imported>Anthony.Sebastian |
imported>Anthony.Sebastian |
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| Anthony Sebastian's Weblog: [http://tonyseb.blogspot.com/] | | Anthony Sebastian's Weblog: [http://tonyseb.blogspot.com/] |
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| Curriculum vitae: see section below
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| [[Biology]]<br> | | [[Biology]]<br> |
| [[Systems biology]]<br> | | [[Systems biology]]<br> |
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| == Anthony Sebastian M.D. Curriculum Vitae ==
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|
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| ANTHONY SEBASTIAN, M.D.
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| Curriculum Vitae
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| [Last edited: 01/09/2007]
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|
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| '''BIRTHDATE AND BIRTHPLACE''' July 11, 1938; Youngstown, Ohio
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|
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| '''RESIDENCE ADDRESS''' 40 Crags Court, San Francisco, CA. 94131; (415) 648-0834 [tel]; (415) 358-5953 [fax]; Anthony_Sebastian@msn.com
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|
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| '''WORKPLACE ADDRESS'''
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|
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| Home Office [academic correspondence]:
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| 40 Crags Court
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| San Francisco, CA. 94131
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| (415) 648-0834 [tel]; (415) 358-5953 [fax]
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|
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| UCSF Office:
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| 1202 Moffitt Hospital, Box 0126
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| University of California
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| San Francisco, CA 94143
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| (415) 476 4336; (415) 476-0986 (fax)
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|
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| '''EDUCATION HISTORY'''
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|
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| 1956-60 University of California, Los Angeles - Bachelor of Science: Chemistry
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| 1961-65 University of California, San Francisco - Doctor of Medicine
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|
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| '''EMPLOYMENT HISTORY'''
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|
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| University of California, San Francisco, School of Medicine, Moffitt Hospital
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|
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| 1965-66 Intern, Internal Medicine, Department of Medicine; 1966-68 Resident, Internal Medicine, Department of Medicine; 1968-70 Giannini Foundation Research Fellowship, Nephrology, Department of Medicine; 1970-71 Assistant Research Physician, Department of Medicine; 1971-78 Assistant Professor of Medicine in Residence; 1971-79 Assistant Director, General Clinical Research Center; 1978-84 Associate Professor of Medicine in Residence; 1979-84 Associate Director, General Clinical Research Center; 1984-98 Co Director, General Clinical Research Center; 1984-present Professor of Medicine; 1998-02 Associate Program Director, General Clinical Research Center; 2002-2006 GCRC Associated Faculty for Special Projects; Managing Editor, The GCRC Journal; 2006-present Member, Clinical and Translational Science Institue: Strategic Opportunities Support Center; Clinical Research Center; 2006-present Citizendium: Editor, Health Sciences; Biology. Citizendium. [Volunteer].
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|
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| '''AWARDS'''
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|
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| UCSF Chancellor’s Champions of Diversity Medal; Belding H. Scribner Medal for Lifetime Achievement, American Society of Nephrology, 2003; UCSF Alumnus of the Year Medal, 2003; Co-Recipient, UCSF Academic Senate 5th Distinguished Clinical Research Lecture, 2005.
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|
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| '''MEMBERSHIPS IN PROFESSIONAL SOCIETIES'''
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|
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| Alpha Omega Medical Honor Society (elected);
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| American Association for the Advancement of Science;
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| American Society for Clinical Investigation (elected);
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| American Society of Nephrology;
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| Association of American Physicians (elected);
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| The Gold-Headed Cane Society (elected);
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| International Society of Nephrology;
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| Western Association of Physicians;
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| Western Society for Clinical Research (elected);
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| American Society for Bone and Mineral Research;
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| American Society of Nutritional Sciences (sponsored);
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| American Society of Clinical Nutrition.
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|
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| '''TEACHING ACTIVITIES (ACTIVITIES LISTED ONLY BEGINNING 1990)'''
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|
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| ''Formal Courses for Medical Students''
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|
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| *Medicine 140.22I Endocrine-Metabolism Pathophysiology. Instructor in charge of organizing 4-week course yearly for third and fourth year medical students. Lecturer, two 2 hour meetings/year, discussion of diet, acid base, kidney, bone pathophysiology
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| *Medicine 140.22A L Pathophysiology of Disease. Director in charge of all Pathophysiology of Disease courses offered to third and fourth year medical students (1980-present); ten 4 week sessions per year, 8 medical subspecialty divisions.
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| *Medicine 140.22C - Renal Pathophysiology. Lecturer, two 2 hr meetings twice yearly, renal acid-base and electrolyte physiology and pathophysiology
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| *Medicine 131 A - Medical Problem Solving, Tutor. 2-hour session weekly, Fall Quarter. Small group tutorial in medical problem-solving techniques
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| *Physiology Mini-Series - Seminar Leader. 2 hr session, Summer Quarter "Nutrition, acid-base, and bone health" 14 first year med students.
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| *IDS 131A-C - Foundations of Patient Care, Faculty Faciltator. 2-hour session biweekly to tri-weekly, Fall, Winter, Spring Quarters, 1st and 2nd year students. Small group sessions in medical problem-solving techniques and foundations of patient care.
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|
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| ''Miscellaneous Teaching Activities (Lectures and Talks)''
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|
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| *Syndromes of Renal K+ Wasting, Stanford Medical School, 4/9/80
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| *Renal Tubular Acidification Defects, House Staff Noon Conference, Medicine, Moffitt Hosp, 10/6/80
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| *Renal Acidosis: Role of Potassium and Aldosterone, S.F. General Hospital, Grand Rounds, 2/12/81
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| *Bartter's Syndrome and Hypercalciuria, VA Hospital, Medicine, Endocrine Metabolism, 3/5/81
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| *Hyperkalemic Renal Tubular Acidosis, Medical Staff Conference, Cole Hall, Moffitt Hospital, 7/29/81
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| *Bartter's Syndrome, Medical Staff Conference, Cole Hall, Moffitt Hospital, 5/11/83
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| *Diet, Acid-Base Balance, and Osteoporosis, Endocrine Grand Rounds, 3/23/88
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| *Diet, Acid-Base Balance, and Bone Health, Nutritional Sciences, UC Berkeley, 5/88
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| *Diet Inorganic Ions and Hypertension: What's Important? Adv. in Internal Medicine, UCSF, 6/21/88
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| *Diet, Acid-Base and Osteoporosis, John Muir Medical Center, 3/18/93
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| *Diet, Acid-Base, Potassium, and Bones, Endocrine Grand Rounds, 5/24/94
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| *Acid-Base, Potassium and Bone, UCB Department of Nutritional Sciences, Berkeley, 11/2/94
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| *Diet, Acid-Base, Potassium and Osteoporosis, Sequoia Hospital Clinical Conference, 4/14/95
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| *Protein Intake and Calcium Loss, International Conference on the Diets of Asia, SF, 11/29/95
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| *Chronic Potassium Bicarbonate Deficiency, Renal Grand Rounds, UCSF, 11/15/95
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| *Effects of Diet on Acid-Base Balance, Renal Grand Rounds, UCSF, 1997
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| *Acid-Base Effects of Diet on Bone and Other Tissues: An Evolutionary Perspective, 1st World Congress of Nephrology, 10/14/01
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| *Evolutionary Perspective on the Acid-Base Effects of Diet, Nephrology Research Seminar, UCSF, February, 2005
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| *Potential Health Benefits Of Supplementing The Diet With Alkalinizing Salts Of Potassium, Nephrology Research Seminar, UCSF, May, 2005
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| *An Evolutionary Perspective On The Acid-Base Effects Of Diet: The Paleolithic Paradigm, UCSF Academic Senate Distinguished Clinical Research Lecture, October, 2005
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| *Potential Contributors To Progression Of Renal Injury And Functional Insufficiency Related To The Chronic Hyperchloremic Acidosis Of Chronic Progressive Renal Disease, Nephrology Research Seminar, November, 2005
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|
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| '''RESEARCH GRANTS'''
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|
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| *National Institutes of Health, Co Investigator, Renin, Angiotensin, Steroids, Ions and Blood Pressure, National Heart, Lung, and Blood Institute, RO1 HL 11046 (1/1/68-12/31/90);
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| *Co Investigator, Disordered Vitamin D Metabolism in Renal Insufficiency,
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| National Inst. Arthritis, Diabetes, Digestive and Kidney Diseases, RO1 AM32631 (9/1/83-11/30/89)
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| *Co-Investigator, Renin, Angiotensin, Steroids, Ions and Blood Pressure
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| National Heart, Lung and Blood Institutes, RO1 HL 11046 (1/1/68 - 12/31/91)
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| *Principal Investigator, HCO3- Salts and Ca- Metabolism in Postmenopausal women
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| (Project of Osteoporosis Program Project Grant) 1987-1992
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| *Co-Investigator, Dietary Potassium as a Determinant of Black Hypertension
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| National Heart, Lung and Blood Institutes, RO1 HL 47943 (9/30/91-6/30/96)
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| *Co Director, General Clinical Research Center
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| Division of Research Resources, MO1 RR 00079 (12/1/62 - 11/30/98)
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| *Principal Investigator, Effects of Chronic Metabolic Acidosis on Bone Loss, Loss of Lean Body Mass and Muscle Strength and Risk of Hip Fracture (Project of Multi-Center Grant, Study of Osteoporotic Fractures)
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| National Arthritis and Muscular-Skeletal Institute, 2RO1 AG/AR05407-12 (5/1/97 - 4/30/2002)
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| *Principal Investigator, Dynamics of Health, Aging, and Body Composition
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| Project of Multi-Center Grant, AG62106 (3/29/96 – 6/30/2004)
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| *Principal Investigator, KHCO3 Prevents NaCL-Induced Bone Resorption in Humans?
