User:Anthony.Sebastian

Anthony Sebastian, M.D.
Anthony_Sebastian@msn.com
Professor of Medicine
University of Caifornia San Francisco (UCSF)

UCSF Faculty Affiliations:

Department of Medicine, Division of Nephrology
General Clinical Research Center, Associated Faculty for Special Projects
UCSF's Clinical and Translational Science Institute (CTSI):
--CTSI Strategic Opportunities Support Center
--CTSI Clinical Research Centers ---Part of a University hospital

• Curriculum Vitae
• Another site for CV: http://base.google.com/base/a/1525701/D4341995594414253957
• Faculty Webpage
• Weblog: http://tonyseb.blogspot.com/
• Recent Textbook Chapter: http://base.google.com/base/a/1525701/D4434672367455340885
• Sebastian Research Contributions: http://base.google.com/base/a/1525701/D4074002977352172532

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Specializations: formal education and independent scholarship

Contributions to Citizendium Articles

Biology
Life
List of biology topics
Origin of life
Potassium in nutrition and human health
Scientific method
Systems biology

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My Notes Pages

Advice_on_writing_CZ_articles
Life/draft/Sebastian_Notes
Systems_biology/draft/Sebastian_Notes
CZ:Sage_advice_on_writing_CZ_articles
CZ:Application_Review_Procedure
CZ:Editor_Application_Review_Procedure
Homeostasis notes

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Original Peer-Reviewed Research Articles

• Sebastian A, McSherry E, Ueki I, Morris RC Jr: Renal amyloidosis, nephrotic syndrome, and impaired renal tubular reabsorption of bicarbonate. Ann Int Med 69:541 548, 1968

• Sebastian A, McSherry E, Morris RC Jr: On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (Type 2 RTA). J Clin Invest 50:231 243, 1971

• Morris RC Jr, McSherry E, Sebastian A: Modulation of experimental renal dysfunction of hereditary fructose intolerance by circulating parathyroid hormone. Proc Nat Acad Sci, USA 68:132 135, 1971

• Sebastian A, McSherry E, Morris RC Jr: Renal potassium wasting in renal tubular acidosis: Its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis. J Clin Invest 50:667 678, 1971

• McSherry E, Sebastian A, Morris RC Jr: Renal tubular acidosis in infants: The several kinds, including bicarbonate wasting, classic renal tubular acidosis. J Clin Invest 51:499 514, 1972

• Short E, Morris RC Jr, Sebastian A, Spencer M: Exaggerated phosphaturic response to circulating parathyroid hormone in patients with familial x linked hypophosphatemic rickets. J Clin Invest 58:152 163, 1976

• Sebastian A, McSherry E, Morris RC Jr: Impaired renal conservation of sodium and chloride during sustained correction of systemic acidosis in patients with type 1, classic renal tubular acidosis. J Clin Invest 58:454 469, 1976

• Hulter HN, Ilnicki LP, Harbottle JA, Sebastian A: Impaired renal H+ secretion and NH3 production in mineralocorticoid deficient glucocorticoid- replete dogs. Am J Physiol 232:F136 F146, 1977

• Sebastian A, Schambelan M, Lindenfeld S, Morris RC Jr: Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism. N Engl J Med 297:576 583, 1977

• Hulter HN, Sigala JF, Sebastian A: K+ deprivation potentiates the renal alkalosis producing effect of mineralocorticoid. Am J Physiol 235:F298 F309, 1978

• Hulter HN, Ilnicki LP, Harbottle JA, Sebastian A: Correction of metabolic acidosis by the kidney during isometric expansion of extracellular fluid volume. J Lab Clin Med 92:602 612, 1978

• Hulter HN, Licht JH, Sebastian A: K+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: Obliteration by amiloride. Am J Physiol 236:F48 F57, 1979

• Hulter HN, Licht JH, Glynn RD, Sebastian A: Renal acidosis in mineralocorticoid deficiency is not dependent on NaCl depletion or hyperkalemia. Am J Physiol 236:F283 F294, 1979

