Gentamicin: Difference between revisions
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==Dosage== | ==Dosage== | ||
The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.<ref name="pmid8913452">{{cite journal |author=Prins JM, Weverling GJ, de Blok K, van Ketel RJ, Speelman P |title=Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy |journal=Antimicrob. Agents Chemother. |volume=40 |issue=11 |pages=2494–9 |year=1996 |pmid=8913452 |doi=}} [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=Citizendium&pubmedid=8913452 Full text at PubMed Central]</ref> Depending on the estimated creatinine clearance (CC) ([http://www.intmed.mcw.edu/clincalc/creatinine.html Online calculator]), the daily intravenous dose is: | The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.<ref name="pmid8913452">{{cite journal |author=Prins JM, Weverling GJ, de Blok K, van Ketel RJ, Speelman P |title=Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy |journal=Antimicrob. Agents Chemother. |volume=40 |issue=11 |pages=2494–9 |year=1996 |pmid=8913452 |doi=}} [http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=Citizendium&pubmedid=8913452 Full text at PubMed Central]</ref> Depending on the estimated creatinine clearance (CC) ([http://www.intmed.mcw.edu/clincalc/creatinine.html Online calculator]), the daily intravenous dose is: | ||
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==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 16:05, 12 January 2008
Dosage
The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.[1] Depending on the estimated creatinine clearance (CC) (Online calculator), the daily intravenous dose is:
- CC more than 80 ml/min - 4 mg/kg
- CC between 50 and 80 ml/min - 3.25 mg/kg
- CC between 30 and 50 ml/min - 2.5 mg/kg
- CC below 30 ml/min - 2 mg/kg
The older Hull and Sarubbi nomogram uses a loading dose followed by smaller maintenance doses depending on renal function.[2]
References
- ↑ Prins JM, Weverling GJ, de Blok K, van Ketel RJ, Speelman P (1996). "Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy". Antimicrob. Agents Chemother. 40 (11): 2494–9. PMID 8913452. [e] Full text at PubMed Central
- ↑ Hull JH, Sarubbi FA (1976). "Gentamicin serum concentrations: pharmacokinetic predictions". Ann. Intern. Med. 85 (2): 183–9. PMID 942138. [e] online