Pharmacogenomics: Difference between revisions

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imported>Robert Badgett
imported>Robert Badgett
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Among drugs frequently cited in adverse drug reactions, 60% are metabolized by enzymes with genetic variations in metabolism. 7% to 22% of randomly selected have such variation.<ref name="pmid11710893">{{cite journal |author=Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W |title=Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review |journal=JAMA |volume=286 |issue=18 |pages=2270–9 |year=2001 |pmid=11710893 |doi=}}</ref>
Among drugs frequently cited in adverse drug reactions, 60% are metabolized by enzymes with genetic variations in metabolism. 7% to 22% of randomly selected have such variation.<ref name="pmid11710893">{{cite journal |author=Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W |title=Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review |journal=JAMA |volume=286 |issue=18 |pages=2270–9 |year=2001 |pmid=11710893 |doi=}}</ref>


An example is the SLCO1B1 Variants and statin-induced myopathy.<ref> The SEARCH Collaborative Group. (2008) [http://content.nejm.org/cgi/content/full/NEJMoa0801936 SLCO1B1 Variants and Statin-Induced Myopathy]</ref>
An example is the SLCO1B1 Variants and statin-induced myopathy.<ref name="pmid18650507"> The SEARCH Collaborative Group. (2008) [http://content.nejm.org/cgi/content/full/NEJMoa0801936 SLCO1B1 Variants and Statin-Induced Myopathy]. New Eng J Med. PMID 18650507</ref>


==Drug efficacy==
==Drug efficacy==

Revision as of 12:17, 24 July 2008

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Pharmacogenomics, or pharmacogenetics, is the "branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (biotransformation)."[1]

Drug toxicity

For more information, see: Drug toxicity.

Among drugs frequently cited in adverse drug reactions, 60% are metabolized by enzymes with genetic variations in metabolism. 7% to 22% of randomly selected have such variation.[2]

An example is the SLCO1B1 Variants and statin-induced myopathy.[3]

Drug efficacy

Heart failure and hypertension may be an examples were there are racial variations in responses to drugs. Presumably these variations are due to pharmacogenomics.

References

  1. Anonymous. Pharmacogenetics. National Library of Medicine. Retrieved on 2008-01-22.
  2. Phillips KA, Veenstra DL, Oren E, Lee JK, Sadee W (2001). "Potential role of pharmacogenomics in reducing adverse drug reactions: a systematic review". JAMA 286 (18): 2270–9. PMID 11710893[e]
  3. The SEARCH Collaborative Group. (2008) SLCO1B1 Variants and Statin-Induced Myopathy. New Eng J Med. PMID 18650507