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| NIH DK53172-02 GMB (3/1/98 - 2/29/2000)
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| *Co-Investigator, Renal Effects of Dietary Chloride in African Americans
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| NIH / HLBI, 1 R01 HL64230-01 (2/15/00 – 1/31/2003)
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| *Co-Investigator, The Effect of Dietary Protein Source on Calcium Metabolism
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| NIH / 1 RO1 AG18893-01 (12/1/01 – 11/30/2006)
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| *Co-Investigator, Kcitrate, Thiazides, or Combination to Prevent Bone Loss
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| NIAMS, AR 00-010 (12/1/01 – 11/30/2002)
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| *Associate Program Director, UCSF/Moffitt-MZ General Clinical Research Center
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| *Co-Investigator, KCitrate to Prevent Age Related Bone Loss: Pilot Study, NIH-NIAMS-BAA-05-02, “Pilot and Feasibility Trials for Osteoporosis”, (current)
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| *American Heart Association, Co-Investigator, Diet K+: Renal Cl- Transport and Blood Pressure in Humans (7/1/86 - 6/30/87)
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| *Research Evaluation and Allocation Committee, UCSF, Principal Investigator, Disorders of Renal Transport and Metabolism (7/1/80 - 6/30/81)
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| *Principal Investigator, Effect of Differences in Diet Potassium-to-Sodium Ratio on Blood Pressure and on Renal Handling and Body Content of Chloride in Normal Subjects and Patients with Essential Hypertension (7/1/84 - 6/30/85 and 7/1/86 - 6/30/87)
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| *Co-Investigator, Dietary Non-Chloride Potassium Salts and Blood Pressure (7/1/86 - 6/30/87)
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| *Co-Investigator, Effect of Sodium Chloride Intake on the Severity of Chronic Metabolic Alkalosis Induced by Oral Bicarbonate Ingestion in Humans 7/1/88 - 6/30/90)
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| *Principal Investigator, Multiple Investigator Award/Shared Equipment (Blood Gas Analyzer) (7/1/88-6/30/89)
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| *Principal Investigator, Multiple Investigator Award/Shared Equipment (High-Pressure Liquid Chromatograph) (7/1/91 - 6/30/92)
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| *Academic Senate, UCSF, Principal Investigator, Multiple Investigator Award for Shared Equipment (Autoanalyzer) (3/1/89 - 6/30/90)
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|
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| '''UNIVERSITY AND PUBLIC SERVICE'''
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| Ad Hoc Review Committee appointments and promotions, Vice Chancellor, Academic Affairs
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| Examiner, Ph.D. qualifying exam for Med. Information Science candidate; UCSF Graduate Division
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| Consultant, UCSF campus, self evaluation regarding compliance with federal regulations relating to accessibility of campus facilities to physically disabled persons
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| Member, UCSF Alumni-Faculty Association, 1990-1992
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| Editor, UCSF Alumni-Faculty Association Bulletin (2 years)
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| Participant, School of Medicine Faculty Leadership Retreat, Asilomar, 1992. Topic: Medical Education
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| Participant, School of Medicine, Chancellor's Cabinet meeting, 3/95: Affirmative Action and Diversity
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| Campaign Chair, School of Medicine Alumni Donations, Class of 1965 (1995, 2000)
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| Member, Chancellor's Steering Committee on Diversity (1995-present)
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| Editor, Bibliographic Resources, UCSF World Wide Web Site on Diversity (1995-1999)
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| Secretary-Treasurer, Poets on Parnussus, UCSF Campus Poetry Society (1995-2000)
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| Participant, Office of the President, Health Care Research Group, Clinical Trials Retreat; Communications Workgroup; 3/19/97
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| Member, Dean’s Review Group, Selection of UCSF Candidates for Burroughs Wellcome Awards, 1999
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| Social and Fundraising Campaign Chair, UCSF Medical School Class ’65, Reunions 1995, 2000, 2005
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| Clinical and Translational Science Award (CTSA) grant application, writer and editor, 2005-2006
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|
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| COMMITTEES
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| UCSF General Clinical Research Center Advisory Committee, Ex Officio
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| SFGH General Clinical Research Center Advisory Committee (1995-present)
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| UCSF Pediatric Clinical Research Center Advisory Committee
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| UCSF School of Medicine Electives Committee, Chair
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| UCSF School of Medicine Nutrition Curriculum Evaluation Committee, Chair
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| UCSF School of Medicine Committee on Curriculum and Educational Policy
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| UCSF School of Medicine Basic Science Review Committee
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| UCSF School of Medicine, Department of Medicine, Ad Hoc Promotion Committee
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| UCSF Academic Senate, Library Committee (Three Year Tenure)
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| UCSF School of Medicine Committee to Design Advanced Pathophysiology Course, Chair
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| UCSF Chancellor's Committee on Diversity, National Kidney Foundation: Honorary Committee for the Champions of Hope Gala Testimonial, Chair
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| UCSF Academic Senate Committee on Research (1997-2000)
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| UCSF School of Medicine, Department of Medicine Standing Promotion Committee (1997-2001)
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| Academic Senate Subcommittee, Selection UCSF Basic Science Candidates for the Steven and Michele Kirsch Foundation Fellowships, Chair (2000)
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|
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| PEER-REVIEW ACTIVITIES
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| Member, Editorial Board, Kidney International, July 1989-June 1990
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| Member, Editorial Board, American Journal of Kidney Diseases, 1988-1993
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|
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| Ad Hoc peer reviews for the following journals:
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| American Journal of Clinical Nutrition
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| American Journal of Kidney Diseases
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| American Journal of Medicine
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| American Journal of Physiology
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| Calcified Tissue International
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| Clinical Science
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| Journal of the American College of Nutrition
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| Journal of Bone and Mineral Research
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| Journal of Clinical Endocrinology and Metabolism
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| Journal of Clinical Investigation
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| Journal of Laboratory and Clinical Medicine
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| Journal of Nutrition
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| Kidney International
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| Lancet
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| Nutrition
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| New England Journal of Medicine
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| MISCELLANEOUS
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|
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| Project Director: Design and installation of GCRC multi-user computer facility, 1986
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| Project Director: Design and Installation of a 25-workstation local area network for the GCRC. 1991-92
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| Course on presenting data and information by Edward Tufte given in San Francisco, March 17, 1994
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| Advances in Internal Medicine Course (Numerous repeats)
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| Clinical Trials Seminars 9/14/95-9/15/95 UCSF
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| American Society of Nephrology Meeting 11/5/95 - 11/8/95 San Diego
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| Nominated for award for “Excellence in Clinical Small Group Instruction” by Class of 1999 (9/96)
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| Nominated for award for “Excellence in Small Group Instruction: Clinical Skills” by class of 2000
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| Nominated for award for “Outstanding Small Group Instruction” by 1st year Medical Students, 1997
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|
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| ORIGINAL RESEARCH ARTICLES PUBLISHED IN PEER REVIEWED JOURNALS
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| 1. Sebastian A, McSherry E, Ueki I, Morris RC Jr:
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| Renal amyloidosis, nephrotic syndrome, and impaired renal tubular reabsorption of bicarbonate.
