Fluconazole

(CC) Image: David E. Volk
Fluconazole.

Fluconazole, IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat oropharyngeal (vaginal) candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with the enzyme 14-α demethylase that converts lanosterol to ergosterol. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage.

Brand Names

• Biocanol®
• Biozolene®
• Diflucan®
• Elazor®
• Flucazol®
• Flucostat®
• Flukezol®
• Flunizol®
• Flusol®
• Pritenzol®
• Triflucan®

External Links

• Fluconazole - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Drug Bank at http://www.drugbank.ca/cgi-bin/getCard.cgi?CARD=DB00196