Platelet glycoprotein GPIIb-IIIa complex

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Platelet Glycoprotein GPIIb-IIIa Complex is a "platelet membrane glycoprotein complex important for platelet adhesion and aggregation. it is an integrin complex containing integrin alphaiib and integrin beta3 which recognizes the arginine-glycine-aspartic acid (rgd) sequence present on several adhesive proteins. as such, it is a receptor for fibrinogen; von Willebrand factor; fibronectin; vitronectin; and thrombospondins."[1]

Role in medicine

A deficiency of GPIIb-IIIa is the cause of Glanzman Thrombasthenia, which causes a prolonged bleeding time.

Antibodies to GPIIb-IIIa is the cause of most cases of chronic idiopathic thrombocytopenic purpura (ITP).

Glycoprotein IIb/IIIa inhibitors are platelet aggregation inhibitors used to treat cardiovascular diseases.

References

  1. ↑ Anonymous. Platelet Glycoprotein GPIIb-IIIa Complex. National Library of Medicine. Retrieved on 2008-01-10.
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