Cyclooxygenase 2: Difference between revisions
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In [[biochemistry]], [[cyclooxygenase 2]] is an [[enzyme]] that is "an inducibly-expressed subtype of [[prostaglandin-endoperoxide synthase]]. It plays an important role in many cellular processes and [[inflammation]]. It is the target of [[Cyclooxygenase 2 inhibitor|cox2 inhibitors]]."<ref>{{MeSH}}</ref> | In [[biochemistry]], [[cyclooxygenase 2]] is an [[enzyme]] that is "an inducibly-expressed subtype of [[prostaglandin-endoperoxide synthase]]. It plays an important role in many cellular processes and [[inflammation]]. It is the target of [[Cyclooxygenase 2 inhibitor|cox2 inhibitors]]."<ref>{{MeSH}}</ref> Like cyclooxygenase 1 and lipoxygenase, its substrate is [[arachidonic acid]]. | ||
Cyclooxygenase 2 is expressed by most [[colorectal cancer]]s and is associated with reduced survival.<ref name="pmid15623626">{{cite journal| author=Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K| title=Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. | journal=Clin Cancer Res | year= 2004 | volume= 10 | issue= 24 | pages= 8465-71 | pmid=15623626 | Cyclooxygenase 2 is expressed by most [[colorectal cancer]]s and is associated with reduced survival.<ref name="pmid15623626">{{cite journal| author=Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K| title=Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer. | journal=Clin Cancer Res | year= 2004 | volume= 10 | issue= 24 | pages= 8465-71 | pmid=15623626 | ||
Revision as of 08:19, 6 October 2010
In biochemistry, cyclooxygenase 2 is an enzyme that is "an inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and inflammation. It is the target of cox2 inhibitors."[1] Like cyclooxygenase 1 and lipoxygenase, its substrate is arachidonic acid.
Cyclooxygenase 2 is expressed by most colorectal cancers and is associated with reduced survival.[2]
Cyclooxygenase 2 inhibitors are medications that block the action of cyclooxygenase 2.
References
- ↑ Anonymous (2024), Cyclooxygenase 2 (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Soumaoro LT, Uetake H, Higuchi T, Takagi Y, Enomoto M, Sugihara K (2004). "Cyclooxygenase-2 expression: a significant prognostic indicator for patients with colorectal cancer.". Clin Cancer Res 10 (24): 8465-71. DOI:10.1158/1078-0432.CCR-04-0653. PMID 15623626. Research Blogging.