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| binomial_authority =  <center>Photo Credit: Janice Carr (1982)</center>
| binomial_authority =  <center>Photo Credit: Janice Carr (1982)</center>
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''Lactobacillus plantarum'' is a [[gram-positive]], [[bacteria]] which ferments plants and is used industrially to make yogurt, cheese, and pickled vegetables. Apart from plants, ''L. plantarum'' is found in the human GI tract and acts as a [[probiotic]] bacteria.  Its ability to survive in the GI tract has made this bacteria a target for further research in using it as a vehicle to deliver recombinant vaccines and treatments for diseases.
 
==Description and significance==
''[[Lactobacillus]] plantarum'' is a [[Gram-positive]], [[bacteria]] which ferments plants and is used industrially to make yogurt, cheese, and pickled vegetables. Apart from plants, ''L. plantarum'' is found in the human GI tract and acts as a [[probiotic]] bacteria.  Its ability to survive in the GI tract has made this bacteria a target for further research in using it as a vehicle to deliver recombinant vaccines and treatments for diseases.<ref name=Kleerebezem>Kleerebezem, Michiel,  Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [http://www.pnas.org/content/100/4/1990.full] Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.</ref>


==Genome structure==
==Genome structure==


In 2003, Michiel Kleerebezem mapped out the complete [[genome]] of ''Lactobacillus plantarum'' WCFS1.  ''Lactobacillus plantarum'' [[strain]] WCFS1 is known to have 3,308,274 base pairs and contains 3,052 protein-encoding genes as well as three [[plasmids]] (1,917-bp, 2,365-bp, and 36,069-bp,) which accounts for its high adaptability. The G+C content of the [[chromosome]] is 44.5%, but the plasmids contain slightly less G+C content. [http://www.pnas.org/content/100/4/1990.full 4]
In 2003, Michiel Kleerebezem mapped out the complete [[genome]] of ''Lactobacillus plantarum'' WCFS1.  ''Lactobacillus plantarum'' [[strain]] WCFS1 is known to have 3,308,274 base pairs and contains 3,052 protein-encoding genes as well as three [[plasmids]] (1,917-bp, 2,365-bp, and 36,069-bp,) which accounts for its high adaptability. The G+C content of the [[chromosome]] is 44.5%, but the plasmids contain slightly less G+C content. <ref name=Kleerebezem>Kleerebezem, Michiel,  Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [http://www.pnas.org/content/100/4/1990.full] Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.</ref>
 
==Cell structure and metabolism==
==Cell structure and metabolism==


''Lactobacillus plantarum'' is a [[gram positive]], [[rod-shaped]], [[organotrophic]], [[aerotolerant]], [[bacteria]] often called lactic acid bacteria because it gets most of its energy from converting glucose to lactate via homolactic and heterolactic fermentation. [[Homolactic fermentation]] uses the [[EMP pathway]] and h[[eterolactic fermentation]] uses the [[phosphoketolase pathway]]. Therefore, ''L. plantarum'' is a [[facultative]] heterofermentative [[lactobacilli]]. [http://microbewiki.kenyon.edu/index.php/Lactobacillus 5]  [http://www.pnas.org/content/100/4/1990.full 4]
''Lactobacillus plantarum'' is a [[Gram-positive]], [[rod-shaped]], [[organotrophic]], [[aerotolerant]], [[bacteria]] often called lactic acid bacteria because it gets most of its energy from converting glucose to lactate via homolactic and heterolactic fermentation. [[Homolactic fermentation]] uses the [[EMP pathway]] and h[[eterolactic fermentation]] uses the [[phosphoketolase pathway]]. Therefore, ''L. plantarum'' is a [[facultative]] heterofermentative [[lactobacilli]]. <ref name=Kenyon>"Lactobacillus." MicrobeWiki. 8 April 2009 Kenyon College.  21 April 2009. [http://microbewiki.kenyon.edu/index.php/Lactobacillus]</ref> <ref name=Kleerebezem>Kleerebezem, Michiel, Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [http://www.pnas.org/content/100/4/1990.full] Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.</ref>


