Healthy obesity
What is Healthy Obesity?
Although obesity is a major risk factor for cardiovascular disease and type 2 diabetes mellitus, about a third of obese individuals maintain healthy cardiometabolic profiles; this phenotype of healthy obesity may be linked to the location of adipose tissue and the metabolic characteristics of the fat. Some data also suggest that weight loss by healthy obese subjects may have an adverse impact on their favorable cardiometabolic profile. [1] [2]
Why is Healthy Obesity Worthwhile investigating?
Investigating why H.O can't be regarded as simply obesity e.g. treatment problems, some weight losing methods actually detrimental to H.O individual
Waste of money to treat all H.O individuals as simply obese?
The Cause of Healthy Obesity?
The role of Adiponectin in H.O
Criticism of Current Data - Does the Healthy Obesity Phenotype Actually Exist?
Investigating whether or not H.O is a genuine phenotype or has this subgroup emerged as a result of methodological/ measurement issues? Are these people healthy and truely obese/ are they obese yet truely healthy?
Conflicting findings of meta-analyses from NEJM and American heart journal etc. the impact of adjusting for physical activity and the role of other parameters. eg. lack of any the metabolic syndrome criteria & no insulin resistance counts as healthy. non metabolic morbidity.
or if that overlaps too much with someone else's section I could cover:
the role of ethnicity: A higher proportion of black healthy obese? Possible underlying mechanism?
Losing weight can be harmful for the healthy obese: (Gaesser 1999)Tijmen van Slageren 18:38, 24 October 2011 (UTC)
Conclusions
References
- ↑ Lee CM et al. (2008) Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis J Clin Epidemiol 61:646-53 PMID 18359190
- ↑ Wildman RP (2009) Healthy obesity Curr Opin Clin Nutr Metab Care 12:438-43 PMID 19474713