Anti-nuclear antibodies
Jump to navigation
Jump to search
In medicine, anti-nuclear antibodies are "autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.[1]
A first and indirect measurement of these antibodies was the 1940-vintage lupus cell preparation, a microscopic procedure no longer used. They include:[2]
- Antineutrophil cytoplasmic antibodies (ANCA)
- Anti-single-stranded DNA (ssDNA)
- Anti-double-stranded DNA (dsDNA)
- Anti-Smith (anti-Sm) and anti-ribonucleoprotein antibodies (anti-RNP)
- Antiphospholipid antibodies
References
- ↑ Anonymous (2024), Anti-nuclear antibodies (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Peter H. Schur and Rober H. Scherling (2004), Chapter 5: Laboratory tests in rheumatic disorders, Practical Rheumatology (Third ed.), Mosby, ISBN 03230299396