Paraneoplastic cerebellar degeneration

In neurology and oncology, paraneoplastic cerebellar degeneration is a type of nervous system paraneoplastic syndrome and is a "cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and gait ataxia; dysarthria; and nystagmus, pathologic. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals."