Rifampin
In medicine, rifampin, also called rifampicin, is "a semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms"[1]
Among its uses is the treatment of staphylococcus aureus.[2] For this purpose, rifampicin (10 mg/kg twice daily, maximum 900 mg twice daily), intravenously for the first week and then given orally, combined with cotrimoxazole (sulfamethoxazole 40 mg/kg/day, trimethoprim 8 mg/kg/day).
External links
The most up-to-date information about Rifampin and other drugs can be found at the following sites.
- Rifampin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
- Rifampin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
- Rifampin - Detailed information from DrugBank.
References
- ↑ Anonymous (2024), Rifampin (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Nguyen S, Pasquet A, Legout L, Beltrand E, Dubreuil L, Migaud H et al. (2009). "Efficacy and tolerance of rifampicin-linezolid compared with rifampicin-cotrimoxazole combinations in prolonged oral therapy for bone and joint infections.". Clin Microbiol Infect 15 (12): 1163-9. DOI:10.1111/j.1469-0691.2009.02761.x. PMID 19438638. Research Blogging.