Healthy obesity

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Although obesity is a major risk factor for cardiovascular disease and type 2 diabetes mellitus, about a third of obese individuals maintain healthy cardiometabolic profiles; this phenotype of healthy obesity may be linked to the location of adipose tissue and the metabolic characteristics of the fat. Some data also suggest that weight loss by healthy obese subjects may have an adverse impact on their favorable cardiometabolic profile.

References

Wildman, R.P. 2009. Healthy Obesity. Current Opinion in Clinical Nutrition and Metabolice Care. 12. 438-443.

Aguilar-Salinas, C.A. et al. 2008. High Adiponectin concentrations Are Associated with the Metabolically Healthy Obese Phenotype. The Journal of Clinical Endocrinology and Metabolism 93 (10). 4075-4079.

Wildman, R.P. et al. 2008. The Obese Without Cardiometabolic Risk Factor Clustering and the Normal Weight With Cardiometabolic Risk Factor Clustering. Archives of Internal Medicine. 158(15). 1617-1624.

Stefan, N. et al. 2008. Identification and Characterization of Metabolically Benign Obesity in Humans. Archives of Internal Medicine 168(15). 1609-1616.

Marini, M.A. et al. 2007. Metabolically Healthy but Obese Women Have an Intermediate Cardiovascular Risk Factor Profile Between Healhty Nonobese Women and Obese Insulin-Resistant Women. Diabetes Care. 30(8). 2145-2147.

Karelis, A.D. et al. 2008. Metabolically healthy but obese women: effect of an energy-restricted diet. Diabetologia. 51. 1752-1754.