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| Ann Int Med 69:541 548, 1968
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|
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| 2. Sebastian A, McSherry E, Morris RC Jr:
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| On the mechanism of renal potassium wasting in renal tubular acidosis associated with the Fanconi syndrome (Type 2 RTA).
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| J Clin Invest 50:231 243, 1971
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|
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| 3. Morris RC Jr, McSherry E, Sebastian A:
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| Modulation of experimental renal dysfunction of hereditary fructose intolerance by circulating parathyroid hormone.
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| Proc Nat Acad Sci, USA 68:132 135, 1971
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|
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| 4. Sebastian A, McSherry E, Morris RC Jr:
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| Renal potassium wasting in renal tubular acidosis: Its occurrence in types 1 and 2 RTA despite sustained correction of systemic acidosis.
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| J Clin Invest 50:667 678, 1971
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|
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| 5. McSherry E, Sebastian A, Morris RC Jr:
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| Renal tubular acidosis in infants: The several kinds, including bicarbonate wasting, classic renal tubular acidosis.
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| J Clin Invest 51:499 514, 1972
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|
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| 6. Short E, Morris RC Jr, Sebastian A, Spencer M:
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| Exaggerated phosphaturic response to circulating parathyroid hormone in patients with familial x linked hypophosphatemic rickets.
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| J Clin Invest 58:152 163, 1976
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|
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| 7. Sebastian A, McSherry E, Morris RC Jr:
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| Impaired renal conservation of sodium and chloride during sustained correction of systemic acidosis in patients with type 1, classic renal tubular acidosis.
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| J Clin Invest 58:454 469, 1976
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|
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| 8. Hulter HN, Ilnicki LP, Harbottle JA, Sebastian A:
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| Impaired renal H+ secretion and NH3 production in mineralocorticoid deficient glucocorticoid- replete dogs.
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| Am J Physiol 232:F136 F146, 1977
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|
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| 9. Sebastian A, Schambelan M, Lindenfeld S, Morris RC Jr:
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| Amelioration of metabolic acidosis with fludrocortisone therapy in hyporeninemic hypoaldosteronism.
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| N Engl J Med 297:576 583, 1977
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|
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| 10. Hulter HN, Sigala JF, Sebastian A:
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| K+ deprivation potentiates the renal alkalosis producing effect of mineralocorticoid.
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| Am J Physiol 235:F298 F309, 1978
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|
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|
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| 11. Hulter HN, Ilnicki LP, Harbottle JA, Sebastian A:
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| Correction of metabolic acidosis by the kidney during isometric expansion of extracellular fluid volume.
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| J Lab Clin Med 92:602 612, 1978
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|
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| 12. Hulter HN, Licht JH, Sebastian A:
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| K+ deprivation potentiates the renal acid excretory effect of mineralocorticoid: Obliteration by amiloride.
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| Am J Physiol 236:F48 F57, 1979
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|
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| 13. Hulter HN, Licht JH, Glynn RD, Sebastian A:
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| Renal acidosis in mineralocorticoid deficiency is not dependent on NaCl depletion or hyperkalemia.
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| Am J Physiol 236:F283 F294, 1979
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|
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| 14. Schambelan M, Sebastian A, Biglieri EG:
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| Prevalence, pathogenesis, and functional significance of aldosterone deficiency in hyperkalemic patients with chronic renal insufficiency.
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| Kidney Int 17:89 101, 1980
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|
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| 15. Hulter HN, Sebastian A, Sigala JF, Licht JH, Glynn RD, Schambelan M, Biglieri EG:
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| Pathogenesis of renal hyperchloremic acidosis resulting from dietary potassium restriction in the dog:role of aldosterone.
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| Am J Physiol 238:F79 F91, 1980
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|
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| 16. Hulter HN, Licht JH, Glynn RD, Sebastian A:
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| Pathophysiology of chronic renal tubular acidosis induced by administration of amiloride.
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| J Lab Clin Med 95:637 653, 1980
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|
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| 17. Hulter HN, Licht JH, Bonner EL Jr, Glynn RD, Sebastian A:
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| Effects of glucocorticoid steroids on renal and systemic acid base metabolism.
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| Am J Physiol 239:F30 F43, 1980
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|
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| 18. Hulter HN, Glynn RD, Sebastian A:
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| Renal and systemic acid base effects of chronic dichloroacetate administration in dogs.
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| Metabolism 29:997 1002, 1980
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|
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| 19. Sebastian A, Sutton JM, Hulter HN, Schambelan M, Poler SM:
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| Effect of mineralocorticoid replacement therapy on renal acid base homeostasis in adrenalectomized patients.
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| Kidney Int 18:762 773, 1980
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|
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| 20. Schambelan M, Sebastian A, Rector FC Jr:
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| Mineralocorticoid resistant renal hyperkalemia without salt wasting (type II pseudohypoaldosteronism): Role of increased renal chloride reabsorption.
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| Kidney Int 19:716 727, 1981
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|
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| 21. Hulter HN, Bonner EL Jr, Glynn RD, Sebastian A:
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| Renal and systemic acid base effects of chronic spironolactone administration.
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| Am J Physiol 240:F381 F387, 1981
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|
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| 22. Hulter HN, Sigala JF, Sebastian A:
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| Effects of dexamethasone on renal and systemic acid base metabolism.
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| Kidney Int 20:43 49, 1981
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|
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| 23. Hulter HN, Toto RD, Bonner EL Jr, Ilnicki LP, Sebastian A:
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| Renal and systemic acid base effects of chronic hypoparathyroidism in dogs.
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| Am J Physiol 241:F495 F501, 1981
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|
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| 24. Hulter HN, Ilnicki LP, Licht JH, Sebastian A:
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| On the mechanism of diminished urinary carbon dioxide tension caused by amiloride.
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| Kidney Int 21:8 13, 1982
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|
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| 25. Jones JW, Sebastian A, Hulter HN, Schambelan M, Sutton JM, Biglieri EG:
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| Systemic and renal acid base effects of chronic dietary potassium depletion in humans.
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| Kidney Int 21:402 410, 1982
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|
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| 26. Hulter HN, Sebastian A, Toto RD, Bonner EL Jr, Ilnicki LP:
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| Renal and systemic acid base effects of the chronic administration of hypercalcemia producing agents: Calcitriol, PTH, and intravenous calcium.
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| Kidney Int 21:445 458, 1982
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|
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| 27. Brenner RJ, Spring DB, Sebastian A, McSherry E, Genant HK, Palubinskas AJ, Morris RC Jr:
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| Incidence of radiographically evident bone disease, nephrocalcinosis, and nephrolithiasis in various types of renal tubular acidosis.
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| N Engl J Med 307:217 221, 1982
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|
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| 28. Hulter HN, Toto RD, Ilnicki LP, Sebastian A:
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| Chronic hyperkalemic renal tubular acidosis induced by KCl loading.
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| Am J Physiol 244:F255 F264, 1983
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|
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| 29. Hulter HN, Toto RD, Ilnicki LP, Halloran B, Sebastian A:
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| Metabolic alkalosis in models of primary and secondary hyperparathyroid states.
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| Am J Physiol 245:450 461, 1983
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|
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| 30. Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A:
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| Effect of diet on plasma acid base composition in normal humans.
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| Kidney Int 24:670 680, 1983
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|
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| 31. Toto RD, Hulter HN, Mackie S, Sebastian A:
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| Renal tubular acidosis induced by dietary chloride.
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| Kidney Int 25:26 32, 1984
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|
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| 32. Maher T, Schambelan M, Kurtz I, Hulter HN, Jones JW, Sebastian A:
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| Amelioration of metabolic acidosis by dietary potassium restriction in hyperkalemic patients with chronic renal insufficiency.
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| J Lab Clin Med 103:432 445, 1984
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|
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| 33. Hulter HN, Toto RD, Sebastian A, Mackie S, Cooke CR, Wilson, TE, Melby JC:
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| Effect of extracellular fluid volume depletion on renal regulation of acid base and potassium equilibrium during prolonged mineral acid administration.
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| J Lab Clin Med 103:854 868, 1984
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|
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| 34. Sebastian A, Schambelan M, Sutton JM:
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| Amelioration of hyperchloremic acidosis with furosemide therapy in patients with chronic renal insufficiency and type 4 renal tubular acidosis.
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| Am J Nephrology 4:287 300, 1984
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|
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| 35. Berger BE, Cogan MG, Sebastian A:
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| Reduced glomerular filtration and enhanced bicarbonate reabsorption maintain metabolic alkalosis in humans.
