Talk:Diabesity

Charlie Player 20:00, 13 October 2009 (UTC) Nicholas Devlin 11:21, 14 October 2009 (UTC)

John Park 12:08, 20 October 2009 (UTC)

Luke, good start, remember to update the bibliography page with your key readings. John, nice selection too. Charlie and Nicholas, im looking forward to read your contribution! Celine Caquineau 09:52, 14 October 2009 (UTC)

John Park GUYS!!!! we need input! I dont want to sound pedantic but getting a wee bit worried about how we are going to write this up. We need to meet up I think, and organise on structure. What each is going to write. etc.

I've put up a brief intro. I know its not very good but at least its a start. I was thinking Diabesity -

Intro - (the increasing trend of obesity, and the huge increase in rates of diabetes )

The relationship between Diabetes and Obesity (causal evidence and studies etc)

The Pathophysiology of how obesity can lead to Diabetes (maybe your bit Luke plus other things)

Treatments

Future work

Collaborations (e.g. Diabesity the EU project etc)

Just a start. !!!! But suggestions please!!!

Katie Rowland 08:26, 20 October 2009 (UTC) Hey everyone,sorry Ive only just got on - only got my account thing activated this morning! I agree we need to get things going, should we meet up to discuss? Or just split the sections? Im happy with that plan John, Im happy to do a section on treatment if no-one else has done that yet? Read the intro you did John and its a great start.

Welcome to Citizendium Katie. John, I think your plan looks really good. Still waiting for Charlie's and Nicholas' inputs... Nancy Sabatier 09:29, 20 October 2009 (UTC)

Katie Rowland 09:32, 20 October 2009 (UTC)I've put in some references for my bibliography section - as I don't know what im supposed to be doing Ive gone along the treatment line - if this is wrong just let me know asap! Also are our review and primary research papers supposed to be put on seperatly in different sections?

Katie, you need indeed to place your references in the appropriate 'reviews' or 'research papers' sections.Celine Caquineau 13:37, 21 October 2009 (UTC)

Overall, I agree with John and Katie, you need to discuss your plan (nice start John)! I encourage you to meet or at least use the talkpage. Luke, you've written your section but you still need to participate in the overall structure and organisation of the article. You also have to update the bibliography page with your references. Charlie and Nicholas, your group need your contributions!!! Charlie, I need to know whether you're still here! Celine Caquineau 13:37, 21 October 2009 (UTC)

I am sorry I have not been on here for a while. I ahve been doing some research into visceral fat deposition, insulin resistance leading to type 2 diabetes. I will put up a draft on Sunday hopefully. I agree we should meet up. When are people free? Charlie Player 13:58, 21 October 2009 (UTC)

Katie Rowland 10:03, 22 October 2009 (UTC) Ive put my very rough draft for the treatment section up, left the references in there as thought we could sort out references out after we have everything up? I think meeting up is a good idea, how about after the app and ob lecture on tueday?

A lot of info, well done guys. Just thinking in the last paragraph you could maybe put in a couple of links to the drugs page e.g for orlistat, some of the diabetic drugs. Only a suggestiong though! Rachael Kirkbride

Wow, a lot of information. This is really good and interesting to read but remembers it's supposed to be an encyclopedia article. Maybe you could try and cut it down a bit which would make it more manageable for other people to read and understand? I agree with Rachael's comment about the link between the diabetic drugs and the page on drug treatment for obesity. This would be a good way of linking together the articles. Otherwise all really good stuff! Amelia Sheldon 14:24, 2 November 2009 (UTC)

I thought it was all very good but i agree with Amelia... It's a slightly overwhelming amount of info! Also i thought that treatment of obesity and t2d was a little bit repetitive in places and a few sentences maybe could be combined... Hugely impressive though! 'Emily Moore 17:25, 2 November 2009 (UTC)'

Hey guys - went through the article yesterday just for grammar and ensuring that our abbreviations were consistent and defined - i.e. NIDDM has been replaced by T2DM etc. Luke the bits in bold in your section are things that I thought could be taken out but thought you should probs take a wee look just to make sure...kinda reckon the other groups are leaving us behind a bit on the impressive stakes with regard to pictures and organisation..I was going to try and sort everyone's references but again decided that each doing our own was probably a better plan just to avoid confusion/incorrect citations - think on tuesday luke, charlie and I said that we thought putting 'so and so et al' in brackets might be the easiest way to avoid number nightmares? Have had a little look for pics and the following links have some ideas but obviously its up to you what you put in your own sections.. http://www.healthrenewal.org/InsulinResistance.shtml http://www.thebody.com/content/treat/art39501.html http://www.joslinresearch.org/PINET/InvestigatorDetail.asp?InvestigatorID=21

I put drug names in bold in the last section but think it could probably do with being split into mini-sub-paragraphs? Also drugs are mentioned in a couple of the other sections including 'exenatide' - think it was in the food reward section? but might be worth a mention? So as this is supposed to be finished by tuesday - gulp! anyone have any objections to meeting up on monday lunch/afternoon/evening or tuesday before/after the lecture?Hannah Frost 17:17, 13 November 2009 (UTC)

Feedback on your article so far

You’ve already got quite a lot here, well done. Your plan is pretty good, although you still don’t seem to have a clear idea of what to put in Section 1. In the introduction you give a definition and background for the concept of Diabesity, which is really good, but I think you really need to define in a few words what type-2 diabetes is at some point too. That could come with a brief reminder of how glucose concentration is regulated in the body, maybe with a simple diagram showing the basic principles of glucose homeostasis (just a suggestion).

The paragraph on Visceral Fat is well documented and again, there’s been quite a lot of work put into it, however, I found it quite difficult to read mainly because of the numerous abbreviations, some of which haven’t even been defined (FFAs, TG, VLDL, LDL, HDL). Remember that Citizendium articles should be understandable to a general public. I know this is still a rough draft but this section will need to be easier to read. Sections on Causes of diabetes: again, good work here but a complete lack of references, remember to add them in the text.

From your Talk page, it appears that some of you made some effort to interact, and give each other inputs. However, Luke has not signed in for ages and seems to have totally disappeared once his contribution has been downloaded. This is not what we expected from you, one of the main objectives of this tutorial is about team work, it is as important as the content of the article itself. So Luke please come back on this page! And Hannah, Celine told me that you joined this group, where are you??

Finally, as Rachael rightly pointed out, your last paragraph has obvious links with the Drug Treatment for Obesity article, so I suggest that you don’t develop it as much but instead refer to that other article. Remember to have a look at what the other groups have done. Nancy Sabatier 14:39, 28 October 2009 (UTC)

In reference to having more discussion on drug therapies, there are a number of potential drug targets and treatments that are currently being translated from the animal model findings.

Nick, you're lots of good stuff on how ER stress causes diabetes, but how does obesity affect ER stress? Luke Kennedy Burke

I agree with Nancy, I can see a lot of work has been done. Diabesity is a vast theme and your introduction should have the key role of stating what are the direction and focus of your article. It should also provide links between the different sections, for the moment it looks a bit too much like several articles rather than one. I also think that you should define key terms like type-2 diabetes by providing links with other articles done in citizendium (Have a look at Diabetes mellitus type 2). It reads well but don’t overuse abbreviations. I suggest you now remove any left-overs from the original template to facilitate the reading. Studies and facts should be referenced in the text and in the ‘References’ section at the end of the article, using the Citizendium references format, I’ve done an example in 'visceral fat' part, so you can have a look how it’s done. The bibliography page needs to be updated accordingly. Finally, Im glad to see that you are already using the talkpage a bit more, I can only encourage you to interact more by commenting on what’s been done and what is left to do; you’ve done loads but there is still a fair amount to do! I have no doubt that you‘ll produce a really good article but all of you need to give inputs now! Celine Caquineau 11:15, 29 October 2009 (UTC)

Luke asked me: 'Our topic is covering the evidence that obesity is a risk factor for type 2 diabetes. This could involved correlative studies, but I have interpretted the question as 'cover the mechanisms that makes obesity a risk factor for type 2 diabetes'. There are several proposed mechanisms, e.g. ER stress, immune response to adipose inflammation, resistin, pre-natal programming, and I think that outlining and arguing the case for each would make for a more interesting citizendium peice and ultimately a better exam essay.What do you think?'

