Talk:Homeopathy/Archive 13: Difference between revisions

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== The structure of water==


I renamed "The debate": "The structure of water". It seems reasonable because 1) "A false debate" was renamed "A common misunderstanding (Hayford is right); 2) The broader question of the structure of water is often considered non-sensical, and we ought to make some clarifications. The random network model of liquid water is not plausible anymore, although most chemists and biochemists consider it as a non-issue.
==APPROVED Version 1.1==


I began my summary of [http://www.rustumroy.com/Roy_Structure%20of%20Water.pdf Structure Of Liquid Water; Novel Insights From Materials Research; Potential Relevance To Homeopathy] (2005) R Roy, WA Tiller, I Bell, MR Hoover - Materials Research Innovations. This is a dense and informative article, that I recommend (32 pages).  I would also recommend the speech given by Rustum Roy, the first author, in a conference on homeopathy at the University of Connecticut. I shared the video in [http://watchknow.org/ Watchknow's] youtube [http://youtube.com/groups_videos?name=watchknow group].
<div class="usermessage plainlinks">Discussion for Version 1.1 stopped here. Please continue further discussion under this break. </div>


I will add as much as I can reasonably can to this state-of-the-art in the field of materials science, help will be appreciated.
The Approval includes two copyedits [http://en.citizendium.org/wiki?title=Homeopathy&diff=100587554&oldid=100587549] [[User:Hayford Peirce|Hayford Peirce]] 19:13, 11 October 2009 (UTC)


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 19:43, 12 September 2008 (CDT)
:I'm not sure how to add yet another archive and get things to show up properly in the header here. Could someone do so? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:22, 11 October 2009 (UTC)


A good beginning. I have just added more, including reference to what I consider to be the most comprehensive body of information and research on the structure of water...by Martin Chaplin.  Feel free to tweak and expand. In particular, I need some help in formatting. [[User:Dana Ullman|Dana Ullman]] 13:38, 13 September 2008 (CDT)
== Beginning with semi-lower-case editorial... ==


I wonder if we should use Chaplin's work as a template. Even Roy and colleagues refer to Chaplin's work as the most comprehensive and the most valuable review! Once again, Dana, you prove that you're the expert here.  
As a first step, I'm going to all footnotes that contain other than bibliographic material or definitions, and either moving the substantive text into the main article, or, in some cases, linking to a subarticle.


I'll compare the relative importance of both works. I'll see what I can do for the formatting. Wikilinks, reference formatting... those kinds of things.(?)
While it may be reasonable, in a printed book or journal, to have bottom-of-the-page notes, in this format, the content of the notes will not be seen unless the reader clicks on them. How many readers do that?  In effect, the text is being hidden. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:37, 11 October 2009 (UTC)


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 14:15, 13 September 2008 (CDT)
== A balanced blog post on the subject ==


*I read: ''Novel Insights From Materials Research; Potential Relevance To Homeopathy'' (2005) R Roy, WA Tiller, I Bell, MR Hoover - Materials Research Innovations. This is a superfluous chaotic article, that I would have rejected without any trace of doubt had I been the referee. In addition, I wish to  point out that Rustum Roy, the first author, is also first author on a paper (same journal) in which it is proved that seawater can burn. It would take me too much time to explain my position, and I'm sure that it would start a prolonged discussion on this page that would lead to nowhere. Let me just say that my reasons to judge as rubbish both papers of Roy are purely scientific, I've nothing  against burning seawater or homeopathy. --[[User:Paul Wormer|Paul Wormer]] 06:07, 24 September 2008 (CDT)
can be found [http://scienceblogs.com/neurotopia/2009/12/homeopathy_the_basics.php here]. --[[User:Daniel Mietchen|Daniel Mietchen]] 09:21, 16 December 2009 (UTC)


:I said "this is a dense and informative article, that I recommend (32 pages)". The reply: it is a "superfluous chaotic article", not fit for publication ("that I would have rejected without any trace of doubt had I been the referee)", or, in simpler terms, "rubbish".  
:I added a comment, as did Paul. Truly delightful, however, is <blockquote>Personally, I would really like to see a homeopathic treatment for dehydration. You'd have to have a compound that causes dehydration, but what would you dilute it in? you can't dilute it in water or saline, because those will rehydrate, and in homeopathy, you have to CAUSE dehydration to cure it...but you can't having anything that CAUSES dehydration because it would have to be diluted to the point where none of the dehydrating agent remains...</blockquote>


: I see that Dana enhanced my text:
:It should be noted that some camping supply stores, in the same aisle as freeze-dried foods, offer cans of "dehydrated water". Ethical staff makes sure that new users understand the purpose of same. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:06, 16 December 2009 (UTC)


: <blockquote>For a theoretical overview of the structure water from a leading professor of material sciences, see Structure Of Liquid Water; Novel Insights From Materials Research; Potential Relevance To Homeopathy (2005) R Roy, WA Tiller, I Bell, MR Hoover - Materials Research Innovations.</blockquote>


:instead of
Howard, you gave the wrong link for Sympathetic magic. It's http://en.citizendium.org/wiki/Sympathetic_magic  And make sure the period at the end does not get connected to the link.  [[User:Chris Day|Chris Day]] 15:26, 16 December 2009 (UTC)


:<blockquote>For a more detailed analysis, see</blockquote>
That's a reasonable way to look at it, which is unusual for a blog. [[User:D. Matt Innis|D. Matt Innis]] 18:43, 16 December 2009 (UTC)


: Which is obviously very supportive of what I was saying. However, this whole situation reminds me too much of bad experiences I had on Wikipedia. Call it a Post-Wikipedia stress disorder... or an idealistic understanding of what "strong collaboration" means. But the bottom line is that I won't be able to take part in any more discussions here, or in any other articles where similar situations can occur. Sorry. I can be reached through email.
::Put it into the External Links. --[[User:Daniel Mietchen|Daniel Mietchen]] 19:27, 16 December 2009 (UTC)
:
:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 00:56, 25 September 2008 (CDT)


::Pierre, sorry to hear that.  I appreciate your work (and learned a few things along the way!). I would have liked to hear Paul's work on water as well, but I suppose it may stray too far from our purpose here, which is to write about Homeopathy. I don't have any problems with having a subpage explaining this thoroughly, just as I think a DNA article could have a subpage explaining all the potential bonds that form. I also think it is just as appropriate to talk about the psychosocial effects of the doctor patient relationship in healing. [[User:D. Matt Innis|D. Matt Innis]] 14:41, 26 September 2008 (CDT)
== Ramanand's changes ==
:::Thank you Matt. You see, the truth for me is that the inclusion of the research by serious experimenters in mainstream science ("normal science", as Kuhn puts it) is not dependant on the quality of their work but on the theoretical work that is done on the plausibility of homeopathy. And the plausibility of homeopathy rests only on the materials science of water, glass containers, and alcohol. This is unfortunate, but, on the other hand, some people like me really want to know how absent molecules work. It is perhaps more politically acceptable to say that homeopathy "is a system of alternative medicine that uses extremely small doses of drugs", "much smaller and specially prepared doses". But it is false. Remember the Avogadro limit. As I said earlier on this talk page, homeopathy uses preparations that contain little or no molecular trace of the initial molecule or extract. The definition of homeopathy in this article is false. Of course, when one tries to discuss what homeopathy is, trying to understand the properties of the solvent, like I do, it brings all kinds of problems: people don't agree on what they're talking about.


:::Put the definition of homeopathy in the homeopathy article: then we'll be in business!
First, the word " most <u>biased</u> medical " is argumentative, does not fit the language of the lede, and is clearly advocacy.
:::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 02:31, 27 September 2008 (CDT)


:::''The psychosocial effects of the doctor patient relationship in healing'' is exactly why I don't reject homeopathy (especially for the illnesses where the regular doctors don't have a good remedy).
The statement supporting homeopathy in the lede, even if the references were solid, belongs, stylistically, in a later section on the mechanisms of homeopathy. One reference is, as far as I can tell, from a Brazilian university with a site in, presumably, Portuguese, which I do not read. We generally don't use non-English references, especially when they are not clearly from peer-reviewed journals or otherwise reviewed sources.  


:::If somebody would be interested, I could explain in some detail why I call the paper by Roy et al.  "scientific rubbish".  Moreover, IMHO, the paper has hardly any bearing on homeopathy (or on the structure of water for that matter). --[[User:Paul Wormer|Paul Wormer]] 02:27, 27 September 2008 (CDT)
The other reference is from Khuda-Bukhsh, whom, I believe, has been in the memory of water controversy, is a review of possible molecular mechanisms of action. On first glance, it's an interesting paper, but does not talk at all about efficacy &mdash; just how homeopathic remedies may work, if they work. It doesn't belong in the lede, although it's not unreasonable to use it as a reference in a later section.


::::A super professor once taught me that we can't ignore the history. The way I see it is that homeopathy started long before scientific medicine, when vitalism was the mainstream. Homeopaths were the mainstream practitioners in the 1800s. I am not an expert on homeopathy, but I am assuming that the concept of "likes cures likes" did not start with doses so low that there were no molecules apparent. In other words, giving small doses of rabies to patients with rabies in the 1800's may well have been in dose limits that were "real" and may well have been the ground-breaking work that gave birth to immunizations, I truly don't know, but would be interested to read about it.  I do know that in the US, at the turn of the century, homeopaths were the majority practitioners until the [[Flexnor report]].  I have also read that, at that time, due to the lack of "modern" labs, most of the homeopathic schools were closed as inadequate and homeopaths were absorbed by medicine by grandfathering them in.  I assume anything that was potentially molecular was accepted, but those that couldn't be explained without invoking spiritualism were not.  Because these low dose remedies had no substance, they weren't dangerous and therefore not regulated by the federal government and was unable to restrict their use to MDs.  Those remedies that were left over could be given by anyone without an MD degree and are what we now know as homeopathy. 
Neither addition works where it is. The first is advocacy and non-neutral. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:45, 7 January 2010 (UTC)
:The use of "biased" is definitely adversarial. [[User:Chris Day|Chris Day]] 21:12, 7 January 2010 (UTC)
:With regard to the rebuttal (it works, and we know how), I am loath to see this article head down the direction of he says, she says tit for tat. [[User:Chris Day|Chris Day]] 21:21, 7 January 2010 (UTC)


::::Those who were treated less than desirably by the medical profession (women for instance), took hold of these alternative methods and developed them.  I'm not sure, but I am thinking that once the idea of Avocadro's limit became apparent, the only explanation at the time was to revert back to the "spiritual" roots that all healthcare once believed.  Now that reductionism is beginning to see it's limits, opening the door for other possibilities such as "the structure of water" to explain what we see (or don't see), opens the door for these same explanations to be used elsewhere.  There is nothing wrong with using scientific thought processes to rethink what homeopaths think they see. We have some bright minds here that could make some really reasonable arguments.  I think that the bar that we need to reach for inclusion in our article should be whether homeopaths are talking about it - or even those that are talking about homeopathy. For that we need to give way to our homeopathic experts and give our science experts a chance to look things over and keep it real, as long as they are willing to do the background work.  It would be wrong to dismiss homeopathic remedies just because we can't explain it.  So let's keep going - take our time and get it right.  I agree that our definition needs work and that the structure of water has some holes in it, but we can discuss them rationally. [[User:D. Matt Innis|D. Matt Innis]] 12:23, 27 September 2008 (CDT)
::The whole article is full of oxymorons, containng both viewpoints, so I don't see anything wrong with what I've inserted, unless the critics' statement is also removed (about what scientists feel). I'm fine if the word <u>biased</u> is removed, if it seems adversarial. The Portuguese and French is only in the references section and shouldn't be a problem.[[User:Ramanand Jhingade|Ramanand Jhingade]] 10:28, 8 January 2010 (UTC)


:::::Fascinating info, Matt, particularly the first para. If true, then I think the entire article ought to be *seriously* rewritten in order to reflect this info. That would explain, for instance, something that has always baffled me: Why the royal Brits have a Royal Homeopath or whatnot to treat them.... Commenting here as a general reader, nothing more.... [[User:Hayford Peirce|Hayford Peirce]] 13:07, 27 September 2008 (CDT)
:::Well, Ramanand, the general CZ, policy, especially in the Charter, is that articles don't equally present all views. They present the preponderance of the expert views, and, in this case, the experts are in health sciences; there isn't a unifying discipline among healing arts. Not all healing arts support homeopathy.
::::::You must be right Matt. I am a strong supporter of the approach you describe: let's "take our time and get it right". This article might become one of Citizendium's most impressive achievements. But to get there, we must let this page become like a big bazaar of ideas; take my mithridatization, for instance. It was proposed for deletion by one author, and another editor concurred. The question is: what's the urgency? Who sets the timeline? Not me, for sure! So I spent some of my precious time to rescue this idea. And found that mithridatization was an important historical-scientific foundation of the philosophical thinking of the founder of the GIRI, a research group devoted to the understanding of homeopathy. See the mithridatization and hormesis section. My intuition had brought me on more solid grounds than I thought. But if I hadn't read your kind and supportive words, I would have left completely this (pseudo?)-collaboration. I wonder if I should urge deletionists to be more collaborative and patient. On the other hand, it is not my job to explain what a gentle expert guidance should look like. What I can say is that it is essential, in well-regulated human interactions, to  ask the originator of a proposition to explain his or her motives or motivations, when the proposition manifestly misses its goal. If the marvels of wiki collaboration don't allow an enhancement of the ethics of deliberation, what will?
::::::And notice that I'm only talking about a successful rescue of content. When Ramanand invokes various frontier science topics (pseudo- or proto- science, if one prefers), in the quantum physics and nanobubbles sections, I view this as a precious reminder, while others will, more or less rightly, judge that it is off-topic. Well, yes, I agree that it is off-topic. But we'll lose much more if we delete without formally asking: "Who wrote this? Why did you think it was important?" It's not wikipedia here. We are committed to authorship and authority. We don't function by the rule "survival of the nerdiest, most active contributor". If Ramanand has little time to explain where he's coming from, let's wait; and some like me will perhaps add some insight which suddenly will make the off-topic intervention precious, albeit surprising.
::::::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 21:14, 27 September 2008 (CDT)


== Environmental Toxicology ==
::::Everyone needs to [[CZ:Neutrality Policy|Neutrally]] present all views. [[User:D. Matt Innis|D. Matt Innis]] 02:31, 9 January 2010 (UTC)
I have added a new section on this subject. There is more research on this topic than I have provided, but this is a good beginning.  [[User:Dana Ullman|Dana Ullman]] 13:38, 13 September 2008 (CDT)
: Dana, I was eager to see something specifically about homeopathy used as an antidote. I was saying, above in the talk page,


:''Beyond placebos (cont'd): in animals''
::The foreign language citations have been a problem in many other articles, not just here.


:''I found a good one. We're dealing with mice, there is a variety of controls, and both principles of homeopathy are involved : 1) a toxin, arsenic, is used to mitigate the effects of arsenic; 2) the doses used are well below Avogadro's limit (no arsenic left). I'dd add that the study was "highly accessed" and published in a BMC journal;''
:I think you mean contradictions or rather or challenges, not oxymorons. An oxymoron would be a "heroically large dose of a homeopathic simillum." An oxymoron is a contradiction in terms.


:And I emphasised, with the following quote, that homeopathy was considered as a near-ideal solution to a hard to solve problem, arsenic intoxication in several poor countries:
:Sorry, I'm in favor of removing both additions. You will need to face the reality that the article will not be as pro-homeopathy as you want, just as others wish it weren't here at all. It's a compromise. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:48, 8 January 2010 (UTC)


<blockquote>our initial aim was to find out suitable antagonists of arsenic poisoning, which should be i) easy to administer, ii) effective in low doses, iii) inexpensive and iv) without any toxic effects of their own. In course of our search, a potentized homeopathic drug, Arsenicum Album-30, was indeed found that showed highly promising results in combating arsenic intoxication in mice (....)</blockquote>
::I applaud, encourage and appreciate collaborative efforts to work toward improvements, but I think this lead still needs significant work to add any substantial improvement to the approved version's lead. [[User:D. Matt Innis|D. Matt Innis]] 02:28, 9 January 2010 (UTC)


:I think that it will be important to devote some room, perhaps in the closing remarks, to the social, economical, and political stakes involved in the acceptance/rejection of homeopathy. On the skeptics' side, homeopathy is a waste of time and public funds (critics are often revolted by the sums of money used by public health officials to beat the dead horse of this antiscientific CAM); a threat to public education (back to the dark ages, magic...);
:::I forgot to wish all of you a Happy (belated) New Year. The presently approved article's Lead isn't 'neutal' at the moment. It should either explain homeopathy plainly or if y'all want criticism in the Lead, it should contain both viewpoints. Where's Dana, by the way, in Germany again?—[[User:Ramanand Jhingade|Ramanand Jhingade]] 09:14, 9 January 2010 (UTC)


:On the homeopathy side, there is a concern that the rejection of this therapeutic is costly in terms of human quality of life, missed occasions to address problems (such as arsenic intoxication) that conventional systems are perhaps too slow to adress, especially in poor countries (I think that the World Health Organization and ''Médecins aux pieds nus'' (Barefoot doctors?) are favourable to homeopathy (?)).
:::: Happy New Year to you, too! Please let me know where you think the present Approved version lead (as opposed to the draft lead) is lacking and I'll be glad to take a look.  Dana approved the current lead, too, but I'm sure he'd take a look if we asked him.  [[User:D. Matt Innis|D. Matt Innis]] 15:00, 9 January 2010 (UTC)


:In other words, it seems justified to describe the wrath of so many conventional scientists, the ridicule thrown on those who dare to study the subject (cf Randi's conferences and public interventions), and, conversely, the disappointment of homeopaths (publication bias (see the bibliography subpage), rejection of the right to respond to critical editorials in mainstream journals.
:::::I'd posted a whole lot of links to homeopathic articles, late last year, but did not have the time to add it in the article. I was expecting someone here to do it, but no one did (not even Dana)! I already wrote what I wanted above, "It should either explain homeopathy plainly (without criticism in the very 1st sentence) or if y'all want criticism in the Lead, it should contain both viewpoints."—[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:34, 12 January 2010 (UTC)
: I don't want to light a fire. It is clear, for me, that controversies require sociological/epistemological considerations.  
:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 18:42, 13 September 2008 (CDT)


==Broad comments==
::::::We certainly can't add every link ever written to this article. This is the overview article in an encyclopedia type format and summarizes homeopathy pretty well, I think.  Again, don't confuse the lead in the Draft with the lead in the main [[Homeopathy]] article. I agree the lead in the draft needs more work and is not an improvement in its current form. [[User:D. Matt Innis|D. Matt Innis]] 12:45, 12 January 2010 (UTC)
I'm afraid I have little time just now to help. Generally I see positive and interesting things. Two points, I think it must be made clear that in general scientists and medics doubt that homeopathy has any basis other than placebo effects; I think this has been lost through the edits and I have tried to restiore the key point simply and clearly. The large clinical trials statement I have edited; the statement as written seemed to imply that the trials were designed deliberately to fail. It's a fact that in general such trials are not supportive. Why that might be could be discussed, but please be careful to keep any such discussion neutral, and the intro is not I think the place for that.[[User:Gareth Leng|Gareth Leng]] 16:36, 13 September 2008 (CDT)


== Is homeopathy plausible? The structure of liquid water ==
:::::::If nothing else, bibliographic links not directly related to the text belong on the bibliography page, preferably in articles. Also, in other articles, there is some selectivity. In some cases, reviews are more appropriate than small primary studies. In other cases, peer review and responsible publications are appropriate. In yet other cases, there is more leeway on publications but the reason needs to be explained.


Gareth, I agree that CZ articles should not contain an excessive number of sections and subsections. But what we're trying to do, before the great day when we submit this article for approval, is to sort out all the info we are gathering, so that we can summarize it and make it more readable (and entertaining).  
:::::::It's not necessarily reasonable to assume someone else will edit and add articles with which they aren't familiar, or with which they might disagree.  


There are dangers to deleting the codes for sections. Some of your edits were clever, but when I see that "Structure of liquid water" was lost in the table of contents, I got worried. The structure of water is the basic issue that we have to address. Your intervention made me realize that, in fact, instead of the dry "fundamental research" we could use "Is homeopathy plausible? The structure of liquid water" as a title for ths section.
:::::::What principles of homeopathy are in not in the lead?  It should go without saying that homeopathists believe what they are doing, or the article wouldn't be here at all. Having a small number of dissenting comments from people who question hematology simply establish it isn't universally accepted, and the details and pros and cons should be in the article, but later. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 13:27, 12 January 2010 (UTC)


If we represent correctly the research that is done on the structure of water (both in homeopathic preparations and in the body), we will be able to determine if the claimed "imprint" made in the water by the homeopathic process can be demonstrated or not; we will be able to say if homeopathy is falsifiable or not.
::::::::RE: provided references from Ramanand, [http://en.citizendium.org/wiki/Talk:Homeopathy/Archive_11#Long_time_no_see_.28post.29.21 this must be the list] and I do remember it, but it's mostly primary research.  They could be used for a more detailed article to support a specific claim where reviews aren't available, but to cite them here would result in too much detail for the general nature of this article. Primary research doesn't belong in a bibliography either.  I'm not sure that we have a subpage that would be appropriate for primary research, though it's an interesting idea for some other project, or way in the future for this one.  Otherwise, I'd think it would be a problem with [[CZ:Maintainability]]. There are other sites that do list all the research for each particular subject. [[User:D. Matt Innis|D. Matt Innis]] 14:51, 12 January 2010 (UTC)


So I reverted your change to reintroduce "stucture of water" as a high priority topic.
:::::::::This is one page ([[Homeopathy/Trials]]) that exists with a tabulated summary of some of the voluminous primary literature. I agree maintainability is an issue.  I bet there are hundreds of articles like this and the main problem is reducing it to the most important articles in the field. If that could be done well it might make a good catalog. [[User:Chris Day|Chris Day]] 17:18, 12 January 2010 (UTC)


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 02:00, 14 September 2008 (CDT)
:::::::::Matt, I made some time to read the entire (presently) approved article. I don't see any sentence saying there is evidence for homeopathy (the feg pdf document I've inserted in the present draft is accepted by 'mainstream' scientists as well). I object to the term 'placebo' in the lead (Edzard Ernst is known to be a ridiculed homeopathic baiter in the U.K.). I also object to the term 'fraud' in the Overview section<blockquote>They also are interested in whether positive results against expectation sometimes reflect manipulation of data or perhaps even fraud. </blockquote>. Like you said, can we edit the (presently) approved article?—[[User:Ramanand Jhingade|Ramanand Jhingade]] 17:34, 23 January 2010 (UTC)
:::::::::David (Ellis), can you please tell me what objections you have to the feg pdf document?—[[User:Ramanand Jhingade|Ramanand Jhingade]] 17:42, 23 January 2010 (UTC)


: That's fine, it wasn't my intention to de-emphasise that as an issue.[[User:Gareth Leng|Gareth Leng]] 05:50, 14 September 2008 (CDT)
(undent)
Placebo in the lead is perfectly appropriate; conventional medicine routinely accepts the placebo effect as a component of therapies.


::Clearly, there is fundamental progress being made on previously unsuspected structure and activity of water. There needs to be stronger connection between water structure and the physiologic effects of homeopathy, as well as verifying that homeopathic remedy preparation affects water. Apropos of the latter, is anyone aware of mass spectrometry of homeopathic remedies, which should be able to verify the presence of clathrates? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 06:50, 14 September 2008 (CDT)
Fraud is mentioned gently as a possibility by some observers, seemingly far more gently than some of the homeopathic claims of the danger of medicine. Sorry, it's not unbalanced.  Please do not go to "known" homeopathic baiters anywhere, else that you start having people bring in medical baiters from homeopathy. The problem with bait is that it often has a hook inside.


:::You may be interested by a recent contribution; I quoted: "the light scattering technologies of Raman spectroscopy and Fourier transform (FT) infra-red (IR) spectroscopy permit examination of remedy samples without fixatives or other potential contaminants (and) allow the co-operative nature of structural differences to be detected".
By edit the presently approved article, no, other than for typos, it's frozen. It is possible to edit the draft, and eventually to have the edited draft become the newly approved.  
:::Inspired by your other question, I created another plausibility section about the other side of the issue: water in living systems. It's empty...
:::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 13:21, 15 September 2008 (CDT)
::::Is this article about homeopathy or the structure of water?  In my opinion it is becoming very unbalanced. [[User:Chris Day|Chris Day]] 02:05, 24 September 2008 (CDT)
:::::"homeopathy ''or'' the structure of water?" I don't understand. Why don't you elaborate on this in the article? Why does an article exploring the plausibility of homeopathy becomes very unbalanced when it deals with the structure of liquid water?
:::::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 03:23, 24 September 2008 (CDT)


::::::I'm assuming a reader wants a general overview of homeopathy. An analogy would be the article on DNA focusing too much on hydrogen bonding. Obviously it is important for the function but does it need to be so much of the article? Water structure is also not well understood with regard to function in this case either, unlike hydrogen bonding with respect to DNA, so masses of detail is not really appropriate.  It should be mentioned, of course, but as it stands now (and it looks like it is likely to expand) it is an analysis of the primary literature discussing individual (controversial) ideas and (controversial) experiments. Some of the connections that are being made from the chemistry of water to the function in diluted states are not even clearly relevant, yet, there seems to be a narrative forming suggesting this is common knowledge that it is important for homeopathic function. In short there is too much certainty being placed on too little data. [[User:Chris Day|Chris Day]] 04:16, 24 September 2008 (CDT)
Again, what specific principles of homeopathy '''are not'' in the lede? --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:03, 23 January 2010 (UTC)


== Changes to lede and Intro ==
:Friends, it has been a while since I check-in here.  I have not re-read most of the new draft, but I can tell you that I do not like the lede paragraph.  It is simply not encyclopedic or impartial.  Anyway, we only recently spent a lot of time approving the previous edition.  I suggest that we let it sit for 3-6 months or more before we re-do it.  [[User:Dana Ullman|Dana Ullman]] 05:28, 1 February 2010 (UTC)


I made some mostly cleanup, clarifying and filling [http://en.citizendium.org/wiki?title=Homeopathy&diff=100387260&oldid=100387257 changes] to the lede and the introduction. If I have changed anything in an unacceptible way, feel free to set me straight. [[User:D. Matt Innis|D. Matt Innis]] 21:50, 17 September 2008 (CDT)
::Dana, I hope you can insert sentences that read something like, "there is scientific evidence for homeopathy", using the PDF for "Scientific framework of homeopathy: evidence-based homeopathy" available at http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/286/354 wherever appropriate.[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:21, 2 March 2010 (UTC)
: I can't parse the phrase "likes cures likes," unless it's an allusion to the title of a story about rodents by Ellis Parker Butler. [[User:Bruce M.Tindall|Bruce M.Tindall]] 22:16, 19 September 2008 (CDT)


== Concerning this long quote ==
=== British House of Commons Science and Technology Committee report ===


I feel that we have to emphasise that, once again, the textbook explanations are wrong (see first sentence of the quote), and that water has a previously unrecognized role in the whole enzymic machinery (following sentences; abridged). And of course, the notion of '''water clustering''' is central.  
The committee commissioned by the British government has reassessed homeopathy as a treatment option under the national health service. It's enquiry sought written evidence and submissions from concerned parties (See [http://www.timeshighereducation.co.uk/story.asp?sectioncode=26&storycode=408852&c=1 News in brief: Homeopathic assessment] and [http://www.parliament.uk/parliamentary_committees/science_technology/s_t_pn05_091020.cfm Evidence check: Homeopathy]). Both sides of the debate were represented and presented written evidence to the committee. In addition there were oral presentations from the following individuals:


It is tempting, as well, to salute the visionary insight of Szent-Gyorgyi.  
*Mr Mike O'Brien QC MP, Minister for Health Services, Department of Health;
*Professor David Harper CBE, Director General, Health Improvement and Protection, and Chief Scientist, Department of Health;
*Professor Kent Woods, Chief Executive, Medicines and Healthcare Products Regulatory Agency
*Professor Jayne Lawrence, Chief Scientific Adviser, Royal Pharmaceutical Society of Great Britain;
*Robert Wilson, Chairman, British Association of Homeopathic Manufacturers;
*Paul Bennett, Professional Standards Director, Boots;
*Tracey Brown, Managing Director, Sense About Science;
*Dr Ben Goldacre, Journalist.
*Dr Peter Fisher, Director of Research, Royal London Homeopathic Hospital;
*Professor Edzard Ernst, Director, Complementary Medicine Group, Peninsula Medical School;
*Dr James Thallon, Medical Director, NHS West Kent;
*Dr Robert Mathie, Research Development Adviser, British Homeopathic Association.


But now, help would be appreciated, especially from the biologists in CZ, and those who will (no doubt) rush to read and enhance this article, during Biology week!
A summary statement from the House of Commons Science and Technology Committee was released with the report in Feb 2010:
{{quote|... the NHS should cease funding homeopathy. It also concludes that the Medicines and Healthcare products Regulatory Agency (MHRA) should not allow homeopathic product labels to make medical claims without evidence of efficacy. As they are not medicines, homeopathic products should no longer be licensed by the MHRA.


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 02:16, 18 September 2008 (CDT)
The Committee concurred with the Government that the evidence base shows that homeopathy is not efficacious (that is, it does not work beyond the placebo effect) and that explanations for why homeopathy would work are scientifically implausible.


I don't think we can emphasise that at all. The essential involvement of water in all protein function is very well recognised, and not controversial (and when people say that textbook explanations are wrong, I am unimpressed and uninterested; to an expert, textbook explanations are always wrong :-)). There is some question about whether at a subatomic level, the water that is in close proximity to macromolecules might be forced into an altered structure. It seems plausible that it might, although there is dispute about whether it does. However to say that '''A''' in a macromolecular matrix the structure of water is distorted is one thing, to say '''B''' that it retains this structure when not confined is something else, and to say '''C''' that this structure could be recognised and used adaptively by biological mechanisms would be something else again. My view as a biologist, is that '''A''' sound interesting but I'm not a chemist. '''B''' seems very unlikely, but I'm not a physicist, and '''C''' is something for which I cannot conceive any mechanism nor can I imagine how any mechanism could have evolved through natural selection.[[User:Gareth Leng|Gareth Leng]] 08:30, 18 September 2008 (CDT)
The Committee concluded - given that the existing scientific literature showed no good evidence of efficacy - that further clinical trials of homeopathy could not be justified.
:Gareth sums up the "expert" opinion accurately here. I can relate to all his comments, especially the 'textbooks are wrong' one. [[User:Chris Day|Chris Day]] 08:56, 18 September 2008 (CDT)


== Definition by Boyd ==
In the Committee’s view, homeopathy is a placebo treatment and the Government should have a policy on prescribing placebos. The Government is reluctant to address the appropriateness and ethics of prescribing placebos to patients, which usually relies on some degree of patient deception. Prescribing of placebos is not consistent with informed patient choice-which the Government claims is very important-as it means patients do not have all the information needed to make choice meaningful.