==Ecology==
==Ecology==
''Lactobacillus plantarum'' is a highly adaptive bacteria that can survive at temperatures between 1º to 60º Celsius and also a great range of atmospheric pressures. The name "plantarum" indicates that this bacteria is a "species of the plants." ''L. plantarum'' is found particularly in fermented plants, such as kimchee. However, it is also found in other fermented foods such as yogurt and cheese and it is also found in animal [[GI tracts]], human saliva and vagina.  [http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_plantarum.html 1] [http://lwicker.myweb.uga.edu/kimchee.htm 3] [http://www.pnas.org/content/100/4/1990.full 4]
''Lactobacillus plantarum'' is a highly adaptive bacteria that can survive at temperatures between 1º to 60º Celsius and also a great range of atmospheric pressures. The name "plantarum" indicates that this bacteria is a "species of the plants." ''L. plantarum'' is found particularly in fermented plants, such as kimchee. However, it is also found in other fermented foods such as yogurt and cheese and it is also found in animal [[GI tracts]], human saliva and vagina.  <ref name=EBI>"Bacteria Genomes - LACTOBACILLUS PLANTARUM" European Bioinformatics Institute. European Molecular Biology Laboratory. 21 April 2009. [http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_plantarum.html]</ref> <ref name=Hwang>Hwang, Hamin. "KimChee and Fermentation." 19 April 2005. 21 April 2009. [http://lwicker.myweb.uga.edu/kimchee.htm]</ref> <ref name=Kleerebezem>Kleerebezem, Michiel,  Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [http://www.pnas.org/content/100/4/1990.full] Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.</ref>
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Image:Yogurt.jpg|Yogurt
Image:Yogurt.jpg|Yogurt
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==Pathology==
==Pathology==
''Lactobacillus plantarum'' 299v is actually considered to be a [[probiotic]]. Due to its ability to survive in the human GI tract for >6 days, ''L. plantarum'' 299v can inhibit the growth of other harmful bacteria such as ''[[E. coli]]'' in the host after contaminated meat consumption.  ''L. plantarum'' 299v is found in various fermented foods such as yogurt, cheese, kimchee, and is recommended to be consumed regularly to support the [[immune system]].  In addition, the ability of ''L. plantarum'' 299v to produce lactic acid helps maintain healthy, low pH levels of the GI tract.  [http://www.pnas.org/content/100/4/1990.full 4[http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_plantarum.html 1] [http://lwicker.myweb.uga.edu/kimchee.htm 3]
''Lactobacillus plantarum'' 299v is actually considered to be a [[probiotic]]. Due to its ability to survive in the human GI tract for >6 days, ''L. plantarum'' 299v can inhibit the growth of other harmful bacteria such as ''[[E. coli]]'' in the host after contaminated meat consumption.  ''L. plantarum'' 299v is found in various fermented foods such as yogurt, cheese, kimchee, and is recommended to be consumed regularly to support the [[immune system]].  In addition, the ability of ''L. plantarum'' 299v to produce lactic acid helps maintain healthy, low pH levels of the GI tract.  <ref name=Kleerebezem>Kleerebezem, Michiel,  Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [http://www.pnas.org/content/100/4/1990.full] Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.</ref> <ref name=EBI>"Bacteria Genomes - LACTOBACILLUS PLANTARUM" European Bioinformatics Institute. European Molecular Biology Laboratory. 21 April 2009. [http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_plantarum.html]</ref> <ref name=Hwang>Hwang, Hamin. "KimChee and Fermentation." 19 April 2005. 21 April 2009. [http://lwicker.myweb.uga.edu/kimchee.htm]</ref>


==Applications to Biotechnology==
==Applications to Biotechnology==


In 2004, Jean-Marie Perrier-Cornet discovered a way to control food fermentation by using ''Lactobacillus plantarum'', a common food bacteria with resistance to a good range of [[temperature]], [[pressure]], and [[pH level]].  A cold [[pasteurization]] method without freezing the food and thus altering the composition of the food is a new technology of interest to the food industry.  Perrier-Cornet found optimization of the procedure when pasteurizing ''L. plantarum'' for 10 min at temperatures between −20 and 25 °C and pressure between 100 and 350 MPa. [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3C-4DS814C-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d553372dfbc5d3db2288cf2b62039f08 6]
In 2004, Jean-Marie Perrier-Cornet discovered a way to control food fermentation by using ''Lactobacillus plantarum'', a common food bacteria with resistance to a good range of [[temperature]], [[pressure]], and [[pH level]].  A cold [[pasteurization]] method without freezing the food and thus altering the composition of the food is a new technology of interest to the food industry.  Perrier-Cornet found optimization of the procedure when pasteurizing ''L. plantarum'' for 10 min at temperatures between −20 and 25 °C and pressure between 100 and 350 MPa. <ref name=Perrier>Perrier-Cornet, Jean-Marie,  Sandra Tapin, Serenella Gaeta and Patrick Gervais. (2004). [http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T3C-4DS814C-4&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=d553372dfbc5d3db2288cf2b62039f08 ]High-pressure inactivation of ''Saccharomyces cerevisiae'' and ''Lactobacillus plantarum'' at subzero temperatures. ''Journal of Biotechnology, 115'' (4), 405-412.</ref>


