Gentamicin: Difference between revisions
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imported>Robert Badgett (New page: ==Dosage== The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.<ref name="pmid8913452">{{cite journal |author=Prins JM, Weverling GJ, de Blok K, ...) |
imported>Robert Badgett (→Dosage) |
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* CC more than 80 ml/min - 4 mg/kg | * CC more than 80 ml/min - 4 mg/kg | ||
* CC between 50 and 80 ml/min -3.25 mg/kg | * CC between 50 and 80 ml/min - 3.25 mg/kg | ||
* CC between 30 and 50 ml/min - 2.5 mg/kg | * CC between 30 and 50 ml/min - 2.5 mg/kg | ||
* CC below 30 ml/min - 2 mg/kg | * CC below 30 ml/min - 2 mg/kg | ||
The older Hull and Sarubbi nomogram uses a loading dose followed by smaller maintenance doses depending on renal function.<ref name="pmid942138">{{cite journal |author=Hull JH, Sarubbi FA |title=Gentamicin serum concentrations: pharmacokinetic predictions |journal=Ann. Intern. Med. |volume=85 |issue=2 |pages=183–9 |year=1976 |pmid=942138 |doi=}} | The older Hull and Sarubbi nomogram uses a loading dose followed by smaller maintenance doses depending on renal function.<ref name="pmid942138">{{cite journal |author=Hull JH, Sarubbi FA |title=Gentamicin serum concentrations: pharmacokinetic predictions |journal=Ann. Intern. Med. |volume=85 |issue=2 |pages=183–9 |year=1976 |pmid=942138 |doi=}} [http://depts.washington.edu/druginfo/Formulary/Aminoglycosides.pdf online]</ref> | ||
==References== | ==References== | ||
Revision as of 07:54, 4 January 2008
Dosage
The Prins nomogram uses simplified once daily dosing with the dose adjusted for renal function.[1] Depending on the estimated creatinine clearance (CC) (Online calculator), the daily intravenous dose is:
- CC more than 80 ml/min - 4 mg/kg
- CC between 50 and 80 ml/min - 3.25 mg/kg
- CC between 30 and 50 ml/min - 2.5 mg/kg
- CC below 30 ml/min - 2 mg/kg
The older Hull and Sarubbi nomogram uses a loading dose followed by smaller maintenance doses depending on renal function.[2]
References
- ↑ Prins JM, Weverling GJ, de Blok K, van Ketel RJ, Speelman P (1996). "Validation and nephrotoxicity of a simplified once-daily aminoglycoside dosing schedule and guidelines for monitoring therapy". Antimicrob. Agents Chemother. 40 (11): 2494–9. PMID 8913452. [e] Full text at PubMed Central
- ↑ Hull JH, Sarubbi FA (1976). "Gentamicin serum concentrations: pharmacokinetic predictions". Ann. Intern. Med. 85 (2): 183–9. PMID 942138. [e] online