Cidofovir: Difference between revisions
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{{Chem infobox | {{Chem infobox | ||
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'''Cidofovir''' ('''CDV''') is an [[antiviral drug]] used to treat herpes [[cytomegalovirus]] (CMV) [[retinitis]] associated with [[HIV]]/[[AIDS]]. It is an analog of the natural nucleoside [[cytosine]] used in [[DNA]]. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. '''Warning''':''Acute renal failure requiring dialysis and/or contributing to death have | '''Cidofovir''' ('''CDV''') is an [[antiviral drug]] used to treat herpes [[cytomegalovirus]] (CMV) [[retinitis]] associated with [[HIV]]/[[AIDS]]. It is an analog of the natural nucleoside [[cytosine]] used in [[DNA]]. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. '''Warning''':''Acute renal failure requiring dialysis and/or contributing to death have occurred with as few as one or two doses of cidofovir''. | ||
== Chemistry == | == Chemistry == | ||
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== External Links == | == External Links == | ||
{{CZMed}} | |||
Latest revision as of 01:44, 10 February 2010
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| cidofovir | |||||||
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| Uses: | antiviral drug | ||||||
| Properties: | cytosine analog | ||||||
| Hazards: | renal failure | ||||||
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Cidofovir (CDV) is an antiviral drug used to treat herpes cytomegalovirus (CMV) retinitis associated with HIV/AIDS. It is an analog of the natural nucleoside cytosine used in DNA. It selectively inhibits the CMV DNA polymerase, probably as the diphosphate, at concentrations 8- to 600-fold lower than needed to inhibit human DNA polymerases. Once incorporated into the growing viral DNA chain, the rate of DNA chain synthesis is reduced. Kidney damage and reduced levels of white blood cells and platelets may occur when using this drug. Warning:Acute renal failure requiring dialysis and/or contributing to death have occurred with as few as one or two doses of cidofovir.
Chemistry
Its chemical name is [(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid and its chemical formula is C8H14N3O6P. It is sold under the brand names HPMPC and Vistide.
External Links
The most up-to-date information about Cidofovir and other drugs can be found at the following sites.
- Cidofovir - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Cidofovir - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Cidofovir - Detailed information from DrugBank.