==Current Research==
==Current Research==


In 2006, Michael Schultz studied the effects of treatment with ''Lactobacillus plantarum'' 299v on immunodeficient mice prone to the development of [[colitis]]. The study found that ''L. plantarum'' 299v administered orally with water to [[interleukin-10]] deficient mice produced significant results of reduced immune-mediated colitis.  This suggests that ''L. plantarum'' 299v has the potential to be used against clinical [[inflammatory bowel disease]]. [http://www3.interscience.wiley.com/cgi-bin/fulltext/113522146/HTMLSTART 7]
In 2006, Michael Schultz studied the effects of treatment with ''Lactobacillus plantarum'' 299v on immunodeficient mice prone to the development of [[colitis]]. The study found that ''L. plantarum'' 299v administered orally with water to [[interleukin-10]] deficient mice produced significant results of reduced immune-mediated colitis.  This suggests that ''L. plantarum'' 299v has the potential to be used against clinical [[inflammatory bowel disease]]. <ref name=Schultz>Schultz, Michael, Claudia Veltkamp , Levinus A. Dieleman , Wetonia B. Grenther , Priscilla B. Wyrick , Susan L. Tonkonogy , R. Balfour Sartor, M.D. (2006). [http://www3.interscience.wiley.com/cgi-bin/fulltext/113522146/HTMLSTART]''Lactobacillus plantarum'' 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. ''Wiley Interscience, 8'' (2), 71-80.</ref>


In 2008, Beatriz del Rio studied the use of live [[recombinant]] ''Lactobacillus plantarum'' as an oral delivery vehicle for a [[Lyme disease]] vaccine to invoke a protective immune response in mice.  Because ''L. plantarum'' can survive in the GI tract, it has been long considered for this type of research.  ''L. plantarum'' successfully expressed [[vaccine]] [[antigens]] inducing immunity in the mice infected with Lyme disease. [http://cvi.asm.org/cgi/reprint/15/9/1429.pdf 2]
In 2008, Beatriz del Rio studied the use of live [[recombinant]] ''Lactobacillus plantarum'' as an oral delivery vehicle for a [[Lyme disease]] vaccine to invoke a protective immune response in mice.  Because ''L. plantarum'' can survive in the GI tract, it has been long considered for this type of research.  ''L. plantarum'' successfully expressed [[vaccine]] [[antigens]] inducing immunity in the mice infected with Lyme disease. <ref name=delRio>Beatriz del Rio, Raymond J. Dattwyler, Miguel Aroso, Vera Neves, Luciana Meirelles, Jos F. M. L. Seegers, and Maria Gomes-Solecki1. (2008) [http://cvi.asm.org/cgi/reprint/15/9/1429.pdf]Oral Immunization with Recombinant ''Lactobacillus plantarum'' Induces a Protective Immune Response in Mice with Lyme Disease. ''Clinical and Vaccine Immunology, 15''. (9), 1429-1435</ref>


In 2009, Alistair W. G. Waugh studied the effects of treatment with ''Lactobacillus plantarum'' 299v on healthy mice induced with [[irritable bowel syndrome]] via rectal administration of 1% allyl isothiocyanate in 30% ethanol. The mice were then force-fed ''L. plantarum'' 299v for up to 28 days.  The results showed that ''L. plantarum'' 299v reduced inflammation and normalized the bowels. [http://www.informaworld.com/smpp/content~content=a909390026~db=all~jumptype=rss  8]
In 2009, Alistair W. G. Waugh studied the effects of treatment with ''Lactobacillus plantarum'' 299v on healthy mice induced with [[irritable bowel syndrome]] via rectal administration of 1% allyl isothiocyanate in 30% ethanol. The mice were then force-fed ''L. plantarum'' 299v for up to 28 days.  The results showed that ''L. plantarum'' 299v reduced inflammation and normalized the bowels.<ref name=Waugh>Waugh, Alistair W. G.,  Rae Foshaug, Sarah Macfarlane, Jason SG Doyle, Thomas A. Churchill, Beate C. Sydora, Richard N. Fedorak. (2009). [http://www.informaworld.com/smpp/content~content=a909390026~db=all~jumptype=rss]Effect of ''Lactobacillus plantarum'' 299v treatment in an animal model of irritable bowel syndrome. ''Microbial Ecology in Health and Disease, 21''. (1), 33-37.
<sup>Superscript text</sup></ref>