Matt, you diluted the definition by Dr.Boyd so much that it did not seem to be his quotation. In any case, it was you who gave us the exact quote in the first place. If what I've done is unacceptable, please let me know.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 20:25, 22 September 2008 (CDT)
Beyond ethical issues and the integrity of the doctor-patient relationship, prescribing pure placebos is bad medicine. Their effect is unreliable and unpredictable and cannot form the sole basis of any treatment on the NHS. <br/>'''Source:''' UK Parliamentary Committee Science and Technology Committee - [http://www.parliament.uk/parliamentary_committees/science_technology/s_t_homeopathy_inquiry.cfm "Evidence Check 2: Homeopathy"]}}


Hi Ramanand, I have two issues with the quote: First, having such a long quote in the lede appears as though we can't explain it in our own words and, second, I don't think the average reader will take the time to try to understand what it says.  How about paraphrasing it for me.
From the full report the committee also stated:  
{{quote|
We conclude that placebos should not be routinely prescribed on the NHS. The funding of homeopathic hospitals — hospitals that specialise in the administration of placebos — should not continue, and NHS doctors should not refer patients to homeopaths.<br/>'''Source:''' [http://www.publications.parliament.uk/pa/cm200910/cmselect/cmsctech/45/45.pdf Evidence Check 2: Homeopathy, Fourth Report of Session 2009–10], House of Commons Science and Technology Committee, 20 October 2009, parliament.uk}}


<blockquote>
In conclusion the chairman of the committee said:
Homeopathy has been defined as, "a therapeutic method which assumes that a deviation from the fundamental mean within reversible limits, can be restored to normal by means of a stimulus, usually applied in the form of drugs, only sub-physiological doses of which are necessary because of hypersensitivity in disease and whose action is always directed toward normal by virtue of altered receptivity to stimuli in disease"<ref>Dr.W.E.Boyd <!--a Scottish Physician--></ref>.
{{quote|
</blockquote>
This was a challenging inquiry which provoked strong reactions. We were seeking to determine whether the Government's policies on homeopathy are evidence based on current evidence. They are not.
[[User:D. Matt Innis|D. Matt Innis]] 09:08, 23 September 2008 (CDT)


:I agree with Matt here.  I think that this quote is too cumbersome and not precise enough to be used in the lead.  I think that we should look for another quote or use our own words. [[User:Dana Ullman|Dana Ullman]] 21:03, 23 September 2008 (CDT)
It sets an unfortunate precedent for the Department of Health to consider that the existence of a community which believes that homeopathy works is 'evidence' enough to continue spending public money on it. This also sends out a confused message, and has potentially harmful consequences. We await the Government's response to our report with interest.<br/>'''Source:''' UK Parliamentary Committee Science and Technology Committee - [http://www.parliament.uk/parliamentary_committees/science_technology/s_t_homeopathy_inquiry.cfm "Evidence Check 2: Homeopathy"]}}


::Dana, much better concerning the quote and you even helped elucidate the "likes cures likes". I am having trouble leaving the latter part of the quote concerning immunizations, etc. as it seems to suggest that immunizations are homeopathic... Can you separate them more.  I think it gives the impresssion that an attenuated virus might be part of a homeopathic remedy. It isn't, is it? Do any homeopathic remedies actually include parts of a virus, or just compounds that mimic the symptoms of the disease that that virus would cause? [[User:D. Matt Innis|D. Matt Innis]] 20:39, 24 September 2008 (CDT)
: The Evidence Check definitely needs to be in the article. It has been hilarious watching the homeopaths squirming around trying to explain it away by butchering the quote from Cucherat's systematic review. It is like those reviews you see on movie posters where it says something like "Tremendous, Exciting (Evening Standard)" and then you go and look and see what the Evening Standard actually say and it is "A tremendous waste of time and money, has difficulty exciting all but the clinically insane". –[[User:Tom Morris|Tom Morris]] 15:12, 3 March 2010 (UTC)


:::Matt, actually, some doses of homeopathic medicines ARE viruses, just in very small dose. For instance, Influenzinum is made fresh every year.  Many (most? all?) homeopathic manufacturers obtain the same 3 types of flu viruses that the Pasteur Institute defines as the most common and that are typically in a "flu shot."  The difference is that the doses are simply smaller than those in a flu shot.  It is commonly sold as a 9C (1:100 dilution NINE times), thus maintaining some molecular dose.  It is also available in the 30C or 200C or 1M (1,000) or higher potencies.  The bottomline is that the homeopathic "principle of similars" is at the heart of vaccinations. 
:: For some reason, I couldn't access Citizendium yesterday at this time. Meanwhile, I got a reply from Dr Peter Fisher to my e-mail in which he says that the individual specific rules of Homeopathy were not followed in prescribing/administering the Homeopathic remedy, so I hope good sense prevails over the 'UK Parliamentary Committee Science and Technology Committee'.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 13:43, 12 March 2010 (UTC)


:::Taking this further, I quote from my new book, "The Homeopathic Revolution: Why Famous People and Cultural Heroes Choose Homeopathy," here's part of the section on Emil von Behring (the father of immunology!):  Emil Adolf von Behring (1854–1917) won the first Nobel Prize in medicine or physiology for his discovery of the diphtheria antitoxin. Later, he discovered the tetanus antitoxin. For many years he served as military captain of the medical corps to the Pharmacological Institute at the University of Bonn, and then was given a position at the Hygiene Institute of Berlin in 1888 as assistant to Robert Koch (1843–1910), one of the pioneers of bacteriology. He then became professor of hygienics in the Faculty of Medicine at the prestigious University of Marburg. Because of his significant discoveries in immunology, Behring retains a highly regarded place in its early history.
:::With regard to "the individual specific rules of Homeopathy were not followed in prescribing/administering the Homeopathic remedy" what is Peter Fisher referring to? How does that impact the report? [[User:Chris Day|Chris Day]] 16:25, 12 March 2010 (UTC)


:::In 1892 Behring actually experimented with serial (homeopathic) dilutions and found paradoxically enhanced immunogenic activity, but he was advised to suppress this experiment due to the aid and comfort it would provide to homeopaths. Only after he won the Nobel Prize did he feel comfortable in making public these experiments (Behring, 1905; Coulter, 1994, 97).
::::As I understand it, the individual specific rules of homeopathy mean that every patient is unique and the remedies appropriate for one will not be appropriate for another. Let's assume this is exactly correct. That would make classic randomized clinical trials, in which there is a standard treatment arm and a control arm, inappropriate, because there is no homeopathic standard.
Behring broke from orthodox medical tradition by recognizing the value of the homeopathic law of similars:
::::"In spite of all scientific speculations and experiments regarding smallpox vaccination, Jenner’s discovery remained an erratic blocking medicine, till the biochemically thinking Pasteur, devoid of all medical classroom knowledge, traced the origin of this therapeutic block to a principle which cannot better be characterized than by Hahnemann’s word: homeopathic. Indeed, what else causes the epidemiological immunity in sheep, vaccinated against anthrax than the influence previously exerted by a virus, similar in character to that of the fatal anthrax virus? And by what technical term could we more appropriately speak of this influence, exerted by a similar virus than by Hahnemann’s word “homeopathy”? I am touching here upon a subject anathematized till very recently by medical penalty: but if I am to present these problems in historical illumination, dogmatic imprecations must not deter me." (Behring, 1905) Reference: Behring, A. E. von. Moderne Phthisiogenetische und Phthisotherapeutische: Probleme in Historischer Beleuchtung. Margurg: Selbsteverlag des Verfassers, 1905. [[User:Dana Ullman|Dana Ullman]] 23:30, 24 September 2008 (CDT)


As you say, vaccination was introduced long before there was any understanding of its mechanisms of action, and Behring was quite reasonable ''at that time'' in pointing out the  analogy between homeopathy and vaccination. At that time there was no clear molecular theory. In particular, it was not understood that there are fundamental limits to how much a solution can be diluted while still retaining some of the diluted material, nor was it understood that physiological mechanisms require a process of molecular interaction. If homeopathy involves specific activation of the immune system, then this should be reflected in specific antibody production, and this is something readily measurable; as far as I know it doesn't result in specific antibody production. If I am right, the analagy might be relevant, but it shouldn't be presented as though it could be an explanation for why homeopathy might work.[[User:Gareth Leng|Gareth Leng]] 04:45, 25 September 2008 (CDT)
::::A very similar problem, however, applies to highly individualized [[pharmacogenomics|pharmacogenomic]] therapies: within a cohort of patients with, say, metastatic breast adenocarcinoma, the experimental hypothesis may be that a given treatment is applicable only to those patients with a specific BRCA gene coding. Panaceamycin is only expected to be effective in patients with that characteristic, and the others should get an aromatase inhibitor, the standard of care. Given there is a treatment, a placebo control is ethically unacceptable.  


:Gareth, the bottom line is that both homeopathy and vaccination have something in common and that is that they both use the "principle of similars."  We both agree that the analogy IS relevant. Although scientists today give their explanations for specific molecular processes for how vaccines work, they ignore the underlying principle that may explain why they do so.
::::RCT's have been designed that still have statistical power, but are testing the diagnostic and treatment model, not panaceamycin.  The clinician selects the treatment and sends an order to the pharmacy, where the pharmacist opens the next blind assignment envelope. If the patient is assigned to the experimental arm, the IV drug unit sent back to the care unit has panaceamycin in it if the genomic model calls for it, and the control treatment if not. If the patient is assigned to control, she gets control. It is the decision to assign that is being tested, more than the drug itself.


:I have no problem maintaining some humility here, and therefore, we should not say that the homeopathic "principle of similars" explains HOW homeopathic medicines work but that this principle in nature may provide an underlying basis for various phenomena, including vaccination, allergy treatments, and homeopathy.
::::In like manner, homeopaths could prescribe a totally individualized remedy, but they would be blinded to whether or not the patient gets the remedy -- control could be placebo, or a medical treatment. With a sufficiently large sample, if the homeopathic model is correct, the patients receiving the remedy should do better.


:By the way, for a drug to help prevent a specific disease, there are various processes of the immune system and other defenses at work, not just antibody production. [[User:Dana Ullman|Dana Ullman]] 13:40, 26 September 2008 (CDT)
::::It is not clear that homeopaths are willing to be tested in such a manner, which should obviate the argument about individualization not being permitted. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:05, 12 March 2010 (UTC)


:: Yes I agree that the analogy is relevant, it's not so much that scientists ignore the principle of similars, as that they simply don't accept its validity as a scientific principle. So only a homeopath would say that both vaccination and homeopathy use the principle of similars, but it's fine to say that hereOf course you're right in that the immune system is more than antibody production. [[User:Gareth Leng|Gareth Leng]] 11:36, 27 September 2008 (CDT)
:::::Brings me back to a question that I have never seen an answer to.  How can remedies be mass marketed and sold off the shelf at places like wal-mart and whole foods and be so effective (as claimed)? These remedies are either robust or need to be highly individualized.  If the latter, I don't see how how a mass market product will work. If the former, then they have indeed being found wanting (no better than placebo). Their defense against accepting the failed results of clinical trials precludes claiming successes from the mass market productsWhich is it? [[User:Chris Day|Chris Day]] 19:15, 12 March 2010 (UTC)


==Nanoparticles==
::::::A question, Chris, that I've asked myself. Let me respond indirectly.  One of the major mass-marketed products is [[Oscillococcinum]], about which I did write an article. What is the sound that is made by the creature from which the simillium is obtained? --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:28, 12 March 2010 (UTC)
?does this have anything to do with homeopathy? [[User:Gareth Leng|Gareth Leng]] 11:16, 24 September 2008 (CDT)


:Nah, I've been waiting to see if that line develops, but I think it's time to take that one out. [[User:D. Matt Innis|D. Matt Innis]] 11:23, 24 September 2008 (CDT)
:::::::Given that they are a £1.5bn industry we can expect to hear a lot of noise like that in the next few months. [[User:Chris Day|Chris Day]] 19:40, 12 March 2010 (UTC)


::Gareth, I would also like to see your post above concerning A, B and C appear in some form in the article. Any chance you can write something up stating something like that in the article proper? [[User:D. Matt Innis|D. Matt Innis]] 11:27, 24 September 2008 (CDT)
:::::::: Howard, you got it right - for example, Ipecacuanha can't be given where Antim. Tart is indicated. Chris, classical homeopaths don't accept 'over the counter'/'off the shelf' products because anything between 2 to 20 remedies are mixed in one 'combination' (Hahnemann used to call such homeopaths the 'mongrel sect'), but since it's popular, the classical homeopaths can't do much about it. In India, homeopathy is a half a Billion $ 'industry' - and that is only counting the medicines sold 'over the counter' and not what is spent on homeopathic doctors - so we're not gonna let people talk rubbish about it. It really works (See the 'feg' pdf document I've posted in the previous section)!—[[User:Ramanand Jhingade|Ramanand Jhingade]] 09:22, 13 March 2010 (UTC)


==Hyperimmune==
Ramanand, you didn't get right the essence of what I was saying: there are statistically powerful testing methods, which have been developed for biological therapies that indeed are individualized, which could answer the homeopathic objection to more traditional randomized clinical trials. I have not seen any evidence that homeopaths are willing to use such methods, but instead continue to insist on either statistically weak retrospective analyses or anecdotal/testimonial evidence. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:21, 13 March 2010 (UTC)
I've deleted a section of text here - hyperimmune responses are those elicited as a result of excess antibody production - don't think this is relevant here. the messenger pathways are complex and I don't think that this is the place for that kind of detail, it seems to be likely to confuse rather than clarify.[[User:Gareth Leng|Gareth Leng]] 04:34, 25 September 2008 (CDT)


==Mithridisation==
:Howard, it is very simple: the homeopaths are perfectly happy to use clinical evidence when it shows that homeopathy works. But when it shows that it doesn't work, then the clinical trial methodology must be at fault! Heads I win, tails you lose. If clinical trials are unable to detect the effects of homeopathy, why is the British Homeopathic Association quote-mining Cucherat? What seems more likely: that homeopathy works but not to the point where the clinical trial can detect it, or homeopaths cynically misuse evidence to support their pre-ordained conclusions? It has been so amusing to watch: our politicians have seen that the <s>King</s> alternative therapist is actually nude. All the homeopaths have been able to do is spin, quote-mine and clutch at straws. [[User:Tom Morris|Tom Morris]] 18:38, 13 March 2010 (UTC)
I'd suggest deletion of this section. Mithridisation seems to be an archaic term. The basis of tolerance to snake venoms seems to be the same as the basis of vaccination - protection is incurred by the production of antibodies to the venom. See e.g. Coral Snake Venom : Antibody Response in Rabbits. ''Nature'' (1967) 213:820-822. [[User:Gareth Leng|Gareth Leng]] 09:06, 25 September 2008 (CDT)


:I agree 100%...with more clean-up soon.  [[User:Dana Ullman|Dana Ullman]] 20:20, 25 September 2008 (CDT)
::I suppose there isn't really anything to do about it until there's a new Editorial Council and a reevaluation of workgroups. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:04, 13 March 2010 (UTC)
::Dana, Gareth,
::I'll copy the contents of [http://en.citizendium.org/wiki?title=Talk%3AHomeopathy&diff=100391271&oldid=100390877 my response to Matt] :
You must be right Matt. I am a strong supporter of the approach you describe: let's "take our time and get it right". This article might become one of Citizendium's most impressive achievements. But to get there, we must let this page become like a big bazaar of ideas; take my mithridatization, for instance. It was proposed for deletion by one author, and another editor concurred. The question is: what's the urgency? Who sets the timeline? Not me, for sure! So I spent some of my precious time to rescue this idea. And found that mithridatization was an important historical-scientific foundation of the philosophical thinking of the founder of the GIRI, a research group devoted to the understanding of homeopathy. See the mithridatization and hormesis section. My intuition had brought me on more solid grounds than I thought. But if I hadn't read your kind and supportive words, I would have left completely this (pseudo?)-collaboration. I wonder if I should urge deletionists to be more collaborative and patient. On the other hand, it is not my job to explain what a gentle expert guidance should look like. What I can say is that it is essential, in well-regulated human interactions, to  ask the originator of a proposition to explain his or her motives or motivations, when the proposition manifestly misses its goal. If the marvels of wiki collaboration don't allow an enhancement of the ethics of deliberation, what will?
And notice that I'm only talking about a successful rescue of content. When Ramanand invokes various frontier science topics (pseudo- or proto- science, if one prefers), in the quantum physics and nanobubbles sections, I view this as a precious reminder, while others will, more or less rightly, judge that it is off-topic. Well, yes, I agree that it is off-topic. But we'll lose much more if we delete without formally asking: "Who wrote this? Why did you think it was important?" It's not wikipedia here. We are committed to authorship and authority. We don't function by the rule "survival of the nerdiest, most active contributor". If Ramanand has little time to explain where he's coming from, let's wait; and some like me will perhaps add some insight which suddenly will make the off-topic intervention precious, albeit surprising.
[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 23:54, 27 September 2008 (CDT)


I think the problem here is that "mithridisation" is a term that has no hits at all on PubMed (and PubMed includes at least some homeopathy journals). It has no presence at all in science because (in referring to desensitisation as a result of chronic exposure to a toxin) it refers to many different kinds of things with quite different mechanisms of action (for example, in the case of venom, it's antibody production, in the case of other drugs it can be receptor downregulation). So while it's reasonable to have an article on mithridisation to clarify its historical usage, I don't think it has a place here, because it doesn't help to understand homeopathy (as far as I can see anyway). Hormesis I'm similarly unsure about. Hormesis (in drug actions) refers to agents that have different actions at low concentrations to those at higher concentrations. This can arise in many well known ways, and again, hormesis is a term used very seldom in the pharmacological literature because it embraces several different mechanisms. In itself, hormesis has nothing to do with homeopathy; we're not talking here about the high dilutions that homeopaths use, nor are we talking about anything outside conventional scientific explanations.
:::The draft is open to rewrite and, while I can't speak for everyone, I'll be glad to look at anything that gets put in it. I agree with Russell. [[User:D. Matt Innis|D. Matt Innis]] 03:17, 14 March 2010 (UTC)


I've no problem with waiting to see if something makes sense with further edits. I was just declaring here that, at present, I don't see where the sections on mithridisation and hormesis can go usefully. [[User:Gareth Leng|Gareth Leng]] 15:55, 28 September 2008 (CDT)
::::Howard, there is a lot of research going on in Homeopathy. Dr.Peter Fisher heads a research group in London and Dr.Rastogi heads a research group in India. I will email them about your suggestion. Tom, please look at the 'feg' .pdf document I posted - it is good, solid evidence that Homeopathy works!—[[User:Ramanand Jhingade|Ramanand Jhingade]] 11:44, 14 March 2010 (UTC)
: No. You said: "I'd suggest deletion of this section."
: [[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 20:24, 28 September 2008 (CDT)
::Isn't that the same thing?  If you "''don't see where the sections can go usefully''" then one would probably "''suggest deletion of this section''". No? I don't see these as being mutually exclusive comments. [[User:Chris Day|Chris Day]] 00:38, 29 September 2008 (CDT)
:::Chris, I'd "''suggest deletion of''" your comment.
::: Just joking. [[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 14:11, 29 September 2008 (CDT)
: Gareth, Matt, I sincerely hope you can consider the opinion of the others before deleting anything. I can explain things (so can Pierre-Alain and Dana), but I don't have the kind of time y'all do, so I request you to be patient.Thanks in advance for co-operating.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 21:58, 28 September 2008 (CDT)


::Pierre-Alain, I don't have a problem giving you time to explain how and why you think is info IS important. It is good, for instance, that you mentioned that the head of GIRI refers to mithridisation, but Gareth is absolutely correct in noting that if it is not mentioned in Pub-med, it may not have notability. On the other hand, hormesis IS big and very notable. [[User:Dana Ullman|Dana Ullman]] 00:25, 29 September 2008 (CDT)
Friends...in due respect, anyone who takes this "report" seriously has an axe to grind or is simply under-informed.
:::My preliminary research on mithridation/mithridatisation (using * can be helpful in pubmed) indicates that Mithridate is considered the first toxicologist. A pubmed + google scholar + dictionary search will reveal that English will tend to speak about Mithridates, about mithridates (=antidotes), about mithridaticum (a specific antidote that was famous for centuries, which contained poisons but also other drugs). My language, French, has a preference for another "plane" ("EN has a preference for reality, FR for reason", as we're taught in translation courses), and will use "mithridatisation" more often - the head of GIRI is French. But still, in the review by Khudar-Buksh we (?; see talk) were talking about (in the lead), the "Mithridates effect" (note that English prefers to point to a reality, the Emperor, and add "effect", rather than to add "ation"  or "ization") is mentioned as well. I'd like to emphasise that notability is not assessed by putting a word in pubmed and hitting the enter key. It's the first step. Here, we have a topic that is important in the history of medicine, which helped at least two researchers on homeopathy to think about homeopathy (you know how the history is useful when thinking about homeopathy). I would say that these historical considerations will be especially useful when we introduce hormesis.
:::The journal "Dose-response", which is entirely devoted to hormesis, doesn't seem to describe hormesis in the same terms as Gareth. In particular, they have published positive results with *very* low doses (right at the point of non-existence of the molecule, Avogadro's limit). It was with cisplatin. These researchers who investigate hormesis wish its mechanisms were well-known, but they aren't. Hence this broad definition; hence the publication of research on tiny, tiny doses. And you have electromagnetic hormesis, a hot topic in this day and age. Nobody assumes that the mechanisms are well known or self-evident, but we call it hormesis.
:::Finally, I would caution against the use of such expressions as "conventional scientific explanations". It is an appeal to authority. Nobody here is an expert on hormesis. Let's take our time.
:::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 14:03, 29 September 2008 (CDT)


== Mechanism of action ==
Any rational person should and must be very suspicious of this "report." The MPs (Members of Parliament) who were a part of the Science and Technology Committee which voted for this anti-homeopathy report comprised of five members, with three members barely eking out their victory. Of the three votes, two members did not attend any of the investigational meetings, one of whom was such a new member of the committee that he wasn't even a member of the committee during the hearings, and the remaining "yes" vote was from Evan Harris, a medical doctor and devout antagonist to homeopathy. This report was not exactly a vote of and for the people.  This information alone should entirely discount this "report" as a kangeroo court report that deserves that round circular file.


Pierre-Alain mentioned Khuda-Bukhsh's research into the mechanism of action of homeopathic remedies. Can we have that in the Lead (is it Lead or Lede?) please.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 22:33, 28 September 2008 (CDT)
The very limited number of people who represented homeopathy were primarily three people. The others were entirely antagonistic to homeopathy or simply uninformed about it (such as the rep from Boots).


:I do not think that Khuda-Bukhsh's research on mechanism of action has any place in the lead. His research on this subject has not been experimentally verified and his research has not been replicated. The lead should only have the most important, basic, and verified info.  And please, Ramanand, please provide summary info in your edits.  You've been told this before...and it IS important. [[User:Dana Ullman|Dana Ullman]] 00:29, 29 September 2008 (CDT)
Despite the use and acceptance of homeopathy throughout the U.K., there is a very active group of skeptics, with significant Big Pharma funding, who work vigorously to attack this system of natural medicine. Even though there is a wide variety of serious and significant pressing issues in British medicine and science today, an active group of skeptics of homeopathy successfully resurrected in October, 2009, a House of Commons committee, called the Science and Technology Committee, with the intent to issue a report on homeopathy. A leading skeptics organization, Sense about Science, that has been pushing for the re-creation of this Committee is led by a former public relations professional who worked for a PR company that represents many Big Pharma companies. Of additional interest is the fact that other Directors of the Sense about Science organization are a mixture of former or present libertarians, Marxists, and Trotskyists who also, strangely enough, seem to advocate for the GMO industry (ironically, libertarians normally advocate for a "live and let live" philosophy, but in this instance, it seems that they prefer to take choice in medical treatment away from British consumers).  


::As an observer of this article I suggest, again, it is becoming far too detailed down to the level of individual papers.  I mentioned this above for the water section and now I see the same thing here.  We need to rise above the details of discussing individual studies. Surely that would be for other articles? [[User:Chris Day|Chris Day]] 00:41, 29 September 2008 (CDT)
Sense about Science is a registered UK charity despite being a political pressure group. As such they have to divulge their sources of income which they do on their website. Not surprisingly, much of this comes from named pharmaceutical manufacturers.  


:: There is already a reference to this review paper (not a research paper) (Khuda-Bukhsh AR (November 2003). "Towards understanding molecular mechanisms of action of homeopathic drugs: an overview") in the lead section:
One of the investigators for the House of Commons Science Committee is a Liberal Democrat MP, Evan Harris. He has collaborated with Sense About Science on various projects, and he was also one of the skeptic demonstrators against the national pharmacy chain, Boots, which sells homeopathic medicines. This advocacy role does not make him an unprejudiced observer as is required for this type of investigation.
::<blockquote>There have been various suggestions about how homeopathic medicines might work,[2][3].</blockquote>
:: the other one being the special issue of Homeopathy (2007) that you brought to our attention, Dana.
::This brings us to the central problem of the definition of homeopathy, again. The sentence goes on:
:: <blockquote>but there is no generally accepted mechanism of action for the extremely small doses used in homeopathy, and this remains a stumbling block to its acceptance by mainstream medicine and science.</blockquote>
::Which is indeed a serious stumbling block, considering that it's not even the issue. Those two references deal with the structure of water, not with the effects of "extremely small doses".  
::Sorry for the digression; Ramanand, are you saying that we should give to the reader a general idea of what these "various suggestions" are? I would say that not doing so would amount to say that they don't *deserve* to be in the lead. I'd say it's self-evident; we have to tell the reader that the scientific research on homeopathy tries to understand the materials science of these preparations.
::[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 02:17, 29 September 2008 (CDT)


I want the mechanism of action to be mentioned in the Lead - that small reference can't even be read. I think Dana can do something about that.[[User:Ramanand Jhingade|Ramanand Jhingade]] 03:33, 30 September 2008 (CDT)
A report from this kangaroo court was issued recommending that the National Health Service stop funding for homeopathy and homeopathic doctors, despite the support for homeopathy and for consumer choice from Mike O'Brien, the country's present Health Minister. This report is only of an advisory nature, and because the Health Minister has already expressed his support for consumers' right to choose their own health care, it is uncertain what, if anything, will result of this report. What was most surprising about this report was that it verified that when people repeat a lie frequently enough, such as "there is no research on homeopathy," many people actually believe it, despite its transparent falsity.[[User:Dana Ullman|Dana Ullman]] 05:33, 7 May 2010 (UTC)


==Like cures like==
== Sources ==
Please, I have edited the lead to remove the suggestion that medicine uses this principle. I do not wish to misrepresent the beliefs of homeopaths in any way at all. However, we must not distort modern medical and scientific beliefs either. The principle of "like cures like" is not one used in any form by modern medicine or science. There are very few principles or laws of any form that are accepted in biology; in physics there are many, because these are founded in a detailed mathematical understanding and are universally applicable. The principle of "like cures like" has no theoretical basis accepted in science. It is quite wrong to say that vaccination is an application of the principle of like cures like; it may be (to some) an illustration of the principle, but modern vaccination is simply an application of contemporary understanding of the immune system. As for the generality of like cures like, remember that medicine used to be contrasted as the application of the opposite principle - allopathy - that medicines should be opposite in action to symptoms. Representing that as a principle was equally inappropriate. [[User:Gareth Leng|Gareth Leng]] 03:13, 29 September 2008 (CDT)


:First, allopathy is NOT the use of opposites.  That would be "contrapathy."  "Allopathy" derives from "other" or "different" from the "pathy" (disease).  In other words, sometimes allopathic medicine uses opposites, sometimes similars, and sometimes something different from the disease itself, though it happens to get rid of symptoms, at least temporarilyAlthough physicians can describe physiologically or biochemically why vaccinations work, it is also true to refer to vaccinations as the use of "like to cure like."  I previously gave a quote from the "father of immunology" about this.  Is there a middle ground where we can say what both of us are trying to say?  I personally do not think that it is simply "coincidence" that two of the few modern medical treatments that augment immune response (vaccination and allergy treatments) just happen to use medicines in small dose that CAUSE a disease in larger dose.  [[User:Dana Ullman|Dana Ullman]] 19:03, 29 September 2008 (CDT)
I'm surprised that this article does not reference or discuss Paul Starr's Pulitzer Prize and the Bancroft Prize winning book on the social transformation of American medicineAny article that wishes to understand the difference between allopathy and homeopathy needs to understand that this debate has less to do with science or medicine and everything to do with politics as the British report makes clear.  [[User:Russell D. Jones|Russell D. Jones]] 15:41, 2 March 2010 (UTC)


Well, consider diseases with the same symptoms; different strains of influenza, and say Weill's disease which has symptoms essentially indistinguisghable from flu. An influenza vaccination will protect against only one or perhaps a few closely related strains of influenza, will have no protective effect against Weill's disease, and in no case will be a cure of any sort against an established infection. So in what sense exactly is this analagous to the principle of "like cures like"? They're not cures, they are preventatives, and they prevent infection by the specific organism, not against like organisms, and do not cure diseases with like symptoms. Allergy desensitisation treatments unlike vaccination, work by depressing immune responsiveness (when they work which is variable, and they can be very dangerous). They work by exposure to the specific agent, not another agent - if you are allergic to housemites and cat fur the symptoms will be the same, you might sometimes "cure" the allergy to housemites by repeated exposure to the house mite allergen (though this is very often ineffective), but if that works you will still be allergic to cat fur (except in rare cases, such as oral allergy syndrome).
:At one time, it was indeed appropriate to compare allopathy and homeopathy. While some dictionary definitions still use allopathy as a synonym for conventional medicine, I find the modern usage to be more often by CAM practitioners, as that-which-we-do-not-do. (For the record, I happen to find some ''complementary'' medicine useful, or at least worthy of trial in non-critical situations.)


As for this article, I think that what homeopaths believe and do should be displayed clearly, fully and fairly. But there should be no misrepresentation about what scientists and medicine believe in the process. It's fair to say that homeopaths believe that the principle of like cures like underlies vaccination. It would be quite wrong to suggest that scientists or medics think this at all.
:As far as a "modern" comparison, however, I cannot do better than William Osler:
[[User:Gareth Leng|Gareth Leng]] 03:29, 30 September 2008 (CDT)
:<blockquote>A new school of practitioners has arisen which cares nothing for homeopathy and still less for so-called allopathy. It seeks to study, rationally and scientifically, the action of drugs, old and new."(Flexner report, page 162)</blockquote>


George Bernard Shaw offers an interesting perspective on  vaccination and homeopathy. I get the quote from Dana's free chapter (see link above), that I devoured:
:Unquestionably, there was once a competition between something one could legitimately call allopathy, as a "doctrine of opposites", and homeopathy as a "doctrine of similars". Homeopaths often selectively quote Osler as saying that the homeopathic remedies were safer than most allopathic remedies of his era (i.e., late 19th-early 20th century). You'll note that there was insistence on keeping the 1905 quote from von Behring.


<blockquote>The test to which all methods of treatment are finally brought is whether they are lucrative to doctors or not. It would be difficult to cite any proposition less obnoxious to science than that advanced by Hahnemann, to wit, that drugs which in large doses produced certain symptoms, counteract them in very small doses, just as in modern practice it is found that a sufficiently small inoculation with typhoid rallies our powers to resist the disease instead of prostrating us with it. But Hahnemann and his followers were frantically persecuted for a century by generations of apothecary-doctors whose incomes depended on the quantity of drugs they could induce their patients to swallow. These two cases of ordinary vaccination and homeopathy are typical of all the rest.</blockquote>
:It ain't the 20th century any more, and conventional physicians don't prescribe based on opposites, nohow. Yes, there are political residues, but there's now a lot more in the way of evidence-based medicine...and protecting turf. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:37, 12 March 2010 (UTC)


<blockquote>(...) "Here we have the explanation of the savage rancor that so amazes people who imagine that ''the controversy concerning vaccination is a scientific one''. '''It has really nothing to do with science'''. Under such circumstances vaccination would be defended desperately were it twice as dirty, dangerous and unscientific in method as it really is."</blockquote>
::My favorite quote from Paul Starr's book is:  “Because homeopathy was simultaneously philosophical and experimental, it seemed to many people to be more rather than less scientific than orthodox medicine.” [[User:Dana Ullman|Dana Ullman]] 05:37, 7 May 2010 (UTC)


What later determined the acceptance of vaccination, but not homeopathy, may have little to do with what we construct now as conventional logical explanations, post hoc. See Matt's comment's about the Flexner report, and Dana's chapter.
== The memory of sugar ==
[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 21:54, 30 September 2008 (CDT)


== Life time of water clusters ==
is being discussed [http://ff.im/gOS59 here] and provides a nice illustration of the topic. --[[User:Daniel Mietchen|Daniel Mietchen]] 21:56, 3 March 2010 (UTC)


I removed  the view that water clusters are short-lived is "outdated". Every year hundreds of articles appear in the regular peer-reviewed literature (model calculations, many kinds of spectroscopy) that prove the opposite. Why are we to believe the claims of Roy and a few of his disciples? Roy is the person who claims that 13.56 MHz radio waves (of which there are plenty in the ether) decomposes salt water into oxygen and hydrogen and ignites the mixture. If he were right all oceans would be afire.--[[User:Paul Wormer|Paul Wormer]] 08:55, 29 September 2008 (CDT)
:I thought the "memory of sugar" tended to go either to the abdomen or buttocks, depending on genetics? :-)
:"(...) it is pertinent to discuss the evidence suggested by the many scientists who deny water its ‘memory’. (...) They mostly concern arguments involving the ease with which hydrogen bonds between water molecules may break. Individual hydrogen bonds do not last long in liquid water (about a picosecond). Based on this one fact the opinion may be proffered that the mesoscopic structure of water must change on about the same time scale.


:Such arguments are completely fallacious as is easily recognized if metal hydrates or solid water (ice) are considered. In the case of ice the hydrogen bonds also only last for the briefest instant but a piece of ice sculpture can ‘remember’ its carving over extended periods. Cation hydrates exist and are commonly described with particular structure (eg the octahedral Na+(H2O)6 ion) but the individual water molecules making up such structures have but the briefest of residence times (<microseconds).
:Seriously, the discussion at that link is what I'd suggest is an expectation. It is possible to be neutral, I think, and mention, in the lede, that homeopathy is not generally accepted. We still do not have a way of dealing with the situation where homeopathy supporters will support a lede that doesn't consider it reasonably credible. Of course, in no other workgroup do we have an equivalent to the health sciences/healing art splits. Should Religion be joined by Atheism?  Alternatively, is it possible to have a reasonable Atheism article in Religion? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 22:46, 3 March 2010 (UTC)


:What such arguments fail to address is that the behaviour of a large population of water molecules may be retained even if that of individual molecules is constantly changing. Such behaviour is easy to observe: a sea wave may cross an ocean, remaining a wave and with dependence on its history, but its molecular content is continuously changing.
::The problem just isn't there with religion and atheism. If you, say, are interested in philosophy of religion, you can get a degree in it regardless of whether you are an atheist or a theist (or something else entirely). I say this from experience - I have a BA in Philosophy, Religion and Ethics from a Catholic college but am an atheist. There are some - I guess the polite way of saying it is 'non-mainstream' - ways of getting a doctorate in religion. You could become a "Doctor of Scientology" (D.Scn) - I read today that Ron DeWolf - Hubbard's son - had been given one, and stated in court that he wasn't sure whether they gave him the Doctorate before or after he'd been given the Bachelors! Or you could get a phony Ph.D from a diploma mill - as quite a lot of the creationists have. The problem with Healing Arts is that you can quite feasibly become a Healing Arts editor with a degree from a non-mainstream parallel academic institution. When mainstream academia isn't bending over backwards to certify degrees in quackery (as two universities in Britain shamefully have), the quacks create their own academic institutions.


:The remaining evidence presented against the memory of water concerns whether water clusters may retain their organization for time periods greater than a fraction of a second. Evidence denying the long-life of such water clusters is generally based on computer modelling but also includes NMR and diffraction data.5 There are several good reasons why such methods would not show any significant clustering properties for liquid water.
::"Dr" Gillian McKeith "PhD" has a degree from a place called Clayton College of Natural Health in Birmingham, Alabama. Said college is not accredited by any accrediting body recognized by the Department of Education, and a number of states in the U.S. list it as unaccredited on their websites for student loans (etc.). This does not stop McKeith claiming to have a PhD on her website, nor did it stop Channel 4 television or her publisher from touting this to promote her books and TV programme. She also likes to mention how she is a member of the American Association of Nutritional Consultants. You too can be a member of the American Association of Nutritional Consultants if you send them $60! McKeith has pushed notorious nonsense like the idea that green vegetables are good for you because the green shows they have chlorophyll (true), and the chlorophyll will oxidate your blood (how? Human beings are not plants. They tend to get their oxygen through respiration rather than photosynthesis. And even if they were getting their oxygen through photosynthesis, even your local tanning salon lamps aren't quite powerful enough to penetrate your small intestines).


