Selective serotonin uptake inhibitor

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Revision as of 09:30, 10 February 2010 by imported>Robert Badgett (New page: In medicine, '''serotonin uptake inhibitors''' are second-generation antidepressants that potentiate the effect of serotonin by blocking its uptake from the synaptic cleft. ==...)

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In medicine, serotonin uptake inhibitors are second-generation antidepressants that potentiate the effect of serotonin by blocking its uptake from the synaptic cleft.

Examples

Citalopram (generic). Can be combined with bupropion.
Duloxetine. Inhibits cytochrome P-450 CYP2D6.
Fluoxetine (generic). Inhibits cytochrome P-450 CYP2D6.
Paroxetine (generic). Inhibits cytochrome P-450 CYP2D6. May increase death from breast cancer among women taking tamoxifen.^[1]
Sertraline (generic)

References

↑ Kelly, Catherine M; David N Juurlink, Tara Gomes, Minh Duong-Hua, Kathleen I Pritchard, Peter C Austin, Lawrence F Paszat (2010-02-08). "Selective serotonin reuptake inhibitors and breast cancer mortality in women receiving tamoxifen: a population based cohort study". BMJ 340 (feb08_1): c693. DOI:10.1136/bmj.c693. Retrieved on 2010-02-10. Research Blogging.

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