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| Kidney Int 26:205 208, 1984
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|
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| 36. Hulter HN, Licht JH, Sebastian A:
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| Effects of dietary potassium depletion and mineralocorticoid excess on renal Cl conservation in the dog.
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| Am J Physiol 248:F104 F112, 1985
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|
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| 37. Hernandez RE, Cogan MG, Schambelan M, Colman J, Morris RC Jr, Sebastian A:
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| Dietary NaCl determines severity of potassium depletion-induced metabolic alkalosis.
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| Kidney Int 31:1356-1367, 1987
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|
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| 38. Schambelan M, Sebastian A, Katuna BA, Arteaga E:
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| Adrenocortical hormone secretory response to chronic NH4Cl-induced metabolic acidosis.
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| Am J Physiol 252:E454-E460, 1987
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|
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| 39. Carneiro AV, Sebastian A, Cogan MG:
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| Reduced glomerular filtration rate can maintain a rise in plasma bicarbonate concentration in humans.
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| Am J Nephrol 7:450-454, 1987
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|
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| 40. Petri M, Bockerstedt L, Colman J, Whiting-O'Keefe Q, Sebastian A, Hellmann D:
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| Serial assessment of glomerular filtration rate in lupus nephropathy.
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| Kidney Int 34:832-839, 1988
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|
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| 41. Yarbrough S, Nix L, Katz R, Korn M, Sebastian A:
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| Food chloride distribution in nature and its relation to sodium content.
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| J Am Diet Assoc 88:472-475, 1988
| |
|
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| 42. Schambelan M, Sebastian A:
| |
| Pathogenesis and pathophysiologic role of hypoaldosteronism in syndromes of renal hyperkalemia.
| |
| Current Topics in Membrane and Transport 28:351-366, 1987
| |
|
| |
| 43. Sebastian A, Hernandez RE, Portale AA, Colman J, Tatsuno J, Morris RC Jr:
| |
| Dietary potassium influences kidney maintenance of serum phosphorus concentration.
| |
| Kidney Int 37:1341-1349, 1990
| |
|
| |
| 44. Don BR, Sebastian A, Cheitlin M, Christiansen M, Schambelan M:
| |
| Pseudohyperkalemia caused by fist clenching during phlebotomy.
| |
| N Engl J Med 322:1290-1292, 1990
| |
|
| |
| 45. Cogan MG, Carneiro AV, Tatsuno J, Colman J, Krapf R, Morris RC Jr, Sebastian A:
| |
| Normal diet NaCl variation can affect the renal setpoint for plasma pH-HCO-3 maintenance.
| |
| J Am Soc Nephrol 1:193-199, 1990
| |
|
| |
| 46. Moulinier L, Venet T, Schiller NB, Kurtz TW, Morris RC Jr, Sebastian A:
| |
| Measurement of aortic blood flow by Doppler echocardiography: Day to day variability in normal subjects and applicability in clinical research.
| |
| J Am Coll Cardiol 17:1326-1333, 1991
| |
|
| |
| 47. Siegel D, Hulley SB, Black DM, Cheitlin MD, Sebastian A, Seeley DG, Hearst N, Fine R:
| |
| Diuretics, serum and intracellular electrolyte levels and ventricular arrhythmias in hypertensive men.
| |
| JAMA 267(8):1083-1089, 1992
| |
| JAMA (ed.esp.) 1:113-124, 1992
| |
|
| |
| 48. Hagiwara S, Lane N, Engelke K, Sebastian A, Kimme DB, Genant HK:
| |
| Precision and accuracy for rat whole body and femur bone mineral determination with dual X-ray absorptiometry.
| |
| Bone and Mineral 22:57-68, 1993
| |
|
| |
| 49. Sebastian A, Harrris ST, Ottaway JH, Todd KM, Morris RC Jr:
| |
| Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate.
| |
| N Engl J Med 330:1776-1781, 1994
| |
|
| |
| 50. Kusumoto F, Venet T, Schiller NB, Sebastian A, Foster E:
| |
| Measurement of aortic blood flow by Doppler Echocardiography:temporal, technician, and reader variability in normal subjects and the application of generalizability theory in clinical research.
| |
| J Am Soc Echocardiol 8:647-653, 1995
| |
|
| |
| 51. Frassetto L, Sebastian, A:
| |
| Age and systemic acid-base equilibrium: Analysis of published data.
| |
| J Gerontol 51A:B91-B99, 1996
| |
|
| |
| 52. Frassetto LA, Morris RC Jr, Sebastian A:
| |
| Effect of age on blood acid-base composition in adult humans. Role of age-related renal functional decline.
| |
| Am J Physiol 271:F1114-F1122, 1996
| |
|
| |
| 53. Frassetto L, Morris RC Jr, Sebastian A:
| |
| Potassium bicarbonate reduces urinary nitrogen excretion in postmenopausal women.
| |
| J Clin Endocrinol Metab 82:254-259, 1997
| |
|
| |
| 54. Sudhir K, Forman A, Yi SL, Sorof J, Schmidlin O, Sebastian A, Morris RC Jr:
| |
| Reduced dietary potassium reversibly enhances vasopressor response to stress in African-Americans.
| |
| Hypertension 29:1083-1090, 1997
| |
|
| |
| 55. Frassetto LA, Todd KM, Morris RC Jr, Sebastian A:
| |
| Estimation of net endogenous noncarbonic acid production in humans from diet potassium and protein content.
| |
| Am J Clin Nutr 68:576-583, 1998
| |
|
| |
| 56. Schmidlin O, Forman A, Tanaka M, Sebastian A, Morris RC, Jr.:
| |
| Salt induced renal vasoconstriction in salt sensitive African-Americans.
| |
| Hypertension 33:633-639, 1999
| |
|
| |
| 57. Morris RC, Sebastian A, Forman A, Tanaka M, Schmidlin O:
| |
| Normotensive salt-sensitivity: Effects of race and dietary potassium.
| |
| Hypertension 33:18-23, 1999
| |
|
| |
| 58. Morris RC, Schmidlin O, Tanaka M, Forman A, Frassetto L, Sebastian A:
| |
| Differing effects of supplemental KCI and KHCO3: pathophysiological and clinical implications.
| |
| Seminars in Nephrology 19:487-493, 1999
| |
|
| |
| 59. Frassetto LA, Todd KT, Morris RC Jr, Sebastian A:
| |
| Worldwide incidence of hip fracture in elderly women: Relation to consumption of animal and vegetable foods.
| |
| J Geront Med Sci 55A:M585-M592, 2000.
| |
|
| |
| 60. Frassetto LA, Nash E, Morris RC Jr, Sebastian A:
| |
| Comparative effects of potassium chloride and bicarbonate on thiazide-induced reduction in urinary calcium excretion.
| |
| Kidney Intl 58:748-742, 2000
| |
|
| |
| 61. Sellmeyer DE, Stone KL, Sebastian A, Cummings, SR:
| |
| A high ratio of dietary animal to vegetable protein increases the rate of bone loss and risk of fracture in postmenopausal women.
| |
| Am J Clin Nutr 73:118-122, 2001
| |
|
| |
| 62. Frassetto LA, Morris RC Jr, Sellmeyer DE, Todd K, Sebastian A:
| |
| Diet, evolution and aging – the pathophysiologic effects of the post-agricultural inversion of the potassium-to-sodium and base-to-chloride ratios in the human diet.
| |
| Eur J Nutr 40:200-213, 2001
| |
|
| |
| 63. Sellmeyer DE, Schloetter M, Sebastian A:
| |
| Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet.
| |
| J Clin Endocrinol Metab 87:2008-2012, 2002
| |
|
| |
| 64. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr
| |
| Estimation of the net acid load of the diet of ancestral pre-agricultural Homo sapiens and their hominid ancestors.
| |
| Am J Clin Nutr 2002;76:1308-16.
| |
|
| |
| 65. Frassetto, L.A., R. C. Jr Morris, and A. Sebastian.
| |
| Long-term persistence of the urine-calcium-lowering effect of potassium bicarbonate in postmenopausal omen.
| |
| J Clin Endocrinol Metab 2005;90:831-834
| |
|
| |
| 66. Cordain, L., Eaton, S. Boyd, Sebastian, A., Mann, N., Lindeberg, S., Watkins, B.A., O’Keefe, J.H., and Brand-Miller, J.
| |
| Origins and evolution of the Western diet: health implications for the 21st century
| |
| Am J Clin Nutr 81:341-354, 2005
| |
|
| |
| 67. Hwa C, Sebastian A, Aird WC.
