pyrroloquinoline quinone: Difference between revisions
imported>Pedro Silva No edit summary |
imported>Pedro Silva No edit summary |
||
| Line 4: | Line 4: | ||
PQQ was reported to be a [[vitamin]] in [[mouse|mice]] on [[April 24]] [[2003]] by a research team led by Takafumi Kato of the [http://www.riken.go.jp/engn/index.html Japanese Institute of Physical and Chemical Research] ([http://www.brain.riken.jp/labs/mdmd/pqq/ source]). However, these conclusions have been strongly challenged. | PQQ was reported to be a [[vitamin]] in [[mouse|mice]] on [[April 24]] [[2003]] by a research team led by Takafumi Kato of the [http://www.riken.go.jp/engn/index.html Japanese Institute of Physical and Chemical Research] ([http://www.brain.riken.jp/labs/mdmd/pqq/ source]). However, these conclusions have been strongly challenged. | ||
==References== | ==References== | ||
* Role of PQQ as a mammalian enzyme cofactor? | * [http://dx.doi.org/10.1038/nature03322 Leigh M. Felton and C. Anthony, Role of PQQ as a mammalian enzyme cofactor? ] | ||
* | * [Robert Rucker, David Storms, Annemarie Sheets, Eskouhie Tchaparian,Andrea Fascetti Is pyrroloquinoline quinone a vitamin? http://dx.doi.org/10.1038/nature03323] | ||
[[Category:CZ Live]] | [[Category:CZ Live]] | ||
Revision as of 14:23, 4 November 2006
Pyrroloquinoline quinone (PQQ) was originally discovered in 1978 in methanol dehydrogenase fom 'Hyphomicrobium' X. It is present as a non-covalently bound cofactor in several bacterial dehydrogenases involved in the oxidation of alcohols ans sugars. The biochemically relevant redox states are the fully oxidized quinone form, the radical semiquinone form and the reduced quinol. The reduced form is only stable when bound to enzyme or at low pH, whereas the semiquinone is only stable at high pH and anerobic conditions.
PQQ was reported to be a vitamin in mice on April 24 2003 by a research team led by Takafumi Kato of the Japanese Institute of Physical and Chemical Research (source). However, these conclusions have been strongly challenged.
References
- Leigh M. Felton and C. Anthony, Role of PQQ as a mammalian enzyme cofactor?
- [Robert Rucker, David Storms, Annemarie Sheets, Eskouhie Tchaparian,Andrea Fascetti Is pyrroloquinoline quinone a vitamin? http://dx.doi.org/10.1038/nature03323]