Thrombotic thrombocytopenic purpura: Difference between revisions

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imported>Robert Badgett
(New page: In medicine and hematology, '''thrombotic thrombocytopenic purpura''' ('''TTP''') is "an acquired, congenital, or familial disorder caused by platelet aggregation with [[thromb...)
 
imported>Howard C. Berkowitz
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In [[medicine]] and [[hematology]], '''thrombotic thrombocytopenic purpura''' ('''TTP''') is "an acquired, congenital, or familial disorder caused by [[platelet aggregation]] with [[thrombosis]] in terminal arterioles and capillaries. Clinical features include [[thrombocytopenia]]; [[hemolytic anemia]]; [[azotemia]]; [[fever]]; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as [[renal failure]]."<ref>{{MeSH}}</ref>
In [[medicine]] and [[hematology]], '''thrombotic thrombocytopenic purpura''' ('''TTP''') is "an acquired, congenital, or familial disorder caused by [[platelet aggregation]] with [[thrombosis]] in terminal arterioles and capillaries. Clinical features include [[thrombocytopenia]]; [[hemolytic anemia]]; [[azotemia]]; [[fever]]; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as [[renal failure]]."<ref>{{MeSH}}</ref>



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In medicine and hematology, thrombotic thrombocytopenic purpura (TTP) is "an acquired, congenital, or familial disorder caused by platelet aggregation with thrombosis in terminal arterioles and capillaries. Clinical features include thrombocytopenia; hemolytic anemia; azotemia; fever; and thrombotic microangiopathy. The classical form also includes neurological symptoms and end-organ damage, such as renal failure."[1]

Patients with primary TTP may have low von Willebrand factor-degrading protease (ADAMTS13 protein) which allows thrombi due to von Willebrand factor (vWF).[2]

References