Anticoagulation

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Adverse effects

Patients aged 80 years or more may be especially susceptible to bleeding complications with a rate of 13 bleeds per 100 person-years.

Patients with cancer are more likely to have bleeding complications, especially if they have Stage III (regionally extensive) or IV (metastatic) cancer. Regardless of the extent of cancer, the risk of bleeding was less than the risk of recurrent embolism and thromboembolism:

Rates of major bleeding and recurrent embolism and thromboembolism (VTE)

		No cancer	Cancer
			Stage I or II	Stage III	Stage IV
Major bleeding	Events per 100 patient-years	8.6	3.4	19.1	42.8
	Hazard ratio	1	0.5	2.15	4.8
Recurrent VTE	Events per 100 patient-years	12.8	14.5	44.1	54.1
	Hazard ratio	1	1.9	5.3	4.6
Adapted from Table 3 of Prandoni et al.

See also

• Anticoagulant

External links

The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines