Caffeine: Difference between revisions
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'''Caffeine''', contained in [[coffee]] and other drinks, is a mild stimulant and "is the most widely used psychoactive drug in the world."<ref name="isbn0-07-142280-3">{{cite book |author=O'Brien, Charles |authorlink= |editor=Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred |others= |title=Goodman & Gilman's The Pharmacological Basis of Therapeutics |edition=11th |chapter=Chapter 23. Drug Addition and Drug Abuse |chapterurl= |language= |publisher=McGraw-Hill |location=New York |year=2006 |origyear= |pages= |quote= |isbn=0-07-142280-3 |oclc= |doi= |url=http://www.accessmedicine.com/resourceTOC.aspx?resourceID=28 |accessdate=}}</ref> | '''Caffeine''', contained in [[coffee]] and other drinks, is a mild stimulant and "is the most widely used psychoactive drug in the world."<ref name="isbn0-07-142280-3">{{cite book |author=O'Brien, Charles |authorlink= |editor=Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred |others= |title=Goodman & Gilman's The Pharmacological Basis of Therapeutics |edition=11th |chapter=Chapter 23. Drug Addition and Drug Abuse |chapterurl= |language= |publisher=McGraw-Hill |location=New York |year=2006 |origyear= |pages= |quote= |isbn=0-07-142280-3 |oclc= |doi= |url=http://www.accessmedicine.com/resourceTOC.aspx?resourceID=28 |accessdate=}}</ref> | ||
Cessation of caffeine intake can lead to withdrawal symptoms.<ref name="pmid1528206">{{cite journal |author=Silverman K, Evans SM, Strain EC, Griffiths RR |title=Withdrawal syndrome after the double-blind cessation of caffeine consumption |journal=The New England journal of medicine |volume=327 |issue=16 |pages=1109–14 |year=1992 |month=October |pmid=1528206 |doi= |url= |issn=}}</ref> | |||
==Pharmacology== | ==Pharmacology== | ||
Revision as of 11:40, 10 October 2008
Caffeine, contained in coffee and other drinks, is a mild stimulant and "is the most widely used psychoactive drug in the world."[1]
Cessation of caffeine intake can lead to withdrawal symptoms.[2]
Pharmacology
Caffeine competitively antagonizes adenosine receptors. This antagonism prevents adenosine's inhibition of intracellular cyclic AMP. Cyclic AMP is a second messenger that increases sympathetic stimulation and increases norepinephrine and dopamine release[1]
References
- ↑ 1.0 1.1 O'Brien, Charles (2006). “Chapter 23. Drug Addition and Drug Abuse”, Keith Parker; Laurence Brunton; Goodman, Louis Sanford; Lazo, John S.; Gilman, Alfred: Goodman & Gilman's The Pharmacological Basis of Therapeutics, 11th. New York: McGraw-Hill. ISBN 0-07-142280-3.
- ↑ Silverman K, Evans SM, Strain EC, Griffiths RR (October 1992). "Withdrawal syndrome after the double-blind cessation of caffeine consumption". The New England journal of medicine 327 (16): 1109–14. PMID 1528206. [e]