• Schambelan M, Sebastian A, Biglieri EG: Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency. Kidney Int 17:89 101, 1980

• Hulter HN, Sebastian A, Sigala JF, Licht JH, Glynn RD, Schambelan M, Biglieri EG: Pathogenesis of renal hyperchloremic acidosis resulting from dietary potassium restriction in the dog:role of aldosterone. Am J Physiol 238:F79 F91, 1980

• Hulter HN, Licht JH, Glynn RD, Sebastian A: Pathophysiology of chronic renal tubular acidosis induced by administration of amiloride. J Lab Clin Med 95:637 653, 1980

• Hulter HN, Licht JH, Bonner EL Jr, Glynn RD, Sebastian A: Effects of glucocorticoid steroids on renal and systemic acid base metabolism. Am J Physiol 239:F30 F43, 1980

• Hulter HN, Glynn RD, Sebastian A: Renal and systemic acid base effects of chronic dichloroacetate administration in dogs. Metabolism 29:997 1002, 1980

• Sebastian A, Sutton JM, Hulter HN, Schambelan M, Poler SM: Effect of mineralocorticoid replacement therapy on renal acid base homeostasis in adrenalectomized patients. Kidney Int 18:762 773, 1980

• Schambelan M, Sebastian A, Rector FC Jr: Mineralocorticoid resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption. Kidney Int 19:716 727, 1981

• Hulter HN, Bonner EL Jr, Glynn RD, Sebastian A: Renal and systemic acid base effects of chronic spironolactone administration. Am J Physiol 240:F381 F387, 1981

• Hulter HN, Sigala JF, Sebastian A: Effects of dexamethasone on renal and systemic acid base metabolism. Kidney Int 20:43 49, 1981

• Hulter HN, Toto RD, Bonner EL Jr, Ilnicki LP, Sebastian A: Renal and systemic acid base effects of chronic hypoparathyroidism in dogs. Am J Physiol 241:F495 F501, 1981

• Hulter HN, Ilnicki LP, Licht JH, Sebastian A: On the mechanism of diminished urinary carbon dioxide tension caused by amiloride. Kidney Int 21:8 13, 1982

• Jones JW, Sebastian A, Hulter HN, Schambelan M, Sutton JM, Biglieri EG: Systemic and renal acid base effects of chronic dietary potassium depletion in humans. Kidney Int 21:402 410, 1982

• Hulter HN, Sebastian A, Toto RD, Bonner EL Jr, Ilnicki LP: Renal and systemic acid base effects of the chronic administration of hypercalcemia producing agents: Calcitriol, PTH, and intravenous calcium. Kidney Int 21:445 458, 1982 Brenner RJ, Spring DB, Sebastian A, McSherry E, Genant HK, Palubinskas AJ, Morris RC Jr: Incidence of radiographically evident bone disease, nephrocalcinosis, and nephrolithiasis in various types of renal tubular acidosis. N Engl J Med 307:217 221, 1982

• Hulter HN, Toto RD, Ilnicki LP, Sebastian A: Chronic hyperkalemic renal tubular acidosis induced by KCl loading. Am J Physiol 244:F255 F264, 1983

• Hulter HN, Toto RD, Ilnicki LP, Halloran B, Sebastian A: Metabolic alkalosis in models of primary and secondary hyperparathyroid states. Am J Physiol 245:450 461, 1983

• Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A: Effect of diet on plasma acid base composition in normal humans. Kidney Int 24:670 680, 1983

• Toto RD, Hulter HN, Mackie S, Sebastian A: Renal tubular acidosis induced by dietary chloride. Kidney Int 25:26 32, 1984

• Maher T, Schambelan M, Kurtz I, Hulter HN, Jones JW, Sebastian A: Amelioration of metabolic acidosis by dietary potassium restriction in hyperkalemic patients with chronic renal insufficiency. J Lab Clin Med 103:432 445, 1984