| |
| Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap.
| |
| Endothelium 2005;12:139-51.
| |
|
| |
| 68. Morris RC, Jr., Schmidlin O, Frassetto LA, Sebastian A.
| |
| Relationship and interaction between sodium and potassium.
| |
| J Am Coll Nutr 2006;25:262S-70S.
| |
|
| |
| 69. Frassetto LA, Morris RC, Jr., Sebastian A.
| |
| A practical approach to the balance between acid production and renal acid excretion in humans.
| |
| J Nephrol 2006;19 Suppl 9:S33-S4
| |
|
| |
| 70. Schmidlin, O., Forman, A., Sebastian, A., and Morris, R. C. Jr.
| |
| Salt-Sensitivity in Normotensive African Americans: Does Excessive Renal Reclamation of Dietary NaCl Initiate Its Pressor Effect?
| |
| Hypertension 2006. [Accepted for publication]
| |
|
| |
|
| |
|
| |
|
| |
| LETTERS
| |
|
| |
| 1. Sebastian A, Morris RC Jr:
| |
| Improved mineral balance and skeletal metabolism in postmenopausal women treated with potassium bicarbonate.
| |
| N Engl J Med 331:279, 1994
| |
|
| |
| 2. Sebastian A, Morris RC Jr:
| |
| Mineral balance in postmenopausal women treated with potassium bicarbonate.
| |
| N Engl J Med 331:1312-1313, 1994
| |
|
| |
| 3. Sebastian A, Frassetto L, Sellmeyer,S, Morris RC Jr:
| |
| Where’s the beef?
| |
| US News & World Report Nov 2000
| |
|
| |
| 4. Sebastian A, Sellmeyer DE, Stone KL, Cummings SR:
| |
| Dietary animal-to-vegetable protein ratio and rate of bone loss and risk of fracture in
| |
| postmenopausal women.
| |
| Am J Clin Nutr 74:411-412, 2001
| |
|
| |
| 5. Sebastian A.
| |
| Estimating Diet Net Acid Load : Reply to T Remer and F Manz.
| |
| Am J Clin Nutr 2003;78:803-4.
| |
|
| |
| 6. Sebastian A.
| |
| Low versus high meat diets: effects on calcium metabolism.
| |
| J Nutr 2003;133:3237-8.
| |
|
| |
| 7. Cordain L, Eaton SB, Sebastian A, Mann N, Lindeberg S, Watkins BA, O'Keefe JH, Brand-Miller J.
| |
| Reply to SC Cunnane's Letter-to-Editor: Origins and evolution of the Western diet: implications of iodine and seafood intakes for the human brain.
| |
| Am.J.Clin.Nutr. 2005;82:483-4.
| |
|
| |
| 8. Sebastian A, Frassetto L, Morris RC, Jr.
| |
| Authors' Response: Long-Term Persistence of the Urine Calcium-Lowering Effect of Potassium Bicarbonate in Postmenopausal Women.
| |
| J Clin Endocrinol Metab 2005;90:4417-a.
| |
|
| |
| 9. Sebastian A.
| |
| Protein consumption as an important predictor of lower limb bone mass in elderly women [Letter].
| |
| Am.J.Clin.Nutr. 2005;82:1355-1356
| |
|
| |
|
| |
|
| |
| BOOK CHAPTERS
| |
|
| |
|
| |
| 1. Sebastian A, McSherry E, Morris RC Jr:
| |
| Metabolic acidosis with special reference to the renal acidoses.
| |
| The Kidney, edited by Brenner BM, Rector FC Jr. WB Saunders Company, Philadelphia, Chapter 16, 1976
| |
|
| |
| 2. Morris RC Jr, McInnes RR, Epstein CJ, Sebastian A, Schriver CR:
| |
| Genetic and metabolic injury of the kidney.
| |
| The Kidney, edited by Brenner BM, Rector FC Jr. WB Saunders Company, Philadelphia, Chapter 27, 1976
| |
|
| |
| 3. Schambelan M, Sebastian A:
| |
| Hyporeninemic hypoaldosteronism.
| |
| Advances in Internal Medicine, edited by Siperstein MH. Year Book Medical Publishers, Chicago, Vol 24, 1978
| |
|
| |
| 4. Schambelan M, Sebastian A, Hulter HN:
| |
| Mineralocorticoid excess and deficiency syndromes.
| |
| Contemporary Issues in Nephrology, edited by Stein JH, Brenner BM. Churchill Livingstone, NY, Vol II, 1978
| |
|
| |
| 5. Sebastian A, Hulter HN, Rector FC Jr:
| |
| Metabolic alkalosis.
| |
| Contemporary Issues in Nephrology, edited by Stein JH, Brenner BM. Churchill Livingstone, NY, Vol II, 1978
| |
|
| |
| 6. Sebastian A, Hulter HN, Schambelan M:
| |
| Renal hyperchloremic acidosis with hyperkalemia. Type 4 renal tubular acidosis (RTA).
| |
| Proceedings, VIIth International Congress of Nephrology, edited by Barcelo R, Bergeron M, Carriere S, Dirks JH, Drummond K, Guttmann RD, Lemieux G, Mongeau J G, Seely JF. S. Karger, Montreal, 1978
| |
|
| |
| 7. Sebastian A, Morris RC Jr:
| |
| Renal tubular acidosis.
| |
| Strauss and Welt's Diseases of the Kidney, edited by Early LE, Gottschalk CG. Little, Brown and Company, Boston, Vol II, 1979
| |
|
| |
| 8. Morris RC Jr, Sebastian A:
| |
| Disorders of the renal tubule that cause disorders of fluid, acid base, and electrolyte metabolism.
| |
| Clinical Disorders of Fluid and Electrolyte Metabolism, edited by Maxwell MH, Kleeman CR. McGraw Hill Book Company, NY, 1979
| |
|
| |
| 9. Gonick HC, Fraser D, Sebastian A:
| |
| Renal tubular disorders.
| |
| Current Nephrology, edited by Gonick HC. Houghton Mifflin Professional Pub, Boston, 1979
| |
|
| |
| 10. Morris RC Jr, Sebastian A:
| |
| Renal tubular acidosis and Fanconi's syndrome.
| |
| Metabolic Basis of Inherited Disease, edited by Stanbury JB Wyngaarden JB, Fredrickson DS. McGraw Hill, NY. 1983
| |
|
| |
| 11. Cogan MG, Liu F Y, Berger BE, Sebastian A, Rector FC Jr:
| |
| Metabolic alkalosis.
| |
| Med Clin N Amer, edited by Kurtzman NA, Batlle DC. WB Saunders, Philadelphia. 1983
| |
|
| |
| 12. Sebastian A, Schambelan M, Hulter HN, Kurtz I, Hernandez RE, Biglieri EG, Morris RC Jr:
| |
| Acid base and electrolyte disorders associated with adrenal disease.
| |
| Fluid, Electrolyte and Acid Base Disorders, edited by Arieff A, DeFronzo R. Churchill Livingstone, NY. 1985
| |
|
| |
| 13. Schambelan M, Sebastian A:
| |
| Hypoaldosteronism.
| |
| Current Therapy in Endocrinology and Metabolism, edited by Bardin CW, Krieger DT. BC Decker, Philadelphia. 1985
| |
|
| |
| 14. Sebastian A, Schambelan M, Hulter HN, Maher T, Kurtz I, Biglieri EG, Rector FC Jr, Morris RC Jr:
| |
| Hyperkalemic renal tubular acidosis.
| |
| Renal Tubular Disorders, edited by Buckalew V, Gonick H. Marcel Decker Publishers, NY. 1985
| |
|
| |
| 15. Frassetto, LA, R. Morris, and A. Sebastian.
| |
| The natural dietary potassium intake of humans: The effect of diet-induced potassium-replete, chloride-sufficient, chronic low-grade metabolic alkalosis, or stone age diets for the 21st Century.
| |
| Nutritional Aspects of Osteoporosis, 2nd Ed., edited by P. Burkhardt, B. Dawson-Hughes, and R. P. Heaney, Amsterdam: Elsevier/Academic Press, 2004, p. 349-365.
| |
|
| |
| 16. Frassetto, L.A., C. Morris, and A. Sebastian.
| |
| Effects of diet acid load on bone health.
| |
| Nutritional Aspects of Osteoporosis, 2nd Edition, edited by P. Burkhardt, B. Dawson-Hughes, and R. P. Heaney, Amsterdam: Elsevier/Academic Press, 2004, p. 273-295.
