Connective tissue disease: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Robert Badgett
mNo edit summary
 
(5 intermediate revisions by 2 users not shown)
Line 1: Line 1:
{{subpages}}
{{TOC|right}}
In [[medicine]] and [[rheumatology]], '''connective tissue diseases''' are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., [[collagen]], [[elastin]], or the [[mucopolysaccharide]]s."<ref>{{MeSH}}</ref>
In [[medicine]] and [[rheumatology]], '''connective tissue diseases''' are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., [[collagen]], [[elastin]], or the [[mucopolysaccharide]]s."<ref>{{MeSH}}</ref>


==Classification==
==Classification==
[[Autoimmune disease]]
[[Autoimmune disease]]
* [[Dermatomyositis]]
* [[Dermatomyositis]] - may have [[autoantibody|autoantibodies]] to [[histidine-tRNA ligase]] (anti-synthetase, [[Jo-1 antibody]]) and to PM-Scl nucleolar antigen complex
* [[Systemic lupus erythematosus]]
* [[Mixed connective tissue disease]] (MCTD). MCTD is an overlap between systemic lupus erythematosus, scleroderma, and polymyositis. Most patients with MCTD have [[autoantibody|autoantibodies]] to [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP)
* [[Mixed connective tissue disease]]
* [[Polymyalgia rheumatica]]
* [[Polymyalgia rheumatica]]
* [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s)
* [[Rheumatoid arthritis]] - 80% a positive [[rheumatoid factor]] ([[autoantibody|autoantibodies]] against [[gamma-chain immunoglobulin]]s)
Line 11: Line 12:
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=11014971 }} </ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=clinical.uthscsa.edu/cite&retmode=ref&cmd=prlinks&id=11014971 }} </ref>
* [[Scleroderma]] - most have [[Antinuclear antibody|antinuclear antibodies]] or [[autoantibody|autoantibodies]] to [[centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70)
* [[Scleroderma]] - most have [[Antinuclear antibody|antinuclear antibodies]] or [[autoantibody|autoantibodies]] to [[centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70)
* [[Systemic lupus erythematosus]]
Cartilage disease
Cartilage disease
* [[Relapsing Polychondritis]]
* [[Relapsing Polychondritis]]
Collagen disease
Collagen disease
* [[Alport Syndrome]]
* [[Alport Syndrome]]
* [[Ehlers-Danlos Syndrome]]
* [[Ehlers-Danlos Syndrome]]
* [[Osteogenesis Imperfecta]]
* [[Osteogenesis Imperfecta]]
==Diagnosis==
===Autoimmune disease===
Connective tissue disease due to [[autoimmune disease]] may have detectable [[autoantibody|autoantibodies]] to [[autoantigen]]s such as:
*  [[Histidine-tRNA ligase]] (anti-synthetase, [[Jo-1 antibody]]) and to PM-Scl nucleolar antigen complex with [[dermatomyositis]].
* [[U1 small nuclear ribonucleoprotein]]s (anti-U1 snRNP OR anti-U1 RNP) with [[mixed connective tissue disease]].
* [[Gamma-chain immunoglobulin]]s in [[rheumatoid arthritis]].
* [[SS-A antigen]] (Anti-Ro antigen) or [[SS-B antigen]] (Anti-La antigen) with [[Sjogren's Syndrome]]
* [[Centromere]] or [[DNA topoisomerase I]] (Anti-Scl-70) with [[scleroderma]]


==References==
==References==
<references/>
<references/>[[Category:Suggestion Bot Tag]]

Latest revision as of 12:00, 1 August 2024

This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.

In medicine and rheumatology, connective tissue diseases are "a heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides."[1]

Classification

Autoimmune disease

Cartilage disease

Collagen disease

Diagnosis

Autoimmune disease

Connective tissue disease due to autoimmune disease may have detectable autoantibodies to autoantigens such as:

References