Sulfonamide: Difference between revisions
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imported>David E. Volk (New page: {{subpages}} In chemistry, a '''sulfonamide''' is an amide of a sulfonic acid, with the general chemical equation R-SO<sub>2</sub>-NH<sub>2</sub>, where either of the nitrogenous h...) |
imported>Howard C. Berkowitz No edit summary |
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In chemistry, a '''sulfonamide''' is an [[amide]] of a [[sulfonic acid]], with the general chemical equation R-SO<sub>2</sub>-NH<sub>2</sub>, where either of the nitrogenous hydrogen atoms may be replaced by other chemical groups. A large class of [[antibiotic]]s are based on the sulfonamide structure. | In chemistry, a '''sulfonamide''' is an [[amide]] of a [[sulfonic acid]], with the general chemical equation R-SO<sub>2</sub>-NH<sub>2</sub>, where either of the nitrogenous hydrogen atoms may be replaced by other chemical groups. A large class of [[antibiotic]]s are based on the sulfonamide structure. | ||
==Discovery== | |||
Sulfanilamide was the first clinically useful sulfonamide, no longer used due to toxicity. Gerhard Domagk, who was working on antibacterial, discovered its prototype, Prontosil, in 1935. The French researcher, Daniel Bovet, determined that only the sulfanilamide subunit of Prontosil had antibacterial. | |||
Domagk was awarded a Nobel Prize in 1939, but the Nazi government made him refuse it. | |||
Revision as of 02:44, 15 November 2010
In chemistry, a sulfonamide is an amide of a sulfonic acid, with the general chemical equation R-SO2-NH2, where either of the nitrogenous hydrogen atoms may be replaced by other chemical groups. A large class of antibiotics are based on the sulfonamide structure.
Discovery
Sulfanilamide was the first clinically useful sulfonamide, no longer used due to toxicity. Gerhard Domagk, who was working on antibacterial, discovered its prototype, Prontosil, in 1935. The French researcher, Daniel Bovet, determined that only the sulfanilamide subunit of Prontosil had antibacterial.
Domagk was awarded a Nobel Prize in 1939, but the Nazi government made him refuse it.