| |
|
| |
| 17. Sebastian A, Hernandez RE, Schambelan M:
| |
| Disorders of renal handling of potassium.
| |
| The Kidney, edited by Brenner BM, Rector FC Jr. WB Saunders Company, Philadelphia. 1986
| |
|
| |
| 18. Schambelan M, Sebastian A:
| |
| Adrenal Gland.
| |
| Cecil Essentials of Medicine, edited by Andreoli TE, Carpenter CCJ, Plum F, Smith LH Jr. WB Saunders Company, Philadelphia. 1986
| |
|
| |
| 19. Bastl C, Sebastian A:
| |
| Adrenal hormones.
| |
| Clinical Disorders of Fluid and Electrolyte Metabolism, edited by Maxwell MH, Kleeman CR, Narins RG. McGraw Hill Book Co, NY. 1987
| |
|
| |
| 20. Schambelan M, Sebastian A:
| |
| States of aldosterone deficiency or pseudodeficiency.
| |
| Hormone Resistance and Other Endocrine Paradoxes, edited by Cohen M, Foa P. Springer-Verlag, NY 1987
| |
|
| |
| 21. Morris RC Jr, Sebastian A:
| |
| Potassium-responsive hypertension.
| |
| Hypertension:Pathophysiology, Diagnosis, and Management, 2nd Ed., edited by Laragh JH and Brenner BM. Raven Press Ltd, NY 1995
| |
|
| |
| 22. Frassetto LA, Morris RC Jr, Todd KT, Sebastian A::
| |
| Chronic low-grade metabolic acidosis in normal adult humans: Pathophysiology and consequences women’s health and menopause.
| |
| Women’s Health and Menopause, edited by Paoletti R, Crosignani P, Kenemans N, Jackson A Kluwer Academic. 1999, p. 15-23
| |
|
| |
| 23. Morris RC Jr, Frassetto LA, Schmidlin,O, Forman A, Sebastian A:
| |
| Expression of osteoporosis as determined by diet-disordered electrolyte and acid-base metabolism.
| |
| Nutritional Aspects of Osteoporosis, edited by Burckhardt P, et al., Academic Press, San Diego, 2001, p. 357-378
| |
|
| |
| 24. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC Jr:
| |
| An evolutionary perspective on the acid-base effects of diet:
| |
| Acid-Base Disorders and Their Treatment, Gennari, J, et al., eds., Marcel Dekker, Inc., 2005
| |
|
| |
| 25. Sebastian A, Frassetto LA, Morris RC Jr:
| |
| The Acid-Base Effects Of The Contemporary Western Diet: An Evolutionary Perspective
| |
| The Kidney: Physiology and Pathophysiology, 4th Edition,
| |
| edited by Drs. Robert J. Alpern and Steven C. Hebert, Elsevier [In Press] 2007
| |
|
| |
| 26. Eaton SB, Cordain L, Sebastian A.:
| |
| The Ancestral Biomedical Environment
| |
| The Endothelium, William C. Aird, editor, Cambridge University Press [submitted]
| |
| REVIEWS AND INVITED ARTICLES
| |
|
| |
| 1. Sebastian A:
| |
| The clinical spectrum of renal potassium wasting.
| |
| Calif Med 110:493 500, 1969
| |
|
| |
| 2. Morris RC Jr, McSherry E, Kranhold JF, Sebastian A:
| |
| Modulation of proximal and distal tubule function in the Fanconi syndrome.
| |
| Birth Defects:Original Article Series 6:22 23, 1970
| |
|
| |
| 3. Morris RC Jr, Sebastian A, McSherry E:
| |
| Renal acidosis.
| |
| Kidney Int 1:322 340, 1972
| |
|
| |
| 4. Sebastian A:
| |
| Renal tubular acidosis.
| |
| Calif Med 116:34 43, 1972
| |
|
| |
| 5. Sebastian A, Morris RC Jr:
| |
| Renal tubular acidosis.
| |
| Clin Nephrol 7:216 230, 1977
| |
|
| |
| 6. Sebastian A, Hulter HN, Kurtz I, Maher T, Schambelan M:
| |
| Disorders of distal nephron function.
| |
| Am J Med 72:289 307, 1982
| |
|
| |
| 7. Schambelan M, Sebastian A:
| |
| Type IV renal tubular acidosis: pathogenetic role of aldosterone deficiency and hyperkalemia], Acidose renale tubulaire de type IV:role pathogene du deficit en aldosterone et de l'hyperkaliemie.
| |
| Nephrologie 6:135-137, 1985
| |
|
| |
| 8. Sebastian A, Schambelan M:
| |
| Renal hyperkalemia.
| |
| Seminars in Nephrology 7:223-238, 1987
| |
|
| |
| 9. Sebastian A:
| |
| Thiazides and bone.
| |
| Am J Med 109:429-430 2000
| |
|
| |
| 9. Morris RC Jr, Sebastian A:
| |
| Alkali therapy in renal tubular acidosis: Who needs it?
| |
| JASN 2002; 2186-2188
| |
|
| |
| 10. Sebastian A.
| |
| Evolution, diet, acid-base, and bone.
| |
| The GCRC Journal Fall/Winter 2003/2004:8-11, 2004. http://gcrc.ucsf.edu/ftproot/Fall-Winter%202003%202004%20GCRC%20Journal.pdf
| |
| 11. Sebastian A.
| |
| Isoflavones, protein, and bone.
| |
| Am.J.Clin.Nutr. 81 (4):733-735, 2005.
| |
|
| |
|
| |
| Papers Personally Read by Dr. Sebastian at Scientific Meetings
| |
| 1. Sebastian A, Morris E, Ueki I, Morris RC Jr:
| |
| Persisting renal potassium wasting in patients with renal tubular acidosis.
| |
| Abst, Am Soc Nephrol 2:59, 1968 (2nd Annual Meeting)
| |
|
| |
| 2. Sebastian A, Morris E, Morris RC Jr:
| |
| On the mechanism of inappropriately high urinary pH in classic renal tubular acidosis.
| |
| Abst, Am Soc Nephrol 3:59, 1969 (3rd Annual Meeting)
| |
|
| |
| 3. Sebastian A, McSherry E, Morris RC Jr:
| |
| Impaired renal conservation of sodium during sustained correction of acidosis in classic ("distal") renal tubular acidosis.
| |
| Abst, Am Soc Nephrol 5:71, 1971 (5th Annual Meeting)
| |
|
| |
| 4. Sebastian A, McSherry E, Morris RC Jr:
| |
| Relationship between H+ secretion and fluid reabsorption of the proximal nephron (PN) of man.
| |
| Abst, Proc, V Int'l Congress Nephrol 5:841, 1972
| |
|
| |
| 5. Sebastian A, McSherry E, Schambelan M, Connor D, Biglieri EG, Morris RC Jr:
| |
| Renal tubular acidosis (RTA) in patients with hypoaldosteronism caused by renin deficiency.
| |
| Clin Res 21:706, 1973. Am Fed Clin Res (Annual meeting, 1972)
| |
|
| |
| 6. Sebastian A, McSherry E, Morris RC Jr:
| |
| On the mechanism of the inappropriately low urinary carbon dioxide tension (U PCO2) in classic (type 1) renal tubular acidosis (cRTA).
| |
| Clin Res 22:544A, 1974. Am Fed Clin Res (Annual Meeting, 1973)
| |
|
| |
| 7. Sebastian A, Schambelan M:
| |
| Amelioration of type 4 renal tubular acidosis (RTA) in chronic renal failure (CRF) with furosemide.
| |
| Abst, Am Soc Nephrol 10:82A, 1977 (10th Annual Meeting) Kidney Int 12:534, 1977
| |
|
| |
| 8. Sebastian A, Hulter HN, Schambelan M:
| |
| Renal hyperchloremic acidosis with hyperkalemia: Type 4 renal tubular acidosis.
| |
| Abst, Proc, VII Int'l Congress Nephrol 7:351, 1978
| |
|
| |
| 9. Sebastian A, Frassetto L, Sellmeyer D, Merriam R, Kurtz I, Morris RC Jr:
| |
| Acid-base effects of diet on bone and other tissues: an evolutionary perspective.
| |
| Abst. Am Soc Nephrol 12:160P, 2001 (1st World Congress)
| |
|
| |
| 10. Sebastian A.
| |
| Dietary protein content and the diet's net acid load: opposing effects on bone health.