• Hulter HN, Toto RD, Sebastian A, Mackie S, Cooke CR, Wilson, TE, Melby JC: Effect of extracellular fluid volume depletion on renal regulation of acid base and potassium equilibrium during prolonged mineral acid administration. J Lab Clin Med 103:854 868, 1984

• Sebastian A, Schambelan M, Sutton JM: Amelioration of hyperchloremic acidosis with furosemide therapy in patients with chronic renal insufficiency and type 4 renal tubular acidosis. Am J Nephrology 4:287 300, 1984

• Berger BE, Cogan MG, Sebastian A: Reduced glomerular filtration and enhanced bicarbonate reabsorption maintain metabolic alkalosis in humans. Kidney Int 26:205 208, 1984

• Hulter HN, Licht JH, Sebastian A: Effects of dietary potassium depletion and mineralocorticoid excess on renal Cl conservation in the dog. Am J Physiol 248:F104 F112, 1985

• Hernandez RE, Cogan MG, Schambelan M, Colman J, Morris RC Jr, Sebastian A: Dietary NaCl determines severity of potassium depletion-induced metabolic alkalosis. Kidney Int 31:1356-1367, 1987

• Schambelan M, Sebastian A, Katuna BA, Arteaga E: Adrenocortical hormone secretory response to chronic NH4Cl-induced metabolic acidosis. Am J Physiol 252:E454-E460, 1987

• Carneiro AV, Sebastian A, Cogan MG: Reduced glomerular filtration rate can maintain a rise in plasma bicarbonate concentration in humans. Am J Nephrol 7:450-454, 1987

• Petri M, Bockerstedt L, Colman J, Whiting-O'Keefe Q, Sebastian A, Hellmann D: Serial assessment of glomerular filtration rate in lupus nephropathy. Kidney Int 34:832-839, 1988

• Yarbrough S, Nix L, Katz R, Korn M, Sebastian A: Food chloride distribution in nature and its relation to sodium content. J Am Diet Assoc 88:472-475, 1988

• Schambelan M, Sebastian A: Pathogenesis and pathophysiologic role of hypoaldosteronism in syndromes of renal hyperkalemia. Current Topics in Membrane and Transport 28:351-366, 1987

• Sebastian A, Hernandez RE, Portale AA, Colman J, Tatsuno J, Morris RC Jr: Dietary potassium influences kidney maintenance of serum phosphorus concentration. Kidney Int 37:1341-1349, 1990

• Don BR, Sebastian A, Cheitlin M, Christiansen M, Schambelan M: Pseudohyperkalemia caused by fist clenching during phlebotomy. N Engl J Med 322:1290-1292, 1990

• Cogan MG, Carneiro AV, Tatsuno J, Colman J, Krapf R, Morris RC Jr, Sebastian A: Normal diet NaCl variation can affect the renal setpoint for plasma pH-HCO-3 maintenance. J Am Soc Nephrol 1:193-199, 1990

• Moulinier L, Venet T, Schiller NB, Kurtz TW, Morris RC Jr, Sebastian A: Measurement of aortic blood flow by Doppler echocardiography: Day to day variability in normal subjects and applicability in clinical research. J Am Coll Cardiol 17:1326-1333, 1991

• Siegel D, Hulley SB, Black DM, Cheitlin MD, Sebastian A, Seeley DG, Hearst N, Fine R: Diuretics, serum and intracellular electrolyte levels and ventricular arrhythmias in hypertensive men. JAMA 267(8):1083-1089, 1992 JAMA (ed.esp.) 1:113-124, 1992

• Hagiwara S, Lane N, Engelke K, Sebastian A, Kimme DB, Genant HK: Precision and accuracy for rat whole body and femur bone mineral determination with dual X-ray absorptiometry. Bone and Mineral 22:57-68, 1993

• Sebastian A, Harrris ST, Ottaway JH, Todd KM, Morris RC Jr: Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate. N Engl J Med 330:1776-1781, 1994

• Kusumoto F, Venet T, Schiller NB, Sebastian A, Foster E: Measurement of aortic blood flow by Doppler Echocardiography:temporal, technician, and reader variability in normal subjects and the application of generalizability theory in clinical research. J Am Soc Echocardiol 8:647-653, 1995