:Computer simulations only operate for nanoseconds of simulated time, although taking hours or days of real time. Such short periods are insufficient to show longer temporal relationships, for example those produced by oscillating reactions.6 They also involve relatively few water molecules (of the order of 100–1000 or so) over small (nanometre) dimensions, insufficient for showing large scale (not, vert, similarmicron) effects. They utilize models for the water molecules that are inherently flawed, showing poor correspondence to the real experimental properties of water (except for those properties on which they were individually based) and hence poor at predicting known properties and likely to be highly inaccurate at predicting unknown properties.7 NMR and diffraction both determine individual water molecules as structures averaged from throughout the sample (akin to averaging the world’s population of men and women and coming up with an illusory ‘average’ person) and are incapable of detecting imprecise and mobile clusters where components may change."
::Another graduate of the Clayton College of Natural Health is cancer quack Hulda Clark who sells a whole variety of magic 'zapping' toys that make funny noises and shine lights and do little more to cure cancer than extract money from punters - I mean, cancer sufferers.
:[[Martin Chaplin]], expert on water structure, courtesy of [[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 14:32, 29 September 2008 (CDT) (you can find this if you follow reference 2 in our article)


::Why don't we quote Roy and also reference Chaplin, but also give Paul Wormer an opportunity to add something. However, Paul should not bring to this table other statements by Roy that deal with other subjects. I have no opinion or expertise on the fire and water issues, but let's maintain a focus here on THIS subject. [[User:Dana Ullman|Dana Ullman]] 19:10, 29 September 2008 (CDT)
::Take any philosopher of religion or even most theologians - they'll certainly be able to say something useful on an article about atheism in the Religion WG. Same for the non-believers within the same fields. The problem with Healing Arts is it lets people with completely bonkers views about reality approve articles on their favourite pseudoscience. If the claims of the homeopaths were true (and, blimey, even our politicians can tell what a big pile of nothing the evidence of two hundred years of homeopathy has amounted to), then most of the articles in the Biology and Chemistry workgroup need rewriting.


:::Before I saw this reaction, I answered Pierre [[here]]. As I say there, this discussion saps my energy and obstructs me from writing other stuff for CZ, so I stop participating in it. Good luck with your superstition about liquid water, I find that it degrades the quality of CZ, mais c'est la vie. --[[User:Paul Wormer|Paul Wormer]] 05:01, 30 September 2008 (CDT)
::I'll repeat myself again: we need to fix the Healing Arts bug. It is nothing more than a bug. It is a bug that is bringing down the great work done by other WGs. It says to anyone who has spent years of their life working on getting a PhD in physics or literature or psychology or whatever that you can get a fake degree from a non-accredited university and also be considered an expert on the same level. How can I, in good conscience, tell the experts in my field to contribute given this significant vulnerability in the Editorship system? –[[User:Tom Morris|Tom Morris]] 01:21, 4 March 2010 (UTC)


::::Certainly this is not a homeopathic superstition, is it? Shouldn't it be in the [[Water]] article. Perhaps Paul could talk about it over there and then we can just link it here.  I think this gets too technical for what I envision as an introductory article on homeopathy, as I expect this is why it was in a reference rather than in the article.    [[User:D. Matt Innis|D. Matt Innis]] 08:39, 30 September 2008 (CDT)
:::Religion seemed the obvious parallel, but we could, I suppose, have an Absolute Pacifism workgroup with Military -- not that quite a few professional soldiers don't hate war. Why can Engineering debunk a hoax theory but Health Sciences cannot? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 02:15, 4 March 2010 (UTC)


== Famous People and Homeopathy ==
::::Howard, you're one of the eight CharteristsAre you a loud and strong voice therein trying to *remove* Healing Arts as a Workgroup, so that some of this nonsense could then be addressed in the future in a rational way? [[User:Hayford Peirce|Hayford Peirce]] 02:49, 4 March 2010 (UTC)
In the lead, there is reference to many famous people who use and/or advocate for homeopathySome of you may know that my newest book is a highly referenced review of hundreds of the most respected "cultural heroes" of the past 200 years, including literary greats, politicians, corporate leaders, clergy and spiritual leaders, sports superstars, musicians, artists, monarchs, and film/tv celebrities.  For details, see:  http://www.homeopathicrevolution.com/ (see the link to the Table of contents).  See this review from a peer-review journal:  http://ecam.oxfordjournals.org/cgi/content/extract/nen024  Due to conflict of interest issues, I will not add these references and will let others decide if it is worthy of inclusion. By the way, reference in the lead section is to the British Royal Family.  This book has the most detailed chapter on the history of monarchs' involvement in homeopathy, and the Foreword to this book is written by Dr. Peter Fisher, the Physician to Her Majesty Queen Elizabeth II. [[User:Dana Ullman|Dana Ullman]] 22:21, 29 September 2008 (CDT)


:I'm thinking that this is not the place. There are lots of celebrities that use all sorts of controversial cures, Steve McQueen comes to mind. It's another form of "appeal to authority" that I see as a distraction for an article, though as a marketing tool I'm sure it works well, but we don't want to go there. [[User:D. Matt Innis|D. Matt Innis]] 08:52, 30 September 2008 (CDT)
:::::Compromise in the Charter Committee, I believe, means that the Workgroup and some other details will be passed, without detailed guidance, to the Editorial Council. Personally, I am urging the draft to go to discussion and markup, so we can proceed to the next steps after ratification. While this is an especially galling problem, there are less egregious workgroup structure problems that also need addressing and can't happen at the Charter level. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 03:21, 4 March 2010 (UTC)


:: I'm comfortable with selected historical references, uncomfortable with anything that might look like celebrity endorsement. I am happy with adding Dana's book to the bibliography list linked to the review and with a brief account of its coverage; I'll ddo that when I have the time (please forgive me here).[[User:Gareth Leng|Gareth Leng]] 08:56, 30 September 2008 (CDT)
::::Even with Pacifism and the Military, there is an implicit understanding that most of the facts are the same. The Pacifist will agree with the General that the U.S. dropped the bomb on Hiroshima or that Nelson died in 1805. They have different opinions, but they do not care out their own ''facts'' in quite the same way as the Healing Arts gang. [[User:Tom Morris|Tom Morris]] 07:32, 4 March 2010 (UTC)


:::That sounds reasonable, thanks Gareth. [[User:D. Matt Innis|D. Matt Innis]] 09:00, 30 September 2008 (CDT)
:::::No, the analogy may hold. There are those that will insist that any enemy can be defeated through passive resistance and good thoughts, just as some of the healing arts believe that it is utterly wrong to immunize against an infectious organism or use an antibiotic against one. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 07:43, 4 March 2010 (UTC)


: Appeal to authority is when an expert of x says that we should believe him on y, when the link between x and y is not in fact clear.
::::::Tom mentions non-mainstream ways of getting doctorates in religion. In fact the Archbishop of Canterbury still has the legal power to award them, which might explain why Church of England bishops always seem to be Dr. [[User:Peter Jackson|Peter Jackson]] 14:29, 12 March 2010 (UTC)
: What Dana has done is that he has collected a serie of case reports of people whose lives were changed by a therapy that they have no expertise on.  


: The large RCTs are heavily criticized for their lack of external validity, or lack of accordance with the principles and practice of homeopathy. A recent meta-analysis by the Lancet called for the end of homeopathy trials (it's all placebo! it's all water!); its transparency, methodology and interpretations were violently criticized and even mocked.
==How well does it work?==


: Dana, in response to this deadlock situation, brings the problem in the citizen's arena, with case reports which should have a sociopolitical impact and should appeal to common sense. He makes the case of clinical plausibility (while Roy, Chaplin and others bring the biological-physical plausibility in the citizen's arena as well. See my comments under the crystals section).
We use double-blind studies to tell how well a particular medicine works. The person handout out the medicine does not know whether it's a "real medicine" just a sugar pill. In the case of pain relievers, the potency of an [[analgesic]] is rated in terms of how much more effective it is than a [[placebo]].


:Of course, the fact that notable physicians and scientists "came out of the medicine closet" (Darwin, William Osler, Cushing, von Behring, etc.) and left a trace of their acceptance of homeopathy (and of its effects on their lives) is impressive (good marketing??), and can be taken as a fallacious appeal to authority. But none of these people contended that they had found how homeopathy works biologically or that it works (statistically) and that we should accept their expert opinion. They wrote or said, despite of the risks associated with such an endorsement, that it worked for them. I'd say those are very, very interesting case reports.
If I recall correctly, as much as 75% to 90% of the effective pain relief you get from the pills comes from the placebo effect: you take your aspirin or ibuprofen or (without knowing it) your sugar pill, and your headache starts going away within an hour no matter what. The real stuff is only slightly better.  


:Because now, the mainstream scientific opinion is that they all experienced placebo effects motivated by pseudoscientific beliefs.
Given all that, how would we design a study to compare homeopathic treatment with conventional treatment? Is it possible to conduct a blind study, if the way the healer deals with the patient is a key ingredient of the therapeutic effect?


:NB: We may find interesting things about the Flexner report and the dissapearance of homeopathy in America.
For that matter, how can we compare Freudian [[psychoanalysis]] to Berne's [[transactional analysis]] or modern [[rational-emotive therapy]] or to a frank chat with a trusted friend or mentor (like Father O'Malley down at the local Catholic church)?
:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 00:31, 1 October 2008 (CDT)


There is a misconception here; the placebo effect has nothing to do with pseudoscientific beliefs; it is a strong, robustly demonstrated effect caused by suggestion or of expectation; exactly how the placebo effect works is not known, but that it is often a very significant effect is - which is why all drug tests must be placebo controlled. [[User:Gareth Leng|Gareth Leng]] 04:35, 1 October 2008 (CDT)
* I daresay one result of a careful attempt to measure outcomes could be that "bedside manner" is much more important than we've allowed ourselves to realize.  


Sorry if I promoted this misconception. But my point here is that the the suggestion or the expectation, for these bright minds, is that homeopathy can't work. It is not true to say that the placebo effect has nothing to do with pseudoscientific beliefs: the expectations are often motivated by beliefs.
But I ask again, how do we study and quantify it? --[[User:Ed Poor|Ed Poor]] 02:04, 28 March 2010 (UTC)


Let me point out as well that, no matter how significant placebos may be, they are often considered unethical, as I pointed out in the [[EBM]] page, because it's basically negligence. All drug tests must be placebo controlled? Controversial.
::If one were to review the entire body of experiments that Thomas Edison conducted on electricity, one would have to say that the vast majority of his experiments were failures...and one might fall into a trap by saying that he was a failure.  Of course, we KNOW that this is not true.  Just because some studies have shown that homeopathic medicines don't work, there is a greater body of research to show that it does.  The trick is to know WHEN homeopathic medicines work...and when they don't.


Those case reports may refute that we're dealing with placebos.  
:: If anyone here wants to review a body of homeopathic research on a specific group of diseases (respiratory allergies) that have primarily been published in high impact conventional journals, such as the Lancet and the BMJ, you might consider reading this review of research I co-authored in a peer-review journal:  http://www.ncbi.nlm.nih.gov/pubmed/20359268  -- you can read the entire article online at:  www.altmedrev.com (It is in the Spring, 2010, issue, article #6).  [[User:Dana Ullman|Dana Ullman]] 05:43, 7 May 2010 (UTC)


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 12:31, 1 October 2008 (CDT)
== Unsupported assertions ==


In the course of making a general edit of the article, I've moved the list of "celebrity endorsements"--which, however interesting, is essentially what they are--to a footnote.  This gives adequate detail for purposes of putting teeth on the general claim. My concern about having the long list in the article itself is that this seems to imply that CZ is very impressed that all of these people have, perhaps once, received homeopathic treatment.  But, believe me, not all of us are.  It's equally unimpressive to me that Nancy Reagan relied on horoscopes, and all sorts of very smart people (I remember one philosophy grad student--of all things--in particular) take them half-seriously.
The current text has "Even in Europe, homeopathy is practiced by many conventional physicians, including 30-40% of French doctors and 20% of German doctors." and in the next paragraph "Some medical doctors, particularly in Germany, France, and several other European countries prescribe homeopathic medicines for wide variety of both self-limiting conditions and serious diseases with a high rate of patient satisfaction." There are no supporting citations.


One other point: we absolutely do need a ''source'' for such a detailed list of names--I'd ask Dana or someone to add that in. --[[User:Larry Sanger|Larry Sanger]] 13:33, 1 October 2008 (CDT)
This is obviously redundant; we need ''at most'' one of these statements. However, neither strikes me as believable without support, so I am inclined to delete both. Anyone care to comment before I edit? [[User:Sandy Harris|Sandy Harris]] 15:29, 26 June 2010 (UTC)
--[[User:Larry Sanger|Larry Sanger]] 13:33, 1 October 2008 (CDT)


:Needless to say, we should all be honored that Larry is participating in this article.  Thanx. Although I consider this information to be worthy of inclusion in the article itself and not just the footnote, I will let others decide this. This information is in part an "appeal to authority" but it is also notable history.  Homeopathy has a long history of support from the most respected cultural heroes of the past 200 years, not just monarchs but leading literary greats, sport superstars, corporate leaders, world leaders, and on and on.  My own father was a pediatric allergist and professor emeritus at UCLA, and although he was skeptical of homeopathy, he was impressed to learn that Yehudi Menuhin was the President of a leading British homeopathic organization. The bottomline is that we all use different information to determine whether something is worthwhile or not, and "scientific research" is not the only means to this end, especially since there are many barriers to good research (just ask any surgeon--surgery is not amenable to double-blind studies; and just ask any psychologist; let alone the limitations on availability of research funding). 
:Your point about unsupported assertions has come up before, and the current text, in my opinion, is significantly misleading. "homeopathy is practiced by many conventional physicians" does not, as much as some may want it to do so, imply that conventional positions endorse all of homeopathy. By definition, if they are conventional physicians, they are ''not'' practicing homeopathy as alternative medicine, but are using some complementary techniques from homeopathy. When I was last in my internist's office, I banged my shoulder against a piece of equipment. He rubbed it a bit. Does that mean he practices massage therapy?
:Actually, my new book provides detailed references to each person mentioned in the footnote...and a lot of others.  It may be more beneficial to not simply reference the website for this book but the book itself. I have no problem providing the information in the book, but I would prefer if someone else placed the specific reference in the article (it was published by North Atlantic Books, Berkeley, 2007).  Because one of the amazing and well-referenced stories in the book is of Charles Darwin, I chose to provide some summary information at my website:  http://www.homeopathic.com/articles/view,128  (If anyone here considers this worthy of reference in the article, I would prefer if he/she placed it there.) 


:For those people who wish to beef up this article, my new book is a veritable treasure trove of historical and modern-day information about homeopathySee for yourself. [[User:Dana Ullman|Dana Ullman]] 17:50, 1 October 2008 (CDT)
:"Patient satisfaction" is a purely subjective assessment and is in no way evidence of efficacyI could take the sentence starting "Some medical doctors..." and substitute "chemically pure water that has not been exposed to a simillium" and demonstrate high patient satisfaction.  


==Water Crystals==
:I agree with deleting both. Even if citations are offered, they must be of a quality that indicates that homeopathic methods are a significant part of the practice of these physicians and they are not using it with the intent of creating placebo effects. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:05, 26 June 2010 (UTC)
Does [http://en.citizendium.org/wiki?title=Homeopathy&diff=100392193&oldid=100392123 this] have anything to do with homeopathy? We have to draw the line somewhere. Just because somebody thought of something doesn't mean we have to write about it - and more importantly - paint it as mainstream.  These things take time. [[User:D. Matt Innis|D. Matt Innis]] 08:50, 30 September 2008 (CDT)
:Chaplin, Roy, Emoto, Wüthrich (a Nobel 2002 co-laureate (multidimensional nuclear magnetic resonance spectroscopy in the study the structure of proteins)), and others took part in a new documentary on water, [http://www.intentionmediainc.com/water.php Water: The Great Mystery], which is promoted by the [http://www.whatthebleep.com/ What the bleep] site. As most of us know, What the bleep (do we know) was a huge success, despite of the fact that it wasn't featured in most theaters (and mainstream science, evidently). It's a growing phenomenon, and it's causing great controversy.
:If we choose to ignore this movement of citizen+expert (pseudo?) science, we decide that they're not bringing a paradigm that ''may'' better explain water and homeopathy. We may as well reject Roy and Chaplin's works, which are already rejected by mainstream journals (in the sense that they don't get a fair hearing or a right to properly respond; our colleague Dana received an answer from FASEB's editor which exemplifies my point quite well). Where do we draw the line indeed: Roy and Chaplin with Emoto in a documentary for the general public, not ok? Roy and Chaplin in the scientific community, ignored or misrepresented, ok?
:I'm not assuming that you have already made your mind, Matt, and I understand that this contribution seemed far-fetched. I wouldn't accept it "as is".
:I think that we need a philosopher of science. I will consult [http://sciencepolicy.colorado.edu/about_us/meet_us/carl_mitcham/courses_taught/5110/classic_sts/structure_of_scientific_revolutions.pdf The structure of scientific revolutions], by Thomas Kuhn.
:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 21:20, 30 September 2008 (CDT)
:: As you say, the work is rejected in mainstream circles. We know that things are rejected that might subsequently gain acceptance; science in general does not claim that its theories are true, only that they are the best explanations currently available by their criteria. As editors we must seek to report facts and disputes neutrally, without appearing to take sides in disputes. Where appropriate, we report that a theory is not generally accepted (or is generally rejected) by science and medicine (as shorthand for the community of academic scientists and medics), if we are sure that this is the case. Scientists and medics get things wrong lots of the time and don't always agree with each other. Fringe theories can be covered on Citizendium, but their status should be clear and they should be written about neutrally, without editorial endorsement or denigration. If you want to cover a theory about the structure of water, it must also cover its status and any known objections to it that explain its status. I think this will be a diversion from this article, which is about homeopathy. Personally I think that this article would be better served by a simple acknowledgement that there is no accepted understanding of how homeopathy might work, that some ideas have been suggested (with references) but these are not at present accepted as adequate scientific explanations. Sometimes, the less said the better, especially where I don't think anyone would claim to be able to explain how homeopathy might work, any more than I would claim to know how placebos work.[[User:Gareth Leng|Gareth Leng]] 12:05, 1 October 2008 (CDT)
The debate on the scientific plausibility of homeopathy, today, as I quoted above (Chaplin answering to Paul) and emphasised both in the article and the talk page, is that
:a)the establishment rejects as null and void the notion that water can retain anything (no memory of water, no long-term structures). It can be stated in two sentences
:b)the other side, represented by mainstream researchers who went nuts / came to a high degree of sophistication, questioned the textbook assumptions that make the structure/memory of water look like a mere superstition.


This can be explained, but in more than two sentences and with several links to the water page and to several subpages that we may create. If this technique, which was used in Diderot's Encyclopedia to insert paradigmatic considerations, can be a middle-ground (between your less-is-better and my less-is-biased), so be it. The requirement is that this article must state clearly that the subpage is a scientific refutation that has not been addressed by the mainstream (a refutation which states that the ''assumption'' a) is, according to the evidence presented by b), not scientifically defendable).
:: It is a fact that at universities in Germany and Austria there are chairs and lectures on homeopathy (in Vienna also at the veterinary university). There are doctors who practice both. --[[User:Peter Schmitt|Peter Schmitt]] 23:10, 26 June 2010 (UTC)


This is in the best interest because those who think a), which makes the majority of CZ's potential readers, won't have to listen to what the mainstream circles don't address. But they will find the response, stated in all fairness to its degree of sophistication, if they want to.  
::: I have no problem if the two sentences ar combined. I think we've gone over this several times on the talk pages.  As Peter points out, there are obviously well established 'conventional' medical professionals that use homeopathy for treatment of medical conditions.  This is pretty much common knowledge at this point, so I don't see the need for citing a source for the mere fact that some medical physicians use homeopathy in their practices.  However, when we add specific numbers such as 30-40%, it does seem to beg for a reference.  It shouldn't be hard to find such a reference if it is out there.  Otherwise, removing the numbers and just stating the fact shouldn't be a problem.


I reiterate that Kuhn's work and philosophy of science may be useful. We do have 2 paradigms here. Materials science vs. molecular science. Mesoscopic vs. microscopic. Water vs. H2O. Things aren't that bad after all: both sides are not talking about the same thing.
::: I don't think we will be able to find any scientific sources that conclude that they use it only on undereducated healthy people as a placebo. In fact, I think the opposite is more likely the case. [[User:D. Matt Innis|D. Matt Innis]] 01:22, 29 June 2010 (UTC)


A subpage for that as well?
Would someone who has access care to correct the glaring English mistake in the first paragraph of this approved article? [[User:Ro Thorpe|Ro Thorpe]] 00:16, 2 July 2010 (UTC)


:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 14:41, 1 October 2008 (CDT)
:I'm sorry, Ro, I must have a blind spot that is preventing me from seeing this glaring error. Could you be so kind as to point it out? [[User:D. Matt Innis|D. Matt Innis]] 01:42, 2 July 2010 (UTC)
::Actually, I'd suggest this was a whole different article not a subpage. In the context of the "homeopathy related articles" subpage above, that would be a subtopic. It would also be a subtopic of water ([[Water/Related Articles]]). [[User:Chris Day|Chris Day]] 14:55, 1 October 2008 (CDT)


== literary greats and politicians ==
::Oh, so go ahead and shoot me!  I found it (after reading your request for Hayford to repair it :) [[User:D. Matt Innis|D. Matt Innis]] 01:46, 2 July 2010 (UTC)


Why should we, or anyone else for that matter, be impressed by the assertion that "literary greats and politicians" have advocated for homeopathy? If you told me that Sabin, Salk, DeBakey, and people of that ilk practiced it I would be more impressed. [[User:Hayford Peirce|Hayford Peirce]] 13:24, 1 October 2008 (CDT)
:::Bang, bang - but you've removed it! Many thanks! [[User:Ro Thorpe|Ro Thorpe]] 12:16, 2 July 2010 (UTC)


:It is irrelevant as far as i can tell. Or is the idea that great thinkers do not denounce homeopathy? But being great in one field does not preclude ignorance in other unrelated fields. Actually, even being great in genetics does not preclude you being a dunce in biochemistry and ''vice versa''. [[User:Chris Day|Chris Day]] 15:02, 1 October 2008 (CDT)
I provide many solid references to the use of homeopathic medicines by physicians in Europe in an article I wrote at: http://www.huffingtonpost.com/dana-ullman/homeopathic-medicine-euro_b_402490.html  (It is NOT my intent for anyone to reference this article in OUR article at this website.  Instead, we can use many of the references provided. This article also has many references throughout the article showing that people who use homeopathic medicines tend to have more education than those who don't.)


::I'll wait a day or so, then remove it unless there are strenuous objections from others. [[User:Hayford Peirce|Hayford Peirce]] 15:10, 1 October 2008 (CDT)
I urge us to be very careful in significant changing this article because a lot of time and thought went into it previously. [[User:Dana Ullman|Dana Ullman]] 18:05, 14 July 2010 (UTC)


:::The other edit that is needed in the sentence is "Many well-known people, including literary greats and politicians, '''have used or''' have advocated for homeopathy..."  They could have used it and found it worthless.  Or have used it and found it fabulous and therefore now advocate for it.  I've "used" that little red string on the Band Aid (R) pack and found it hit or miss, I've "used" the string on the old Quaker Oats (R) box and found it absolutely useless.  I find that for me, a cold lasts seven days if I use Vitamin C and one week if I do not. [[User:Aleta Curry|Aleta Curry]] 16:28, 1 October 2008 (CDT)
== Review by a sceptical layman (i.e. me) ==


I would strenuously object to the deleting of this information about the various respected cultural heroes who used or advocated for homeopathy.  See my recent writing above under the earlier topic about famous people. I can also add:  Facts are facts, and these facts are notable. As for famous physicians and scientists, the list of such individuals whose experiences or quotes are discussed in my book include:  Charles Darwin, Sir John Forbes, Sir William Osler ("the father of modern medicine"), Emil Adolf von Behring ("the father of immunology"), Sidney Ringer, Charles Frederick Menninger (founder of the Menninger Clinic), August Bier (inventor of spinal anasthesia), Harold Randall Griffith (father of modern anesthesia), Royal S. Copeland, William J. Mayo and Charles H. Mayo (founders of the Mayo Clinic), C. Everett Koop, Brian Josephson (Nobelist).  That said, it IS notable that so many literary greats, world leaders, and other cultural heroes used or advocated for homeopathy because such information suggests that homeopathy is some type of "new age" treatment or some type of "quack" therapy.  While it may not be notable if there were only a handful of such individuals, it is helpful for people to know that so many cultural heroes used AND appreciated this often neglected and often misunderstood medical system.  [[User:Dana Ullman|Dana Ullman]] 18:44, 1 October 2008 (CDT)
I'm reviewing the draft. Here is a rough summary of my changes and concerns:
:You don't explain why it is notable that a writer uses homeopathy, no matter how famous he may be -- why should we be impressed by the fact, say, that Ernest Hemingway, say, used it? Maybe William Faulkner used acupuncture.  And maybe 60 other Nobel Prize-winning authors went to regular doctors. What do writers know about medicine?  Or even about their own health? I used to know a lot of famous science-fiction writers, names on request -- I wouldn't trust their advice about medical matters as much as I would my internist's. Also, I don't know that we can take at face value citations that come from your own book. [[User:Hayford Peirce|Hayford Peirce]] 18:59, 1 October 2008 (CDT)


::In due respect, I do feel that I have explained why it IS notable when famous cultural heroes, whether they be literary greats, world leaders, clergy, corporate leaders, and other major people who have had a major influence on culture, have used or advocated for homeopathy.  That said, there is a range of use and/or advocacy that varies from each cultural heroes.  For instance, I have uncovered only one instance in which the Mayo brothers mentioned homeopathy in a mildly postive way, while most others listed above, including Sir William Osler, von Behring, Bier, Menninger, and Josephson have given many positive statements over many years.  My point is also that smart and successful people who are not physicians still have their own experiences with homeopathy (and have their own intellectual appreciation of its system and its principles), and these experiences are valid, are notable, and have had an impact on culture. I am therefore curious how many of you have gone to the website previously mentioned...and then saw the one sample chapter that I placed online...the one on literary greats...see it here:  http://www.homeopathicrevolution.com/pages/excerpt.jsp  Enjoy it...it may even intrigue you to read more chapters...and to learn more about the richness of homeopathy's history and present status. [[User:Dana Ullman|Dana Ullman]] 00:38, 2 October 2008 (CDT)
* I rewrote the paragraph in the lede section about the "long safety record". The reason homeopathy has a long safety record is the very same reason that not travelling has a long safety record: if something is inert and chemically indistinguishable from the delivery mechanism, it will be safe. Safety and efficacy is a balancing act. The reason homeopathy is safe is precisely because it isn't efficacious.


:::Okay, I can't seem to get my meaning across to you.  Let's try it this way. You start a list, or a Catalog (Larry would like that), of famous people, writers, politicians, etc., who have either used, or tried, or advocated for homeopathy, you can mix them all together, I don't care. Maybe some of them used it and subsequently died, but I won't worry about that.  You make '''your''' list.  And then I'll make '''my''' list -- of all the thousands, hundreds of thousands, and even, dare I say, millions of famous writers, actors, politicians, sports stars, etc. who '''haven't''' used homeopathy.  Out of 40 U.S. Presidents, say, are there two who have advocated for it? If so (and I seriously doubt it), that means that there are '''also''' 40 or so who '''haven't'''.  You cite [[Boris Becker]], the tennis player -- I could cite a hundred other tennis players, all of them equal to Becker, more or less, who haven't used it. Can't you see that this is a fatuous argument.  If you '''must''', start a Catalog on a separate tag at the top of the page and list all the people you want.  Just as long as this long list of totally irrelevant names isn't in the article itself. [[User:Hayford Peirce|Hayford Peirce]] 22:47, 2 October 2008 (CDT)
* I'm not wild about long, windy footnotes about Romanization. I've thus split off the Romanization note about the word "[[qi]]" on to a separate page.


Hayford, first, please avoid the exaggerated exasperation of me not understanding you. I understand you, but I simply disagree.  Most (not all) of the people in my book went out of their way to advocate for homeopathy.  That is notable.  If you have a list of cultural heroes who have equally strong positions against homeopathy and have gone on record for doing so, that can be notable.  The fact that many other tennis players used some other medical treatment other than homeopathy has no place in this article, and your suggestion that it may have a place is flippant. Let's take each other seriously and work collaboratively.  You're working a lot now on this article. I hope that you are beginning to educate yourself on its principles and methodology, its history and present status, and its clinical and basic science research. Homeopathy provides a real treasure trove of truly fascinating bodies of information and experience.  [[User:Dana Ullman|Dana Ullman]] 23:12, 2 October 2008 (CDT)
* The section that is disputed about the number of practitioners in France and Germany is ''in the wrong place''. The way in which homeopathy is prescribed or accessed doesn't seem to be to be a principle of homeopathy - homeopathy is homepathy whether it is prescribed by a homeopath or bought over the counter. I've thus moved it into the section which used to be titled "Professional homeopaths: who are they?" which I have retitled "Homeopathy in practice". This section seems to be the place to discuss provision, prescription, education, regulation and the like.


== Typical homeopathy consultation  ==
* The paragraph starting "Homeopathic remedies can be prescribed by professional homeopaths" seems to be a tricky one. Depending on the country and the regulatory regime, homeopathy can be prescribed by a wide variety of people. Sadly (in my opinion), in Britain, quacks of all sorts can have their merry way with the public. Pretty much anyone can set themselves up as an alternative practitioner, so long as they don't make their claims too specific. But in other countries, this varies. It seems the important distinction that needs to be made is that homeopathy - unlike, for want of a better description, ''real'' medicine - can be prescribed by anyone.


This section should be greatly expanded, made another top-level section, and include information about what the patient says to the practitioner, how the practitioner examines the patient, as well as what typically goes through the head of the practitioner thereafter (how the homeopath decides upon the remedy), how the remedy is prepared and administered, etc.--and whether the practitioner ever refers a patient to a physician.  There should also, in this section, be some ''critical'' remarks reflecting the views of mainstream medicine about what is going on in such consultations, and also some comparison and contrast between such consultations and regular physician consultations.  Such a narrative would shed great light on the nature of homeopathy, I suspect. --[[User:Larry Sanger|Larry Sanger]] 14:45, 1 October 2008 (CDT)
* The rest of the section on "A typical homeopathic visit" seems to have some glaring problems. The homeopath is supposed to have EMT training in order to be "adequately trained"? (Heh. Surely, if heart attacks are the problem, what you need to do is to dilute high-fructose corn syrup into non-existence and it'll clear right up? I thought they believed in the law of similars. What's a defibrilator doing in the homeopath's office?) But anyway, this adequate training is according to ''who''? According to government regulations? According to the homeopathic groups? According to us? According to some third-party regulator like the [http://www.cnhc.org.uk/pages/index.cfm CNHC]?


== Linked articles ==
* The article describes "classical homeopathy" at length, but I haven't seen any discussion of what the alternatives are to classical.


The linked articles, [[History of Homeopathy]] and [[Homeopathic proving]] appear to have been imported from Wikipedia a year or two ago, and, except for Chris adding an image, don't appear to have had any substantive changes since then. As I understand the CZ rules on Wikipedia material, unless it is actively updated, it should be deleted.
* There is a lot of repetition of parts of the article. The 'Principles' section is repeated in the section on 'The claims for homeopathy'.


The material in those articles may be in this main one. Are the links to them, or the articles themselves, still needed? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:53, 1 October 2008 (CDT)
* No criticism seems to be made of the "treating the whole person" idea. I'm not even sure that this is a desirable thing. If I break my arm, I want my arm fixed, not someone to waffle about my "disturbance in the overall homeostasis of the overall being". In fact, when I broke my arm as a child, I'm very glad that I had access to a surgeon to fix it. This kind of rhetoric seems to be just an evasion tactic - if the studies don't show that homeopathy actually fixes anything (and, well, it wasn't going to put the bones in my elbow back together), then they can justify this kind of thing by pointing out that the person feels vaguely better in some holistic sense.


:It depends what our experts say. One of our approved articles, [[Barbara McClintock]], has changed very little from the original wikipedia version. [[User:Chris Day|Chris Day]] 15:55, 1 October 2008 (CDT)
* The paragraph about corticosteroids seems to be totally out of place. Oh, it sort of makes sense - it is a follow on from the last paragraph about homeopathy and asthma.


== Accuracy and clarity, please ==
I've got a more radical suggestion. This article obviously needs a fairly ground-up rewrite. Here's what I reckon we should do. The current article seems to have been put together in a rather piecemeal way. Instead, I think the best way is to see if we can come together and work out a list of the fundamental questions that a good article on homeopathy should answer - then build a simple structure around those questions, and fill them in. We may be able to repurpose some of the text from the existing article.


Hi all,
I'd suggest the following list of questions:


I find the opening sentence confusing, and I think opening sentences in CZ articles should be easy for the layman to understand.
# What is homeopathy?
# Is there any known mechanism for homeopathy?
# Is homeopathy clinically effective?
# What are the main issues of contention regarding homeopathy?
# Why have there been campaigns against homeopathy like the 10:23 campaign?
# What is the history of homeopathy? Who is Samuel Hahnemann?
# How is homeopathic care provisioned and regulated in different countries?


I suggest simply 'Homeopathy, or homoeopathy, is a system of alternative medicine Its practitioners, called homeopaths, intend it to be a therapeutic method.'  Then go on to explain the method of using small doses of drugs, blah blah.
Before formulating a structure for any potential rewrite, I'm interested in seeing if anyone has any other questions that they'd want to add. –[[User:Tom Morris|Tom Morris]] 12:30, 4 July 2010 (UTC)


Also, in reading the Note no. 6, I was directed to an advertisement for Dana's book. Now, I have no problem with Dana quoting from his own work if it is definitive on the subject. My problem is that the cited reference does not reflect what the note says that it does, specifically, that the British Royal family has advocated homeopathy since the 1830s. Such a broad and bold statement should be accompanied by specific examples. A simple (even factual) statement that HRH Royal Name is Patron of the Society for Better Widgets does not cut it, as the Royals patronise a great many societies in which they may or may not have any expertise.
:Tom, I only have a few minutes right now, but let me share a thought or two. My greatest unanswered question is "what is the cognitive process of a homeopath in a patient interaction?" In other words, homeopaths say that every remedy is individualized. Whenever I posed this question to Dana, it was brushed aside, saying that one had to be a trained homeopath to understand.


This makes me question the validity of other notes, without having the least bit of interest in examining them all for accuracy. I feel that readers should not question the validity of CZ notes, that sort of thing makes us lose credibility very quickly.
:Odd, but I have written quite a few articles on differential diagnosis in medicine, and some of my most interesting professional work is in expert systems to "individualize" (e.g., what dosage forms are most convenient for the patient and are most likely to be taken on schedule? What other diseases are present -- are there synergistic as well as problem interactions? Are there patient preferences?  Are certain side effects more or less likely? Somehow, I manage to muddle through this sort of thing, yet I keep being told there are Inner Secrets to Homeopathy that prevent a straightforward explanation. Now, I'm not a classic layman in conventional medicine, but I can't think of a field where I don't have a basic understanding and the ability to quickly get a much deeper understanding -- and also know what I don't know. In the last six months or so, I've had to do the research to do peer interactions, on the specific diseases of people (two- and four-legged) for whom I'm an advocate and case manager -- involving [[human iron metabolism]], [[feline squamous cell carcinoma]], and [[peripheral nerve myelin protein 22]] and [[inflammatory polyneuropathy]]. But I can't begin to understand how a homeopath thinks?