| |
| Am J Clin Nutr 2005;82:921-2.
| |
|
| |
|
| |
| 11. Sebastian A.
| |
| Isoflavones, protein, and bone.
| |
| Am J Clin Nutr 2005;81:733-5.
| |
|
| |
| 12. Sebastian A.
| |
| An Evolutionary Perspective On The Acid-Base Effects Of Diet
| |
| UCSF Academic Senate’s 5th Distinguished Clinical Research Lecture, October 12, 2005
| |
|
| |
| SELECTED ABSTRACTS (SINCE 1980 [1965-1979 OMITTED)
| |
|
| |
| 1. Bonner EL Jr, Hulter HN, Ilnicki LP, McTigue M, Sebastian A:
| |
| Renal and systemic acid base and electrolyte response to chronic administration of L and DL lactic acid in dogs.
| |
| Clin Res 28:438A, 1980
| |
|
| |
| 2. Hulter HN, Bonner EL Jr, Glynn RD, Sebastian A:
| |
| Pathogenesis of metabolic alkalosis induced by chronic administration of 1,25 dihydroxyvitamin D3 in dogs.
| |
| Clin Res 28:448A, 1980
| |
|
| |
| 3. Hulter HN, Glynn RD, Sebastian A:
| |
| Renal and systemic acid base effects of chronic dichloroacetate administration in dogs.
| |
| Clin Res 28:448A, 1980
| |
|
| |
| 4. Schambelan M, Sebastian A, Biglieri EG:
| |
| Plasma 18 hydroxycorticosterone (1OHB) and aldosterone (A) in isolated hypoaldosteronism (IH): Evidence that 18 dehydrogenation is normal.
| |
| Clin Res 28:481A, 1980
| |
|
| |
| 5. Jones JW, Sebastian A, Schambelan M, Hulter HN, Sutton JM, Biglieri EG:
| |
| Stimulation of renal chloride reabsorption by dietary potassium deprivation in humans.
| |
| Clin Res 28:534A, 1980
| |
|
| |
| 6. Schambelan M, Sebastian A, Pearce D:
| |
| Potassium chloride therapy impairs urinary diluting ability in Bartter's syndrome: A reinterpretation of the chloride leak hypothesis.
| |
| Kidney Int 19:137, 1981
| |
|
| |
| 7. Hulter HN, Toto RD, Bonner EL Jr, Ilnicki LP, Sebastian A:
| |
| Renal and systemic acid base effects of chronic hypoparathyroidism.
| |
| Clin Res 29:466A, 1981
| |
|
| |
| 8. Maher T, Schambelan M, Kurtz I, Hulter HN, Jones J, Sebastian A:
| |
| Correction of metabolic acidosis by dietary potassium restriction in hyperkalemic patients with chronic renal insufficiency.
| |
| Clin Res 29:470A, 1981
| |
|
| |
| 9. Toto RD, Hulter HN, Sebastian A, Ilnicki LP:
| |
| Chronic renal metabolic alkalosis in models of primary and secondary hyperparathyroidism.
| |
| Clin Res 29:478A, 1981
| |
|
| |
| 10. Kurtz I, Maher T, Jones JW, Sutton JM, Schambelan M, Hulter HN, Rector FC Jr, Morris RC Jr, Sebastian A:
| |
| Familial chloride resistant renal alkalosis and hypokalemia with fasting hypercalciuria and medullary nephrocalcinosis: A unique variant of Bartter's syndrome without impaired renal diluting ability.
| |
| Clin Res 29:555A, 1981
| |
|
| |
| 11. Schambelan M, Sebastian A, Biglieri EG, Morris RC Jr, Kurtz I, Maher T, Rodriguez J:
| |
| Amelioration of hypokalemia by amiloride in diverse syndromes of renal potassium wasting.
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| Clin Res 29:556A, 1981
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|
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| 12. Hulter HN, Toto RD, Ilnicki LP, Halloran B, Sebastian A:
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| Metabolic alkalosis in experimental hyperparathyroidism: Roles of continuous PTH excess and of plasma 1,25 (OH)2D3 concentration.
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| Kidney Int 21:235, 1982
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|
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| 13. Kurtz I, Maher T, Hulter HN, Schambelan M, Sebastian A:
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| Effect of diet on plasma acid base composition in normal humans.
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| Kidney Int 21:236, 1982
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|
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| 14. Toto RD, Hulter HN, Ilnicki LP, Piyamanothamkul Y, Sebastian A:
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| Model of chronic hyperkalemic renal tubular acidosis without mineralocorticoid deficiency, renal ablation or pharmacologic agents.
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| Kidney Int 21:240, 1982
| |
|
| |
| 15. Schambelan M, Kater CE, Biglieri EG, Sebastian A:
| |
| Response of plasma 18 hydroxycorticosterone and aldosterone to infusion of des-asp 1-1-angiotensin II demonstrates a generalized reduction of adrenal zona glomerulosa function in isolated hypoaldosteronism.
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| Endocrine Society Program, 64th Ann Meet:189, 1982
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|
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| 16. Schambelan M, Sebastian A:
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| Pathogenesis of indomethacin induced hyperkalemia and type 4 renal tubular acidosis.
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| Program, Vth International Conference Prostaglandins Florence):772, 1982
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|
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| 17. Peters W, Schambelan M, Sebastian A, Biglieri EG:
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| Aldosterone ameliorable hyperkalemia induced by angiotensin converting enzyme inhibition.
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| Kidney Int 23:131, 1983
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|
| |
| 18. Toto RD, Hulter HN, Sebastian A:
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| Renal tubular acidosis induced by dietary chloride.
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| Clin Res 31:443A, 1983
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|
| |
| 19. Toto RD, Hulter HN, Sebastian A, Cooke CR, Melby JC:
| |
| Effect of ECF volume depletion on renal regulation of plasma [HCO3- ] during chronic mineral acid feeding.
| |
| Clin Res 31:519A, 1983
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|
| |
| 20. Hernandez R, Schambelan M, Cogan M, Morris RC Jr, Sebastian A:
| |
| Restricting diet potassium stimulates renal chloride reabsorption in humans: A defense mechanism against potassium depletion induced renal metabolic alkalosis.
| |
| Kidney Int 25:276, 1984
| |
|
| |
| 21. Schambelan M, Hernandez R, Sebastian A:
| |
| Renin secretion in humans is decreased by potassium depletion.
| |
| Kidney Int 25:336, 1984
| |
|
| |
| 22. Kurtz I, Hernandez R, Schambelan M, Biglieri EG, Rector FC Jr, Morris RC Jr, Sebastian A:
| |
| The results of tests of renal diluting ability do not support the hypothesis that NaCl transport in the loop of Henle is impaired in Bartter's syndrome.
| |
| Kidney Int 25:170, 1984
| |
|
| |
| 23. Schambelan M, Sebastian A:
| |
| Interaction of potassium (K+) and the renin angiotensin system (RAS) on aldosterone secretion in normal and pathophysiologic states.
| |
| Int Congress of Endocrinology, 7th Ann Meet:49, 1984
| |
|
| |
| 24. Lui FYH, Gaudiani LM, Sebastian A, Schambelan M:
| |
| Acquired pseudohyperaldosteronism (PHA) occurring as a complication of glomerulonephritis.
| |
| Kidney Int 27:146, 1985
| |
|
| |
| 25. Hernandez R, Kurtz I, Schambelan M, Colman J, Rector FC Jr, Morris RC Jr:
| |
| Can tests of renal diluting ability reveal the proximate cause of Bartter's syndrome?
| |
| Kidney Int 29:190, 1986
| |
|
| |
| 26. Yarbrough S, Nix L, Katz R, Korn M, Sebastian A:
| |
| The quantitative distribution of chloride in raw foods and relation to sodium content.
| |
| Kidney Int 29:262, 1986
| |
|
| |
| 27. Carneiro AV, Sebastian A, Cogan M:
| |
| Reduced glomerular filtration rate can perpetuate hyperbicarbonatemia in humans.
| |
| Xth International Cong. of Nephrology, 1987
| |
|
| |
| 28. Toffelmire E, Hernandez R, Carneiro A, Sebastian A, Schambelan M:
| |
| Plasma rennin activity in humans is directly related to dietary potassium.
| |
| Am Soc Neph 33:288, 1988
| |
|
| |
| 29. Sebastian A, Hernandez RE, Portale AA, Colman J, Tatsuno J, Morris RC Jr:
| |
| Normal variations of diet potassium influence set-point at which kidneys maintain serum phosphorus concentration.
