Melanocyte-stimulating hormone: Difference between revisions
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'''Sexual Function''' | '''Sexual Function''' | ||
Activation of MC4R plays a role in erectile function in males while MC3R is believed to induce [[lordosis]] in females. | Activation of MC4R plays a role in erectile function in males while MC3R is believed to induce [[lordosis]] in females. | ||
{{Image|Table.jpg|centre|700px|'''The Melanocortin Receptors''', adapted from Yang ''et al.'' (2003) | {{Image|Table.jpg|centre|700px|'''The Melanocortin Receptors''', adapted from Yang ''et al.'' (2003)}} | ||
==References== | ==References== | ||
{{Reflist}} | |||
Latest revision as of 04:18, 14 May 2023
Melanocyte-stimulating hormones are a group of peptides produced via the cleavage of pro-opiomelanocortin (POMC).
Inflammation α-MSH has potent anti-inflammatory effects although its precise mechanism is not fully understood, it is believed to influence vascular permeability and thus may act by decreasing it.
Cardiovascular Central application of γ- MSH (MC3R specific agonist, can induce tachycardia, while the bradychardia that occurs following electrical stimulation of the arcuate nucleus can be inhibited by the administration of SHU-9119 into the DVC. As it acts through MC4R this highlights a potential role for this receptor in mediating cardiovascular control.
Natriuresis γ-MSH acts on MC3R in the kidney to promote natriuresis, and hence a deficiency of this peptide, or a mutation of the receptor results in salt-sensitive hypertension in mice.
Sexual Function Activation of MC4R plays a role in erectile function in males while MC3R is believed to induce lordosis in females.
