Salsalate: Difference between revisions
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In [[pharmacology]], '''salsalate''', also called '''salicylsalicylic acid''' and '''disalicylic acid''', is a [[medication]] which is a [[non-steroidal anti-inflammatory agent]]. Salsalate is related to acetylsalicylic acid ([[aspirin]]), but unlike acetylsalicylic acid, salsalate does not irreversibly inhibit [[cyclooxygenase]] and thus is not an [[anti-platelet agent]]. | In [[pharmacology]], '''salsalate''', also called '''salicylsalicylic acid''' and '''disalicylic acid''', is a [[medication]] which is a [[non-steroidal anti-inflammatory agent]]. Salsalate is related to acetylsalicylic acid ([[aspirin]]), but unlike acetylsalicylic acid, salsalate does not irreversibly inhibit [[cyclooxygenase]] and thus is not an [[anti-platelet agent]]. | ||
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==Drug toxicity== | ==Drug toxicity== | ||
Tinnitus may happen, but is unlikely if the total daily dose is 3 grams or less.<ref name="pmid20231565" | Tinnitus may happen, but is unlikely if the total daily dose is 3 grams or less.<ref name="pmid20231565"/> | ||
Gastrointestinal toxicity is less than with other [[non-steroidal anti-inflammatory agent]]s.<ref name="pmid2181673">{{cite journal| author=Roth S, Bennett R, Caldron P, Hartman R, Mitchell C, Doucette M et al.| title=Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study. | journal=Semin Arthritis Rheum | year= 1990 | volume= 19 | issue= 4 Suppl 2 | pages= 11-9 | pmid=2181673 | doi= | pmc= | url= }} </ref><ref name="pmid2625689">{{cite journal| author=Lanza F, Rack MF, Doucette M, Ekholm B, Goldlust B, Wilson R| title=An endoscopic comparison of the gastroduodenal injury seen with salsalate and naproxen. | journal=J Rheumatol | year= 1989 | volume= 16 | issue= 12 | pages= 1570-4 | pmid=2625689 | doi= | pmc= | url= }} </ref> | Gastrointestinal toxicity is less than with other [[non-steroidal anti-inflammatory agent]]s.<ref name="pmid2181673">{{cite journal| author=Roth S, Bennett R, Caldron P, Hartman R, Mitchell C, Doucette M et al.| title=Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study. | journal=Semin Arthritis Rheum | year= 1990 | volume= 19 | issue= 4 Suppl 2 | pages= 11-9 | pmid=2181673 | doi= | pmc= | url= }} </ref><ref name="pmid2625689">{{cite journal| author=Lanza F, Rack MF, Doucette M, Ekholm B, Goldlust B, Wilson R| title=An endoscopic comparison of the gastroduodenal injury seen with salsalate and naproxen. | journal=J Rheumatol | year= 1989 | volume= 16 | issue= 12 | pages= 1570-4 | pmid=2625689 | doi= | pmc= | url= }} </ref> | ||
Latest revision as of 19:14, 1 September 2024
In pharmacology, salsalate, also called salicylsalicylic acid and disalicylic acid, is a medication which is a non-steroidal anti-inflammatory agent. Salsalate is related to acetylsalicylic acid (aspirin), but unlike acetylsalicylic acid, salsalate does not irreversibly inhibit cyclooxygenase and thus is not an anti-platelet agent.
Salsalate may reduce the Glycosylated hemoglobin A1c in patients with diabetes mellitus type 2.[1]
Drug toxicity
Tinnitus may happen, but is unlikely if the total daily dose is 3 grams or less.[1]
Gastrointestinal toxicity is less than with other non-steroidal anti-inflammatory agents.[2][3]
References
- ↑ 1.0 1.1 Goldfine AB, Fonseca V, Jablonski KA, Pyle L, Staten MA, Shoelson SE et al. (2010). "The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial.". Ann Intern Med 152 (6): 346-57. DOI:10.1059/0003-4819-152-6-201003160-00004. PMID 20231565. Research Blogging.
- ↑ Roth S, Bennett R, Caldron P, Hartman R, Mitchell C, Doucette M et al. (1990). "Reduced risk of NSAID gastropathy (GI mucosal toxicity) with nonacetylated salicylate (salsalate): an endoscopic study.". Semin Arthritis Rheum 19 (4 Suppl 2): 11-9. PMID 2181673. [e]
- ↑ Lanza F, Rack MF, Doucette M, Ekholm B, Goldlust B, Wilson R (1989). "An endoscopic comparison of the gastroduodenal injury seen with salsalate and naproxen.". J Rheumatol 16 (12): 1570-4. PMID 2625689. [e]