Well, the group should decide.Diabesity is a vast theme. Keep the task in mind:'Cover the evidence (including genetics) that obesity is a risk factor for Type 2 diabetes'! But im happy for you to cover what you think is interesting as long as you make the case for it in your introduction and that you link it well with what you already have. and remember it's an article for an encyclopaedia not an essay. Celine Caquineau 11:28, 29 October 2009 (UTC)

Nice work guys, it's pretty interesting to read. The paragraphs are sometimes quite chunky. A few pictures could help, especially in the mechanisms of insulin resistance bit. Neil R. J. Watson 15:43, 2 November 2009 (UTC)

You've put in a lot of work by the looks of things, you just need to do a bit of work on the appearance so there's better congruence between different contributions. A very interesting topic though! Mark Cairns 16:05, 2 November 2009 (UTC)

Really enjoyed reading your article. It's great how you seem to include a broad spectrum of possiblities (as in genetics, possible subcellular links, as well as immunological). I know there's an issue with adding images because of copyright infringement - but if you can somehow manage to add a few images that would be great help as the previous comments stated. Otherwise, great job! Amira Mahmoud

Progress so far

This is a tough theme but really is one of very major importance. It's hard to see the wood for the trees here, - and yes the literature is very confusing and very fast moving. But start by painting the big picture clearly. Start with the scale of the problem - how strong is the link between obesity and type 2 diabetes, what is type 2 diabetes, what do we think are the common direct causes, why do we think this is a causal link with obesity - and of course remember that not all obese people get diabetes and not all diabetics are overweight. Gareth Leng 15:24, 1 November 2009 (UTC)

A really good article. Very comprehensive. It would be good if you could work on the format e.g. use titles to break up the text and add pictures. Lowri Phillips 12:11, 3 November 2009 (UTC)

I think all the components of this article are excellently written so well done there!! my only little suggestion is that in the section of genetics of diabesity you could put in a link to the other topic 'Genetics and Obesity' so that the reader can be guided to other related topics on citizendium. Rachael White 13:10, 3 November 2009 (UTC)

Excellent article and very easy to understand. Maybe add some visual aids as there's a lot of text!Juliet Carmichael 16:31, 4 November 2009 (UTC)

I found this article very informative and easy to read. My only criticism is that there are no diagrams to break up the text, but on the whole an excellent article....said Katherine Laura Greenall (talk)

Feedback

Well done; massive amount of work here, some pieces of exceptionally fluid and lucid writing, and a good diagram. A very thorough job.Gareth Leng 17:59, 22 November 2009 (UTC)

Im glad to see that you have taken the previous comments in consideration. It's a really clear and interesting article with good diagrams. Nice article, well done! References and the bibliography page could do with a bit of tidying up!Celine Caquineau 11:22, 23 November 2009 (UTC)

Luke's references

My apologies for not posting these at the bottom. I thought it was better to have my references alongside the text. I am unable to add them at the moment. Thanks for your comments!

Normalization of obesity-associated insulin resistance through immunotherapy http://www.nature.com/nm/journal/v15/n8/full/nm.2001.html

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice http://www.nature.com/nm/journal/v15/n8/full/nm.1994.html

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters http://www.nature.com/nm/journal/v15/n8/full/nm.2002.html

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity http://www.nature.com/nm/journal/v15/n8/full/nm.1964.html

The protein kinase IKKepsilon regulates energy balance in obese mice http://www.cell.com/retrieve/pii/S0092867409007934

T-ing up inflammation in fat http://www.nature.com/nm/journal/v15/n8/full/nm0809-846.html