Fluconazole: Difference between revisions
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imported>David E. Volk (New page: {{subpages}} right|thumb|350px|{{#ifexist:Template:Fluconazole structure.jpg/credit|{{Fluconazole structure.jpg/credit}}<br/>|}}Fluconazole. '''Flucon...) |
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[[Image:Fluconazole structure.jpg|right|thumb| | [[Image:Fluconazole structure.jpg|right|thumb|200px|{{#ifexist:Template:Fluconazole structure.jpg/credit|{{Fluconazole structure.jpg/credit}}<br/>|}}Fluconazole.]] | ||
'''Fluconazole''', IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat [[oropharyngeal]] (vaginal) [[candidiasis]] and [[cryptococcal meningitis]] in AIDS. Fluconazole interacts with the enzyme [[14-α demethylase]] that converts [[lanosterol]] to [[ergosterol]]. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage. | '''Fluconazole''', IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat [[oropharyngeal]] (vaginal) [[candidiasis]] and [[cryptococcal meningitis]] in AIDS. Fluconazole interacts with the enzyme [[14-α demethylase]] that converts [[lanosterol]] to [[ergosterol]]. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage. | ||
Revision as of 17:52, 25 January 2008
Fluconazole, IUPAC name 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol, is a synthetic triazole antifungal agent that is used to treat oropharyngeal (vaginal) candidiasis and cryptococcal meningitis in AIDS. Fluconazole interacts with the enzyme 14-α demethylase that converts lanosterol to ergosterol. Becasue ergosterol is an essential component of the fungal cell membrane, inhibition of ergosterol results in increased cellular permeability and cellular leakage.
Brand Names
- Biocanol®
- Biozolene®
- Diflucan®
- Elazor®
- Flucazol®
- Flucostat®
- Flukezol®
- Flunizol®
- Flusol®
- Pritenzol®
- Triflucan®