Gyrification/Addendum

Quantitative measures of gyrification

Commonly used measures of the exent of cortical folding include:

• Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle L^2 norms} :
  • $LN_{G}={\tfrac {1}{4\pi }}\textstyle {\sqrt {\sum _{A}K^{2}}}$, with $K=k_{1}k_{2}$ being the Gaussian curvature, computed from the two principal curvatures $k_{1}$ and $k_{2}$
  • $LN_{M}={\tfrac {1}{4\pi }}\textstyle \sum _{A}H^{2}$, with $H={\tfrac {1}{2}}(k_{1}+k_{2})$ being the Mean curvature and $A$ the area of the surface in question
• Folding index
  • $FI={\tfrac {1}{4\pi }}\textstyle \sum _{A}k^{\ddagger }$, with $k^{\ddagger }=|k_{1}|(|k_{1}|-|k_{2}|)$
• Intrinsic curvature index
  • $ICI={\tfrac {1}{4\pi }}\textstyle \sum _{A}K^{+}$, with $K^{+}$ being the positive Gaussian curvature
• Curvedness
  • $C={\sqrt {\tfrac {k_{1}^{2}+k_{2}^{2}}{2}}}$
• Sharpness of folding
  • $S=(k_{1}-k_{2})^{2}$
• Bending energy
  • $E_{b}=\int _{A}{(k_{1}+k_{2})}^{2}dA$
• Willmore energy
  • $E_{W}=\int _{A}{(k_{1}-k_{2})}^{2}dA=\int _{A}{H}^{2}dA-\int _{A}{K}dA$
• Gyrification index
  • $GI_{slice}(n)={\tfrac {A(n)_{outer}}{A(n)_{inner}}}$, with $n$ indicating the number of the slice, and Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle A(n)_{outer}} and Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle A(n)_{inner}} being the outer and inner cortical contour in that slice. Anatomically, the inner contour can be thought of as representing the pia mater, the outer one the arachnoid mater. The latter correspondence is rough, since the arachnoid also encloses venous sinuses.
  • Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle GI_{mesh} (n) =\tfrac{A(n)_{outer}}{A(n)_{inner}}} , with $n$ indicating the number of the region, and Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle A(n)_{outer}} and Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle A(n)_{inner}} being the outer and inner cortical surface area in that region. The anatomical correspondences apply equally to the slice-based and regional definitions.
• Gyrification-White index
  • Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle GWI =\tfrac{A_{gw}}{A_{gc}}} , with $A_{gw}$ being the surface area of the boundary between grey matter and white matter
• White matter folding
  • Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle WMF =\tfrac{A_{gw}}{{V_w}^{2/3}}} , with Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle V_w} being the volume of the white matter
• Cortical complexity
• Fractal dimension
• Shape index
• Roundness
  • Failed to parse (SVG (MathML can be enabled via browser plugin): Invalid response ("Math extension cannot connect to Restbase.") from server "https://wikimedia.org/api/rest_v1/":): {\displaystyle RN =\tfrac{A}{^3\sqrt{36 \pi V^2}}}