• Frassetto L, Sebastian, A: Age and systemic acid-base equilibrium: Analysis of published data. J Gerontol 51A:B91-B99, 1996

• Frassetto LA, Morris RC Jr, Sebastian A: Effect of age on blood acid-base composition in adult humans. Role of age-related renal functional decline. Am J Physiol 271:F1114-F1122, 1996

• Frassetto L, Morris RC Jr, Sebastian A: Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women. J Clin Endocrinol Metab 82:254-259, 1997

• Sudhir K, Forman A, Yi SL, Sorof J, Schmidlin O, Sebastian A, Morris RC Jr: Reduced dietary potassium reversibly enhances vasopressor response to stress in African-Americans. Hypertension 29:1083-1090, 1997

• Frassetto LA, Todd KM, Morris RC Jr, Sebastian A: Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein content. Am J Clin Nutr 68:576-583, 1998

• Schmidlin O, Forman A, Tanaka M, Sebastian A, Morris RC, Jr.: Salt induced renal vasoconstriction in salt sensitive African-Americans. Hypertension 33:633-639, 1999

• Morris RC, Sebastian A, Forman A, Tanaka M, Schmidlin O: Normotensive salt-sensitivity: Effects of race and dietary potassium. Hypertension 33:18-23, 1999

• Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A: Differing effects of supplemental KCI and KHCO3: pathophysiological and clinical implications. Seminars in Nephrology 19:487-493, 1999

• Frassetto LA, Todd KT, Morris RC Jr, Sebastian A: Worldwide incidence of hip fracture in elderly women: Relation to consumption of animal and vegetable foods. J Geront Med Sci 55A:M585-M592, 2000.

• Frassetto LA, Nash E, Morris RC Jr, Sebastian A: Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion. Kidney Intl 58:748-742, 2000

• Sellmeyer DE, Stone KL, Sebastian A, Cummings, SR: A high ratio of dietary animal to vegetable protein increases the rate of bone loss and risk of fracture in postmenopausal women. Am J Clin Nutr 73:118-122, 2001

• Frassetto LA, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A: Diet, evolution and aging – the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet. Eur J Nutr 40:200-213, 2001

• Sellmeyer DE, Schloetter M, Sebastian A: Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 87:2008-2012, 2002

• Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr Estimation of the net acid load of the diet of ancestral pre-agricultural Homo sapiens and their hominid ancestors. Am J Clin Nutr 2002;76:1308-16.

• Frassetto, L.A., R. C. Jr Morris, and A. Sebastian. Long-term persistence of the urine-calcium-lowering effect of potassium bicarbonate in postmenopausal omen. J Clin Endocrinol Metab 2005;90:831-834

• Cordain, L., Eaton, S. Boyd, Sebastian, A., Mann, N., Lindeberg, S., Watkins, B.A., O’Keefe, J.H., and Brand-Miller, J. Origins and evolution of the Western diet: health implications for the 21st century Am J Clin Nutr 81:341-354, 2005

• Hwa C, Sebastian A, Aird WC. Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap. Endothelium 2005;12:139-51.

• Morris RC, Jr., Schmidlin O, Frassetto LA, Sebastian A. Relationship and interaction between sodium and potassium. J Am Coll Nutr 2006;25:262S-70S.

• Frassetto LA, Morris RC, Jr., Sebastian A. A practical approach to the balance between acid production and renal acid excretion in humans. J Nephrol 2006;19 Suppl 9:S33-S4

• Frassetto LA, Lanham-New SA, Macdonald HM, Remer T, Sebastian A, Tucker KL, Tylavsky FA. Standardizing terminology for estimating the diet-dependent net acid load to the metabolic system. Journal of Nutrition 2007;137:1491-2.

• Schmidlin, O., Forman, A., Sebastian, A., and Morris, R. C. Jr. What initiates the pressor effect of salt in salt-sensitive humans? Observations in normotensive blacks. Hypertension 2007;49:1032-9

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