==References==
==References==
#"Bacteria Genomes - LACTOBACILLUS PLANTARUM" European Bioinformatics Institute. European Molecular Biology Laboratory. 21 April 2009. <http://www.ebi.ac.uk/2can/genomes/bacteria/Lactobacillus_plantarum.html>
<references/>[[Category:Suggestion Bot Tag]]
#Beatriz del Rio, Raymond J. Dattwyler, Miguel Aroso, Vera Neves, Luciana Meirelles, Jos F. M. L. Seegers, and Maria Gomes-Solecki1. (2008) Oral Immunization with Recombinant ''Lactobacillus plantarum'' Induces a Protective Immune Response in Mice with Lyme Disease. ''Clinical and Vaccine Immunology, 15''. (9), 1429-1435
#Hwang, Hamin. "KimChee and Fermentation." 19 April 2005. 21 April 2009. <http://lwicker.myweb.uga.edu/kimchee.htm>
#Kleerebezem, Michiel,  Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). Complete genome sequence of ''Lactobacillus plantarum'' WCFS1. ''Proceedings of the National Academy of Sciences, 100'' (4), 1990-1995.
#"Lactobacillus." MicrobeWiki. 8 April 2009 Kenyon College.  21 April 2009. <http://microbewiki.kenyon.edu/index.php/Lactobacillus>
#Perrier-Cornet, Jean-Marie,  Sandra Tapin, Serenella Gaeta and Patrick Gervais. (2004). High-pressure inactivation of ''Saccharomyces cerevisiae'' and ''Lactobacillus plantarum'' at subzero temperatures. ''Journal of Biotechnology, 115'' (4), 405-412.
#Schultz, Michael, Claudia Veltkamp , Levinus A. Dieleman , Wetonia B. Grenther , Pricilla B. Wyrick , Susan L. Tonkonogy , R. Balfour Sartor, M.D. (2006). ''Lactobacillus plantarum'' 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. ''Wiley Interscience, 8'' (2), 71-80.
#Waugh, Alistair W. G.,  Rae Foshaug, Sarah Macfarlane, Jason SG Doyle, Thomas A. Churchill, Beate C. Sydora, Richard N. Fedorak. (2009). Effect of ''Lactobacillus plantarum'' 299v treatment in an animal model of irritable bowel syndrome.  ''Microbial Ecology in Health and Disease, 21''. (1), 33-37.
<sup>Superscript text</sup>

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Lactobacillus plantarum
Lactobacillus.jpg
Scientific classification
Domain: Bacteria
Phylum: Firmicutes
Class: Bacilli
Order: Lactobacillales
Family: Lactobacillaceae
Genus: Lactobacillus
Species: plantarum
Binomial name
Lactobacillus plantarum

Photo Credit: Janice Carr (1982)

Description and significance

Lactobacillus plantarum is a Gram-positive, bacteria which ferments plants and is used industrially to make yogurt, cheese, and pickled vegetables. Apart from plants, L. plantarum is found in the human GI tract and acts as a probiotic bacteria. Its ability to survive in the GI tract has made this bacteria a target for further research in using it as a vehicle to deliver recombinant vaccines and treatments for diseases.[1]

Genome structure

In 2003, Michiel Kleerebezem mapped out the complete genome of Lactobacillus plantarum WCFS1. Lactobacillus plantarum strain WCFS1 is known to have 3,308,274 base pairs and contains 3,052 protein-encoding genes as well as three plasmids (1,917-bp, 2,365-bp, and 36,069-bp,) which accounts for its high adaptability. The G+C content of the chromosome is 44.5%, but the plasmids contain slightly less G+C content. [1]

Cell structure and metabolism

Lactobacillus plantarum is a Gram-positive, rod-shaped, organotrophic, aerotolerant, bacteria often called lactic acid bacteria because it gets most of its energy from converting glucose to lactate via homolactic and heterolactic fermentation. Homolactic fermentation uses the EMP pathway and heterolactic fermentation uses the phosphoketolase pathway. Therefore, L. plantarum is a facultative heterofermentative lactobacilli. [2] [1]

Ecology

Lactobacillus plantarum is a highly adaptive bacteria that can survive at temperatures between 1º to 60º Celsius and also a great range of atmospheric pressures. The name "plantarum" indicates that this bacteria is a "species of the plants." L. plantarum is found particularly in fermented plants, such as kimchee. However, it is also found in other fermented foods such as yogurt and cheese and it is also found in animal GI tracts, human saliva and vagina. [3] [4] [1]

Pathology

Lactobacillus plantarum 299v is actually considered to be a probiotic. Due to its ability to survive in the human GI tract for >6 days, L. plantarum 299v can inhibit the growth of other harmful bacteria such as E. coli in the host after contaminated meat consumption. L. plantarum 299v is found in various fermented foods such as yogurt, cheese, kimchee, and is recommended to be consumed regularly to support the immune system. In addition, the ability of L. plantarum 299v to produce lactic acid helps maintain healthy, low pH levels of the GI tract. [1] [3] [4]

