Pravastatin: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
(typo)
mNo edit summary
 
(5 intermediate revisions by 3 users not shown)
Line 1: Line 1:
{{subpages}}
{{subpages}}
[[Image:Pravastatin structure.jpg|right|thumb|350px|{{#ifexist:Template:Pravastatin structure.jpg/credit|{{Pravastatin structure.jpg/credit}}<br/>|}}Pravastatin, a class I statin.]]
{{Image|Pravastatin structure.jpg|right|350px|Pravastatin, a class I statin.}}


'''Pravastatin''', or pravastatina (Spanish), pravastatin sodium, pravastatine (French) or  pravastatinum (Latin), is a class I statin used to treat [[hypercholesterolemia]] (high cholesterol) and prevent heart attacks and stroke and diminish [[athlerosclosis]].  It is similar in structure and function to the other class I statins [[mevastatin]], [[lovastatin]] and [[simvastatin]].  It is an antilipemic fungal metabolite isolated from ''Nocardia autotrophica''. It is a competitive  hydroxymethylglutaryl COA reductase (HMG CoA reductase) inhibitor.  Unlike lovastatin and simvastatin, it is an active compound without prior hydrolysis due to its increased hydrophilicity.  Inhibition of HNG CoA reductases results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.
'''Pravastatin''', or pravastatina (Spanish), pravastatin sodium, pravastatine (French) or  pravastatinum (Latin), is an [[Antilipemic agent|Antilipemic]] [[medication]]. It is a class I [[statin]] used to treat [[hypercholesterolemia]] (high cholesterol) and prevent [[myocardial infarction|heart attacks]] and stroke and diminish [[athlerosclosis]].  It is similar in structure and function to the other class I statins [[mevastatin]], [[lovastatin]] and [[simvastatin]].  It is an antilipemic fungal metabolite isolated from ''Nocardia autotrophica''. It is a competitive  hydroxymethylglutaryl COA reductase (HMG CoA reductase) inhibitor.  Unlike lovastatin and simvastatin, it is an active compound without prior hydrolysis due to its increased hydrophilicity.  Inhibition of HNG CoA reductases results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.


Its IUPAC chemical name is (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid and its chemical formula is C<sub>23</sub>H<sub>36</sub>O<sub>7</sub>.
Its IUPAC chemical name is (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid and its chemical formula is C<sub>23</sub>H<sub>36</sub>O<sub>7</sub>.


== brand names ==
== Brand names ==
<div class= style="-moz-column-count:3; column-count:3;">
*Compactin  
*Compactin  
*Elisor  
*Elisor  
Line 19: Line 20:
*Selipran  
*Selipran  
*Vasten
*Vasten
</div>
==External links==
{{CZMed}}[[Category:Suggestion Bot Tag]]

Latest revision as of 12:01, 6 October 2024

This article is a stub and thus not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Pravastatin, a class I statin.

Pravastatin, or pravastatina (Spanish), pravastatin sodium, pravastatine (French) or pravastatinum (Latin), is an Antilipemic medication. It is a class I statin used to treat hypercholesterolemia (high cholesterol) and prevent heart attacks and stroke and diminish athlerosclosis. It is similar in structure and function to the other class I statins mevastatin, lovastatin and simvastatin. It is an antilipemic fungal metabolite isolated from Nocardia autotrophica. It is a competitive hydroxymethylglutaryl COA reductase (HMG CoA reductase) inhibitor. Unlike lovastatin and simvastatin, it is an active compound without prior hydrolysis due to its increased hydrophilicity. Inhibition of HNG CoA reductases results in increased clearance of circulating LDL. Pravastatin also inhibits hepatic synthesis of VLDL, the precursor for LDL, reducing circulating cholesterol and LDL cholesterol.

Its IUPAC chemical name is (3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid and its chemical formula is C23H36O7.

Brand names

  • Compactin
  • Elisor
  • Lipostat
  • Mevalotin
  • Mevastatin
  • Mevinolin
  • Oliprevin
  • Pravachol
  • Pravaselect
  • Selectin
  • Selipran
  • Vasten

External links

The most up-to-date information about Pravastatin and other drugs can be found at the following sites.