Glycosylated hemoglobin A: Difference between revisions
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'''Glycosylated hemoglobin A''', also referred to by it medically most important component '''Hb A1c''', is blood test used to monitor the treatment of [[diabetes mellitus type 1]] and [[diabetes mellitus type 2]]. Glycosylated hemoglobin A are "minor [[hemoglobin]] components of human [[erythrocyte]]s designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time."<ref>{{MeSH}}</ref> | '''Glycosylated hemoglobin A''', also referred to by it medically most important component '''Hb A1c''', is blood test used to monitor the treatment of [[diabetes mellitus type 1]] and [[diabetes mellitus type 2]]. Glycosylated hemoglobin A are "minor [[hemoglobin]] components of human [[erythrocyte]]s designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time."<ref>{{MeSH}}</ref> | ||
The following table helps convert Hb A1c values to average daily blood glucose levels.<ref name="pmid18540046">{{cite journal |author=Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ |title=Translating the A1C assay into estimated average glucose values |journal=Diabetes Care |volume=31 |issue=8 |pages=1473–8 |year=2008 |month=August |pmid=18540046 |doi=10.2337/dc08-0545 |url=http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=18540046 |issn=}}</ref> | |||
* 5% = 97 mg/dL | |||
* 6% = 126 mg/dL | |||
* 7% = 154 mg/dL | |||
* 8% = 183 mg/dL | |||
* 9% = 212 mg/dL | |||
*10% = 240 mg/dL | |||
*11% = 269 mg/dL | |||
*12% = 298 mg/dL | |||
For each 1% change in Hb A1c approximates a 30 mg/dL change in the average daily glucose.<ref name="pmid18540046"/> | |||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 21:39, 3 September 2008
Glycosylated hemoglobin A, also referred to by it medically most important component Hb A1c, is blood test used to monitor the treatment of diabetes mellitus type 1 and diabetes mellitus type 2. Glycosylated hemoglobin A are "minor hemoglobin components of human erythrocytes designated A1a, A1b, and A1c. Hemoglobin A1c is most important since its sugar moiety is glucose covalently bound to the terminal amino acid of the beta chain. Since normal glycohemoglobin concentrations exclude marked blood glucose fluctuations over the preceding three to four weeks, the concentration of glycosylated hemoglobin A is a more reliable index of the blood sugar average over a long period of time."[1]
The following table helps convert Hb A1c values to average daily blood glucose levels.[2]
- 5% = 97 mg/dL
- 6% = 126 mg/dL
- 7% = 154 mg/dL
- 8% = 183 mg/dL
- 9% = 212 mg/dL
- 10% = 240 mg/dL
- 11% = 269 mg/dL
- 12% = 298 mg/dL
For each 1% change in Hb A1c approximates a 30 mg/dL change in the average daily glucose.[2]
References
- ↑ Anonymous (2024), Glycosylated hemoglobin A (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ 2.0 2.1 Nathan DM, Kuenen J, Borg R, Zheng H, Schoenfeld D, Heine RJ (August 2008). "Translating the A1C assay into estimated average glucose values". Diabetes Care 31 (8): 1473–8. DOI:10.2337/dc08-0545. PMID 18540046. Research Blogging.