Applications to Biotechnology

In 2004, Jean-Marie Perrier-Cornet discovered a way to control food fermentation by using Lactobacillus plantarum, a common food bacteria with resistance to a good range of temperature, pressure, and pH level. A cold pasteurization method without freezing the food and thus altering the composition of the food is a new technology of interest to the food industry. Perrier-Cornet found optimization of the procedure when pasteurizing L. plantarum for 10 min at temperatures between −20 and 25 °C and pressure between 100 and 350 MPa. [5]

Current Research

In 2006, Michael Schultz studied the effects of treatment with Lactobacillus plantarum 299v on immunodeficient mice prone to the development of colitis. The study found that L. plantarum 299v administered orally with water to interleukin-10 deficient mice produced significant results of reduced immune-mediated colitis. This suggests that L. plantarum 299v has the potential to be used against clinical inflammatory bowel disease. [6]

In 2008, Beatriz del Rio studied the use of live recombinant Lactobacillus plantarum as an oral delivery vehicle for a Lyme disease vaccine to invoke a protective immune response in mice. Because L. plantarum can survive in the GI tract, it has been long considered for this type of research. L. plantarum successfully expressed vaccine antigens inducing immunity in the mice infected with Lyme disease. [7]

In 2009, Alistair W. G. Waugh studied the effects of treatment with Lactobacillus plantarum 299v on healthy mice induced with irritable bowel syndrome via rectal administration of 1% allyl isothiocyanate in 30% ethanol. The mice were then force-fed L. plantarum 299v for up to 28 days. The results showed that L. plantarum 299v reduced inflammation and normalized the bowels.[8]

References

  1. 1.0 1.1 1.2 1.3 1.4 Kleerebezem, Michiel, Jos Boekhorst, Richard van Kranenburg, Douwe Molenaar, Oscar P. Kuipers, Rob Leer, Renato Tarchini, Sander A. Peters, Hans M. Sandbrink, Mark W. E. J. Fiers, Willem Stiekema, René M. Klein Lankhorst, Peter A. Bron, Sally M. Hoffer, Masja N. Nierop Groot, Robert Kerkhoven, Maaike de Vries, Björn Ursing, Willem M. de Vos*, and Roland J. Siezen. (2003). [1] Complete genome sequence of Lactobacillus plantarum WCFS1. Proceedings of the National Academy of Sciences, 100 (4), 1990-1995.
  2. "Lactobacillus." MicrobeWiki. 8 April 2009 Kenyon College. 21 April 2009. [2]
  3. 3.0 3.1 "Bacteria Genomes - LACTOBACILLUS PLANTARUM" European Bioinformatics Institute. European Molecular Biology Laboratory. 21 April 2009. [3]
  4. 4.0 4.1 Hwang, Hamin. "KimChee and Fermentation." 19 April 2005. 21 April 2009. [4]
  5. Perrier-Cornet, Jean-Marie, Sandra Tapin, Serenella Gaeta and Patrick Gervais. (2004). [5]High-pressure inactivation of Saccharomyces cerevisiae and Lactobacillus plantarum at subzero temperatures. Journal of Biotechnology, 115 (4), 405-412.
  6. Schultz, Michael, Claudia Veltkamp , Levinus A. Dieleman , Wetonia B. Grenther , Priscilla B. Wyrick , Susan L. Tonkonogy , R. Balfour Sartor, M.D. (2006). [6]Lactobacillus plantarum 299V in the treatment and prevention of spontaneous colitis in interleukin-10-deficient mice. Wiley Interscience, 8 (2), 71-80.
  7. Beatriz del Rio, Raymond J. Dattwyler, Miguel Aroso, Vera Neves, Luciana Meirelles, Jos F. M. L. Seegers, and Maria Gomes-Solecki1. (2008) [7]Oral Immunization with Recombinant Lactobacillus plantarum Induces a Protective Immune Response in Mice with Lyme Disease. Clinical and Vaccine Immunology, 15. (9), 1429-1435
  8. Waugh, Alistair W. G., Rae Foshaug, Sarah Macfarlane, Jason SG Doyle, Thomas A. Churchill, Beate C. Sydora, Richard N. Fedorak. (2009). [8]Effect of Lactobacillus plantarum 299v treatment in an animal model of irritable bowel syndrome. Microbial Ecology in Health and Disease, 21. (1), 33-37. Superscript text