Antineoplastic agent/Related Articles
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- See also changes related to Antineoplastic agent, or pages that link to Antineoplastic agent or to this page or whose text contains "Antineoplastic agent".
Parent topics
- Cancer [r]: A generic term for a large group of diseases that can affect any part of the body; one defining feature is the rapid creation of abnormal cells that grow beyond their usual boundaries, and which can then invade adjoining parts of the body and spread to other organs. [e]
- Immunology [r]: The study of all aspects of the immune system in all animals. [e]
- Oncology [r]: The medical diagnosis and treatment of neoplasia, using pharmacologic, radiation, immunologic and surgical techniques; relevant formal subspecialties are medical oncology in internal medicine and radiation oncology in radiology; surgeons also may specialize in neoplasia [e]
Subtopics
Alkylating agents
Nitrogen mustard agents
- Cyclophosphamide [r]: A medication and immunosuppressive agent used to treat lymphoma and leukemia. [e]
- Chlorambucil [r]: Add brief definition or description
- Melphalan [r]: Add brief definition or description
- Chlormethine [r]: Add brief definition or description
- Ifosfamide [r]: Add brief definition or description
- Trofosfamide [r]: Add brief definition or description
- Prednimustine [r]: Add brief definition or description
Alkyl sulfonates
- Busulfan [r]: Add brief definition or description
- Treosulfan [r]: Add brief definition or description
- Mannosulfan [r]: Add brief definition or description
Ethylene imines
ATC/DDD group L01AC.
Nitrosoureas
ATC/DDD group L01AD.
Epoxides
ATC/DDD group L01AG.
Other alkylating agents
ATC/DDD group L01AX.
Antimetabolites
- Antimetabolite [r]: A group of drugs that suppress various metabolic mechanisms, and are useful in cancer chemotherapy and other therapy often of autoimmune disease [e]
ATC/DDD group L01B.
Folic acid analogues
- Folic acid [r]: Nutrient required for a normal pregnancy. [e]
- Folic acid analog antimetabolite [r]: Inhibitors of the enzyme, dihydrofolate reductase converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are used as antineoplastic agents and immunosuppressants [e]
ATC/DDD group L01BA. Examples include:
- Methotrexate [r]: An inhibitor of tetrahydrofolate dehydrogenase, which prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA; it has a wide range of medical applications. [e]is an inhibitor of tetrahydrofolate dehydrogenase and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA."[5]
- Raltitrexed [r]: Add brief definition or description
- Pemetrexed [r]: Add brief definition or description
Purine analogues
ATC/DDD group L01BB. Examples include:
- Mercaptopurine [r]: Add brief definition or description is an "antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
- Tioguanine [r]: Add brief definition or description
- Cladribine [r]: Add brief definition or description
- Fludarabine [r]: Add brief definition or description
- Clofarabine [r]: Add brief definition or description
- Nelarabine [r]: Add brief definition or description
Pyrimidine analogues
ATC/DDD group L01BC. Examples include:
- Cytarabine [r]: Add brief definition or description"pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties."[7]
{{r|fluorouracil {{r|tegafur {{r|carmofur {{r|gemcitabine {{r|capecitabine {{r|azacitidine {{r|decitabine
Plant alkaloids and other natural products
ATC/DDD group L01C.
Vinca alkaloids and analogues
- Vinca alkaloid [r]: Add brief definition or description
- Vincristine [r]: Add brief definition or description
- Vinblastine [r]: Add brief definition or description
ATC/DDD group L01CA.
Podophyllotoxin derivatives
ATC/DDD group L01CB.
Colchicine derivatives
ATC/DDD group L01CC.
Taxanes
ATC/DDD group L01CD.
Other plant alkaloids and natural products
ATC/DDD group L01CX.
ATC/DDD group L01D.
Actinomycines
ATC/DDD group L01DA.
ATC/DDD group L01DB.
Other cytotoxic antibiotics
ATC/DDD group L01DC.
Other antineoplastic agents
ATC/DDD group L01X.
Platinum compounds
- Cisplatin [r]: Add brief definition or description
- Carboplatin [r]: Add brief definition or description
ATC/DDD group L01XA.
Methylhydrazines
ATC/DDD group L01XB.
Monoclonal antibodies
ATC/DDD group L01XC. Examples include:
Anti-EGRF
- Epidermal growth factor [r]: Add brief definition or description
- Panitumumab [r]: Add brief definition or descriptionan "antibody that blocks receptors for epidermal growth factor (Entrez protein); approved for advanced colon cancer".[8]
Anti-EpCAM
- Edrecolomab [r]: Add brief definition or descriptionis monclonal antibody against EpCAM (Entrez protein). Edrecolomab is a "anticolorectal carcinoma antibody for treatment of advanced colorectal carcinoma".[9]
=Anti-ERBB2
- Trastuzumab [r]: Add brief definition or description"HER2 (Entrez protein) antibody that lengthens remission time in metastatic breast cancer."
Anti-CD3 and anti-EpCAM
- Catumaxomab [r]: Add brief definition or description Is a monoclonal antibody against CD3 (Entrez protein)and EpCAM (Entrez protein). "Extracorporeal PBMNC coating with catumaxomab may be an option to control intravascular cytokine release induced by therapeutic antibodies".[11]
Anti-MS4A1 (CD20 antigen)
- Rituximab [r]: Add brief definition or description is a "genetically engineered anti-CD20 (Entrez protein) antibody for the treatment of B-cell lymphoma".[12]
Anti-SIGLEC3 (CD33)
- Gemtuzumab [r]: Add brief definition or descriptionis an "anti-CD33 (Entrez protein) antibody calicheamicin conjugate".[13]
Anti-CD52=
* Alemtuzumab is a "a therapeutic antibody directed against the CDw52 antigen (Entrez protein) expressed by the lymphocytes and has proven lytic abilities both in vitro and in vivo; has been sequenced".[14]
Anti-VEGF
- Bevacizumab [r]: Add brief definition or descriptionis an "anti-VEGF (Entrez protein) monoclonal antibody consisting of humanized murine antibody with antigen-binding, complementary-determining regions from murine VEGF".[15]
Sensitizers used in photodynamic/radiation therapy
ATC/DDD group L01XD.
Protein kinase inhibitors
ATC/DDD group L01XE
- Imatinib [r]: Add brief definition or description
- Gefitinib [r]: Add brief definition or description
- Erlotinib [r]: Add brief definition or description
- Sunitinib [r]: Add brief definition or description
- Sorafenib [r]: Add brief definition or description
- Dasatinib [r]: Add brief definition or description
- Lapatinib [r]: Add brief definition or description
- Nilotinib [r]: Add brief definition or description
- Temsirolimus [r]: Add brief definition or description