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== '''[[Warfarin]]''' ==
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''by [[User:Robert Badgett|Robert Badgett]], [[User:David E. Volk|David E. Volk]], and [[User:Chris Day|Chris Day]] <small>(and [[User:Caesar Schinas|Caesar Schinas]])</small>''
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==Footnotes==
{{Image|Warfarin structure.jpg|right|200px|Structure of Warfarin.}}  
 
'''[[Warfarin]]''' (IUPAC name
4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one), also widely called coumadin, is a an anticoagulant medication used prophylactically to suppress the formation of embolism and thrombosis from conditions such as atrial fibrillation, deep venous thrombosis, and pulmonary embolism.
 
Originally designed to be a rat poison, warfarin works as an anticoagulant by suppressing the enzyme epoxide reductase in the liver, thereby suppressing the formation of the reduced form of vitamin K epoxide, which is needed for the synthesis of many coagulation factors. As a drug, it is often sold as the sodium salt of warfarin.
 
===Discovery===
The dangers of feeding livestock spoiled sweet clover hay were known in the 1920’s<ref>Wardrop D, Keeling D (2008) The story of the discovery of heparin and warfarin ''Brit J Haematol'' 141:757-63</ref> and scientists at the University of Wisconsin-Madison were spearheading the problem on multiple fronts. R.A. Brink and W.K. Smith were attempting to breed a new variety of clover that was free of the toxic effect and Karl Paul Link's laboratory was attempting to isolate the killer compound. Farmers were already hurting due to the Great Depression and despite knowing they should not feed their livestock such hay, they could not afford to buy uncontaminated supplies. This disease that was affecting many livestock throughout the US became known as "sweet clover disease".<ref>Duxbury BM, Poller L (2001) The oral anticoagulant saga: past, present, and future ''Clin Appl Thrombosis/Hemostasis'' 7:269–75 PMID 11697707</ref>
 
''[[Warfarin|.... (read more)]]''
 
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Latest revision as of 09:19, 11 September 2020

The Mathare Valley slum near Nairobi, Kenya, in 2009.

Poverty is deprivation based on lack of material resources. The concept is value-based and political. Hence its definition, causes and remedies (and the possibility of remedies) are highly contentious.[1] The word poverty may also be used figuratively to indicate a lack, instead of material goods or money, of any kind of quality, as in a poverty of imagination.

Definitions

Primary and secondary poverty

The use of the terms primary and secondary poverty dates back to Seebohm Rowntree, who conducted the second British survey to calculate the extent of poverty. This was carried out in York and was published in 1899. He defined primary poverty as having insufficient income to “obtain the minimum necessaries for the maintenance of merely physical efficiency”. In secondary poverty, the income “would be sufficient for the maintenance of merely physical efficiency were it not that some portion of it is absorbed by some other expenditure.” Even with these rigorous criteria he found that 9.9% of the population was in primary poverty and a further 17.9% in secondary.[2]

Absolute and comparative poverty

More recent definitions tend to use the terms absolute and comparative poverty. Absolute is in line with Rowntree's primary poverty, but comparative poverty is usually expressed in terms of ability to play a part in the society in which a person lives. Comparative poverty will thus vary from one country to another.[3] The difficulty of definition is illustrated by the fact that a recession can actually reduce "poverty".

Causes of poverty

The causes of poverty most often considered are:

  • Character defects
  • An established “culture of poverty”, with low expectations handed down from one generation to another
  • Unemployment
  • Irregular employment, and/or low pay
  • Position in the life cycle (see below) and household size
  • Disability
  • Structural inequality, both within countries and between countries. (R H Tawney: “What thoughtful rich people call the problem of poverty, thoughtful poor people call with equal justice a problem of riches”)[4]

As noted above, most of these, or the extent to which they can be, or should be changed, are matters of heated controversy.

Footnotes

  1. Alcock, P. Understanding poverty. Macmillan. 1997. ch 1.
  2. Harris, B. The origins of the British welfare state. Palgrave Macmillan. 2004. Also, Oxford Dictionary of National Biography.
  3. Alcock, Pt II
  4. Alcock, Preface to 1st edition and pt III.