Sildenafil

sildenafil
IUPAC name: Synonyms: Viagra® Formula:
Uses:	Erectile Dysfunction
Properties:	PDE-5 inhibitor
Hazards:	cardiovascular risks
Mass (g/mol): CAS #:

Sildenafil, widely known as Viagra®, is a medication used to treat erectile dysfunction. It was the first commercialized selective phosphodiesterase type 5 (PDE-5) inhibitor and was immediately popular both for treating erectile dysfunction and for recreational use. Sildenafil works by binding to phosphodiesterase type-5 enzymes, competing with the natural ligand cyclic guanine monophosphate (cGMP), which is structurally similar to sildenafil. Vardenafil, a newer and more potent PDE-5 inhibitor, is nearly identical to sildenafil, while tadalafil is considerably different in structure.

Sildenafil - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine). Template:MedMaster Template:DrugBank

References

J. D. Corbin and S. H. Sharron. "Molecular Biology and Pharmacology of PDE-5-Inhibitor Therapy for Erectile Dysfunction". J. Androl. 24: S38-S41.