| |
| Kidney Int 35:387, 1989
| |
|
| |
| 30. Cogan MG, Carneiro AV, Tatsuno J, Colman J, Morris RC Jr, Sebastian A:
| |
| Normal diet NaCl variations influence renal set-point for plasma pH-HCO-3 maintenance during alkali ingestion.
| |
| Kidney Int 35:452, 1989
| |
|
| |
| 31. Don BR, Strewler GJ, Sebastian A, Schambelan M:
| |
| Renal PTH resistance ostetitis fibrosa cystica, and normotensive primary aldosteronism: A new disorder.
| |
| Am Soc Neph 1989
| |
|
| |
| 32. Morris RC Jr, Sebastian A, Forman AH, Peeks RA
| |
| Potassium bicarbonate has greater antihypertensive potency than potassium chloride in patients with essential hypertension.
| |
| J Am Soc Nephrol 3:533, 1992
| |
|
| |
| 33. Sebastian A, Harris ST, Ottaway JH, Todd KT, Morris RC Jr
| |
| Effect of potassium bicarbonate on calcium and phosphorus balance and biochemical markers of bone formation and resorption in postmenopausal women.
| |
| J Am Soc Nephrol, 1992
| |
|
| |
| 34. Hagiwara S, Lane N, Engelke K, Sebastian A, Kimmel DB, Genant HK
| |
| Rat femur bone mineral measurement with dual x-ray absorptiometry.
| |
| 9th International Workshop on Bone Densitometry, 1992
| |
|
| |
| 35. Sudhir K, Forman A, Yi S_L, Sebastian A, Morris RC Jr.
| |
| Normalizing dietary potassium intake attenuates responses to cold and mental stress in salt-loaded African Americans.
| |
| Am Soc Hypertension, 1993
| |
|
| |
| 36. Frassetto L, Morris RC Jr, Sebastian A
| |
| Effect of age on blood acid-base composition.
| |
| J Am Soc Nephrol, 5:367, 1994
| |
|
| |
| 37. Morris RC Jr, O'Connor M, Forman A, Peeks R, Sebastian A
| |
| Supplemental dietary potassium with KHCO3 but not KCl attenuates essential hypertension.
| |
| J Am Soc Nephrol, 6:645, 1995
| |
|
| |
| 38. Frassetto,L, Morris RC Jr, Sebastian A
| |
| Potassium bicarbonate improves nitrogen balance in postmenopausal women.
| |
| J Am Soc Nephrol, 6:308, 1995
| |
|
| |
| 39. Frassetto LA, Morris RC Jr, Sebastian A
| |
| Potassium bicarbonate increases serum growth hormone concentration in postmenopausal women.
| |
| J Am Soc Nephrol, 29th Annual Meeting, 1996
| |
|
| |
| 40. Frassetto L, Todd KM, Morris RC Jr, Sebastian A:
| |
| Role of diet net acid load on hip fracture incidence worldwide.
| |
| J.Am Soc Nephrol, 30th Annual Meeting, 1997
| |
|
| |
| 41. Frassetto L, Todd KM, Morris RC Jr, Sebastian A:
| |
| Estimation of net endogenous acid production in humans from diet potassium and protein content.
| |
| Nephrology, 3(May S1):S341A, 1997
| |
|
| |
| 42. Frassetto LA, Nash E, Morris RC Jr, Sebastian A:
| |
| Effect of potassium salts on thiazide-induced renal calcium retention.
| |
| J Am Soc Nephrol, 31st Annual Meeting, 1998
| |
|
| |
| 43. Sebastian A, Frassetto LA, Sellmeyer DE, Merriam RL, Morris RC Jr:
| |
| Estimation of the net acid load of the diet of pre-agricultural Homo sapiens and their hominid ancestors.
| |
| J Am Soc Nephrol, 12: 9A, 2001
| |
|
| |
| 44. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC Jr:
| |
| Diet-induced potassium-replete chloride-sufficient chronic low-grade metabolic alkalosis as the naturally-selected optimal systemic acid-base state of humans.
| |
| J Am Soc Nephrol, 12:140A, 2001
| |
|
| |
| 45. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC Jr:
| |
| Acid-grain: why contemporary diets are net acid-producing.
| |
| J Am Soc Nephrol, 12:140A, 2001
| |
|
| |
| 46. Sebastian A, Frassetto LA, Sellmeyer DE, Morris RC Jr:
| |
| The natural dietary potassium intake of humans exceeds current intakes minimally by a factor of four.
| |
| J Am Soc Nephrol, 12:40A, 2001
| |
|
| |
| 47. Sellmeyer DE, Schloetter M, Sebastian A:
| |
| Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet.
| |
| J Bone Min Res, 16 Suppl 1:S215, 2001
| |
|
| |
| 48. L.A. Frassetto, R. C. Morris, Jr., and A. Sebastian.
| |
| Dietary Sodium as a Determinant of Bone Resorption Rate and Bone Mineral Density in Postmenopausal Women.
| |
| J.Am.Soc.Nephrol., 2004. (Abstract)
| |
|
| |
| 49. L.A. Frassetto, R. C. Jr Morris, and A. Sebastian.
| |
| Long-term persistence of the urine-calcium-lowering effect of potassium bicarbonate in postmenopausal women.
| |
| J.Am.Soc.Nephrol. 14: 2003. (Abstract)
| |
|
| |
| 50. L. A. Frassetto and A. Sebastian.
| |
| Diet-induced potassium-replete chloride-sufficient chronic low-grade metabolic alkalosis as the naturally-selected optimal systemic acid-base state of humans: Implications for humans.
| |
| The First Bay Area Clinical Research Symposium Book of Abstracts 65, 2003.
| |
|
| |
| 51. Frassetto LA, Morris RC, Jr., Sebastian A. Dietary Sodium as a Determinant of Bone Resorption Rate and Bone Mineral Density in Postmenopausal Women.
| |
| J.Am.Soc.Nephrol. 2004;15:512A
| |
|
| |
| 52. Perry S, Tylavsky FA, Ryder KA et al.
| |
| The net acid-producing American diet adversely affects whole body and hip bone density assessed cross-sectionally in older individuals.
| |
| Abstracts of the American Society for Bone and Mineral Research--27TH Annual Meeting 2005;Poster Presentation # SA306 (abstr).
| |
|
| |
|
| |
| ABSTRACTS ON PHILOSOPHY OF MIND
| |
|
| |
|
| |
| 1. Sebastian, A.
| |
| Consciousness Made ‘Easy’: The Perspective of a Lay Enthusiast
| |
| Toward a Science off Consciousness Conference: Tucson 2000
| |
| Accepted for Poster Presentation
| |
|
| |
| 2. Sebastian, A.
| |
| A Gedankenexperiment that Establishes In Principle the Ability of Humans To Construct Consciously Experiencing Machines.
| |
| Toward a Science off Consciousness Conference: Tucson 2004
| |
| Accepted for Poster Presentation
| |
|
| |
| 3. Sebastian, A.
| |
| Defining “Experience” As Prerequisite To Explaining “Conscious Experience”
| |
| Toward a Science off Consciousness Conference: Tucson 2006
| |
| Accepted for Poster Presentation
| |
|
| |
|
| |
| ARTICLES IN RECREATIONAL LINGUISTIC
| |
|
| |
| 1. Sebastian A. Spreadsheet logology on the PC. Word Ways 1988;21:211-9.
| |
| 2. Sebastian A, Merriam R. On reflexivity in words. Word Ways 1988;21:131-4.
| |
| 3. Sebastian A. Spreadsheet logology: Letter-shifts. Word Ways 1989;22:165-70.
| |
| 4. Sebastian A. Electronic Word Search Programs. Word Ways 1989;22:67-71.
| |
| 5. Sebastian A. American Forests. Word Ways 1991;24:30.
| |
| 6. Sebastian A. New Yorkers. Word Ways 1991;24:30.
| |
| 7. Sebastian A. The linguistic genetic message. Word Ways 1992;25:26-32.
| |
| 8. Sebastian A, Merriam R. Fourwords. Word Ways 1994;27:76-9.
| |
| 9. Sebastian A. On converting numbers into words. Word Ways 1994;27:59-62.
| |
| 10. Sebastian A. Chalet comb pair dee dual psalmer's daze? Word Ways 1998;31:71-2.
| |
| 11. Sebastian A. Shell icon party tuna somber stay? Word Ways 1998;31:71.
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|
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|
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