[[User:Aleta Curry|Aleta Curry]] 16:20, 1 October 2008 (CDT)
:In fairness, I'm not sure how much time I'm willing to expend on homeopathy, at least unless I get comparable collaboration on less controversial, and possibly useful to more people, health science articles (to say nothing of other fields). [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 13:26, 4 July 2010 (UTC)


: Aleta, I agree that you that the opening is not good.  Just as the article on acupuncture doesn't need to say that people who practice acupuncture are called acupuncturists (this is somewhat obvious and is unnecessary for the 1st paragraph), the 2nd sentence is useless...and the 3rd sentence is insulting and has no meaning. I will take a stab at rewriting this opening and am open to feedback.
== Luc Montagnier ==


: It seems that Aleta has not read my book or may not have seen some of the above comments about it, but the chapter on monarchs in this book is the most definitive body of information on the use of homeopathy by monarchs presently available. The fact that the British Royal Family does advocate for homeopathy and has a long established history of doing so is notable. They choose their subjects of advocacy very carefully. As for "expertise," Prince Charles was the President of the British Medical Association. You seem to be seriously under-estimating his and others expertise.  It seems that you are suggesting that only "medical doctors" or "scientists" are experts on health subjects, when, in fact, they are like our President Bush, a politician who uses "select intelligence" rather than real intelligence.  Please correct me if I'm wrong, but isn't one of the differences between wikipedia and citizendium that CZ is written by experts, while on wiki, experts are often considered to have an "conflict of interest.[[User:Dana Ullman|Dana Ullman]] 19:05, 1 October 2008 (CDT)
French virologist Luc Montagnier has said at a prestigious international conference when he presented a new method for detecting viral infections that it bore close parallels to the basic tenets of homeopathy. This has been published in the 'Sunday Times' (London), as well as 'The Australian' - here's a link to the article: http://www.theaustralian.com.au/news/health-science/nobel-laureate-gives-homeopathy-a-boost/story-e6frg8y6-1225887772305
:I hope one of you (at least Dana) make time (I don't have the time) to insert this matter into this article.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 16:26, 5 July 2010 (UTC)
Here's another link: http://epaper.timesofindia.com/Archive/skins/pastissues2/navigator.asp?login=default&AW=1279125246109
[[User:Ramanand Jhingade|Ramanand Jhingade]] 16:37, 14 July 2010 (UTC)


::Aleta, thanks for the critique!  We need more, so keep it coming. Dana, don't take anything personally, these guys don't bite ;-)  Do rememeber, it's not written by the experts, it's gently guided by the experts.  That doesn't mean authors have to be gentle, just professional.  Of course, that also includes experts that disagree, even in their own fields, much less the controversial ones.  But, that is what should make a collaborative effort more credible, if you don't implode :-)  
::I certainly have no intention of amending the article with newspaper articles, especially those that indicate nothing but a "close parallel." Has Dr. Montagnier's proposal been discussed in mainstream journals?  
::[[User:D. Matt Innis|D. Matt Innis]] 19:40, 1 October 2008 (CDT)


::::I have really tried to stay out of this, but citing Prince Charles as qualified to comment, because he has been president of the British Medical Association -- an honorary role -- is as plausible as saying Her Majesty Queen Elizabeth II is qualified to compare the AS90 and M109 155mm howitzers because she is current Colonel-in-Chief of the Royal Artillery Regiment. For Aleta, the Queen might really have a conflict of interest, since she is also current Colonel-in-Chief of the Royal Regiment of Australian Artillery.
::The first article, in ''The Australian'', mentions a "memory of water" type argument, and cites rejection by other scientists. I'd note that his Nobel was for virology, not physical chemistry. The second is behind a paywall. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:58, 14 July 2010 (UTC)


::::The second paragraph of the lead comes across as sneering at "mainstream physicians". A point I have made, and Gareth has observed as well, is that there are types of randomized clinical trials that are highly appropriate and statistically valid in dealing with individualized medical testing, as in pharmacogenetics. That which is being tested in such a trial is not the "remedy", but the means of selecting the remedy in a statistically significant group.  
:::Hi friends!  Actually, I got sent this link to a recent issue of the "New Scientists" by none other than Nobelist Brian Josephson:  <http://www.newscientist.com/article/mg20727682.300-60-seconds.html>


::::There's also a continuing suggestion that randomized clinical trials are necessarily placebo controlled. This is simply not consistent with current principles of medical ethics, as articulated by the World Medical Association current version of, and commentary on, the '''Declaration of Helsinki'''. I offer some analysis in the article I wrote here on [[informed consent]]. If there is a recognized medical treatment for a condition, then the control arm will receive the "gold standard" treatment, not placebo. See point #29 (and footnote) at http://www.wma.net/e/policy/pdf/17c.pdf.
:::"Clear as a Nobel"
:::Luc Montagnier, the French virologist who won a Nobel prize in 2008 for linking HIV with AIDS, last week made controversial claims that highly dilute solutions of harmful viruses and bacteria emit low-frequency radio waves, allegedly from watery nanostructures formed around the pathogens. Similar claims have been made for homeopathic remedies.[[User:Dana Ullman|Dana Ullman]] 17:40, 14 July 2010 (UTC)


::::Dana, I do not claim to know, in detail, how a homeopath approaches a consultation or treatment. I would, in turn, ask the homeopaths to stop characterizing what people in medical sciences think and do. There is not the slightest question that at the time of Hahnemann, no one had a particular idea of molecular medicine, so suggesting Jenner's 1796 work on vaccination as somehow justifying 21st century ideas of immunologic theory, in my mind, is questionable.
::::That link goes to the daily news summary, not anything on homeopathy.  As quoted, though, they are "controversial claims". No details. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:57, 14 July 2010 (UTC)


::::I will again give my opinion, formed, in part, by nearly 40 years of analyzing physician communication in order to build clinical decision support software, that words as basic as symptom and diagnosis are being used quite differently by homeopaths and contributors with a background in conventional medicine and medical sciences. Too many errors, in conventional medicine, come from imprecise wording; much current work in reducing medical error is focused just on confusion caused by misunderstood terminology.
:::::It is necessary to have that link in this article to show that homeopathic remedies are not 'placebos', as some people allege.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:40, 16 July 2010 (UTC)


::::May I suggest that this article would be more valuable if the sneering were reduced, and, to take Larry's suggestion, do things like detail exactly what is done at a homeopathic history-taking, consultation, or whatever the correct word or phrase is done at a professional encounter? I assure you that anyone experienced in medical history and physical examination, even without getting into specialized areas, could give a quite specific, organized description of what happens in a first encounter. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 21:24, 1 October 2008 (CDT)
::::::It is another piece in the puzzle.  It is primary research, but it is by a Nobel Prize winner, so it is news about homeopathy.  We shouldn't treat it as scientific fact, but it is a fact that a prominent scientist has made the statement that involves a quality of water.  It is in no way scientific consensus, an in fact may lead to this guys ruin for whatever reason.  We have included news about the British Medical Association's recent position statement concerning homeopathy and [http://www.theaustralian.com.au/news/health-science/nobel-laureate-gives-homeopathy-a-boost/story-e6frg8y6-1225887772305 this article] specifically mentions that statement as wellThis is the draft, so I won't categorically remove something that is written comprehensively, neutrally, and objectively about the subject. [[User:D. Matt Innis|D. Matt Innis]] 12:59, 17 July 2010 (UTC)
:::::I don't know what Prince Charles has to say about homeopathy but this summer he had the following to say about GM crops. [http://www.guardian.co.uk/environment/2008/aug/13/prince.charles.gm.farming "the biggest disaster, environmentally, of all time"]. He also said that biotech corporations are "''conducting a gigantic experiment with nature, and the whole of humanity, which has gone seriously wrong''". This sensationalist, and frankly ignorant, kind of comment is exactly why we should ignore celebrity testimonials. [[User:Chris Day|Chris Day]] 21:48, 1 October 2008 (CDT)
::::::He's also well-known for his (expert, hehe) views on architecture. They can be mentioned prominently in any architectural articles that CZ generates. [[User:Hayford Peirce|Hayford Peirce]] 22:55, 1 October 2008 (CDT)


See also my new comments above in the section, Literary Greats and Politicians.  The bottomline is that it IS news and therefore noteworthy when certain cultural heroes speak on certain subjects...history is made by such actions, and these advocacies play a role in culture.  When just one or a handful of cultural heroes express support, it may not be noteworthy, but when larger and diverse groups of cultural heroes do so, it is once again noteworthy, especially for bodies of information like CZ that seek to be encyclopedic.  Lord (and others) know that the sources of our information must not just be reductionistic science but more comprehensive sources too.  [[User:Dana Ullman|Dana Ullman]] 00:50, 2 October 2008 (CDT)
(undent) Matt, you give it a perfectly good context--as news. It doesn't show, or not show, anything about homeopathic remedies being placebos, or effective, or ineffective, or any particular clinical correlation. As far as I understand, he's made an observation in physical chemistry and RF fields interacting with water, nothing else. I sincerely hope he's not hurt, as he was incredibly dignified while there were attempts to discredit his initial discovery and characterization of HIV -- his Nobel was very deserved.  [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:42, 17 July 2010 (UTC)


::An impressive list. Some very great people on it, but I'm afraid I seem not to be finding something. You remind me, though, that everyone on that list deserves at least a stub article, and I shall create those; for that I thank you. Indeed, I am familiar with most; I had already contributed to the Osler article, and started the Bier and Griffith articles.
:My point in providing the link to the NEW SCIENTIST is to verify that this research is "notable," and as such, a short note is worthy here. [[User:Dana Ullman|Dana Ullman]] 05:35, 21 July 2010 (UTC)
::*Sir [[William Osler]], (1849-1919). Certainly one of the greatest healers and teachers of history. The textbook he started, teaching the art as well as science of medicine, is still being updated today. Those updates tend to be more in the science than the art, because in Osler's day, there wasn't very much science.
::*[[Auguste Bier]] (1861 - 1949); invented spinal anesthesia and intravenous regional sympathetic block
::*[[Harold Griffith|Harold Randall Griffith]] anesthesiologist; introduced total skeletal muscle relaxation for surgery in 1942
::*[[C. Everett Koop]](1916-) pediatric surgeon and U.S. Surgeon General
::*[[Brian Josephson]] (1940-) Nobel laureate in Physics


::I had not known that Griffith and Bier had homeopathic as well as allopathic training, and I have personally experienced both the Bier block and the muscle paralyzation (well, I was already unconscious for the latter), but watched the surgery for decompression of my right radial nerve with no pain control other than the Bier block.


::It concerns me, however, that you cite very good physicians who did most, or all, of their work before there was any molecular understanding of the drugs they used. Curare, lidocaine, ethylene, and guanethidine are certainly not used in homeopathic dosesCurare is obsolete in medicine, because, years after Griffith's work, enough became known of the molecular pharmacology involved that much better agents could be synthesized.
::Matt, you are wonderfully reasonable.  Howard is not accurate when he says that Montagnier has "made an observation".  Montagnier conducted RESEARCH, and he wrote about it in a peer-review journal. He spoke about it to a group of fellow Nobel Prize winners.  And ALL of this was so notable that the "New Scientist" commented about it...and linked it directly to homeopathy. I have no problem if we choose to have the word "controversial" used in describing this new workThe fact of the matter is that this new work discusses "electromagnetic signaling" which may help explain how homeopathic medicines may work. [[User:Dana Ullman|Dana Ullman]] 18:29, 9 September 2010 (UTC)


::So, I'd be far more likely to agree that homeopathic training was key to their success. Literally, they did not know the principles by which their drugs worked; much of the theory was developed decades later. Now, if you were to quote contemporary physicians that have been trained in both homeopathic and allopathic techiques, and can use molecular medical principles if they choose, I'd be much more impressed than by work done no later than the 1940s.  
:::Then why isn't the peer-reviewed journal cited, rather than ''Wired'' and ''The Australian''? Further, one may write (e.g., an editorial) ''in'' a peer-reviewed journal, but not have one's work peer-reviewed ''by'' that journal. The peer review process becomes more credible if another independent researcher reproduces of these results. Please provide citations of these events if you want me to believe this is substantive.


::I'm afraid these come across as an appeal to authority, but without enlightening the value of homeopathy. Could you provide some current physicians as respected in both fields? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 02:06, 2 October 2008 (CDT)
:::Nobel Prize winners, rather by definition, tend to be specialists. One might speak on medicine to a group of Chemistry laureates, and have no special critical review.  


:::Perhaps this information is more responsible for popularity.  Maybe as long as we write it in such a way as to qualify that these people may have helped make it popular, but making it clear that this doesn't add validity to it's usefulness would help the reader understand how something that medical science does not support can be so popular. I also think that, in order to protect the integrity of CZ, rather than citing Dana's book, we cite the sources that Dana uses in his book and put Dana's book in the bibliography. [[User:D. Matt Innis|D. Matt Innis]] 07:40, 2 October 2008 (CDT)
:::It's interesting that we are still arguing how homeopathic medicines "may" work, when it's rather routine to understand the molecular pharmacology of conventional medicines. Sorry, this still comes across as hand-waving for something with a trivial base of evidence.


::::Matt, that's a good way to handle it. To take something that I consider a U.S. shame in conventional medicine, consider direct-to-consumer ads for prescription drugs, and now medical devices as specific as a coronary stent. Interventional cardiologists are much troubled by conflicting large trials about whether to use stents, and if so, what kind of stent. I follow the literature fairly well, and the issues are extremely complex. I doubt many of those cardiologist could coach a winning football team, so why is a football coach (and a good one) pushing complex devices?
::::Have I fired five or six rounds? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:38, 9 September 2010 (UTC)


::::I think it's perfectly fair to say that some of these outstanding physicians were formally trained in homeopathy as well as allopathy, but to make clear that much current relevant theory &mdash; not clinical trials, but the conceptual models that came first &mdash; I cannot see much similarity between the action of what is seen as a preparation that helps the wisdom of the body, and a drug that paralyzes the wisdom of muscles required for breathing.
== Evidence that homeopathy works ==


::::Apropos books and such, if I might make a suggestion that I use for my own published material.  Even when I cite public domain peer-reviewed publications, I try to mention that on the talk page to avoid the suspicion of conflict of interest. If I quote from one of my commercially published books, it's usually a very specific illustrative point. When I mention my books in a bibliography subpage, I make a point of including potentially competitive ones, although it's a narrow subject. In some cases, when I had an illustrative and funny example, I paraphrased it and put it on a signed articles subpage. Just some thoughts that I think help CZ credibility. Now, there were times at The Other Place when I kept correcting an error, and finally cited the definition in a peer-reviewed, public domain technical specification of which I was an author or coauthor. History is a little softer to use than explaining the difference among an Internet Service Provider core router and an interprovider border router and a customer border router. In the latter case, I was not speaking of history, but of current research in which I was involved, and was accepted in peer review. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 11:36, 2 October 2008 (CDT)
I hope one of you (at least Dana) can insert sentences that read something like, "there is scientific evidence for homeopathy", using the PDF for "Scientific framework of homeopathy: evidence-based homeopathy" available at http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/286/354 wherever appropriate. I haven't seen anyone object to it here anyway.[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:15, 21 July 2010 (UTC)


== Activity today ==
== the word "skeptic" ==


Good to see lots of good activity today.  I know sometimes it looks confusing, but after re-reading, I think the net movement was good.  I agree with Larry that the section about the homeopathic consultation could use some expansion so we can know what to expect; do they treat cancer? Do they use MRIs? Do they refer?, etc..  I was afraid we'd open a bag or worms with the "name dropping" and I still don't think it belongs in this type of an article, other than perhaps a brief mention - I know the Prince of Wales made a speech in which he advocated the increaseed usage of homeopathy, so that is probably important for many reasons.  The rest is just good advertising (though I raised a brow when I saw C. Everett Koop - the past US Surgeon General), so I guess there is some value there.
Wasn't it decided a long time ago that aside from the two existing examples in the article that pro-homeopathy advocates (and anyone else) could NOT use the word "skeptic" in future edits?  Just want to make sure. [[User:Hayford Peirce|Hayford Peirce]] 21:50, 5 August 2010 (UTC)


There are several places where the same concepts are repeated in section after section, so some consolidation might be in order.  Remember that sometimes less is more. There is no reason to say things more than once; it is more important to place it so that the ideas flow in order and questions are answered even before the reader thought to ask them. In particular, there are several places that pronounce that Hahneman developed it....  and several places that the memory of water concept is explained again and again.  If I am reading this article all in one sitting, I only want to read that once.
:I remember that as a specific ruling by Larry. In my experience, it's almost always used by advocates of a position; the neutrality policy wouldn't be hurt if it were banned. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 22:41, 5 August 2010 (UTC)


Hope this helps.  How close are we to approval?
::But what about people who ''are'' skeptics? Are we not allowed to say that Michael Shermer - who runs the Skeptic's Society and publishes ''Skeptic'' magazine - is a skeptic? [[User:Tom Morris|Tom Morris]] 23:02, 5 August 2010 (UTC)
[[User:D. Matt Innis|D. Matt Innis]] 19:33, 1 October 2008 (CDT)


== Interdisciplinary cooperation ==
:::As a direct quote or a self-identification, sure. As condescension to disbelievers, no. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:04, 5 August 2010 (UTC)


It's worth repeating two things about randomized clinical trials
::::Ah, but is it? I consider 'skeptic' to be much less of an insult than 'homeopath'! –[[User:Tom Morris|Tom Morris]] 23:06, 5 August 2010 (UTC)
*They are not always placebo controlled (see [[informed consent]]) if there is a recognized treatment
*They can be adapted to individualized treatment.


Could we agree on a term, acceptable to homeopaths and people involved in "the other side", to describe a clinical trial adapted to individualized treatment? This is, for example, something that is being done in [[pharmacogenetics]], where treatments are selected based on an individual's genetic coding. If so, I'd like to develop an article that discusses the methodology of such trials.
:::::I think it is -- it comes up repeatedly in fringe articles, be they moon landing hoax, UFO, etc. -- anything not a true believer. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:13, 5 August 2010 (UTC)


An issue that may have hurt homeopathic trials of the past is that that large trials of the path used a broader separation by major diagnosis. Just as placebo control is not always appropriate,  
::::::If *I* use the word, Tom, it's a compliment.  If Dana uses it, it's pejorative.  That's why Larry (or someone) banned it from this article, if I recall correctly. (I have 20 years' of Skeptical Inquirer on my bookshelf.) [[User:Hayford Peirce|Hayford Peirce]] 23:21, 5 August 2010 (UTC)


What such a trial tests is not necessarily the drug/remedy, but the method used to assign patients to categories of treatment. Cruder versions of such methodology might subdivide, for example, breast cancer patients into premenopausal and postmenopausal. An area where I've participated in some research is the first drug to be used for high blood pressure: there are 3 or 4 choices, all of which are roughly equivalent in the general population. When one starts looking at pre-diabetic states or active diabetes, pregnancy, and possibly ethnicity, the choices are not equal.
== What the...? ==


In other words, the trial is not examining whether a thiazide diuretic or a beta-adrenergic receptor antagonist or a calcium channel blocker or an angiotensin-II converting enzyme inhibitor is effective against early hypertension. We know they all are, in a large population. What we don't know, but strongly suspect, is that there are subpopulations where each class would be a best or worst choice. '''What is being tested is the ability to recognize the subpopulation''', not the remedy.
<blockquote>Homeopaths respond to these concerns by noting that using homeopathic medicines can delay or reduce the use of conventional medicines that are ineffective and dangerous.</blockquote>


If homeopathic treatment is such that every patient of every homeopath will get completely different treatment, there's no way to test the treatment; there's no way to compare it. I really doubt that is the case. What is true in medicine is that first nothing was available for women with metastatic breast cancer, and then a few randomly selected protocols (e.g., CMF, 5-drug Cooper), but now the clinician checks menopausal status, the presence of the BRCA2 gene, receptor sensitivity, etc. With some, but sadly not all, subpopulations, it is possible to say "there's a good chance you will die of something other than breast cancer.
If this were The Other Wiki, that'd be an instant "citation needed"! I know homeopaths like to bang on about the evil 'allopaths', but do they honestly respond to the [[opportunity cost]] argument with a reversed opportunity cost argument? That's so... indescribably crazy. I certainly would like some verification on that. –[[User:Tom Morris|Tom Morris]] 00:42, 6 August 2010 (UTC)
:Remember our motto: '''be bold''' -- remove it, and let whoever put it there back it up with some facts if they want to restore it. [[User:Hayford Peirce|Hayford Peirce]] 01:42, 6 August 2010 (UTC)


Competent physicians constantly improve methodology and throw out ineffective treatment. So far, I'm hearing testimonials going back to the 18th century, and some possible means of water memory that, as yet, have no linkage to biological mechanisms. I think we can all do better than that, right here. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 14:20, 2 October 2008 (CDT)
::Oh, now we're bold, haha. It's a response to the use of homeopathy for use with things like childhood ear infections, a commonly self limiting condition that is often treated with antibiotics which have unwanted and sometimes dangerous side effects. It probably could be explained a little better when it's all cleaned up. After all, that is the homeopath response. [[User:D. Matt Innis|D. Matt Innis]] 21:50, 7 August 2010 (UTC)


==Urgent==
:::On the other hand, I can point to many medical studies advising against antibiotics in uncomplicated otitis media. Going back to Osler at the turn of the 20th century, he correctly pointed out that "allopathic" drugs were often harmful -- but he then said both homeopathy and (classically defined) allopathy were "cults" that needed to be replaced. One doesn't need to turn to homeopathy to find best practices that avoid both overprescribing and underprescribing. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 21:59, 7 August 2010 (UTC)
Sorry to interrupt, Howard.  


I recently edited the plausibility section (see [http://en.citizendium.org/wiki?title=Homeopathy&diff=100393586&oldid=100393551 here]). Paul Wormer, who has left the discussion and the article, told us: "Good luck with your superstition about liquid water, I find that it degrades the quality of CZ, mais c'est la vie."
::::Yup, absolutely agree. [[User:D. Matt Innis|D. Matt Innis]] 01:10, 8 August 2010 (UTC)


Now, I received an important email which has an incidence on these recent edits. I won't discuss these personal matters, but I can, however, provide an example of what is expected from me: [http://en.citizendium.org/wiki?title=Homeopathy%2FBibliography&diff=100392049&oldid=100391841 before]; [http://en.citizendium.org/wiki?title=Homeopathy/Bibliography&diff=next&oldid=100392049 after]
== principle of infintesimals ==


My recent edits of the plausibility section I was talking about will receive the same treatment, since they were also (my own honest) attempts to adapt Paul's contributions.
I'm thinking that [http://en.citizendium.org/wiki?title=Homeopathy%2FDraft&diff=100701656&oldid=100701655this principle] needs defining.  I'm thinking that the 'principle of infintesimals' is the concept that is controversial.  Perhaps one of our homeopaths could explain? [[User:D. Matt Innis|D. Matt Innis]] 12:32, 12 August 2010 (UTC)
:Throughout this article, the infinitesimal dose and law of similars have been used interchangeably, but they aren't the same. http://www.similima.com/org20.html has given a brief description of the "infinitesimal dose". The law of similars is just, "using the most similar remedy" - to put it plainly. I don't have the time to check and insert those changes, but I hope you Matt, or may be Dana can do so. The infinitesimal dose can also be defended with the "memory of water" and Monsieur Montagnier's research (see Dana's post above).-[[User:Ramanand Jhingade|Ramanand Jhingade]] 13:49, 13 August 2010 (UTC)
::Certainly using them interchangeably is not accurate. [[User:D. Matt Innis|D. Matt Innis]] 15:05, 13 August 2010 (UTC)
:::I think the term "interchangeably" was wrong to use - what I meant was that the term "law of similars" is used in the article and draft article, when it's supposed to be "the infinitesimal dose", in some places.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:50, 13 August 2010 (UTC)
::::So it seems to me that infinitesimal dose needs to be defined.  The law of similars can obviously involve large doses of products.  Obviously Homeopaths use more than infinitesimal doses in their treatments; otherwise we wouldn't have side effects from a nasal product that has zinc in it. We are not getting this point across. [[User:D. Matt Innis|D. Matt Innis]] 17:47, 13 August 2010 (UTC)


I will let editors take care of my "superstition about liquid water". My conscience dictates that I should not obey and revert what I just did (it was before I received this email).
::::<font color=red>I don't think it's worth the time, since that will also be criticized here (maybe you can use the web-site I mentioned above to do that). The nasal product, "Zicam" wasn't a homeopathic product at all, because it had milligram doses of zinc, which is against homeopathic principles. Homeopathic remedies start with mother tinctures and can go up to higher potencies (more dilute) from there.</font>—[[User:Ramanand Jhingade|Ramanand Jhingade]] 09:50, 23 August 2010 (UTC)


If editors agree that discussing and editing with me is a waste of time, energy and a regression for CZ, well, be assured that I'll know how to professionally and politely deal with all this. CZ will remain the most promising project because it welcomes and respects experts. All experts.
:::::Zicam was marketed as homeopathic, and licensed under special regulations applying to homeopathic products. Sorry, for legal purposes in the US, it ''was'' a homeopathic product. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:49, 24 August 2010 (UTC)


[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 16:13, 2 October 2008 (CDT)
:::::<font color=green>I know it was, but it was against homeopathic principles.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:39, 25 August 2010 (UTC)</font>


:Help me understand what is at the links you gave, and how you'd like it regarded. I'm especially confused about the link, in the bibliography part, which links to the home page of a journal, ''Materials Science Innovations'' that describes itself as <blockquote>Because of its super peer review procedures, the journal is especially suited for the publication of results which are so new, so unexpected, that they are likely to be rejected by tradition-bound journals</blockquote> The journal is produced by Maney Publishing UK, but I get link errors trying to go to Maney's home page or "about us". Their jobs page does seem to work.
(undent) Please do not use color for emphasis.


:Please correct me if I misunderstand, but is this journal, its review process, and the specific paper by Roy the key thing that you think is relevant to the CZ homeopathy article, or am I taking that out of context?  This journal claims to have a nontraditional peer review process, and, while this is not the place for it, I do believe, especially in the U.S. and with its funding conventions for research journals, there are some systemic problems to address.
In the context of the  United States, your simple statment that it "was against homeopathic principles" is legally irrelevant, as the FDA makes the decision if something is to be regulated as a homeopathic preparation (or food supplement), exempt from a good deal of the regulation of other drugs, or if it is a conventional regulated substance. The FDA determined Zircam was homeopathic, and, while I suppose you might argue, in an article about homeopathy and the FDA, such an argument is irrelevant here. If you reject the argument that a governmental organization cannot make such decisions for a country, then I can argue that homeopathy can't be accepted as a national means of practice in India.


:Increasingly, though, I'm confused on the role of detailed discussions about new theories about the properties of water ''in an article on homeopathy''. Let me try an analogy. In 1929 or so, Sir Alexander Fleming published a paper saying a substance, later called penicillin, inhibited the growth of ''Staphylococci'' in culture plates. During WWII, it was tried in people. It was a good deal later when the molecular activity of penicillin, in interfering with mucopeptide synthesis in the cell wall of bacteria, was understood.
With all things that it approves, the FDA depends on the manufacturer's application.  More is accepted is fact in a homeopathic New Drug Application that isn't required to undergo controlled trials. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:57, 5 September 2010 (UTC)


:Today, however, if one publishes an article on a new class of drugs, both the structure and unusual properties are discussed, but it is also expected to explain how these characteristic affect specific biological subsystems at a molecular level: they interfere with the synthesis of some protein, or sensitize a cellular surface receptor, or increase intersynaptic levels of a neurotransmitter by blocking reuptake.
== Answer to an "unanswered question": Popularity is no metric of efficacy ==


:Let's assume that all manner of unsuspected properties of water have been identified, and in thoroughly reproduced experiments in reputable journals. I do not, however, then see how this maps to those properties have specific effects on human cells that have a health benefit. That is where I lose the thread of what things from physical chemistry have to do with homeopathic medicine.
Sorry, but the addition "The simple reason for homeopathy's growing popularity is because it works." is completely unacceptable without overwhelming evidence that it does work.  Were this to be accepted without sourcing, the logic could be applied to popularity of politicians, especially not in office, supporting the premises their programs work.


:What am I missing in your rewrites? I'm also confused about what qi means in this context and why it is significant. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:52, 2 October 2008 (CDT)
I propose to delete this. Popularity is relevant to marketing but not efficacy. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:48, 24 August 2010 (UTC)


::(apologies for indentation changes and inline comments; tell me if you hate it and I'll go back to the traditional way. Inline, with signatures, is something I find to reduce the size of talk page posts)[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 20:05, 2 October 2008 (CDT)
:Those questions were begging for an answer. If you delete my answer, you must  delete the questions preceding my statement as well!—[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:45, 25 August 2010 (UTC)
::a very short answer, for the reasons explained above
::qi: it's Paul's contribution.
::Roy's paper: like Chaplin's, its a bone of contention (skeptics of homeopathy discuss these papers)
::biological mechanisms: I have begun to address this, after Gareth's intro (in water in living systems). My addition is... judge for yourself. For more on this, you can read Dana's work. (keyword: nanopharmacology)
:::Pierre-Alain, I cringe a little every time I hear the phrase "skeptics of foo"; it has a negative connotation, to me, as "unbeliever", or, when used in a very similar context in theological discussions, can imply "sinner who will go to the Pit if they do not accept the True Faith." Will you bear that in mind? I certainly have scientific disagreements with colleagues, even with a largely shared context. I don't speak of "skeptics" of [[link state routing]] or [[clindamycin]] for certain infections. I hear their arguments and often agree to disagree, or agree on specialized requirements for both. Your use of "skeptics" suggests anyone that does not accept homeopathy, at least to the extent one accepts conventional medicine, is wrong and needs to be converted to the True Way. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 20:05, 2 October 2008 (CDT)


::peer review, super peer review, etc.: we need a section on the difficulties associated we publishing in mainstream journals when dealing with homeopathy. See Dana's recent responses in this talk page (and mine). I also put useful references in the bibliography subpage, a long time ago).
::Your statement, unsourced, was not an answer. It was purely your opinion, phrased as informal commentary. Also, it is a rather sweeping opinion that goes to the heart of the article, with no evidence behind it. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:45, 25 August 2010 (UTC)
:[[User:Pierre-Alain Gouanvic|Pierre-Alain Gouanvic]] 18:07, 2 October 2008 (CDT)


::::'''We'''? It would be more accurate to say that advocates of homeopathy have difficulty publishing in mainstream journals, and the entire peer-reviewed journal process deserves its own article. Sometimes journals reject things for good reasons, and sometimes for bad. Two people named  Barry J. Marshall and J. Robin Warren won an all-expenses-paid trip to Stockholm to accept the 2005 The Nobel Prize in Physiology or Medicine for their discovery of "the bacterium ''[[Helicobacter pylori]]'' and its role in [[gastritis]] and [[peptic ulcer]] disease". Earlier, what is perhaps the most prestigious single journal, the ''[[New England Journal of Medicine]]'', rejected their paper. I haven't stopped reading the NEJM as a valued source. In this case, they continued submitting and presenting, until their work was considered the standard in the diagnosis and treatment of gastrointestinal diseaseIn general, however, I find the peer-reviewed system is generally fair, and, so far, I have not seen here the level of correlation among cellular mechanisms, molecular pharmacology, and clinical correlates that would meet the standards needed to publish a report on a new class of antibiotics.  
:::While Howard is right in saying that "popularity" is not a metric of efficacy, popularity is (by definition) its own metric, and statistics about homeopathy's popularity now and in the past has a place in an encyclopediaFurther, I give reference to a half-dozen
surveys that further verify that people who tend to receive homeopathic care tend to be more educated than those who don't.


::::Be very, very careful in assuming that CZ is an appropriate place for homeopaths' arguments that the medical establishment discriminates against them. I am hearing a great deal of desire that this article take such a position, or that the article should assume that homeopathy works. In contrast, look at [[biogenic amine receptor]]. It's still very stubby, but that would be the sort of structure I'd need to see for any serious proposal to accept a given class of medicine. [[Second-generation antidepressant]] is even stubbier, and, while there is solid evidence that certain of the drugs often work for certain of the conditions, that article needs its place for "skeptics" about there being alternatives, safety issues, and their use for conditions other than depression. Filling in the gaps in an article like that seems more core to CZ than being a place of argument about lack of faith in a paradigm that, other than believers, seems to be lacking quite a few details of how and why it works. You haven't said it to me, but comments such as "you can't know it until you try it" are pure emotional arguments and, IMHO, do not belong in CZ. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 20:05, 2 October 2008 (CDT)
:::The following link to an article that I authored provides references to this information (please know that I am not suggesting that we link to this article but only to use the references in this article in our encyclopedia listing:  http://www.huffingtonpost.com/dana-ullman/homeopathic-medicine-euro_b_402490.html  [[User:Dana Ullman|Dana Ullman]] 19:14, 9 September 2010 (UTC)


:::There are quite a few issues of the scientific journal publication process, many which have nothing to do with homeopathy. In principle, for example, work done under U.S. government funding is public domain, but most journals are not online and are very expensive. Just having the authors put their work on webpages, however, doesn't deal with the review process, which is where a good deal of the journal subscription cost goes. There's no simple answer.
::::''Post hoc, ergo prompter hoc?'' I can give even more studies that verify more people who drink milk become heroin addicts. Popularity is a principally a metric of efficacy -- of marketing. If it is significant here, Lady Gaga should be even more expert than Dana, and probably has a better figure. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:20, 9 September 2010 (UTC)


:::If you wanted to have a sentence or two in this article saying something like "non-mainstream fields, including homeopathy, may suffer from problems in the [[peer-reviewed scientific publication]] process", I would not object, and I would help write an article on the process. That the process may be hostile to homeopathy, however, is an editorial comment that belongs in this article only if sourced or as a signed article.
== Allopathy ==


:::The purpose of this article is to describe homeopathy, and, reasonably enough, to describe there is resistance to it in mainstream journals. I do not see it as remotely appropriate to CZ to have the homeopathy article arguing that the scientific establishment is biased against homeopathy. Stating that, with a source, is acceptable. Arguing the point is in no way neutral.
"Today, "allopathy" is used by practitioners of alternative and complementary medicine, like homeopaths, osteopaths, naturopaths, chiropractors and so on to refer to conventional, western medicine."


