Platelet glycoprotein GPIIb-IIIa complex
Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]
Role in medicine
A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.
Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).
Glycoprotein IIb/IIIa inhibitors are platelet aggregation inhibitors used to treat cardiovascular diseases.
References
- ↑ Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.