Sildenafil

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Sildenafil3.jpg
sildenafil
IUPAC name:
Synonyms: Viagra®
Formula:
 Uses: Erectile Dysfunction
 Properties: PDE-5 inhibitor
 Hazards: cardiovascular risks
Mass (g/mol): CAS #:


Sildenafil, widely known as Viagra®, is a medication used to treat erectile dysfunction. It was the first commercialized selective phosphodiesterase type 5 (PDE-5) inhibitor and was immediately popular both for treating erectile dysfunction and for recreational use. Sildenafil works by binding to phosphodiesterase type-5 enzymes, competing with the natural ligand cyclic guanine monophosphate (cGMP), which is structurally similar to sildenafil. Vardenafil, a newer and more potent PDE-5 inhibitor, is nearly identical to sildenafil, while tadalafil is considerably different in structure.

References

J. D. Corbin and S. H. Sharron. "Molecular Biology and Pharmacology of PDE-5-Inhibitor Therapy for Erectile Dysfunction". J. Androl. 24: S38-S41.

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