:::In this specific matter, there is also a huge gap that has not been bridged. Assume that peer-reviewed journals had agreed to everything about water memory. Just as a medical journal will normally want an explanation of the molecular pharmacology of a new drug, I believe it a reasonable editorial standard to say "if water memory causes homeopathic effects, the way water changes biological effects is XXXX."  I have not yet seen anything beyond "well, homeopathic preparations may alter water", and "there are theories about water memory". Unless there is a clear connection between the two, it isn't even original research, but guessing that doesn't belong in a CZ article. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:35, 2 October 2008 (CDT)
Since practitioners of conventional, western medicine rarely use the term, however, there's no good argument to insist on calling them allopaths. Yes, there are a few historical references, especially when talking of osteopathic vs. allopathic medical schools, but the term used by conventional western physicians tends to be...conventional western physicians.
==Approval?==
Matt raised the issue of approval, I think rightly. I believe that it is important to focus on what is needed to make it possible for this article to be approved speedily, to avert the danger that it becomes an andless drain on energy. Some issues are best delegated to other articles where they can be developed in a more leisurely and considered way.


My view, for what it is worth, is that the issue is not whether homeopathic remedies work, there is I think probably quite wide acceptance that they might work at least for some people in some cases. The issue is rather ''why'' they work. Scientists such as myself believe that they probably work via the placebo effect; i.e. the phenomenon that when people expect that a treatment will work, an expectation strongly bolstered by the confidence and authority of the physician, then often there is an improvement in reported symptoms. The belief that the placebo effect is responsible is part a reflection of the robustly demonstrated power of suggestion in many cases, and part a reflection that no explanation of alternative mechanisms has come close  to convincing scientists or medics generally as being plausible. There have been many suggestions of possible mechanisms, as far as I can see they either involve proposals that the homeopathic remedies are contaminated in some way (clathrates, silica particles), or that they do contain some active material (in the case of low potency remedies only, i.e. not strictly homeopathic), or they involve some alteration in water structure (generally discounted but a topic still under some consideration). An alteration in water structure would not comprise an explanation, as the really key issue remains, of how a change in water structure could be detected by a biological mechanism, and how that detection mechanism might be coupled to adaptive biological responses. With no explanation for the latter, a change in water structure is not an explanation of the efficacy of homeopathy, but is simply an assertion that homeopathic preparations might be physically different from pure water.
Ramanand, if I refused to call you anything other than Jean-Paul, would that change your name? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:57, 24 August 2010 (UTC)


I will later suggest some changes that I think are needed to contemplate approval.[[User:Gareth Leng|Gareth Leng]] 04:40, 3 October 2008 (CDT)
:Practitioners of alternative and complementary medicine, like homeopaths, osteopaths, naturopaths, chiropractors and so on refer to conventional, western medicine as "allopathy" even today. If you don't like it, you can add something like, "conventional, western physicians do not refer to themselves as allopaths".[[User:Ramanand Jhingade|Ramanand Jhingade]] 15:50, 25 August 2010 (UTC)


:Has anyone heard that saying that a true sculptor is the one who can look at a block of stone and see the figure that needs help to come out? At present, this article is a block of stone, perhaps with some odd rocks stuck to the outside.  
::Each profession defines what it calls itself. That is not the role of other professions. Would you accept the specific words "practitioners of conventional western medicine call homeopaths frauds?"  No?  Then why do you have the right to define a name, regarded by many as either historically inaccurate -- they don't use the principle of opposites -- or a sneering attack?. I wouldn't have the slightest objection if homeopaths called themselves Similarists, Hahnemannists, etc. -- but that is how they characterize themselves, not how they characterize others. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:44, 25 August 2010 (UTC)
===Ruling needed===
Mr. Jhingade reinserted "although osteopaths, homeopaths, naturopaths and other alternative medicine practitioners continue to call it allopathy." I will remove this unless an Editor says otherwise, as I believe it has been ruled that one discipline is not permitted to define a name for another. Shall I say "although biologically-oriented scientists consider homeopaths to be quacks? (noise made by the simillium of [[Oscillococcinum]], of course)"  At best, this might go in the [[allopathy]] article.  


:Seriously, there is a good deal of material that might both support (or not) homeopathic ideas, which either has enough non-homeopathic information to stand and develop on their own, or have gotten so convoluted here that their relationship to homeopathy proper is vague. The structure of water is the best example; there are others. I'll come back.  
Osler deprecated both allopathy and homeopathy by the time of the Flexner report, although, somewhat earlier, he had attacked some of the drugs used by self-descibed allopaths. I'd note the latter was 19th century.


:I'm going to hypothesize that this article were about the only kind of medicine that was practiced. If so, one of the first things that would be explained is the scope of practice of homeopathic physicians, what cognitive processes the physician uses at the first encounter in coming up with a plan, and the process of continuing care. There is very, very little about the first. For example, a patient presents from an auto accident, with multiple long bone fractures, a traumatic amputation of the left hand below the wrist (clean, and someone brought along the hand), looking "shocky", and let's say a BP of 70/30, a hematocrit of 19%, is having trouble breathing, and reports having been kicked in the chest. What does a homeopath do here? Does the homeopath treat this, or call for a trauma surgeon? A boarded emergency physician, incidentally, would do immediate stabilization, probably do additional chest examination, FAST ultrasound, and at least PA and lateral X-ray views of the chest, if not spiral CT. There would be no question that the patient needs to be under the care of a trauma surgeon.  What is the role of homeopathy in such a situation? 
Be very careful, incidentally, in using "osteopath" versus "osteopathic physician". The latter, in the US, does use "allopath" but in a very narrow context dealing with the history of schools. Undergraduate and graduate medical education from traditionally "osteopathic" or "allopathic" education is largely identical, although some additional manipulative techniques may be taught in ''some'' historically osteopathic programs -- or by qualified faculty in historically "allopathic" programs. Assuming equal certification, with many boards merging, the scope of practice of DO's and MD's are identical.  U.S. osteopathic physicians do not use the term allopathy in regular practice. Indeed, I know a few that don't use manipulation or any special osteopathic methods. As an aside, in the state of Virginia, to perform acupuncture, one must be licensed as a physician; the two I used were, respectively an MD with a OMD degree from Vietnam and a OB/GYN certification from FACOG; the other was an DO internist board-certified in internal medicine.


:If it would be constructive, I can describe several other scenarios, both of chronic complaints and things that would be considered life-threatening, and try to help elicit "what would a homeopath do?"  This is not a trap for homeopaths; if they have some means of handling major trauma, then it would be a great opportunity to explain what it is.
In the UK -- I can't speak authoritatively  for the rest of Europe -- osteopathy is indeed a CAM discipline and its practitioners' scope of practice is not the same as a physician.  


:For the non-emergent situation, I suspect both homeopathic and non-homeopathic physicians do something along the lines of history and physical. To me, it is apparent that the two groups do not use terms such as [[symptom]], [[diagnosis]], [[sign]], [[drug]], etc., in the same way. If consistent definitions are not possible, we need to find unambiguous words so a medical person reading the article does not say "nonsense, that's not a symptom." That person can, instead, say "OK, this is how the homeopath takes a history and decides on examinations and tests."
I would add that the opinions of naturopaths are irrelevant to this article.


:Rather than to into the esoterica of water, I think it is fair to say that homeopaths do not understand, in a scientific sense, how their treatments affect molecular biology, the standard in conventional medicine. Nevertheless, I would be willing to say that there is a good deal of case reporting that says homeopathy may be useful for some things defined in a way a non-homeopath would understand, and then talk about what would be done.
Could we please stop refighting this revert battle?  My impression is that rulings have been made.[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:30, 5 September 2010 (UTC)


:Popularity is not really relevant. Accurate numbers of homeopaths and patients that see homeopaths for all of their treatment would be informative. It's fair to say that homeopaths have difficulty getting their work into mainstream journals, and then link to an article on mainstream biomedical journal reviewing and publication, which has issues separate from homeopathy.  
:Practitioners of alt. med. still call it allopathy (Look at the American Association of Osteopathic Physicians web-site, the National Center for Homeopathy web-site and so on). I'm sure Dana will support me on this one. I'm looking forward to a ruling too and I believe such a ruling will support the homeopaths' viewpoint, because this article is titled Homeopathy and not, "Criticism of Homeopathy".—[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:44, 6 September 2010 (UTC)


:Neither homeopaths nor pharmacogeneticsts' approaches are handled well by the basic randomized clinical trial of a treatment, but I suggest -- and some of this may be appropriate for a more detailed article -- that linkage to an article on emerging trends in clinical trials may be useful. Just as one aside, there seems to be a littile misinformation on RCT's; all are controlled but not all are placebo-controlled. Split off an article about attacks on homeopathy, simply because it leads to emotion on all sides and gets away from the core information needed here.
::If you are arguing from the perspective of the American Association of Osteopathic Physicians, you are either ignorant of the historical reason they do that, or deliberately making a false argument that American osteopathic physicians, as distinct from osteopaths in Europe, are in any way "alternative". DOs pass the same undergraduate and graduate certifications as MDs.  I suppose I'll have to remind one of my DO friends, a world authority on field and disaster medicine, that he's "alt" and the surgeons shouldn't listen to him. If nothing else, there ''is'' a distinction between alternate and complementary.  


:I have other ideas, but I will merely mention one and then stop going on for too long. Hormesis is a part, I believe, of the broader disciplines of dose-response studies and pharmacokinetics. There are totally non-homeopathic situations in which issues that could be considered hormesis come up. I believe that a separate article or set of articles, linked from here, would work much better from an editorial sense that produces multiple values of articles, not one fight. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 07:51, 3 October 2008 (CDT)
::As far as the National Center for Homeopathy website, what part of "one discipline doesn't specify what another calls itself" do you fail to grasp?  I'm sure I can find medical sites that call homeopaths frauds and quacks; would you accept that designation? I'd have to go back into the archives, but I seem to recall that Larry ruled on this a long, long time ago. Dana does not have any editorial authority over what non-alternative practitioners call themselves.  


::I disagree with Gareth's suggestion that we need to understand the mechanism of action for homeopathic medicines before we can consider seeking approval of this article.  Aspirin was used by doctors for almost a century BEFORE there was any understanding of how it worked, but I do not know a single doctor who chose to not prescribe it due to this deficiency.  Further, the explanations for how and why drugs work change decade to decade, and in this light, having an explanation does not mean that this explanation is true. I have no problem acknowledging that there isn't at present consensus how homeopathic medicines work, but we can and should acknowledge that there are several plausible hypotheses. As for attacks on homeopathy, there IS a place for this part of homeopathy's history in THIS article.  That said, we should not dwell on them.  [[User:Dana Ullman|Dana Ullman]] 12:52, 3 October 2008 (CDT)
::If you think these comments are "attack on homeopathy", I refer you to the commentary of Dirty Harry Callaghan regarding the .44 Magnum. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 01:46, 7 September 2010 (UTC)


::::Gareth never said we need to know the mechanism before the article is approved. I interpret his comments as saying we need to remove attempts to describe the mechanism when there is little or no evidence of their relevance to the topic beyond speculation. While there are hypotheses out there we do not need to describe them in detail, and maybe not at all, especially when there is little quality work out there.  See Gareths comments below for his specific points re: specific experimental data that is cited. [[User:Chris Day|Chris Day]] 13:27, 3 October 2008 (CDT)
== Matt's reversions ==


::::: That's right Chris, I'm sorry to have misled you Dana. My feeling is that it's better to say briefly that we don't understand some things than to get into what are really rather flimsy speculations that seem to sound profound but which fall apart rather readily. There's nothing to be feared from declaring that some things are not understood; believe me, I'm a scientist and there's plenty we don't understand.[[User:Gareth Leng|Gareth Leng]] 17:06, 3 October 2008 (CDT)
Matt, I see you have already reverted what I had added. I don't want to indulge in any "edit warring", so please restore what I had added. I have mentioned the reasons in the sections preceding this.[[User:Ramanand Jhingade|Ramanand Jhingade]] 16:20, 25 August 2010 (UTC)


::::::I think you all just said the same thing, so I think we are on the same page.  I agree that it is not our purpose to prove or disprove homeopathy here, we just report the reality of what it is. It's an alternative system.  That means it is not part of mainstream, likely because there is no plausible explanation other than placebo - which Pierre points out is unethical for conventional medicine to use. If there were a plausible explanation and if the RCTs proved its validity, then it would no longer be alternative and this would be a part of health sciences instead of healing arts.  That says nothing about its value either way, it is not for us to decide.  I am quite sure that homeopathy is the best treatment option for someone out there.  I also agree that what we really want to know is how a homeopath decides what he/she is going to use.. and yes, is there ever a time when they would not treat, or refer?  In other words, do homeopaths consider that homeopathy has a niche, or is it a panacea for all ills?  I do think the science is important and all of these things have a place, but probably in articles of their own that we can mention and link to.  Dana, is there anything else we need to include (anything that we are missing) before we would move to approve? [[User:D. Matt Innis|D. Matt Innis]] 20:38, 3 October 2008 (CDT)
:Since you merely identify this a "Matt's reversions", it's difficult to what you specifically have in mind. Did Matt move the questionable material here for discussion? If he did, then it's appropriate to discuss it here, within policy limits, before it goes back.


:::Let me start by saying that I could draft proposed language that, based on the information in the article, appears to be what you are saying are principles of homeopathy, from the standpoint of a homeopath.  You'd be free to comment, revise, etc., but I'd like to try specifics to show where I am having problems.
:If he deleted without making it clear what he was deleting, or why he was making a Healing Arts Editor decision to delete it, he needs to put it here. Otherwise, you cannot simply demand that it be put back without consensus or an Editor ruling. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:51, 5 September 2010 (UTC)


:::No country of which I know requires understanding of the complete mode of action before approval. Most industrialized countries, however, require demonstration of safety and efficacy, and a number of countries, such as the U.K., also have strong initiatives to establish that a new drug is superior to accepted treatment. There is also an increasing tendency for Institutional Review Boards, which review the safety of proposed experiments in humans, to ask for more and more explanation of mode of action, but also potential dangers as would be suggested by molecular pharmacology.
:I'm in a hurry, but will make a quick reply. I hope Matt brings things here for discussion in future.—[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:38, 6 September 2010 (UTC)


:::Demonstrating efficacy is considerably more of a challenge, and I must again ask that some homeopath clarify terms and expand on the professional interaction. In conventional drug testing, which is agreed not to be workable for highly individualized treatments such as pharmacogenetics, efficacy is determined by testing the treatment against a randomized group of patients with a common diagnosis, and comparing the outcome with the current best treatment if one exists (placebo is ethical only if there is no treatment).
== "Attack piece" ==


:::Correct me if I misunderstand, but it appears, from the article, that homeopaths do not accept the concept, as used in conventional medicine, of "common diagnosis". Patients do not have diagnoses, but have sets of "symptoms", which I put it quotes because I strongly suspect that homeopaths do not use [[symptom]] in the same way as is used in conventional medicine. I will reiterate that a major problem with acceptance of this article is that some seemingly basic words mean different things to homeopaths and medical scientists. Even differentiating between "homeopathic symptom" and "allopathic symptom" would be a good start. I believe a much more detailed description of a homeopathic consultation would go a long way in identifying and clarifying these apparent discrepancies.
The statement "Some other researchers claim that there is scientific evidence that homeopathy helps in many problems and diseases[3]" was added with the edit note that "the lede can't be an attack piece."


:::I have previously suggested, and Gareth commented upon, that the randomized clinical trial approach proposed to test pharmacogenetic therapy would be suitable for testing individualized homeopathic prescriptions. I have not yet gotten any comment on that from a homeopath. Perhaps I have misunderstood, but I essentially hear that homeopaths don't want to be subjected to any form of randomized clinical trial.
The lede also cannot be a place where non-substantive opinion can be used to "neutralize" the main thrust of expert opinion. Again and again, it's been pointed out that CZ's current neutrality policy does not mean that equal emphasis must be given to each position.


:::Are you saying, however, that the standards of approval of all therapies should be at the level of which allowed aspirin to be used?  Are you also saying that there should be the same level of hazard warning for homeopathic preparations as there are for aspirin, such its drug-drug (e.g., aspirin with anticoagulants) or drug-disease (e.g., asthma or gastrointestinal bleeding) or caution (e.g., benefits of aspirin specifically must outweigh the risks of Reyes' Syndrome in susceptible patients)? Do homeopaths support the idea of a centralized body, with all the problems they have, that serves as a registry of adverse events?
I recommend deletion of the above statement as far too general, and, for that matter, worded in a manner that really doesn't counter but says "well, yes but..."  There's an old medical story about a radiologist who crawls, bloody and battered, into his emergency room. Asked what happened, he said it was "consistent with being mugged."  Things in the lede need a bit more substance than "consistent with."  [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:19, 5 September 2010 (UTC)


:::While the level of substantiation of claims on talk pages is lower than in an article, I would appreciate if you avoided sweeping statements such as "I don't know a single doctor who chose not to prescribe it..."  Given aspirin was introduced in 1899, you could not know of all the doctors who made choices not to prescribe it. As I have mentioned above, there are significant reasons today not to prescribe it, just as there are specific indications to approve it. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 13:25, 3 October 2008 (CDT)
:I don't see any probs with that ref and I'm sure Dana, the only other Homeopath here will support me on that.[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:34, 6 September 2010 (UTC)


::::Yes, Howard, I get the impression from what I have read (Dana, correct me if I am wrong) that remedies are chosen strictly based on symptoms (what conventional medicine would call signs and symptoms as determined by what conventional medicine would consider something akin to a physical examination) without regard to whether a disease has been diagnosed or not.  Remember, homeopathy was here long before Pasteur or Koch.  The question is whether the system has changed since its inception to include the use of modern tools such, i.e. MRI/blood work/US.  These would be interesting to know and help illuminate the reader as to the skills of the practitioner.  Having said that, considering that some people who practice homeopathy are MDs, they likely use all the tools at their disposal, but we also know that some lay people are buying products in health food stores based on word of mouth or self evaluation using software, etc.  So I think it's a little of everything.. Dana? [[User:D. Matt Innis|D. Matt Innis]] 20:54, 3 October 2008 (CDT)
== Similars and "allopathic drugs" ==


== qi ==
First, I contend there is no such thing, in modern terms, as an allopathic drug.  Got any references, such as Goodman and Gilman, that use the term?  No, homeopathic texts don't get to define practices in general medicine. Taking a recent addition that I believe must be either radically changed or updated, I quote:


Pierre-Alain Gouanvic wrote: ''qi: it's Paul's contribution.''  Although I had the intention to keep silent, this short sentence annoys me so much that I feel that I must defend myself.  
:"Recent research has shown that some conventional drugs, which are normally used to do something, can do the opposite also - a rebound effect, similar to homeopathy's law of similars.<ref>{{cite journal |author=Kales A, Scharf MB, Kales JD |title=Rebound insomnia: a new clinical syndrome |journal=Science (journal) |volume=201 |issue=4360 |pages=1039–41 |year=1978 |month=September |pmid=684426 |doi= |url=}}</ref><ref>{{cite journal |author=Kirkwood CK |title=Management of insomnia |journal=J Am Pharm Assoc (Wash) |volume=39 |issue=5 |pages=688–96; quiz 713–4 |year=1999 |pmid=10533351 |doi= |url=}}</ref>
<ref>{{cite journal |author=Tsutsui S |title=A double-blind comparative study of zolpidem versus zopiclone in the treatment of chronic primary insomnia |journal=J. Int. Med. Res. |volume=29 |issue=3 |pages=163–77 |year=2001 |pmid=11471853 |doi= |url=http://openurl.ingenta.com/content/nlm?genre=article&issn=0300-0605&volume=29&issue=3&spage=163&aulast=Tsutsui |last2=Zolipidem Study |first2=Group}}</ref><ref>{{cite journal |author=Hohagen F, Rink K, Käppler C, ''et al.'' |title=Prevalence and treatment of insomnia in general practice. A longitudinal study |journal=Eur Arch Psychiatry Clin Neurosci |volume=242 |issue=6 |pages=329–36 |year=1993 |pmid=8323982 |doi= 10.1007/BF02190245|url=}}</ref>.
<ref>{{cite book | last = Reber | first = Arthur S. | authorlink = | coauthors = Reber, Emily S. | title = Dictionary of Psychology | publisher = Penguin Reference | date = 2001 | location = | pages = | url = | doi = | id = | isbn = 0-140-51451-1}}</ref><ref>{{cite journal |author=Kales A, Soldatos CR, Bixler EO, Kales JD |title=Early morning insomnia with rapidly eliminated benzodiazepines |journal=Science (journal) |volume=220 |issue=4592 |pages=95–7 |year=1983 |month=April |pmid=6131538 |doi= |url=}}</ref>
<ref>{{cite journal |author=Lee A, Lader M |title=Tolerance and rebound during and after short-term administration of quazepam, triazolam and placebo to healthy human volunteers |journal=Int Clin Psychopharmacol |volume=3 |issue=1 |pages=31–47 |year=1988 |month=January |pmid=2895786 |doi= 10.1097/00004850-198801000-00002|url=}}</ref><ref>{{cite journal |author=Kales A |title=Quazepam: hypnotic efficacy and side effects |journal=Pharmacotherapy |volume=10 |issue=1 |pages=1–10; discussion 10–2 |year=1990 |pmid=1969151 |doi= |url=}}</ref>.
<ref>{{cite journal |author=Hilbert JM, Battista D |title=Quazepam and flurazepam: differential pharmacokinetic and pharmacodynamic characteristics |journal=J Clin Psychiatry |volume=52 Suppl |issue= |pages=21–6 |year=1991 |month=September |pmid=1680120 |doi= |url=}}</ref><ref>{{cite journal| journal =Pharmacopsychiatry | year =1989 | month =May | volume =22| issue =3| pages =115–9| title =Can a rapidly-eliminated hypnotic cause daytime anxiety? | author =Adam K | coauthors =Oswald I| pmid =2748714| doi =10.1055/s-2007-1014592}}</ref>"


Let me copy what I wrote to Pierre [[Talk:Homeopathy/Bibliography| here]]:
First, it's impossible to respond to this deluge of citations without any details. Second, for these to be "allopathic" drugs, based on the "principle of opposites", the papers must include that language. Do they?


''  You changed my wording on qi. May I remind you that I simply shortened the following sentence (p. 600): &nbsp; &nbsp; [...] before and after implantation of “qi,” or intention, by Dr. Yan Xin, the best known of China’s Qigong grandmasters.''
Second, it's a leap to equate a rebound phenomenon to allopathy; the dose-over-time, molecular control mechanisms, etc., are much more than "opposites". One of the classic examples of rebound, nasally applied vasoconstrictors, doesn't take place when the dose and duration are properly controlled. In general, if the vasoconstrictor is needed for long enough to cause rebound, use of antiinflammatories, such as corticosteroids, cromolyns, or antihistamines should be under active consideration to replace the  direct vasoconstrictor.


The page reference, p. 600, is to  a page in the paper of Roy ''et al.''. Previously, I had extended Pierre's summary of Roy's paper by entering this fact about qi. After seeing my change, Pierre inserted "putative", which is Pierre's interpretation. Roy does not imply in any way that the QiGong work is putative, hence this judgmental  adjective does not belong in a summary of the paper.
It was with considerable restraint that I didn't immediately move this to the talk page. Ironically, there are very pleasant, collaborative discussions going on in a number of military and history articles. Maybe getting to kill people makes for more restrained discussion. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:04, 5 September 2010 (UTC)


I think Roy's paper is rubbish and one other citizen called the paper  "utter garbage" (see my talk page). To underpin my opinion I want to point out that there are only four ''experimental''  figures on water in Roy's paper.
:The rebound effect is well documented and accepted in medical circles, so please don't delete that sentence or the refs I inserted (I've improved on the way it used to read, so pls take a look).—[[User:Ramanand Jhingade|Ramanand Jhingade]] 08:31, 6 September 2010 (UTC)
# Fig. 4 is from a reputable journal and are experiments at 1 GPa (is 10,000 atmosphere = 145,000 psi). Roy et al.  claim that shaking of water generates this kind of pressure so that this paper is relevant.
# Fig. 13 is textbook material, disputed by nobody.
# Fig. 16 originates from: Tiller WA, Dibble E, Kohane MJ (2001) ''Conscious acts of creation: the emergence of a new physics.'' Pavior Publishing, Walnut Creek. A magnetic field of the strength of the Earth's magnetic field changes the pH of water by 1 (makes water less acidic).
# Fig. 17 (completely illegible and therefore  useless) originates from  Zuyin L (1997) ''Scientific QiGong Exploration.''  Amber Leaf Press, Malvern, PA. It supposedly gives the effect of qi on Raman spectra of tap (!) water.


I've tried to locate the last two references in university libraries in Holland, so that I could borrow them through Dutch interlibrary loan, they are not available.  
::Well documented? "Rebound effect' doesn't appear in the index of the standard textbook, ''Goodman and Gilman's The Pharmacologic Basis of Therapeutics (9th Edition)''. Now, as I have mentioned, the term "rebound" is indeed used in very specific contexts, such as the response of nasal mucosa to topical vasoconstrictors.  


Finally, the question arises: is the "homeopathic memory" of liquid water due to high pressure (shaking), weak magnetic fields, or qi? Roy ''et al.'' do not give the answer.
::"can lead to the opposite effect, when stopped - a rebound effect, which means they are following homeopathy's law of similars." is not especially an improvement. Of course there are drugs that have adverse effects when stopped inappropriately. Corticosteroids, selective neurotransmitter uptake inhibitors and opioids all come to mind. "Similars" have nothing to do with it, in the sense that a corticosteroid, in a Proving, would be inflammatory. Instead, the adrenal cortex has reduced its production of endogenous steroids because it has sensed a certain blood level.  


--[[User:Paul Wormer|Paul Wormer]] 05:07, 3 October 2008 (CDT)
::It's vaguely amusing to hear you comment about people ignorant of homeopathy, when there seem to be so many opportunities to be unaware of molecular pharmacology. But, there are different tastes -- where's the eye of newt and blood of bat when you need them? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 01:18, 7 September 2010 (UTC)


::Yes, Paul and Pierre, I appreciate your valiant efforts here to get to the heart of the cases for and against homeopathy, that is importantYou have illustrated to all of us that we are talking about very minute forces, weak fields, and very theoretical concepts that are just not far enough along in the review process for us to be able to cite anyone in any authorative way as being related to how homeopathy might work.  I have no problem with mentioning them here and then exploring them in separate articles - especially if the earth sciences and biologists could take a serious look at it, then we can link to it. [[User:D. Matt Innis|D. Matt Innis]] 21:23, 3 October 2008 (CDT)
==Dead link==
http://www.medscape.com/viewarticle/511604 Reference 102 about the value of talking to patients. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:08, 5 September 2010 (UTC)


==Beginning clean-up==
:Then I suggest we remove the sentence attributed to Vandenbroucke.[[User:Ramanand Jhingade|Ramanand Jhingade]] 13:56, 6 September 2010 (UTC)
*I've deleted the section on quantum mechanics. First, the text below had nothing to do with quantum mechanics. It described some reports of the biological effects of focussed electromagnetic fields on tissue growth. These interventions alter the electrical excitability of cells, with diverse effects depending on cell type. They seem to have nothing to do with homeopathy. The suggestion that homeopathic remedies work on frequencies is unclear to me (after reading about it) and certainly very unclear what these have to do with e-m fields. I saw no prospects of this section becoming acceptable I'm afraid, if there is something worth following up, I suggest another article is the place for it.[[User:Gareth Leng|Gareth Leng]] 07:25, 3 October 2008 (CDT)


*I've deleted the empt section heading on solitons. I looked them up and have written a stub [[soliton]]. I cannot see any plausible link to homeopathy; the claimed association of solitons with homeopathy appears to rest on some misunderstandings.[[User:Gareth Leng|Gareth Leng]] 07:52, 3 October 2008 (CDT)
==Thankless CZ==
Editing CZ is a thankless job. I'm sure the people who are ignorant about a subject (like Homeopathy) can move on to Facebook, Orkut, Linked in, Twitter or some other networking site/s and make a lot of friends and get to know them really well - we hardly know anything about each other here. Howard, you're probably a nice guy I can get to know better and probably dine with. Sandy, Im sure I can make an interesting 'date'. Why don't y'all look for me on Facebook?—[[User:Ramanand Jhingade|Ramanand Jhingade]] 13:56, 6 September 2010 (UTC)
:I have nothing against friendship, and I do think I've found a number of good friends here. Nevertheless, the essence of what I see as appropriate writing at CZ depends on courtesy, but above all, logic -- western if you will -- and evidence. I have a LinkedIn account, but not Facebook, Twitter, etc. -- and don't want them. On the other hand, I am very active on an assortment of professional mailing lists. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:50, 6 September 2010 (UTC)


*I've liooked up clathrates and written [[Clathrate]]. I can't see any link unless it is proposed here that the effects of homeopathic remedies reflect contamination, which I don't think is the case. I suggest deleting this from the present article, but perhaps the text might go to the Talk page of [[clathrate]] for incorporation there?
:: First off, I greatly doubt either of us would enjoy a date. 'Sandy' is a short form of 'Alexander', and I'm neither unattached nor gay.
:: Second, some of your other apparent assumptions are just as bogus. People generally aren't here for social networking, but to contribute toward building an encyclopedia. Nor does not being an expert on homeopathy preclude contributing.
:: I'm resisting the urge to write a more pointed reply because it would violate [[CZ:Professionalism#What_behaviors_are_unprofessional.3F]]. [[User:Sandy Harris|Sandy Harris]] 23:47, 6 September 2010 (UTC)


* I suggest deleting at least the second paragraph of mithridisation. I've added the link to the external links page and moved the reference so these would survive. I'd delete it simply because I could not make sense of it as written. I'm not saying that it's rubbish, only that if I can't understand the logic my guess is that others won't either[[User:Gareth Leng|Gareth Leng]] 08:18, 3 October 2008 (CDT)
==Confusing deletions==
It's somewhat difficult to tell why things are deleted when the only reasons given are in edit notes, which aren't always easily accessible if, for example, minor edits follow them in the log.


* I've looked up the silicate literature, see here PMID 11212084 PMID 11212083 and PMID 11212090 ([http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B8CWK-4MDGN93-2&_user=809099&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000043939&_version=1&_urlVersion=0&_userid=809099&md5=0a53347caaf27c3e5ff83392c75e7c91]; "Experience has taught us that outstanding results are generally merely due to artifacts, of which the paper of Milgrom et al is a reminder"; J-L Demangeat and B Poitevin). On this basis I'd suggest deleting this section. Briefly, it seems that differences in NMR results achieved with homeopathic solutions and pure water seem to be an artifact arising from silicon chips displaced from the tubes containing the homeopathic solution. As far as I can see that is all there is to the silicate story. [[User:Gareth Leng|Gareth Leng]] 09:47, 3 October 2008 (CDT)
This was deleted, possibly due a claim that it was unsourced -- yet it is sourced. It's a reasonable statement and belongs in the article. <blockquote>This does not mean that that people treated with homeopathy do feel better as a result - the clinical literature clearly shows this, but Vandenbroucke suggested that this could be because its practitioners treatments spend more time with people than doctors do. "Even if people give you the wrong explanation about what you seek treatment for, the fact that they spend a long time speaking with you might help," Vandenbroucke suggests.<ref>[http://www.medscape.com/viewarticle/511604 medscape]</ref></blockquote>


* Nano bubbles: I'd suggest deleting this section. I've looked at "Permanent physio-chemical properties of extremely diluted aqueous solutions of homeopathic medicine"[http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WXX-4CRXKVD-7&_user=809099&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_version=1&_urlVersion=0&_userid=809099&md5=ba47c2b6b27a84dae0bac33b8710c6c0]. First it doesn't mention nanobubbles. Second it reports that "The only clear and simple behaviour common to all samples, is the increase of the parameter χE as a function of time. an increase of [excess conductivity] over time" in solutions exposed to successive dilution and succusion. Most relevantly, this was true of dilutions of water as well as for dilutions of homeopathic remedies. Most irritatingly the abstract describes "some significant experimental results were obtained." As they applied no statistical tests whatsoever. They state that "Some differences appear to be related to the preparation procedure, and to depend on the degree of dilution or the method of dynamization, but the correlation is not yet clear." This work seems below my threshold of "worthy of serious consideration."[[User:Gareth Leng|Gareth Leng]] 10:31, 3 October 2008 (CDT)
"Homeopaths contend that flawed trials cannot be used to show that homeopathic treatment is ineffective <u>(please read the previous paragraph for information about the positive trials)</u>." This new sentence, especially the underlined words, is argumentative rather than informative. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:50, 6 September 2010 (UTC)</i>


:I agree that these sections seem to drag on and don't answer how they are related to homeopathy directly, however, rather than deleting, how about consolidating them together in one short section on "explanations, past and present" or something like that. If homeopaths consider these as explanations, then they probably do need to be mentioned. [[User:D. Matt Innis|D. Matt Innis]] 21:32, 3 October 2008 (CDT)
:I didn't do the above editing, though I support it.  Just because Vandenbroucke says that statement does not mean it is true, especially when there is at present no data to support it.  This idea borders on the preposterous that the "extra" time that homeopaths spend with their patients leads to the therapeutic benefits that homeopathic patients experience. If THAT were the case, then, psychologists would be our finest healers (and sadly, they are not). Although the first interview with a homeopath is typically an hour, the follow-up visits are usually 10-30 minutes, just a little longer than a conventional MD.


::From a pure lower-case editorial position, if something is considered an explanation, it's reasonable to expect why it is considered a credible explanation. Either leave out the explanation completely, or have it reasonably tied into why it is credible, not "foobar explains and Dr. Foobar is highly respected". Again, I can't emphasize how much I believe this article would be improved by dropping the speculative water properties and getting into real fundamentals like the details of a homeopathic consultation and treatment plan, whether they have a niche and when/if they refer, etc. On this talk page, I repeatedly asked one homeopath, who said he used tests such as blood counts, to explain how the results affected his treatment plan &mdash; a question that any medical doctor should be prepared to answer. I am not holding homeopaths to a higher standard than anyone who can legally prescribe a test.
:As for "flawed" trials, see my longer message in the next section where I talk about the importance of "internal validity" in trials AND "external validity."  [[User:Dana Ullman|Dana Ullman]] 01:09, 14 September 2010 (UTC)


::My grandmother thought that anything could be cured with enough chicken soup and enough seltzer. Both modifications of water, right? :-) [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 21:44, 3 October 2008 (CDT)
==Dana Ullman's thoughts on this article to date==


:::If she grew up during the depression in the US, then it is likely that it was more water than chicken ;-) [[User:D. Matt Innis|D. Matt Innis]] 22:22, 3 October 2008 (CDT)
Sorry to be away from the article for so long...


