Fosfomycin

(CC) Image: David E. Volk
Fosfomycin, an antibiotic

Fosfomycin, also called phosphomycin, phosphonomycin and fosfonomycin, is a broad spectrum antibiotic chemical produced by Streptomyces fradiae. It is used to treat uncomplicated urinary tract infections (UTIs) in females for susceptible Escherichia coli and Enterococcus faecalis strains. It concentrates in the kidneys and bladder, and also reduces nephrotoxicity and ototoxicity associated with platinum-based anti-tumor drugs. The phosphoenolpyruvate analog irreversibly inhibits the enzyme enolpyruvate transferase, thus preventing the synthesis of N-acetylmuramic acid, a chemical necessary for building bacterial peptidogycan cell walls. It is sold under the brand names Monurol® and Veramina®.

Its IUPAC chemical name is [(2R,3S)-3-methyloxiran-2-yl]phosphonic acid and its chemical formula is C₃H₇O₄P.

External links

• Fosfomycin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
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