:::::Martin, please do not delete the sections on nano-bubbles and on clathrates. Let integrate some of Martin Chaplin's writings on these subjectsThe shaking of the solutions clearly create bubbles and nano-bubbles.  That is knownTo clarify, the references provided do not mention bubbles, but they do show how homeopathic medicines influence thermodynamics...with two good references[[User:Dana Ullman|Dana Ullman]] 12:36, 4 October 2008 (CDT)
I am very concerned about this present “draft” of the homeopathy articleI feel that it has lost its “encyclopedic” tone, and instead, it is a mixture of encyclopedic information along with strong “point of view” skepticismAlthough I do not have a problem with proper skepticism, it is the tone of it AND where it is placed in the article that is critical.   


== Trying to understand the homeopathic model ==
For instance, in the very top portion of this article are paragraphs #3 and #4 which are not encyclopedic in tone or content.


I put up a first draft article of [[Koch's postulates]], with modern modifications. Improvements are welcomeIt is my hope that it could serve as a point of reference for elucidating some aspects of homeopathy I don't yet understand, and no, I'm not talking about remedies and water.
I will try to avoid doing “editing” the article myselfInstead, I will propose here in the TALK section my ideas for what should be said, and I hope that those people who want to maintain a high-quality objective and encyclopedic article will make appropriate changes to the Draft.  Needless to say, I will not sign my name, as a Healing Arts Editor, to anything that does not maintain a certain objective tone.  And by “objective tone,I obviously do not mean that this article should just a promo for homeopathy.


Am I correct, Dana (or whoever wants to take a crack from the homeopathic standpoint) that the basic idea of Koch's postulates is not consistent with the homeopathic model of diagnosing and healing based on [[symptom]]s? I note that homeopaths and non-homeopaths may use "symptom" differently, but I think we would get a lot farther on the article by articulating homeopathic diagnosis and treatment planning than arguing about the physical chemistry of water.
:My sincere thanx for whoever re-formating my contribution so that we can communicate about them in bit-sizeable chunks.  Good work!  [[User:Dana Ullman|Dana Ullman]] 15:37, 14 September 2010 (UTC)


Really, I'm putting aside the Avogadro issue. My biggest problem with the article is that I do not have a clear idea of how homeopaths, with modern diagnostic tools available, evaluate a patient and form a course of therapy.   
=== Dana on 3rd paragraph===
Ultimately, I recommend some changes in the 3rd paragraph…here’s what I suggest for replacement for this paragraph.   


For that matter, there has been no discussion at all about how homeopaths deal with trauma. Would a homeopath treat, refer, or collaborate with a multiple gunshot wound victim, with a compound fracture of an extremity, a bullet entry wound in the chest (and the patient is having difficulty breathing), and entry and exit wounds through the intestines? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 19:01, 3 October 2008 (CDT)
::While many medical practitioners prescribe some homeopathic remedies, a significant majority of the scientific and conventional medical community (including a number of national medical representative bodies like the British Medical Association), consider homeopathy to be unfounded and pseudoscientific.[1] Skeptics of homeopathy insist that there is no plausible mechanism to explain how the remedies might work, given that many of them are so dilute that they contain not a single molecule of the active ingredient. However, homeopaths and scientists from varied specialties, including Nobel Prize winning virologist Luc Montagnier, assert that there are viable theories about how homeopathic medicines may act, though as yet, no one explanation has been verified.  Advocates assert that the homeopathic “principle of similars” is, in part, the basis for modern day immunizations, allergy treatments, and select other conventional treatments (ie, the use of Ritalin and other amphetamine-like drugs used to treat hyperactive children), while critics have compared it to sympathetic magic.


:I hope you saw my answer in two sections above. I would suggest putting your finger in the holes and yell "MEDIC"! :-) [[User:D. Matt Innis|D. Matt Innis]] 21:36, 3 October 2008 (CDT)
::: I wrote the current text. To me it seems accurate and encyclopedic, much better than either what it replaced or your suggestion.


::Yes, but it was my ''mother'' who grew up during the Depression. I must thank her for teaching me to be an excellent cook: with her cooking, I took it over when I was about 11. The Depression recipe that was most common was her elder brother's favorite sandwich: chill Campbell's Condensed Vegetable Meat Soup until firm, cut slices, put on Wonder Bread or equivalent, and perform an act reminiscent of eating.
::: My "While the founder of modern homeopathy was a medical doctor, some modern medical practitioners do prescribe some homeopathic remedies, and some governments do recognise homeopathy as legitimate treatment" instead of your "While many medical practitioners prescribe some homeopathic remedies" gives more arguments favorable to homeopathy, but states them more carefully, your "many" seems dubious to me.


::A little more seriously, since some of my work has involved decision support and patient simulation in emergency and trauma medicine, I'd act in various ways, depending if I were in the role defined as a layman first responder, a paramedic licensed for Advanced Trauma Life Support, or the leader of the trauma team in the receiving ER. In the latter two roles, after doing a very fast primary survey, one of the first steps would be respiratory support. It would not be appropriate to describe the primary surgery, or the first steps in definitive care, but, perhaps ironically, one of the first steps would be [[rapid sequence intubation]] (RSI), a good part of the anesthesia portion being an update of the [[curare]] work by [[Harold Griffith]], physician with allopathic and homeopathic training. First starting [[oxygen]], then pretreatment with [[fentanyl]], [[lidocaine]], [[atropine]], and a defasciculating dose of a [[nondepolarizing neuromuscular blocking agent]] such as [[rocuronium]], none of these in homeopathic doses would precede anesthesia, full paralysis, and [[tracheal intubation]]. Slamming in an ultrashort-acting [[anesthetic]] such as [[etomidate]], followed by a paralyzing agent such as the depolarizing agent [[succinylcholine]] or a full dose of rocuronium (there is discussion on the best choice &mdash; dare I say [[randomized controlled trial]]?[http://www.anesthesia-analgesia.org/cgi/content/full/101/5/1356]]. Once the patient was anesthetized and paralyzed, an appropriate tube would be inserted in the trachea, connected to oxygen &mdash; and then (virtual) I would start secondary assessment, knowing the patient is not going to asphyxiate while his chest injury is assessed in more detail.
::: My "the consensus of medical and scientific opinion is that homeopathy is unfounded." seems to me a simple statement of fact.


::I'm really not trying to show off here, but make a point that someone oriented to conventional medicine can explain how they decide what to do, in what order, and, in the example above, can usually describe molecular mechanisms for every drug above, and the anatomical/surgical reason that the RSI  (including preoxygenation and IV access) would come first. I can go write an article on assessment (physical at least; hard to get history from an unconscious patient) in a trauma emergency. There are a host of other things that would be going on around that patient, such as very controlled fluid support following [[permissive hypotension]] before his impending visit to the operating room.
::: I removed the claim that it is "pseudoscientific", which seems to me true but unnecessary here. Criticism is fine; gratuitous insults are not.


::Am I asking anything that would not be perfectly reasonable to ask in an article on "medicine", or perhaps "trauma medicine"? There are things now in the lede such as the [[body's wisdom]], and I don't know what that is. I do know that patient, without some distinctly aggressive intervention, may be dead in minutes unless he gets advanced respiratory support &mdash; first getting him on artificial ventilation, then doing differential diagnosis of the respiratory problem, since the basic [[symptom]]s of [[pneumothorax]] or [[tension pneumothorax]] or [[hemothorax]] look alike without additional physical examination and imaging.
::: I do not think the British Medical Association or your "However, ..." or "Advocates assert ..." belong in the lede. The lede needs to be a simple summary of key points. The BMA, Montaignier and Ritalin might all be discussed later, but they do not belong here. [[User:Sandy Harris|Sandy Harris]] 03:34, 14 September 2010 (UTC)


::I could also use a non-emergency but life-threatening situation, and describe very specifically how the evaluation and treatment plan would emerge. Matt, one of my favorite books, which I first read as a teenager, is ''Not as a Stranger'', a novel about a depression-era physician, who is challenged by a friend and skeptical lawyer, about all the things the protagonist doesn't know &mdash; why the heart beats, how an anesthetic works, the mechanisms of death, etc. I read that every so often, and, over the years, have seen how each of those challenges can now be answered. In homeopathy, however, I see adherence to what appears to be a mystical model, and the authorities cited being largely in the 19th century or earlier.
Greetings, Sandy...we've not interacted yet...let's work together.  First, the claim in the present draft that "There is no plausible mechanism..." is false and has no place here.  There ARE plausible explanations, though simply none that have been confirmed. [[User:Dana Ullman|Dana Ullman]] 15:20, 14 September 2010 (UTC)


::Is "How Homeopathy Develops and Improves" an unreasonable section to expect? <s>[[Evidence-based medicine]]</s> evidence-based homeopathy? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 10:37, 4 October 2008 (CDT)
:: It depends on the interpretation of the word "plausible". Certainly there are explanations, but I'd say none are plausible. [[User:Sandy Harris|Sandy Harris]] 02:31, 15 September 2010 (UTC)


== Section on "The skeptical view of homeopathy" ==
: Sandy suggests above that my reference to "many physicians" prescribing homeopathic medicines "seems dubious."  Perhaps it would help if he re-read our article here where in the "Homeopathy in Practice" section gives some specific figures:  "In Europe homeopathy is practiced by many conventional physicians, including 30-40% of French doctors and 20% of German doctors. Some homeopathic treatment is partly covered by some European public health services, including in France and Denmark. In France, 35% of the costs of homeopathic medicine prescribed by a medical doctor are reimbursed from health insurance."...Clearly, the term "many" is not dubious.  [[User:Dana Ullman|Dana Ullman]] 15:48, 14 September 2010 (UTC)


At the present time, this section seems to suggest that the fundamental reason for questioning homeopathy is that the mechanism of homeopathic remedies is not understood, and starts to drift into those deep waters. I suggest that much more fundamental issues are involved in the lack of acceptance of homeopathy by mainstream biology and medicine.  I write the points below not to attack homeopathy, but either to have homeopaths clarify any misconceptions, or to have these more basic issues addressed as reasons for skepticism.
:: See the discussion under "unsupported assertions" above. Those claims do belong somewhere in the article, if they can be supported, but the lede as it stands seems to me a good summary. [[User:Sandy Harris|Sandy Harris]] 23:21, 14 September 2010 (UTC)


As I understand it, and I have tried to clarify in the lead, homeopathy does not recognize the concept of "disease", in the sense of a pathological malfunction of metabolic or mechanical functions of the human body. If, as has been stated, homeopaths only recognize collections of symptoms (the word "symptom" being used in a homeopathic context), it is logical to infer they reject the concept of infectious disease and treatment intended to prevent or destroy pathogenic organisms. While homeopaths have said they use laboratory tests, it is completely unclear how they would make use of hematological or biochemical abnormalities that do not correlate with any externally visible [[symptom]] or [[sign]] (links indicate medical definitions are used).
: I have a question for Sandy and Howard and other skeptics.  At present, in this lede, there is the sentence:  "To a skeptic, the 'principle of similars' is merely an appeal to sympathetic magic." Out of curiosity, do you believe that there is a certain wisdom of the body?  Do you believe that the human organism tries to adapt to infection and/or stress by creating symptoms in order to survive?  If you answer YES or MAYBE to EITHER of these questions, then using drugs that mimic the body's defenses make sense, and as such, we HAVE to delete or change this ill-founded sentence.  Please also remember that the "high potencies" is only a part of homeopathy and that most homeopathic medicines sold in health food stores and pharmacies today are in small, material doses.  It is inappropriate (and inaccurate) to assume that ALL homeopathic medicines are in doses beyond Avogadro's number. [[User:Dana Ullman|Dana Ullman]] 16:34, 14 September 2010 (UTC)


[[Differential diagnosis]] is a fundamental concept in medicine, which seems the antithesis of categorizing groups of symptoms. A set of patients presenting to an emergency room with a [[symptom]] or [[chief complaint]] of chest pain, perhaps described as a sensation of [[sternum|substernal]] pressure with radiation of pain into the left arm, from the medical viewpoint, all could be having the same symptoms for completely different reasons. Each one of those reasons would involve a different pathological mechanism, and, other than common supportive measures such as the relief of pain, would call for quite different treatment. If homeopaths reject the idea that there could be different causes for the same presentation, and different appropriate treatments for each.
:: That sentence is fine. What we believe is not at issue. The paragraph is trying to summarise the position about homeopathy of skeptics and critics. I'd say that, if anything, it understates their revulsion. Granted, other parts of the article should give a much more favorable view, but the negative views should be there as well. [[User:Sandy Harris|Sandy Harris]] 23:21, 14 September 2010 (UTC)


I'll be happy to draft a new section, but I believe its present form is unacceptable, in that it assumes the controversy is about mechanism of action of homeopathic remedies, rather than the evaluation of the patient and the determination of a treatment plan that might or might not involve remedies at all -- or do homeopaths (serious question) do not believe in surgery? Something that basic has not been mentioned, and needs to be discussed, not more esoterica about water. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 00:18, 4 October 2008 (CDT)
:::Individual belief is outside the scope of the article, but no, I don't think there is a "wisdom of the body", and, using the medical definition of [[symptom (medical)|symptom]], the body doesn't create any symptoms -- the mind does. Symptoms are subjective, and signs are objective. A sign may be evidence of a defense mechanism, but it's far more likely to be evidence of a disease process.


:I think this is a reasonable request and would very much like to see Dana take a shot at it and give us some direction, particularly concerning your assumptions about diagnosis and infectious disease and if homeopaths see limits to their system - which may not belong in the skeptical section at all.
:::The great fallacy I see here is the assumption that proving-based drug mimic the actual defenses. The body's direct defenses against ''[[Clostridium tetani]]'' exotoxin in [[tetanus]] are immunologic. Those defenses are supported by administering synthetic tetanus immune globulin -- we learned to avoid the horse serum preparation as too risky -- to give initial passive immunity, and tetanus toxoid to build active immunity. These don't "mimic" the defenses; they '''are'''  the defenses.  The body really doesn't have defenses against the neurologic effects of the toxin, but benzodiazepines, neuromuscular blocking agents, baclofen and dantrolene provide what, I suppose, could be called "symptomatic" relief. Without getting into all the receptors, we have a pretty decent idea '''how''' these drugs reduce the spasticity; we don't need to go the route of finding similars.  


== How homeopaths think ==
:::I'm not opposed to using unusual explanations when there are no better ones. "Wisdom of the body" sounds like something for a Religion Editor. I do use complementary methods when I have some reason to believe in a favorable risk-benefit. As soon as I hear that something is risk free, alarm bells go off. There are always tradeoffs. I'm facing a terrible one now, as the American Veterinary Medical Association described euthanasia as a means of comfort care that has the side effect of death -- yet I have a beloved cat who has a greater will to live than any human I've ever encountered. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:56, 14 September 2010 (UTC)


I added [http://en.citizendium.org/wiki/Homeopathy#How_does_a_homeopath_think.3F this section] and some to the next section in an effort to develop a picture of what I think a typical homeopathic consultation would look like from what I have been able to pick up from sources on the web and from school curriculums. Take a look and see if it is a realistic outlook and feel free to make any changes that you feel are necessary as I appreciate collaboration and would prefer if they were not all my words. [[User:D. Matt Innis|D. Matt Innis]] 09:55, 4 October 2008 (CDT)
The text you are questioning is "There is no plausible mechanism to explain how the remedies might work, given that many of them are so dilute that they contain not a single molecule of the active ingredient. To a skeptic, the "principle of similars" is merely an appeal to sympathetic magic." I think that is OK as it stands.


:Thanks for getting the ball rolling, though I have reworked this...and will add more later.  [[User:Dana Ullman|Dana Ullman]] 11:12, 4 October 2008 (CDT)
It could be replaced with something that both states the skeptical position better and mentions that not everyone is skeptical:


== Explaining reversion of "inaccurate statement" ==
: To a skeptic, there is neither any solid evidence that homeopathy is effective nor any plausible explanation of why it should be, and the "principle of similars" is merely an appeal to sympathetic magic. Homeopaths, however, believe that they have good answers to these criticisms.


Dana deleted, which was within his rights, what he simply called an "inaccurate statement"
::Close.  Let me urge that [[sympathetic magic]] show as a wikilink, as it is not just a throwaway pejorative, but an anthropological term that shows up across many cultures. Consider dropping the "merely". When I wrote the article on sympathetic magic, it wasn't intended to disparage, but to explain a cultural pattern.
<blockquote>This theory also rejects the concept of diseases to be treated, and deals purely with the benefits to be gained by giving drugs that emulate symptoms&mdash;groups of symptoms, rather than diagnoses, are the fundamental treatment objectives.</blockquote>


I apologize if I have been incorrect, not having the benefit of homeopathic training, but there has been a constant thread, from homeopathic contributors to this article, about the rejection of the "medical" model, and the preference for dealing with "individualized sets of symptoms" and invoking the [[body's wisdom]] rather that try to deal with a "disease" that needs to be "corrected"Would someone, incidentally, either write a definition of [[body's wisdom]], or replace it with something a little less mystical?
::Is it necessary to bring up both the Avogadro argument ''and'' similars in the lede, purely from a standpoint of complexity?  Yes, I understand that potentiation is an argument that can be countered with the Avogadro point, but similars seem more basic than potentiation in understanding the core argument of homeopathy.   


If that terminology was incorrect, it's been in the article for some time. Why, then, was it not removed? 
::I am ''not'' trying to be argumentative when I say that arguing that the principle of similars is an equivalent or superior explanation, to a drug that was designed using molecular structure-activity relationships, is inflammatory. It's one thing for the homeopaths to say why their own preparations work, but it's pushing too hard to say that the homeopaths have better explanations for the drugs developed under different paradigms. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 02:46, 15 September 2010 (UTC)


There are very fundamental questions here. Without going through the revision history, at least some of this came from Ramanand, not Dana. Yet, after quite a bit of wrangling, there has been much discussion of the physical chemistry of water, and very little concise and specific information on how homeopaths assess patients, choose treatments, and when and if they refer or work collaboratively. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 10:44, 4 October 2008 (CDT)
=== 4th paragraph===
I believe that the present 4th paragraph has NO place in the top section. Discussion of the “possible dangers” from the patient or the doctor’s decision to not use conventional treatments has NO place here. If others wish to insert this information under its proper section, I do not have a problem, though we must then acknowledge:  Homeopaths respond to the possible dangers from using homeopathic medicines in replacement of conventional medical care by asserting that there are much greater dangers by using conventional medicines as a first method of treatment.


:Howard, it has been said that having a little bit of knowledge can be dangerous.  It is true here IF one thinks that their little bit of knowledge is a good or adequate picture of truth. Because you seem to have new passion towards homeopathy, as evidenced by your editing here, I have urged you to read about this field. I hope you do that.
: It probably needs mention of the fact that homeopaths retort that conventional medicines may also have large risks. I'm inclined to think it does belong in the lede, since these risks are a basic issue about homeopathy. However, I don't feel remarkably strongly about that and would be interested in hearing other opinions. [[User:Sandy Harris|Sandy Harris]] 03:44, 14 September 2010 (UTC)


:I have no idea how long this statement was here, and I apologize if I didn't change it earlier, but as you know, I have bene working on other parts of this article. [[User:Dana Ullman|Dana Ullman]] 11:36, 4 October 2008 (CDT)
::I would prefer to see it go unless the homeopaths present a statistical risk-benefit argument, based on modern medical practices, not 1900, that the hypothesis is true that the clinical outcome is better with homeopathic treatment than medical or no treatment. The risks of most medical treatments are quantifiable, as are the benefits, with the understanding that statistical aggregates do not apply to individuals.


::Dana, this is the second time you have referred, I hope not sarcastically, to my new interest or "passion" for homeopathy. Where I do have a passion is for the reputation of Citizendium as a reliable source of information, reviewed by experts, ideally in complementary disciplines.  
::There are any number of times I've chosen something with significant risk, because there was reasonable evidence the risk was greater than the benefit. Obviously, a cardioplegia solution that stopped my beating heart was risky, but the risk of not having the open-heart surgery was greater.  There was reliable data for risk at each stage of the procedure.


::My interest goes toward statements made on Citizendium. When some seem to be based on (relatively) ancient sources, such as Hahnemann on miasmas, I begin to become concerned. In the spirit of collaboration and contributing work where I do have expertise, I added the article [[Koch's postulates]] yesterday. It is an early draft and needs constructive criticism; I'm not sure how deeply I should go into the current sequence- and immunologic-based principles and literature.
::When other children would chant "your mother wears army boots," I'd point out that they were part of her uniform. The "medical treatment is more dangerous", without substantial data, rings equally relevant to me. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:34, 14 September 2010 (UTC)


::Nevertheless, you used the term "miasm", did not provide a recent definition, and I looked up Hahnemann's descriptions. They seem rather blatantly at odds with Koch's postulates. At least in the case of ''Neisseria gonorrheae'', I have personally taken samples from a patient, cultured it, identified it, and then handed the treating physician the laboratory results. This being some years ago, ''N. gonorrheae'' was still penicillin-sensitive, and, when I did repeated cultures after treatment, they were bacteria-free and the patient's symptoms and signs were gone. I can give non-anecdotal references, but your reference to miasms, and the actual text of the definer thereof, hardly encourages me to read more about homeopathic alternatives.
::: "I would prefer to see it go unless ..." is not clear to me. Are you saying that text on homeopathic rejoinders should not be inserted, or that we should follow Dana's suggestion and remove the current 4th paragraph from the lede? [[User:Sandy Harris|Sandy Harris]] 05:30, 14 September 2010 (UTC)


::Would you care to redefine (versus [[history of homeopathy]]) miasm, in terms that are reasonably consistent with some aspects of the Hahnemann-named infections diseases that are demonstrably false by anyone who is willing to gain (using your phrase ) "a little bit of knowledge" &mdash; perhaps undergraduate Microbiology 101? [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 11:53, 4 October 2008 (CDT)
::::Unless the homeopathic rejoinder has strong statistical support, it should not be in the article. It's one thing if there is a formal risk-benefit analysis proving a hypothesis, but if it's no more than "well, medical treatments are dangerous," it's irrelevant defense. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 06:25, 14 September 2010 (UTC)


In due respect, the formal risk-benefit analysis needs to go BOTH ways.  What evidence do you have for the "dangers" of receiving homeopathic treatment...and please do not give individual cases.  I do have access to numerous cost-effectiveness studies showing significant cost savings to people who utilize homeopathic medicines.  [[User:Dana Ullman|Dana Ullman]] 15:34, 14 September 2010 (UTC)


===Next deletion===
:Bluntly, it does not need to go both ways. Homeopathy is desperately trying to claim a place at the table in the face of enormous evidence that molecular medicine is effective. It seems your position is that homeopathy and medicine are of equal status and that every claim against homeopathy must be counterattacked by one about medicine.  If, indeed, homeopathy is so much an alternative to medicine, this is useless.
Dana now removed the words in italic, with the The premise of homeopathy is ''that the [[sign]]s and [[symptom]]s that accompany a particular set of symptoms, using a homeopathic definition of symptoms,'' with the edit explanation "Previous changes were wrong and confusing".  


This is a collaborative effort. Often, someone writing something that is wrong and confusing elicits a contribution that is correct and clear. I have been asking for some specifics other than structure of water for, I believe, several weeks. I have been chastised for challenging a homeopath who claimed to "use lab tests" to explain when and how they were used, and in what way they affected treatment decisions.  
:Incidentally, it would be wise for you to identify your financial interests in the promotion of homeopathy, such as (from http://www.homeopathic.com/main/bio_dana.jsp):
:*Dana Ullman, M.P.H. (Masters in Public Health, U.C. Berkeley) is "homeopathic.com" and is widely recognized as the foremost spokesperson for homeopathic medicine in the U.S.
:*Dana founded Homeopathic Educational Services, America's largest publisher and distributor of homeopathic books, tapes, software, and medicine kits. For 10 years he served as formulator and spokesperson for a line of homeopathic medicine manufactured by Nature's Way, one of America's leading natural products companies.


Please, Dana, write something that is correct, but that addresses the points that were raised, and perhaps incorrectly, by my summarization of what I have been hearing from homeopaths. The memory of water doesn't come into my skepticism; my skepticism is much more related to the apparent sole dependence on groups of symptoms and aiding the body's wisdom, rather than diagnosing an etiology and correcting the causative factors of that etiology.  
:See Bob Badgett's developing article on [[conflict of interest]]. It is one thing for a practitioner to charge for professional services, but it is generally considered unethical for physicians to refer patients to testing facilities, publications, etc., from which they derive income.  


We can do that with case studies if that would be helpful. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 10:58, 4 October 2008 (CDT)
:You are the one making the claims that medicine is so dangerous. I didn't make claims about ""dangers" of receiving homeopathic treatment", which is a change of subject. I will say, however, that it is dangerous to seek homeopathic treatment in lieu of medical treatments of established efficacy. Now, that seems a backing-off from the dangers of conventional medicine, but there seems a dearth of such studies from sources not vested in homeopathy. Again, these studies need to be overwhelming to dispute the CZ policy of providing the mainstream view.  


:To clarify, a homeopath may use lab tests to make an diagnosis. S/he usually draws from the patient's specific experienced symptoms (physical and psychological), in light of whatever diagnosis they may have, to determine which homeopathic medicine is indicated.  That said, some homeopaths are not licensed health care providers and cannot order lab tests.  These clinicians simply use the diagnosis given the patient by other clinicians, but then, the homeopath prescribes a medicine based on the overall syndrome of the patient. Please know that I am not pointing any finger at you (I have no idea who wrote something that I am editing).  I am just trying to be as accurate as possible.
:"NPOV", incidentally, is WP-speak and discouraged here.  


:I personally do not see much purpose in CZ for case studies. [[User:Dana Ullman|Dana Ullman]] 11:42, 4 October 2008 (CDT)
:Incidentally, apropos of being encyclopedic, how about contributions other than your single subject? Some of us are interested in building an encyclopedia, not fighting a never-ending battle with single-issue advocates or, as Sandy responded to Ramanand, social networking. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 16:48, 14 September 2010 (UTC)


====On harmony (I did not write about that) and miasms====
:: Wow, Howard, you're now getting disperate...and I'm sorry to see this. First, for your information, I was personally asked by Larry Sanger (the founder of Citizendium) to edit here, and he asked me to become a Healing Arts Editor. I have never hid any fact about my background.  In fact, most people appreciate my knowledge and expertise, except those few people who are threatened by facts, research, references to data, and the substantiation of information.
With the explanation "Totally changed. "Harmony" is not in homeopathic texts!", Dana added new and presumably corrected text. I would appreciate some citations here, but let me '''emphasize''' some things that seem quite new for the article. "Practitioners of classical homeopathy usually conduct a '''conventional medical diagnosis (or acknowledge the diagnosis previously determined by other medical workers)''' but ultimately seek to treat the overall syndrome of the person, not just a single diagnosis or any local condition. Homepaths inquire with the patient about his/her unique symptoms and place stronger emphasis on these unique symptoms, as well as a person's psychological state, to determine which homeopathic medicine may be indicated for the sick individual. Hahnemann, homeopathy's founder, was one of the earliest physicians to acknowledge genetic links to chronic illness, and he used the term '''"miasm"''' to refer to diseased states and syndromes that are passed on genetically. Homeopaths believe that people have different layers of illness, and once a homeopathic medicine effectively '''seemingly removes one layer of illness,''' a new different syndrome sometimes emerges and requires a new homeopathic medicine.


Please tell me if I am wrong, but the article, for some time, has disagreed with the idea of "conventional medical diagnosis".
:: You and Sandy were asking me for "evidence" that conventional medicine has certain risks.  While I could have laughed at this seemingly innocent (or naive) request, I simply responded by asking you to provide evidence that there was danger to homeopathic treatment.  Instead of providing this evidence, you have chosen a different strategy to get your bias into this article.  Let's avoid such tactics...and let's try to work together to write something fair, accurate, verifiable, and encyclopedic. [[User:Dana Ullman|Dana Ullman]] 22:26, 14 September 2010 (UTC)


I tried to find more information on precisely what a '''miasm''' may be, and, in [[History of homeopathy]], found some of Hahnemann's work from '''1816'''. Among other things, he wrote <blockquote>He introduced the theory that three fundamental 'miasms' underlie of all the chronic diseases of mankind: 'Syphilis', 'Sycosis' (suppressed gonorrhoea), and 'Psora'. Miasma, from the Greek for 'stain', was an old medical concept, used for "pestiferous exhalations". In Hahnemann's words: "...a child with small-pox or measles communicates to a near, untouched healthy child in an invisible manner (dynamically) the small-pox or measles, … in the same way as the magnet communicated to the near needle the magnetic property..."</blockquote>
:::No, I don't believe it is possible to collaborate with you to write something that is fair, accurate, and is not far more supportive of the benefits of homeopathy than is supportable by the views recognized by the bulk of medical opinion and data. I believe the best I can do is point out evasions, selective and often inaccurate statements about pharmacology, misquotations (e.g., saying Sandy or I asked for "evidence" medicine has risks), and what I believe to be a significant conflict of interest. I do so in discussion here, to be sure other members of the community see it, rather than jump into revert wars.


First, Dana, please indicate if I should assume conventional physicians also base their principles and practices from work in 1816.  Second, are the miasms described, in an article that does not seem to have undergone substantial changes since December 2006, accurate as to what Hahnemann wrote, and, if so, did homeopaths start believing that ''[[Treponema pallidum]]'', ''[[Neisseria gonorrheae]]'', and ''[[Variola major]]'' might have something to do with, respectively, [[syphilis]], [[gonorrhea]], and [[smallpox]]? Would a homeopath prescribe, respectively, benzathine [[penicillin]] G or [[ceftriaxone]] for the first two? Any therapy for smallpox, is, of course, experimental, but would a modern homeopath try smallpox vaccine, [[cidofovir]], and Vaccinia immune globulin (VIG)?
:::I have never suggested that medical treatment does not has risks; medical treatment ''always'' has risks. What I find to be hand-waving is the implication that homeopathy has no risks, including the delay of effective treatment.


I'm sorry, but Citizendium to take Hahnemann as an authoritative reference is about as authoritative as taking an 1816 allopathic physician as current best practice. I ask that there be some specificity and more recent references in the main article. If the [[history of homeopathy]] article incorrectly uses "miasm", by current homeopathic standards, since you just used it, I would appreciate an updated and specific definition and citation.
:::You will note that I have asked for an Editor ruling on what I consider continued misues of von Behring as an authority that homeopathy works. I find it sad that regardless of what was done to design a treatment, the data-free argument that similars ''might'' be an explanation continues to be brought up.  


Incidentally, no qualified physician would argue that treatments will reveal new problem. In the specific trauma case I described, the point of rapid sequence intubation was to keep the patient alive long enough to do the next level of diagnosis and treatment. Pneumothorax and hemothorax both might receive tube [[thoracotomy]] as an emergency intervention, but, while much of the presentation is similar, I need to know which it is before knowing if the tube, for example, should be inserted in the second/third versus fifth/sixth intercostal space.
:::Larry Sanger is not a health professional, and, I suspect, asked you to be a Healing Arts Editor because you are visible in that field. I would be much less antagonistic to your contributions were you to focus on what homeopaths believe and do, rather than the frequent -- and frequent inaccurate -- attacks on medicine, such as your condescending remark that there are no antifungal and antiviral agents of demonstrated efficacy, and, indeed, demonstrated risk. Indeed, the risk of unmodified amphotericin B has led to significant molecular work to reduce toxicity. You give the impression, however, that Hahnemann got it all right in the early 19th century, and medicine continues to get it wrong.  


Again, I am asking no more detail than I would expect in a CZ article on medicine. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 11:26, 4 October 2008 (CDT)
:::Professional collaboration does not require that participants like one another. It does not help when they are patronizing, and, if they can't take focused criticism without changing the subject, perhaps the kitchen of knowledge is a bit too hot. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 22:53, 14 September 2010 (UTC)


As I say, I don't know who wrote the deleted text, ''For homeopaths, health is best described as a state of "harmony" of the body; mentally, emotionally and physically. For them, disease then becomes a state of "disharmony". They are not as concerned with what they consider the material manifestations that develop with chronic disease such as hypertension, high cholesterol, smoking, diabetes, heredity, etc.. They concern themselves with what they consider the root cause of the "disharmony" that led to these same signs and symptoms - i.e. job dissatisfaction. They would then address all of these with their remedies. As such, contemporary medical diagnoses, while helpful in determining the end result of the "disharmony" that perhaps led to the heart attack, is only one factor that the homeopath uses to make a homeopathic diagnosis as to what they consider to be the root cause of the patient's symtpoms in the first place - the disharmony.  Once they feel they fully understand the cause of the patient's "dis-stress", they use the law of similars to look for the most likely cure. The law of similars is like using fat and oil to make soap that is then used to clean away fat and oil. They consider their most important function is to find something in nature that is the best match for the particular symptoms that are being displayed by the patient. They challenge themselves to find the right combination of things in nature that will cause the patient, both mentally and physically, to manifest those symptoms.''
Howard, my concern about your editing is that you are just fabricating fights. You wrote above that I said
"there are no antifungal and antiviral agents of demonstrated efficacy." Where (!) did I say OR simply imply that?  Nowhere!  I even repeated my point that we all have to be careful in making broad statement such as the "collective weight of evidence". THIS is what I mean by "straw men."  You create arguments with yourself by making up what I say.


I see a wholesale substitution, with no talk page explanation. No, I wouldn't have been comfortable with the earlier language as well. Until yesterday, however, I had confined myself to the talk page, hoping to suggest things to the experts, and only made editorial corrections to the article. At this point, however, I am simply trying to pin down things that seem to be what homeopathic contributors/citations said, although in a way that confused me. I would not dream of thinking I was authoritative on what homeopaths do, but I am quite prepared to do so in conventional medicine. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 11:26, 4 October 2008 (CDT)
:Where did you imply that? In an unsigned entry following mine of    Howard C. Berkowitz 04:25, 14 September 2010 (UTC)
:''I am surprised and even a bit shocked to hear your assertion that antibiotics are effective for viral and fungal infections,''
:Obviously, I disagree, because I then listed numerous examples of antimicrobials effective against such infections.
:If you want to accuse me of starting fights with myself, I'll simply conclude that one of me will always win. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:38, 15 September 2010 (UTC)


::Hey, I wrote that... thought is was pretty good, but it was mostly a summary from a homeopath's website that I looked at.  I am not attached to anything I write, as long as an improvement is made.  Keep swimming, just keep swimming... [[User:D. Matt Innis|D. Matt Innis]] 12:03, 4 October 2008 (CDT)


:Howard, You are obviously a smart smart guy, but I urge you to think more thoroughly before writing on this Talk pageYou assert above some surprise that homeopaths are relying upon information discovered by Hahnemann in 1816What makes you think that Hahnemann and homeopaths since him have not added to this initial discoveryYour statement is offensive, even though I know that this was not your intent.  I am, however, more concerned that you are wasting your and my time by your long posts that make unfounded assumptionsAnother concern that I have is your tendency to askDo homeopath prescribe this conventional drug or that conventional drug for a specific disease?  You're asking an overly simplistic question that can only have a complex answer. This article makes it clear that some homeopaths are MDs, some are DOs, some are RNs and PAs and DCs and NDs, and some have no licenseIn any case, homeopaths are a part of an overall health care team and can and do refer to other specialists, whether they prescribe or can prescribe a conventional drug or not. [[User:Dana Ullman|Dana Ullman]] 11:55, 4 October 2008 (CDT)
To clarify (again), my point is not that there are no risks to homeopathic treatment.  However, IF we wish to highlight that there are certain risks to homeopathic treatment, we also have to acknowledge that it is widely recognized that there are much greater risks from conventional medical treatment.  [[User:Dana Ullman|Dana Ullman]] 03:43, 15 September 2010 (UTC)
 
: Certainly we should say somewhere in the article that there are also risks with other treatments, and that one of the arguments for homeopathy is that many of its remedies are low-risk. However, "it is widely recognized that there are much greater risks from conventional medical treatment" strikes me as something an encyclopedia cannot subscribe to without a lot more evidence.
 
: In any case, I do not think a detailed discussion of risk issues belongs in the lede. I am inclined to thin the lede should raise the question, and in my opinion the current text does that adequately. [[User:Sandy Harris|Sandy Harris]] 04:12, 15 September 2010 (UTC)
 
::I agree that a detailed discussion is out of place in the lede. If I may, I'll offer a fairly well-established risk of using homeopathic therapy as a first resort: [[myocardial infarction]] (heart attack). Assuming there are no contraindications to thrombolytic therapy, the window for optimal benefit from thrombolysis is 3-6 hours after onset, with declining benefit out to 12 hours. Thrombolysis can reverse the damage to the heart muscle if done within the window. I can cite any number of conditions where death can occur in hours or days  without definitive therapy--tetanus is one. Of course, the best treatment for tetanus is prevention -- and TDAP and other immunizations are not designed by the principle of similars.
 
::It's one thing to say that homeopathic remedies might be lower-risk in non-emergent situations, but that isn't what is being said. Of course, one could also say "it is widely recognized that there are much greater benefits, in serious conditions, from appropriate conventional therapy."  No, appropriate conventional therapy does not, as been charged, extend to antibiotics for uncomplicated otitis media. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:38, 15 September 2010 (UTC)
 
:::In due respect, no one (!) has said or suggested that homeopathic medicines should be a treatment of first resort for heart attacks.  THIS is what I mean by my concern for your tendency to create fights/arguments.  Let's both avoid creating straw men.  That said, I agree with Sandy that the lede should not have a detailed discussion of risks issues, though I would think that we might all agree that it is widely recognized that homeopathic medicines themselves are "basically safe."  Also, can I ask us all to try to avoid inserting our own comments within the comments of other writers because it makes it challenging for people to determine who is saying what.  Thanx.  [[User:Dana Ullman|Dana Ullman]] 16:51, 19 September 2010 (UTC)
 
::::If it's alternative medicine, then it is the first resort. If it's complementary medicine, then there should be guidelines for the scope of practice of homeopathy. In the past, however, Ramanand has said homeopathy should be a first reatment for all manner of conditions.  There was an extensive argument about acute asthmatic attacks, which, as I remember,
 
::::I am not creating a straw man. Please document when homeopathy should not be the treatment of first resort. Otherwise, I'll assume alternative medicine with no limitations.
 
::::Let me clarify my position. I would tend to say that homeopathic medications, themselves, are basically safe. I am very concerned that homeopa<u>thy</u>, as a system of treatment, can be as deadly dangerous as a non-surgeon trying an advanced surgical procedure. You have yet to give information that documents what limitations homeopaths accept.
 
::::Please stop with the straw man accusations. I do not believe that any consensus is possible between alternative (i.e., not complementary) medicine and coventional medicine. Actually, I'd be far more likely to consult a shamanic healer than a homeopath, as there's a fair bit of documentation that shamans have a good understanding of psychosomatic medicine. I don't know what consensus could exist between someone that rejects the idea of treating the pathogens of infectious disease, and someone that has an understanding of modern microbiology. We, sir, are not on the same side and will not be. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:24, 19 September 2010 (UTC)
 
=== Rest of article ===
Further evidence of the strong POV and non-encyclopedic tone of this Draft is:
 
--under OVERVIEW:  The first two sentences are “attack sentence.”  It is clearly inappropriate to provide critique of a subject before adequately describing it FIRST.  Those sentences must be removed or placed elsewhere.
 
: I'd say at least the entire first paragraph and probably the whole "Overview" section should be deleted. None of it is real overview of the field. [[User:Sandy Harris|Sandy Harris]] 03:50, 14 September 2010 (UTC)
 
:: I agree with Sandy.  There is no need for this "Overview" section, though I do believe that we need to place some of this information about the status and popularity of homeopathy in a section "Homeopathy in Practice."  [[User:Dana Ullman|Dana Ullman]] 15:45, 14 September 2010 (UTC)
 
-- under OVERVIEW:  Some sentences here are just confusing, especially this one and especially its last phrase:  They are interested too in why some studies appear to have positive outcomes—do these reflect real efficacy, or can they be accounted for by flaws in study design or in statistical analysis, or "publication bias"—the tendency for small studies with chance positive outcomes to be published while studies with negative or inconclusive outcomes are not.
 
-- under HISTORICAL ORIGINS, it is confusing and surprising how or why Paracelsus was described as an “astrologer.”  This field was not a primary area of his contributions.  Just as the bio for Isaac Newton does not describe him as an astrologer, even though he actually wrote more on THIS subject than on mechanistic physics, we editors here know that Newton’s primary contributions to the modern-day have nothing to do with astrology.  Needless to say, people here who want homeopathy to sound “quackish” tend to provide this biased information.
 
-- under HISTORICAL ORIGINS:  Inaccurate information has been provided about the present status of the word “allopathy.”  There is a long AND significant modern-day usage of this term by conventional medical organizations, medical schools, and state and national governments.  Evidence for this is at:  http://en.wikipedia.org/wiki/Talk:Allopathic_medicine (see “Hopping's huge list of links).  Clearly, the term “allopathy” is still in extremely common usage, and it is simply inaccurate to say that it isn’t.  In this light, Osler’s quote has no meaning here, though it may have a place in the article on “allopathy.”
 
-- under THE LAW OF SIMILARS:  As much as I like the subject of “hormesis,” I do not associate its application with the law of similars nor do I know any reference to that.  As such, the word “hormesis” has no place in THIS section.  We could replace this word, hormesis, with the word “pheromones” because these substances are known to have a powerful effect in extremely small doses AND it is widely known that pheromones from one species are only sensed by those of a “similar” species.
 
-- under CLINICAL TRIALS TESTING THE EFFICACY…
There are many sentences and paragraphs here that I could recommend changes, but I will emphasize those that are most important or most incorrect:
 
I recommend removal of the following short paragraph & its accompanying quote.   
 
::While many of these have indicated positive effects, generally, trials that are larger high-quality trials have tended to show little or no statistically significant effects, as was concluded by the authors of the second Lancet study cited above when they re-analyzed these trials.
:: “There is increasing evidence that more rigorous trials tend to yield less optimistic results than trials with less precautions against bias.”[98]
 
My explanation:  First, the quote does not verify the sentence it is supposed to substantiate.  Second, the article it quotes also asserts that it is a general finding in ALL clinical research that the higher quality trials tend to show less positive results.  Third, the fact of the matter is that there are many high quality trials published in “high impact” journals that have shown statistically significant effects, including the four trials by Reilly, et al, the four trials on the treatment of influenza using Oscillococcinum, and the three trials on childhood diarrhea by Jacobs, et al.
 
We need to be careful in our review of research to avoid skewing the facts with “fudge” words.  For instance, one could say that the “collective evidence” of the thousands of studies conducted by Thomas Edison was that electricity was not possible (because only ONE experiment in 1,000+ worked). 
 
The challenge that we have in describing the efficacy (or lack of it) using homeopathic medicines is that we have to evaluate internal validity (how “high quality” were the trials?) AND external validity (is the specific medicine tested commonly used by homeopaths to treat people with that specific condition?).  Skeptics of homeopathy tend to evaluate the internal validity issues and totally ignore the external validity issues…and BOTH are essentialTo ignore external validity is akin to saying that antibiotics do not work for infections because the “collective weight” of studies on viral, fungal, and bacterial infection shows that these drugs do not work for this common group of diseases.  Get it?
 
:No. I don't get it, because I can demonstrate, ''in vivo'' and ''in vitro'', that antibiotics do work for viral, fungal and bacterial infections. This is hand-waving and hardly encyclopedic.
 
:I have repeatedly challenged you to respond to why homeopaths seem uninterested in the sort of trials used for customized pharmacogenomic medicine, which do have internal and external validity, and never have gotten an answer. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:25, 14 September 2010 (UTC)
 
:: I am surprised and even a bit shocked to hear your assertion that antibiotics are effective for viral and fungal infections, but I have no interest in arguing with you about these subjects here, though these strange assertions may influence your credibility with others.  I take much more seriously your unfounded assertion that homeopaths are not interested in research that has internal and external validity.  What is your evidence here? 
 
:::Shocked? Now, if you are holding to the generally obsolete assertion that antibiotics are purely natural products, that's one thing. Let's see...viral? Neuraminidase inhibitors for influenza (as well as the older amantadine and rimantidine), ribavirin for Lassa fever and possibly other hemorrhagic fevers, protease inhibitors (as part of HAART) in lowering HIV levels...well, interferons might or might not be considered antibiotics, but have distinct roles in treating viral diseases. Fungal? Amphotericin B (amphotericin B lipid complex, amphotericin B cholesteryl sulfate, and liposomal amphotericin B); the conazole series; griseofulvin; flucytosine -- and that's not considering topical-only agents. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:07, 14 September 2010 (UTC)
 
::::Howard, you're missing my point here. My point is that one must be careful using the term "weight of evidence" because such terms group together various disparate treatments for various disparate conditionsAlthough I used the term "antibiotics," perhaps I should have used a name of a specific antibiotic, thereby showing that it may be effective for one type of infection but not for "all types" of infection.  Likewise, testing homeopathic Arnica for one ailment may prove efficacious, but testing it for two other ailments might show that it is ineffective.  One should not say that the "weight of evidence" is that Arnica is not effective.  Instead, it is more accurate to say that Arnica is effective one condition but ineffective for two others.  Get it now?  I hope so...
 
::::My intention is not to "fight."  My intention is for us to work together to provide verifable accuracy.  [[User:Dana Ullman|Dana Ullman]] 22:37, 14 September 2010 (UTC)
 
:::::Now I am confused. When you challenged fungi and viruses, it seemed you were challenging the existence of antimicrobial agents (a better term than antibiotic) for those organisms. I gave counterexamples.
 
::::No person with reasonable competence in [[infectious disease]] suggests there exists Panaceamycin, good for everything, any more than, presumably, Arnica is good for everything. Antimicrobial agents have reasonably well defined spectra, but, since they are directed against mutable living organisms, any competent hospital has a table ("antibiotogram") of the preferred agents for community-acquired and hospital-acquired infections ''in that locality''.
 
::::Now, does the "weight of evidence" support appropriate antibiotic use? Yes! "Appropriate" does not include using antibiotics for self-limiting conditions unlikely to be affected by any antibiotic. Appropriate means considering the overall clinical picture -- sounds like the argument you make about syndromes -- such as not using penicillin G for exquisitely penicillin-sensitive streptococci, if the culture shows coinfection with [[Staphylococcus aureus]] or other penicillinase-secreting organism. One has to consider potential development of resistance, as well as the practical means of administration--if there is no one qualified to inject a parenteral antibiotic in home care, the antibiotic is irrelevant no matter how effective it may be against the organism. If there's a choice in a patient with a hearing loss, you avoid the especially ototoxic aminoglycosides.
 
::::Incidentally, I was just scratching the cognitive process in determining how to treat an infection. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 03:03, 15 September 2010 (UTC)
 
:: Just as doing double-blind and placebo controlled research testing surgical procedures have their methodological and ethical challenges, research on homeopathy has to be sensitive to the method itself.  You cannot just test a homeopathic medicine and its effects on a bacteria in a petrie dish, nor can I test acupuncture by putting a needle in a petric dish full of bacteria.  You've been told this many times in the past, and yet, you repeatedly feign ignorance about homeopathy and homeopathic research.  Please...you're a smart guy. Let's discuss research that does exist.  [[User:Dana Ullman|Dana Ullman]] 15:59, 14 September 2010 (UTC)
 
:::I repeat: there are usable methods that have been described for pharmacogenetic medicine. Let the clinician diagnose the individual treatment and send orders for it to the pharmacy. The pharmacy breaks the blinding code and dispenses either the ordered individual treatment or the control arm, the latter which may or may not be placebo. The safety committee monitors, and, assuming the study goes to completion, statistically evaluates the hypothesis that the experimental treatment arm is superior to control.
 
:::Incidentally, the piece of laboratory glassware is a Petri dish. If, however, you are referring to bacterial sensitivity testing, production tends to be done with radiochemistry, radioimmune reactions, or immunofluorescence. Consider me dumb since I don't know I'm feigning ignorance about homeopathy. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:07, 14 September 2010 (UTC)
 
:::"I've been told"...but by someone I find plausible? You have yet to answer my question about the cognitive process of a homeopathic session, claiming that only a homeopath can understand it, yet no medical discipline makes such a claim of inner mysteries. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:07, 14 September 2010 (UTC)
 
::::Howard, I am perfectly able to describe the cognitive process of a homeopath, but I don't think THAT has a place here.  I've told you this before (many times!), and yet, you repeated request it.  I'm writing this again because it seems that you don't want to remember.  Sadly, you consistently seem to want to pick a fight, and you make these strange claims about homeopathy and homeopaths without evidence.  To me, it just seems that you have a chip on the shoulder.  I have no problems with you making verifiable statements or asking questions, but I do have a problem with you creating boogey-men when none exist. 
 
:::: I will say this:  homeopaths usually prescribe their medicines for the overall "syndrome" of the patient, not just their "disease." [[User:Dana Ullman|Dana Ullman]] 22:46, 14 September 2010 (UTC)
 
:::::I keep repeating it because you keep refusing to answer it, which I remember very well. Apparently, homeopathy is unique among healing arts and health  sciences in not addressing cognition in practitioners.
 
:::::I suppose that if I can't do better than century-old immunology and pronouncements that regardless of the molecular pharmacology that went into developing a drug, our old buddy similars ''might'' be the real explanation.
 
:::::Sadly, you consistently want to pick a fight with anyone who doesn't regard homeopathy as the greatest thing for health. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:14, 14 September 2010 (UTC)
 
--Under GOVERNMENT AND INSTITUTIONAL…
-- If we choose to include reference to the Great Britain’s House of Commons’ Science and Technology’s report on homeopathy, we have to make it clear that this report was voted on by an extremely small minority of its members.  Of the 14 members, 10 did not consider this issue worthy of voting.  Ultimately, a “majority” of only THREE members voted for this anti-homeopathy report.  Of these 3 votes, two members were so new to the Committee that they did not attend a single hearing on the subject of homeopathy.  The third vote for the “report” came from Evan Harris, a vitriolic antagonist to homeopathy who was not re-elected this year, losing to a 20-something year old political neophyte.  Finally, because this report was “advisory” only in nature, the health minister overruled it and didn’t accept its conclusions.  If anyone wants to make reference to THIS report, we have to add these important facts.  I personally suggest that we do not cover this complicated and inconclusive decisions.
 
It should also be noted that whoever wrote the above was obviously also aware of these facts and choose not to present them.  This type of biased reporting should not have a voice here.  Let’s strive for more encyclopedic objectivity. 
[[User:Dana Ullman|Dana Ullman]] 01:21, 14 September 2010 (UTC)
 
:Repeated defenses of homeopathy, with nothing more than supposition and coincidences, don't belong here either. In my opinion, Mr. Ullman, you will not regard anything short of an article that gives homeopathy as much credibility as conventional medicine as acceptable -- and that, sir, is a promo. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:25, 14 September 2010 (UTC)
 
===Logical fallacies===
Take the proposed statement "Advocates assert that the homeopathic “principle of similars” is, in part, the basis for modern day immunizations, allergy treatments, and select other conventional treatments (ie, the use of Ritalin and other amphetamine-like drugs used to treat hyperactive children), while critics have compared it to
sympathetic magic. "
 
If anyone used the principle of similars to plan these treatments, there might be a case. I sincerely doubt, however, that this was ever done; the advocates making after-the-fact, observational rather than molecular, correlations that are extremely dubious.  Take a modern immunization, especially an acellular one -- it is designed on a molecular basis to produce desired immunoglobulins and other specific substances; similars were not involved in the designIt's rather hard to say that "similars" is a ''better'' explanation than what the molecular pharmacologists intended, and can demonstrate.
 
Are there homeopathic provings that demonstrate that large doses of cromolyns cause basophil and mast cell degranulation? If not, the molecular explanation that they desensitize the granules, and in turn block the release of histamine and other inflammatory messengers, is a much better shave with Occam's Razor.
 
I hope we do not have as lengthy a debate on the Tooth Fairy, especially from advocates that are America's leading spokesman for tooth fairies and thus have a financial conflict of interest. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 01:57, 14 September 2010 (UTC)
 
:Just to throw yet another bit of reality, the use of amphetamine-like drugs, as well as non-amphetamine drugs such as Strattera, for attention deficit disorder &mdash; not limited to children &mdash; and not discussing other psychotropic drugs is, to put it mildly, showing selection bias. There's as much evidence of neurotransmitter effects than of "similars". Further, if one were to generalize to other psychotropic drugs, one couldn't use the principles of similars to produce hypomania in a normal control.  It has repeatedly been demonstrated that lithium carbonate, for example, is not euphoriant. In high doses, it's a depressant -- remarkably so, since the subject will be dead. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:25, 14 September 2010 (UTC)
 
:: We cite in this article a quote from Emil Adolph von Behring (the "father of immunology") who asserts, "In spite of all scientific speculations and experiments regarding smallpox vaccination, Jenner’s discovery remained an erratic blocking medicine, till the biochemically thinking Pasteur, devoid of all medical classroom knowledge, traced the origin of this therapeutic block to a principle which cannot better be characterized than by Hahnemann’s word: homeopathic."  Whether physicians today (or yesterday) refuse to believe that the "principle of similars" is utilized in medicine, it still can be asserted that they are consciously or subconsciously utilizing it. This is NOT to say that ALL drugs are prescribed by this principle (Howard creates a straw man argument with his reference to lithium carbonate).  Further, just because there are other explanations for how or why Ritalin works does not take away the fact that the "similars" principle may also be at play.  [[User:Dana Ullman|Dana Ullman]] 16:14, 14 September 2010 (UTC)
 
:::Ah yes. von Behring. 1901 Nobel Prize for 19th century work. Got some authoritative immunology less than a century oldMaybe someone that knew about immunoglobulins?
 
:::"It can be asserted" and "just because there are other explanations" doesn't support similars, any more than the Illuminati ''might'' be responsible for all evil in international relations. "Might" isn't encyclopedic.
 
:::Actually, I prefer the wicker man to the straw man.
 
:::I'm disgusted, but I will not give up because the integrity of CZ means something to me. To stop responding to handwaving would be to give in to the stamina of homeopathic advocates.
 
:::You were the one that brought up various drugs. I added lithium carbonate as one example. How is it a straw man?  In therapeutic doses, it has no effect on non-hypomanic patients. Easy to call things straw men when you don't like them, and drop back to "it can be asserted." The capability of assertion does not make for encyclopedic quality. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:16, 14 September 2010 (UTC)
 
===Regarding 'point of view'===
 
No "point-of-view" disparagement required for conclusions/inferences drawn from science. Any such disparagement itself reflects "point-of-view". The lede as it reads now reflects medical science's judgment of homeopathy. Personally, as a scientist, I consider an open mind a virtue, but I try not to have it so open my skeptical inquirer falls out. [[User:Anthony.Sebastian|Anthony.Sebastian]] 03:16, 14 September 2010 (UTC)
 
:As I've suggested, we have to face the issue that the two advocates appear not to want the general judgment to appear, unless it is immediately accompanied by a Seinfeld-like "but that's OK, and homeopathy works." [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:25, 14 September 2010 (UTC)
 
== Biology-Health Sciences Editor ruling needed ==
 
Immunology clearly falls into these fields, ''not'' Healing Arts. I contend that it is ludicrous for this article to be using von Behring as a source of authority. It's fair enough to mention a 1901 Nobel Prize winner in a historic context, but a ruling is needed if his statements on homeopathy and immunotherapy can be used as substantiation for plausible modes of immune response.  Immunology has progressed a bit in over a century.
 
It's futile to argue this with Mr. Ullman, and I believe we have enough relevant Editors to settle this point. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 18:35, 14 September 2010 (UTC)
:Agreed (sorry for butting in). ([[User:Chunbum Park|Chunbum Park]] 09:56, 15 September 2010 (UTC))
::Don't feel sorry, Chunbum, your particpation and opinion is a valued part of the decision process.
::This appears to be a bigger issue than homeopathy.  It appears that you are asking to limit an editor on an article.  We don't have a mechanism for that.  We've really left that to the devices of other editors to challenge unusual statements by other editors.  I would expect that even Dana would appreciate a immunologist's input, but regardless, they'd both still need resources to cite. I'm not sure that a Health Sciences Editor can overrule a Healing Arts editor on an article, but he can certainly challenge anything that counters his beliefs. I would think the EC or EiC would have to rule on something like that.  Of course, that would be the Managing Editor should the new charter take effect. [[User:D. Matt Innis|D. Matt Innis]] 12:59, 15 September 2010 (UTC)
:::That's much what I was thinking. To take a parallel example relevant to Howard, the article on the [[Iraq War]] might, and in my view should, discuss the question of its legality. But I don't suppose the article is affiliated to the Law Workgroup. So what happens with a hypothetical conflict between, say, Howard and a law editor on that question? I think the new EC has to think about the whole system here, not just leave it to the ME to invent precedents. [[User:Peter Jackson|Peter Jackson]] 15:03, 15 September 2010 (UTC)
::::Perfect example, Peter.  The new charter should allow the new ME to make a decision on the fly based on ample input from everyone (especially editors) and then the EC can take its time to review the ME decision and either overrule it or support it.  Hopefully, that will develop a sort of "case law" that eventually develop into policy based on a democratically expert debated concepts rather than customary consensus. Meanwhile, authors will be able to move on to different content while the decision is reached elsewhere.  [[User:D. Matt Innis|D. Matt Innis]]
 
(undent) All of you make good points, but the specific may be a little easier. If I were to state the problem in EC terms, it is that different disciplines acquire knowledge at different rates. Were this, for example, a Literature article, Oscar Wilde or G. B. Shaw's comments would be relevant. If this were aviation engineering, however, I think it is relatively obvious that Orville and Wilbur Wright's commentary would not be very relevant to an Airbus (most recent model) or Boeing 787 Dreamliner. While I've often wondered how a classic military genius such as Belisarius would do with airmobile forces, he'd have a bit of catching up.
 
Von Behring, and indeed Hahnemann, were giants in their time. Today, however, von Behring wouldn't know how to find  his way to the protein sequencer or the molecular visualization workstation.
 
The policy, therefore, might say that to cite an authority as more than a historic point, that authority has to be reasonably familiar with current concepts. It may be even faster now, but, a few years ago, based on MEDLINE growth, the amount of information in health sciences doubled every seven years. Some fields, such as molecular pharmacology, went from nonexistent to major disciplines.  There's not going to be a citation that "Von Behring is obsolete", but that's a reasonable inference.
 
Peter, I would be absolutely delighted to have an article on the legality of the Iraq War. The article is not now affiliated with law, or several other relevant workgroups, due to the three workgroup limit. In doing the main draft of these articles, I had quite enough to do with the "what" and "how" without getting into the just war theory or international law. I would be happy, over an appropriate beverage, to discuss what I personally consider to be vague language in the UN Charter. 
 
Unquestionably, Matt, workgroups need to be revised. I have been doing some experimentation with subgroups, but they are not a sole answer. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 17:19, 15 September 2010 (UTC)
 
: I think the word "ruling" in the section title is an error. Certainly ''comment'', or even ''contributions'', from those editors would be useful and (I assume) welcomed by all concerned, but I do not think they have the authority to ''rule'' here.
 
: The paragraph quoting von Behrig starts "Scientists and medical doctors today do not think that the principle of similars is generally true or useful, and they explain the efficacy of vaccination without referring to it. Physicians of the 19th century however did consider that the principle could be valuable." That strikes me as fair. Given that context-creating text, I see no objection to the von B quote.
 
: As I see it, there are serious issues with this article, and Howard is right about most of them. However, on this particular point, I see him as tilting at a windmill. [[User:Sandy Harris|Sandy Harris]] 02:52, 16 September 2010 (UTC)
 
:::One never knows...the windmills ''might'' be giants. Seriously, I really don't have a problem with historical quotes in historical contexts. Such contexts, though, would include both Osler's preference for 19th century homeopathy over 19th century allopathy, and his later statement that both allopathy (as used at the time) and homeopathy were both "cults" that needed to be replaced by scientific medicine.
 
:::Recent comments on this talk page, however:
:::<blockquote>Whether physicians today (or yesterday) refuse to believe that the "principle of similars" is utilized in medicine, it still can be asserted that they are consciously or subconsciously utilizing it. This is NOT to say that ALL drugs are prescribed by this principle (Howard creates a straw man argument with his reference to lithium carbonate). Further, just because there are other explanations for how or why Ritalin works does not take away the fact that the "similars" principle may also be at play. Dana Ullman 16:14, 14 September 2010 (UTC) </blockquote>
::: made me concerned that advocate(s) wanted to reintroduce the von B quote ''without'' the qualifiers, and suggesting that similars ''are'' the mechanism of medical immunization. That is not acceptable and is flatly wrong. I suspect that some of the molecular immunologists building acellular vaccines may never have heard of similars and certainly aren't designing with that principle, rather than protein structure-activity.
:::Lithium carbonate is hardly a straw man, as its activity would not be demonstrated in a proving on a non-hypomanic individual, only toxic effects in high doses.  When things demonstate exceptions to basic concepts such as similars and proving, they become significant negative data. "It can be asserted" is hardly encyclopedic, thinking of the classic assertion that if my aunt had testicles, she'd be my uncle.--[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:33, 17 September 2010 (UTC)
[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:26, 17 September 2010 (UTC)
 
== Followup on Anthony's comment about alternative medicine ==
 
While I agree with your addition, I wonder if it goes far enough. Complementary and alternative medicine, while often grouped together, are not the same. Alternative medicine, to use NCCAM's definition, is a ''substitute'' for conventional medicine, while complementary medicine can be [[integrative medicine|integrated]] with conventional medicine. Rather by definition, alternative medicine will not agree with conventional medicine, and never the twain shall meet.
 
It's not implausible that there ''could'' be complementary homeopathy, but I find it interesting that the article really doesn't address it. At best, there are arguments that homeopathy is superior to conventional methods for specific disorders. There's some hand-waving that conventional physicians use homeopathic remedies in their practice, but no discussion of the indications and rationale for doing so.  In other articles, there is discussion of the complemntary use of acupuncture, chiropractic, etc.
 
Whether or not homeopathy is CAM rather than AM, this article overwhelmingly treats it as AM. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 21:50, 14 September 2010 (UTC)
 
:Howard, I took a long rest from this article, and it seems that you would really benefit from doing so too.  I realize that by saying this you may now want to edit more often than ever.  My concern is that you are beginning to lash out at me and at this subject in an extremely emotional way. It seems that you are no longer trying to create an encyclopedic article but one that pushes your POV which remain inadequately informed about this subject of homeopathy.  Heck, even when Dr. J sought to reach out to Sandy and be friendly, rather than adverserial, Sandy told him that he wasn't interested.  That's OK too...and Dr. J didn't seek to connect personally.  Let's not make this effort by Dr. J to be as "bad" as you've tried to make it.  [[User:Dana Ullman|Dana Ullman]] 22:54, 14 September 2010 (UTC)
 
::Well, gee. I've been discovered: my whole motivation is attacking homeopathy, and I '''never, ever''' contribute to anything else at Citizendium.  Obviously, [[New Delhi metallo-beta-lactamase-1 enzyme]] is just an attack on homeopathy, as is [[CZ: Pacific War Subgroup]], as is (quite friendly) collaboration on [[opportunistic encryption]].
 
::Why is this in a subsection where I was addressing the complementary and alternative aspects of homeopathy? That was hardly emotional. I neither need nor want your advice or concern on what I should do.
 
::It ''is'' adversarial. Deal with it. Mortality & Morbidity conferences, military After-Action Reviews, engineering design reviews, etc., benefit from an adversarial approach.
 
::As far as I can tell, your definition of "adequately informed" is to accept homeopathy. The Ormus article hurt Citizendium, and I am convinced that homeopathy does as well.  I do know that I have had people refuse to join CZ specifically due to the homeopathy article. I'll believe you want to be encyclopedic when I see you contribute to things other than a single issue.
 
::If I get extremely emotional about something, I tend to be more quiet, and perhaps smile a lot. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:07, 14 September 2010 (UTC)
 
== Encyclopedia Britannica Online: Homeopathy lede ==
 
Possibly of interest:
 
"Homeopathy"
 
"a system of therapeutics, notably popular in the 19th century, which was founded on the stated principle that “like cures like,” similia similibus curantur, and which prescribed for patients drugs or other treatments that would produce in healthy persons symptoms of the diseases being treated."
 
"This system of therapeutics based upon the “law of similars” was introduced in 1796 by the German physician Samuel Hahnemann. He claimed that a large dose of quinine, which had been widely used for the successful treatment of malaria, produced in him effects similar to the symptoms of malaria patients. He thus concluded that all diseases were best treated by drugs that produced in healthy persons effects similar to the symptoms of those diseases. He also undertook experiments with a variety of drugs in an effort to prove this. Hahnemann believed that large doses of drugs aggravate illness and that the efficacy of medicines thus increases with dilution. Accordingly, most homeopathists believed in the action of minute doses of medicine."
 
"To many patients and some physicians, homeopathy was a mild, welcome alternative to bleeding, purging, polypharmacy, and other heavy-handed therapies of the day. In the 20th century, however, homeopathy has been viewed with little favour and has been criticized for focusing on the symptoms rather than on the underlying causes of disease. Homeopathy still has some adherents, and there are a number of national and international societies, including the International Homoeopathic Medical League, headquartered in Bloemendaal, Neth."
 
http://www.britannica.com/EBchecked/topic/270182/homeopathy
 
[[User:Anthony.Sebastian|Anthony.Sebastian]] 03:27, 16 September 2010 (UTC)
 
:The first two paragraphs, I hope, are not controversial. The talk page controversy, however, has significantly involved both homeopathic attempts to claim medical logic, as well as a broader assumption, by the homeopathy advocates, that homeopathy needs to be regarded as having equal credibility to conventional medicine.  Attempts to claim that the principle of similars is the underlying mechanism for medical treatments developed, or validated, using methods of molecular pharmacology fall under my first point. Closely coupled is the homeopathic argument that homeopathy mimics body defenses manifested as symptoms, when the actual defense is quite different than the symptom producing factor -- tetanus is a good example, where the defenses are immunoglobins that have no particular symptom-producing quality, but the symptoms of  spasticity and convulsions are caused ("indirectly") by the exotoxin of ''[[Clostridium tetani]]'' and can be lethal. The defenses neutralize the toxin, and, coupled with antibiotics and surgery, eradicate the source of the toxin.
 
:In other words, there's a refutation of molecular medical arguments, but no molecular explanation of how similars affect the body. Hand-waving about memory of water isn't on the same level as immune reactions that can be demonstrated ''in vitro'' and ''in vivo'', or structure-activity interactions with cellular receptors. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:12, 16 September 2010 (UTC)
 
== "Alternative Medicine and the Laws of Physics" ==
 
Of possible interest:
 
Alternative Medicine and the Laws of Physics
 
Robert L. Park
 
''Skeptical Inquirer'', Volume 21.5, September / October 1997
 
http://www.csicop.org/si/show/alternative_medicine_and_the_laws_of_physics/
 
[[User:Anthony.Sebastian|Anthony.Sebastian]] 03:59, 16 September 2010 (UTC)
:Having read the article I feel a neutral way of presenting homeopathy would be something like "it is a type of medicine supported by neither scientific reasoning nor data. that being said this is what homeopaths think: 1, 2, 3." ([[User:Chunbum Park|Chunbum Park]] 05:40, 16 September 2010 (UTC))
 
:: I think that overstates the case. Homeopathy is based on a system that includes reasoning which is at least pseudo-scientific. There is data, though much of it is of dubious quality; in particular, "data" is not the plural of "anecdote". I don't think your text above is neutral in any sense I'd recognise.
 
:: The current draft includes "the consensus of medical and scientific opinion is that homeopathy is unfounded." I think that is accurate, neutrally stated, and sufficiently direct.
 
:: That said, I do think we should link to highly critical articles such as that one, possibly the [http://rationalwiki.org/wiki/Homeopathy rational wiki] page, and certainly the [http://xkcd.com/765/ lovely cartoon] they use. [[User:Sandy Harris|Sandy Harris]] 07:40, 16 September 2010 (UTC)
 
::: See rational wiki's article "Citizendium" first. [[User:Anthony.Sebastian|Anthony.Sebastian]] 03:57, 17 September 2010 (UTC)
 
== Suggest ending Main Article draft at end of lede ==
 
Let reader use Biblio to get further information. Concentrate on thorough Biblio subpage. 06:39, 17 September 2010 (UTC)
 
: I don't think that is an adequate approach for an encyclopedia. We want a reasonably detailed explanation here. That said, the article could likely be shortened significantly without losing anything valuable. [[User:Sandy Harris|Sandy Harris]] 12:14, 17 September 2010 (UTC)
 
::At home much resource cost that could be going into even copy edit of other articles, articles that deal with topics that are likely to have more serious users? I'd wager that a good part of the hit count on this article is due to people at other wikis looking for controversy.
 
::That being said, I'm not sure how feasible it is under present policy. Assume three Health Sciences and Biology Editors are willing to nominate the truncated approach for Approval. Healing Arts Editors say it is not Approvable.  It would be one thing for a Mathematics Editor to question approval for a cryptographic topic written by a computers person, but we've gotten through effective collaboration among, say, Computers, Mathematics, and Military. Health Sciences and Healing Arts, among the workgroups, are the only case where we have different workgroups for fundamentally different views on the same subject area. It's a bug, not a feature; we don't have separate-but-equal Religion and Atheism workgroups. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:53, 17 September 2010 (UTC)
 
== Definition ==
 
The current definition reads "System of alternative medicine that asserts — contrary to scientific evidence — that substances known to cause specific syndromes of symptoms can also, in very low and specially prepared doses, help to cure people who are ill with a similar syndrome of symptoms." I think that is a moderately awful definition. The problems I see are:
: The "contrary to scientific evidence" bit, or similar text, has been added at least twice and reverted at least once. I don't think it belongs in the definition.
: "syndrome of symptoms" is used twice. That's ghastly stylistically, "syndrome" is a technical medical term that may not belong here, and in any case, I suspect "syndrome of symptoms" is redundant. What else could you have a syndrome of? Or does a syndrome include more than just symptoms?
My version would be: A system of alternate medicine based on the idea that substances known to cause particular combinations of symptoms can, in very low and specially prepared doses, help to cure people who are ill with similar symptoms.
(sig added later [[User:Sandy Harris|Sandy Harris]] 23:14, 17 September 2010 (UTC))
 
""Syndrome of sympoms", indeed, is ghastly. Unfortunately, it touches on a difference between homeopathic and current medical thinking that is as important as similars. Modern physicians look first for an etiological diagnosis: what is the cause of the patient's distress? (Note here that "symptom" is being used in a lay sense here -- there are differences of theory as well).  Homeopaths consider that the "disease model", not patient-centric, and often reject a causality-based approach. Their focus is on the products of the cause (in medical thinking) or the body wisdom expressing its defenses.
 
:A better wording would be welcome, but the rejection of etiologic thinking, and the focus on similars as a means of reducing symptoms, is fundamental. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 15:53, 17 September 2010 (UTC)
 
Sandy's version:
*A system of alternate medicine based on the idea that substances known to cause particular combinations of symptoms can, in very low and specially prepared doses, help to cure people who are ill with similar symptoms.
 
 
My understanding:
*A system of alternate medicine based on the idea that large dosages of substances known to cause particular combinations of symptoms in healthy individuals can, in very low and specially prepared doses, help to cure a person whose illness causes similar symptoms.
[[User:D. Matt Innis|D. Matt Innis]] 21:49, 17 September 2010 (UTC)
 
::I  am quite willing to be corrected here, but I think the idea of an illness that creates similar symptoms is still too close to an etiologic model of disease to be accepted by homeopaths. While I don't have better words, my sense is they would say the symptoms are produced by the "wisdom of the body" as "defenses" and the remedies strengthen the defenses. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 23:59, 17 September 2010 (UTC)
 
 
::: That could be the next sentence.
 
 
:::*A system of alternate medicine based on the idea that large dosages of substances known to cause particular combinations of symptoms in healthy individuals can, in very low and specially prepared doses, help to cure a person whose illness causes similar symptoms.  In essence, they believe that symptoms are produced by the "wisdom of the body" as "defenses" and homeopathic remedies are designed to strengthen those defenses.
 
:::[[User:D. Matt Innis|D. Matt Innis]] 03:22, 18 September 2010 (UTC)
 
::::Add: They do not use the disease model of conventional medicine, in which there is a disease rather than an individual set of symptoms, and treatment directed at a cause of that disease as it presents in multiple patients. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 03:29, 18 September 2010 (UTC)
:::::More work:
:::::*This contrasts with conventional medicine's "disease model" of treatment that looks to treat the disease process and therefore relieve the symptoms.
:::::I'm not sure that's totally true, though.  Many conventional treatments are directed at relieving symptoms, too.
:::::[[User:D. Matt Innis|D. Matt Innis]] 03:54, 18 September 2010 (UTC)
 
(edit conflict) (undent)
There's a different philosophy in symptomatic treatment. If I sprained my ankle badly enough to need surgical repair, the cause would be relevant to a conventional orthopedist who needs to work on the damaged structures. Otherwise, the exact ligament stretch might be known, but it's not of therapeutic benefit. Symptomatic pain relief is the first consideration -- yes, rehabilitation may focus on exact etiology, but, for the sake of argument, assume it's self-limiting.
 
Sometimes, as with uncomplicated childhood otitis media, even if it is bacterial, antibiotic therapy may not be justified. Presumably, though, the child can still get acetaminophen.
 
In both of the cases above, there was awareness of an etiology, but a choice to treat only symptoms. Palliative care is often largely but not exclusively symptomatic -- still, an etiology would be necessary for chemotherapy or radiotherapy to slow the growth of an incurable tumor.  Pain management, though, is symptomatic and even more important. Where does nursing care fit?
 
The homeopaths, however, appear to exclude the idea of treatment based on etiology, as opposed to symptom relief when the cause is either self-limiting or not treatable. I spend hours daily giving comfort care to my cat buddy, relatively little of which is directed at the cancer itself, but much more in nutrition, emotional support and wound care. Indeed, I am using some complementary medicine along with a lot more conventional things.  Homeopathic ideas of symptom-oriented remedies don't enter into it. --[[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:28, 18 September 2010 (UTC)
 
: I don't think either that long definitions are a good idea in general, or that the proposed "next sentences" are needed in this definition. In the article, certainly; in the lede, probably. However, the definition needs to be short and direct. In particular, it needs to be short enough to look reasonable when cited on a related articles page. [[User:Sandy Harris|Sandy Harris]] 04:46, 18 September 2010 (UTC)
 
::If the definition is to be short, then, I believe the rejection of etiology is far, far more significant to homeopathy than the better-known issues of small doses. It appears to me that Hahnemann's insight dealt with symptoms being the essential manifestation of health or not-health, and only ''then'' did he go to the idea of provings and similars. My understanding is that his using provings for malaria had to do with the symptom production of quinine.
 
:::Absolutely, I forgot that we were working on the definition!  You're right, Sandy. [[User:D. Matt Innis|D. Matt Innis]] 21:27, 18 September 2010 (UTC)
 
::I believe there's a comment on this page, from a homeopath, that homeopathic remedies are not always administered in homeopathic femtodoses.
 
::The rejection of etiology  is also key to much of the dispute with medicine, as I mentioned in terms of clinical trials. It is also, however, central to the medical rejection of some homeopathic approaches, such as the principal treatment for malaria being based on reducing ''Plasmodium'' parasites in the blood. Quinine remains a third-line drug for malaria, but its action in reducing fever and chills is due to its ability to suppress the parasites, not (in a medical view) what effects are caused by high doses of quinine. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:56, 18 September 2010 (UTC)
:::Quinine remains a third-line drug for malaria, but its action in reducing fever and chills is due to its ability to suppress the parasites, not (in a medical view) what effects are caused by high doses of quinine.
 
::::I think that's the point; it's not that homeopath's don't care about etiology, they just don't concern themselves with it.  If it causes the same symptoms in a normal person, then it's used to treat the person that has those same symptoms, regardless of the cause. As you say, they might contend that the plasmodium is not what causes the symptoms, rather the symptoms are the body's response to plasmodium. To them it doesn't matter. [[User:D. Matt Innis|D. Matt Innis]] 21:28, 18 September 2010 (UTC)
 
:::::As my grandmother might have said, ah-HAH! Admittedly, I'm taking the example of the worst form of malaria, but a patient presenting with the cerebral form of ''[[Plasmodium falciparum]]'' malaria may well die in 18 hours. In general, the standard of medical care would be [[artemisinin|artemisinin-based combination therapy]], with [[critical care]] support for effects such as  [[acute respiratory distress syndrome]] or [[disseminated intravascular coagulation]].
 
:::::Quinine, in substantial doses and '''in combination with''' doxycycline, tetracycline, or clindamycin, be lifesaving. If I were the patient, however, and someone offered me homeopathic oral doses of oral quinine, I'd prefer a lethal dose of barbiturates, or a large-caliber bullet to the back of the neck (messy but fast).
 
:::::Now, I'd have every respect for a ''complementary'' homeopath that suspected severe falciparum malaria, and immediately transferred the patient to medical care. Assuming such care were available, I'd regard an ''alternative'' practitioner as having, as the lawyers put it, ''depraved indifference for human life.''.  [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 22:02, 18 September 2010 (UTC)
:::::: I suspect the cerebral form would have different symptoms, therefore different remedies as well. A bullet is probably not one of them. ;-) [[User:D. Matt Innis|D. Matt Innis]] 23:40, 19 September 2010 (UTC)
 
:::::::Are you doubting the efficacy of a .45 caliber ACP 254-grain round, which is lead in a hardly homeopathic dose?  Nevertheless, if I had cerebral P. falciparum malaria, I know that active medical treatment is still very iffy. Seriously, we have the problem of any validation here; I cannot imagine an ethics review board that would approve any treatment for such a life-threatening disease without overwhelming laboratory evidence for the control arm. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 22:21, 20 September 2010 (UTC)
 
===Sandy's edit to the definition===
...specifically "help to cure or prevent  illnesses involving similar symptoms."  While a homeopath will have to review this, I don't think "illnesses involving similar symptoms" is really a homeopathic concept. They certainly object to "diseases with similar symptoms", and tend to reject "disease" as a medical conceit. The symptoms are signals of the body's defenses to be strengthened, not the effects of a causative factor. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 04:59, 18 September 2010 (UTC)
 
:I think you're splitting hairs, but, yes, let's hear from a homeopath on this. [[User:D. Matt Innis|D. Matt Innis]] 21:27, 18 September 2010 (UTC)
 
:Sandy's new definition is definitely an improvement. [[User:D. Matt Innis|D. Matt Innis]] 21:32, 18 September 2010 (UTC)
 
::Li'l hard pressed for time. I'm happy with Alexander's definition, but if you guys feel it needs to be simpler, I have a 'simpler definition', which would read:-<blockquote>(Homeopathy is) an alternative system of medicine, which stimulates the natural healing processes of the body (with the help of sub-physiological doses of a remedy, by using its rebound effect), to restore health (homeostasis) in a sick person.</blockquote>
:::The matter in brackets is optional.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 07:36, 19 September 2010 (UTC)
:::Note that it is '''alternative medicine''' and not '''alternate medicine'''.&mdash;[[User:Ramanand Jhingade|Ramanand Jhingade]] 07:44, 19 September 2010 (UTC)
 
::::Unfortunately, "rebound effect" is not a well-defined term, certainly in medicine, so should not be used in a definition unless it is well defined in an article of its own.  The alternate definition depends heavily on homeopathic terminology, such as "natural healing processes", as well as using homeostasis is far broader a context than is used in the biological sciences -- to say nothing amout emerging concepts such as [[allostasis]].
 
::::The proposed new definition also overemphasizes the aspect of small doses and does not address the apparent rejection, by homeopathy, of the idea of "disease". Instead, it speaks of "restoring health", without addressing the  meaning of the state of non-health.
 
:::Please confirm or correct the statement that homeopaths do not believe in the concept of disease, in the sense that disease has an etiologic cause and the cause needs to be corrected. [[User:Howard C. Berkowitz|Howard C. Berkowitz]] 08:30, 19 September 2010 (UTC)
 
::::I agree with Howard here, Ramanand, that your version introduces too many vague terms to be considered for use as a one sentence definition. [[User:D. Matt Innis|D. Matt Innis]] 23:44, 19 September 2010 (UTC)
 
What about <blockquote>A system of alternative medicine based on the idea of stimulating the body's natural healing processes by administering tiny doses of substances which, when given in large doses to healthy individuals, cause similar combinations of symptoms.</blockquote> I agree that Ramanand's definition has some problems, and I think the full version is too long, but it seems to me the point about stimulating natural defenses is central. [[User:Sandy Harris|Sandy Harris]] 03:07, 20 September 2010 (UTC)

Latest revision as of 16:21, 20 September 2010

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APPROVED Version 1.1

The Approval includes two copyedits [1] Hayford Peirce 19:13, 11 October 2009 (UTC)

I'm not sure how to add yet another archive and get things to show up properly in the header here. Could someone do so? Howard C. Berkowitz 19:22, 11 October 2009 (UTC)

Beginning with semi-lower-case editorial...

As a first step, I'm going to all footnotes that contain other than bibliographic material or definitions, and either moving the substantive text into the main article, or, in some cases, linking to a subarticle.

While it may be reasonable, in a printed book or journal, to have bottom-of-the-page notes, in this format, the content of the notes will not be seen unless the reader clicks on them. How many readers do that? In effect, the text is being hidden. Howard C. Berkowitz 19:37, 11 October 2009 (UTC)

A balanced blog post on the subject

can be found here. --Daniel Mietchen 09:21, 16 December 2009 (UTC)

I added a comment, as did Paul. Truly delightful, however, is

Personally, I would really like to see a homeopathic treatment for dehydration. You'd have to have a compound that causes dehydration, but what would you dilute it in? you can't dilute it in water or saline, because those will rehydrate, and in homeopathy, you have to CAUSE dehydration to cure it...but you can't having anything that CAUSES dehydration because it would have to be diluted to the point where none of the dehydrating agent remains...

It should be noted that some camping supply stores, in the same aisle as freeze-dried foods, offer cans of "dehydrated water". Ethical staff makes sure that new users understand the purpose of same. Howard C. Berkowitz 15:06, 16 December 2009 (UTC)


Howard, you gave the wrong link for Sympathetic magic. It's http://en.citizendium.org/wiki/Sympathetic_magic And make sure the period at the end does not get connected to the link. Chris Day 15:26, 16 December 2009 (UTC)

That's a reasonable way to look at it, which is unusual for a blog. D. Matt Innis 18:43, 16 December 2009 (UTC)

Put it into the External Links. --Daniel Mietchen 19:27, 16 December 2009 (UTC)

Ramanand's changes

First, the word " most biased medical " is argumentative, does not fit the language of the lede, and is clearly advocacy.

The statement supporting homeopathy in the lede, even if the references were solid, belongs, stylistically, in a later section on the mechanisms of homeopathy. One reference is, as far as I can tell, from a Brazilian university with a site in, presumably, Portuguese, which I do not read. We generally don't use non-English references, especially when they are not clearly from peer-reviewed journals or otherwise reviewed sources.

The other reference is from Khuda-Bukhsh, whom, I believe, has been in the memory of water controversy, is a review of possible molecular mechanisms of action. On first glance, it's an interesting paper, but does not talk at all about efficacy — just how homeopathic remedies may work, if they work. It doesn't belong in the lede, although it's not unreasonable to use it as a reference in a later section.

Neither addition works where it is. The first is advocacy and non-neutral. --Howard C. Berkowitz 17:45, 7 January 2010 (UTC)

The use of "biased" is definitely adversarial. Chris Day 21:12, 7 January 2010 (UTC)
With regard to the rebuttal (it works, and we know how), I am loath to see this article head down the direction of he says, she says tit for tat. Chris Day 21:21, 7 January 2010 (UTC)
The whole article is full of oxymorons, containng both viewpoints, so I don't see anything wrong with what I've inserted, unless the critics' statement is also removed (about what scientists feel). I'm fine if the word biased is removed, if it seems adversarial. The Portuguese and French is only in the references section and shouldn't be a problem.—Ramanand Jhingade 10:28, 8 January 2010 (UTC)
Well, Ramanand, the general CZ, policy, especially in the Charter, is that articles don't equally present all views. They present the preponderance of the expert views, and, in this case, the experts are in health sciences; there isn't a unifying discipline among healing arts. Not all healing arts support homeopathy.
Everyone needs to Neutrally present all views. D. Matt Innis 02:31, 9 January 2010 (UTC)
The foreign language citations have been a problem in many other articles, not just here.
I think you mean contradictions or rather or challenges, not oxymorons. An oxymoron would be a "heroically large dose of a homeopathic simillum." An oxymoron is a contradiction in terms.
Sorry, I'm in favor of removing both additions. You will need to face the reality that the article will not be as pro-homeopathy as you want, just as others wish it weren't here at all. It's a compromise. --Howard C. Berkowitz 15:48, 8 January 2010 (UTC)
I applaud, encourage and appreciate collaborative efforts to work toward improvements, but I think this lead still needs significant work to add any substantial improvement to the approved version's lead. D. Matt Innis 02:28, 9 January 2010 (UTC)
I forgot to wish all of you a Happy (belated) New Year. The presently approved article's Lead isn't 'neutal' at the moment. It should either explain homeopathy plainly or if y'all want criticism in the Lead, it should contain both viewpoints. Where's Dana, by the way, in Germany again?—Ramanand Jhingade 09:14, 9 January 2010 (UTC)
Happy New Year to you, too! Please let me know where you think the present Approved version lead (as opposed to the draft lead) is lacking and I'll be glad to take a look. Dana approved the current lead, too, but I'm sure he'd take a look if we asked him. D. Matt Innis 15:00, 9 January 2010 (UTC)
I'd posted a whole lot of links to homeopathic articles, late last year, but did not have the time to add it in the article. I was expecting someone here to do it, but no one did (not even Dana)! I already wrote what I wanted above, "It should either explain homeopathy plainly (without criticism in the very 1st sentence) or if y'all want criticism in the Lead, it should contain both viewpoints."—Ramanand Jhingade 08:34, 12 January 2010 (UTC)
We certainly can't add every link ever written to this article. This is the overview article in an encyclopedia type format and summarizes homeopathy pretty well, I think. Again, don't confuse the lead in the Draft with the lead in the main Homeopathy article. I agree the lead in the draft needs more work and is not an improvement in its current form. D. Matt Innis 12:45, 12 January 2010 (UTC)
If nothing else, bibliographic links not directly related to the text belong on the bibliography page, preferably in articles. Also, in other articles, there is some selectivity. In some cases, reviews are more appropriate than small primary studies. In other cases, peer review and responsible publications are appropriate. In yet other cases, there is more leeway on publications but the reason needs to be explained.
It's not necessarily reasonable to assume someone else will edit and add articles with which they aren't familiar, or with which they might disagree.
What principles of homeopathy are in not in the lead? It should go without saying that homeopathists believe what they are doing, or the article wouldn't be here at all. Having a small number of dissenting comments from people who question hematology simply establish it isn't universally accepted, and the details and pros and cons should be in the article, but later. Howard C. Berkowitz 13:27, 12 January 2010 (UTC)
RE: provided references from Ramanand, this must be the list and I do remember it, but it's mostly primary research. They could be used for a more detailed article to support a specific claim where reviews aren't available, but to cite them here would result in too much detail for the general nature of this article. Primary research doesn't belong in a bibliography either. I'm not sure that we have a subpage that would be appropriate for primary research, though it's an interesting idea for some other project, or way in the future for this one. Otherwise, I'd think it would be a problem with CZ:Maintainability. There are other sites that do list all the research for each particular subject. D. Matt Innis 14:51, 12 January 2010 (UTC)
This is one page (Homeopathy/Trials) that exists with a tabulated summary of some of the voluminous primary literature. I agree maintainability is an issue. I bet there are hundreds of articles like this and the main problem is reducing it to the most important articles in the field. If that could be done well it might make a good catalog. Chris Day 17:18, 12 January 2010 (UTC)
Matt, I made some time to read the entire (presently) approved article. I don't see any sentence saying there is evidence for homeopathy (the feg pdf document I've inserted in the present draft is accepted by 'mainstream' scientists as well). I object to the term 'placebo' in the lead (Edzard Ernst is known to be a ridiculed homeopathic baiter in the U.K.). I also object to the term 'fraud' in the Overview section

They also are interested in whether positive results against expectation sometimes reflect manipulation of data or perhaps even fraud.

. Like you said, can we edit the (presently) approved article?—Ramanand Jhingade 17:34, 23 January 2010 (UTC)
David (Ellis), can you please tell me what objections you have to the feg pdf document?—Ramanand Jhingade 17:42, 23 January 2010 (UTC)

(undent) Placebo in the lead is perfectly appropriate; conventional medicine routinely accepts the placebo effect as a component of therapies.

Fraud is mentioned gently as a possibility by some observers, seemingly far more gently than some of the homeopathic claims of the danger of medicine. Sorry, it's not unbalanced. Please do not go to "known" homeopathic baiters anywhere, else that you start having people bring in medical baiters from homeopathy. The problem with bait is that it often has a hook inside.

By edit the presently approved article, no, other than for typos, it's frozen. It is possible to edit the draft, and eventually to have the edited draft become the newly approved.

Again, what specific principles of homeopathy 'are not in the lede? --Howard C. Berkowitz 18:03, 23 January 2010 (UTC)

Friends, it has been a while since I check-in here. I have not re-read most of the new draft, but I can tell you that I do not like the lede paragraph. It is simply not encyclopedic or impartial. Anyway, we only recently spent a lot of time approving the previous edition. I suggest that we let it sit for 3-6 months or more before we re-do it. Dana Ullman 05:28, 1 February 2010 (UTC)
Dana, I hope you can insert sentences that read something like, "there is scientific evidence for homeopathy", using the PDF for "Scientific framework of homeopathy: evidence-based homeopathy" available at http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/286/354 wherever appropriate.—Ramanand Jhingade 08:21, 2 March 2010 (UTC)

British House of Commons Science and Technology Committee report

The committee commissioned by the British government has reassessed homeopathy as a treatment option under the national health service. It's enquiry sought written evidence and submissions from concerned parties (See News in brief: Homeopathic assessment and Evidence check: Homeopathy). Both sides of the debate were represented and presented written evidence to the committee. In addition there were oral presentations from the following individuals:

  • Mr Mike O'Brien QC MP, Minister for Health Services, Department of Health;
  • Professor David Harper CBE, Director General, Health Improvement and Protection, and Chief Scientist, Department of Health;
  • Professor Kent Woods, Chief Executive, Medicines and Healthcare Products Regulatory Agency
  • Professor Jayne Lawrence, Chief Scientific Adviser, Royal Pharmaceutical Society of Great Britain;
  • Robert Wilson, Chairman, British Association of Homeopathic Manufacturers;
  • Paul Bennett, Professional Standards Director, Boots;
  • Tracey Brown, Managing Director, Sense About Science;
  • Dr Ben Goldacre, Journalist.
  • Dr Peter Fisher, Director of Research, Royal London Homeopathic Hospital;
  • Professor Edzard Ernst, Director, Complementary Medicine Group, Peninsula Medical School;
  • Dr James Thallon, Medical Director, NHS West Kent;
  • Dr Robert Mathie, Research Development Adviser, British Homeopathic Association.

A summary statement from the House of Commons Science and Technology Committee was released with the report in Feb 2010:

... the NHS should cease funding homeopathy. It also concludes that the Medicines and Healthcare products Regulatory Agency (MHRA) should not allow homeopathic product labels to make medical claims without evidence of efficacy. As they are not medicines, homeopathic products should no longer be licensed by the MHRA.

The Committee concurred with the Government that the evidence base shows that homeopathy is not efficacious (that is, it does not work beyond the placebo effect) and that explanations for why homeopathy would work are scientifically implausible.

The Committee concluded - given that the existing scientific literature showed no good evidence of efficacy - that further clinical trials of homeopathy could not be justified.

In the Committee’s view, homeopathy is a placebo treatment and the Government should have a policy on prescribing placebos. The Government is reluctant to address the appropriateness and ethics of prescribing placebos to patients, which usually relies on some degree of patient deception. Prescribing of placebos is not consistent with informed patient choice-which the Government claims is very important-as it means patients do not have all the information needed to make choice meaningful.

Beyond ethical issues and the integrity of the doctor-patient relationship, prescribing pure placebos is bad medicine. Their effect is unreliable and unpredictable and cannot form the sole basis of any treatment on the NHS.
Source: UK Parliamentary Committee Science and Technology Committee - "Evidence Check 2: Homeopathy"

From the full report the committee also stated:

We conclude that placebos should not be routinely prescribed on the NHS. The funding of homeopathic hospitals — hospitals that specialise in the administration of placebos — should not continue, and NHS doctors should not refer patients to homeopaths.
Source: Evidence Check 2: Homeopathy, Fourth Report of Session 2009–10, House of Commons Science and Technology Committee, 20 October 2009, parliament.uk

In conclusion the chairman of the committee said:

This was a challenging inquiry which provoked strong reactions. We were seeking to determine whether the Government's policies on homeopathy are evidence based on current evidence. They are not.

It sets an unfortunate precedent for the Department of Health to consider that the existence of a community which believes that homeopathy works is 'evidence' enough to continue spending public money on it. This also sends out a confused message, and has potentially harmful consequences. We await the Government's response to our report with interest.
Source: UK Parliamentary Committee Science and Technology Committee - "Evidence Check 2: Homeopathy"

The Evidence Check definitely needs to be in the article. It has been hilarious watching the homeopaths squirming around trying to explain it away by butchering the quote from Cucherat's systematic review. It is like those reviews you see on movie posters where it says something like "Tremendous, Exciting (Evening Standard)" and then you go and look and see what the Evening Standard actually say and it is "A tremendous waste of time and money, has difficulty exciting all but the clinically insane". –Tom Morris 15:12, 3 March 2010 (UTC)
For some reason, I couldn't access Citizendium yesterday at this time. Meanwhile, I got a reply from Dr Peter Fisher to my e-mail in which he says that the individual specific rules of Homeopathy were not followed in prescribing/administering the Homeopathic remedy, so I hope good sense prevails over the 'UK Parliamentary Committee Science and Technology Committee'.—Ramanand Jhingade 13:43, 12 March 2010 (UTC)
With regard to "the individual specific rules of Homeopathy were not followed in prescribing/administering the Homeopathic remedy" what is Peter Fisher referring to? How does that impact the report? Chris Day 16:25, 12 March 2010 (UTC)
As I understand it, the individual specific rules of homeopathy mean that every patient is unique and the remedies appropriate for one will not be appropriate for another. Let's assume this is exactly correct. That would make classic randomized clinical trials, in which there is a standard treatment arm and a control arm, inappropriate, because there is no homeopathic standard.
A very similar problem, however, applies to highly individualized pharmacogenomic therapies: within a cohort of patients with, say, metastatic breast adenocarcinoma, the experimental hypothesis may be that a given treatment is applicable only to those patients with a specific BRCA gene coding. Panaceamycin is only expected to be effective in patients with that characteristic, and the others should get an aromatase inhibitor, the standard of care. Given there is a treatment, a placebo control is ethically unacceptable.
RCT's have been designed that still have statistical power, but are testing the diagnostic and treatment model, not panaceamycin. The clinician selects the treatment and sends an order to the pharmacy, where the pharmacist opens the next blind assignment envelope. If the patient is assigned to the experimental arm, the IV drug unit sent back to the care unit has panaceamycin in it if the genomic model calls for it, and the control treatment if not. If the patient is assigned to control, she gets control. It is the decision to assign that is being tested, more than the drug itself.
In like manner, homeopaths could prescribe a totally individualized remedy, but they would be blinded to whether or not the patient gets the remedy -- control could be placebo, or a medical treatment. With a sufficiently large sample, if the homeopathic model is correct, the patients receiving the remedy should do better.
It is not clear that homeopaths are willing to be tested in such a manner, which should obviate the argument about individualization not being permitted. --Howard C. Berkowitz 17:05, 12 March 2010 (UTC)
Brings me back to a question that I have never seen an answer to. How can remedies be mass marketed and sold off the shelf at places like wal-mart and whole foods and be so effective (as claimed)? These remedies are either robust or need to be highly individualized. If the latter, I don't see how how a mass market product will work. If the former, then they have indeed being found wanting (no better than placebo). Their defense against accepting the failed results of clinical trials precludes claiming successes from the mass market products. Which is it? Chris Day 19:15, 12 March 2010 (UTC)
A question, Chris, that I've asked myself. Let me respond indirectly. One of the major mass-marketed products is Oscillococcinum, about which I did write an article. What is the sound that is made by the creature from which the simillium is obtained? --Howard C. Berkowitz 19:28, 12 March 2010 (UTC)
Given that they are a £1.5bn industry we can expect to hear a lot of noise like that in the next few months. Chris Day 19:40, 12 March 2010 (UTC)
Howard, you got it right - for example, Ipecacuanha can't be given where Antim. Tart is indicated. Chris, classical homeopaths don't accept 'over the counter'/'off the shelf' products because anything between 2 to 20 remedies are mixed in one 'combination' (Hahnemann used to call such homeopaths the 'mongrel sect'), but since it's popular, the classical homeopaths can't do much about it. In India, homeopathy is a half a Billion $ 'industry' - and that is only counting the medicines sold 'over the counter' and not what is spent on homeopathic doctors - so we're not gonna let people talk rubbish about it. It really works (See the 'feg' pdf document I've posted in the previous section)!—Ramanand Jhingade 09:22, 13 March 2010 (UTC)

Ramanand, you didn't get right the essence of what I was saying: there are statistically powerful testing methods, which have been developed for biological therapies that indeed are individualized, which could answer the homeopathic objection to more traditional randomized clinical trials. I have not seen any evidence that homeopaths are willing to use such methods, but instead continue to insist on either statistically weak retrospective analyses or anecdotal/testimonial evidence. Howard C. Berkowitz 16:21, 13 March 2010 (UTC)

Howard, it is very simple: the homeopaths are perfectly happy to use clinical evidence when it shows that homeopathy works. But when it shows that it doesn't work, then the clinical trial methodology must be at fault! Heads I win, tails you lose. If clinical trials are unable to detect the effects of homeopathy, why is the British Homeopathic Association quote-mining Cucherat? What seems more likely: that homeopathy works but not to the point where the clinical trial can detect it, or homeopaths cynically misuse evidence to support their pre-ordained conclusions? It has been so amusing to watch: our politicians have seen that the King alternative therapist is actually nude. All the homeopaths have been able to do is spin, quote-mine and clutch at straws. –Tom Morris 18:38, 13 March 2010 (UTC)
I suppose there isn't really anything to do about it until there's a new Editorial Council and a reevaluation of workgroups. Howard C. Berkowitz 19:04, 13 March 2010 (UTC)
The draft is open to rewrite and, while I can't speak for everyone, I'll be glad to look at anything that gets put in it. I agree with Russell. D. Matt Innis 03:17, 14 March 2010 (UTC)
Howard, there is a lot of research going on in Homeopathy. Dr.Peter Fisher heads a research group in London and Dr.Rastogi heads a research group in India. I will email them about your suggestion. Tom, please look at the 'feg' .pdf document I posted - it is good, solid evidence that Homeopathy works!—Ramanand Jhingade 11:44, 14 March 2010 (UTC)

Friends...in due respect, anyone who takes this "report" seriously has an axe to grind or is simply under-informed.

Any rational person should and must be very suspicious of this "report." The MPs (Members of Parliament) who were a part of the Science and Technology Committee which voted for this anti-homeopathy report comprised of five members, with three members barely eking out their victory. Of the three votes, two members did not attend any of the investigational meetings, one of whom was such a new member of the committee that he wasn't even a member of the committee during the hearings, and the remaining "yes" vote was from Evan Harris, a medical doctor and devout antagonist to homeopathy. This report was not exactly a vote of and for the people. This information alone should entirely discount this "report" as a kangeroo court report that deserves that round circular file.

The very limited number of people who represented homeopathy were primarily three people. The others were entirely antagonistic to homeopathy or simply uninformed about it (such as the rep from Boots).

Despite the use and acceptance of homeopathy throughout the U.K., there is a very active group of skeptics, with significant Big Pharma funding, who work vigorously to attack this system of natural medicine. Even though there is a wide variety of serious and significant pressing issues in British medicine and science today, an active group of skeptics of homeopathy successfully resurrected in October, 2009, a House of Commons committee, called the Science and Technology Committee, with the intent to issue a report on homeopathy. A leading skeptics organization, Sense about Science, that has been pushing for the re-creation of this Committee is led by a former public relations professional who worked for a PR company that represents many Big Pharma companies. Of additional interest is the fact that other Directors of the Sense about Science organization are a mixture of former or present libertarians, Marxists, and Trotskyists who also, strangely enough, seem to advocate for the GMO industry (ironically, libertarians normally advocate for a "live and let live" philosophy, but in this instance, it seems that they prefer to take choice in medical treatment away from British consumers).

Sense about Science is a registered UK charity despite being a political pressure group. As such they have to divulge their sources of income which they do on their website. Not surprisingly, much of this comes from named pharmaceutical manufacturers.

One of the investigators for the House of Commons Science Committee is a Liberal Democrat MP, Evan Harris. He has collaborated with Sense About Science on various projects, and he was also one of the skeptic demonstrators against the national pharmacy chain, Boots, which sells homeopathic medicines. This advocacy role does not make him an unprejudiced observer as is required for this type of investigation.

A report from this kangaroo court was issued recommending that the National Health Service stop funding for homeopathy and homeopathic doctors, despite the support for homeopathy and for consumer choice from Mike O'Brien, the country's present Health Minister. This report is only of an advisory nature, and because the Health Minister has already expressed his support for consumers' right to choose their own health care, it is uncertain what, if anything, will result of this report. What was most surprising about this report was that it verified that when people repeat a lie frequently enough, such as "there is no research on homeopathy," many people actually believe it, despite its transparent falsity.Dana Ullman 05:33, 7 May 2010 (UTC)

Sources

I'm surprised that this article does not reference or discuss Paul Starr's Pulitzer Prize and the Bancroft Prize winning book on the social transformation of American medicine. Any article that wishes to understand the difference between allopathy and homeopathy needs to understand that this debate has less to do with science or medicine and everything to do with politics as the British report makes clear. Russell D. Jones 15:41, 2 March 2010 (UTC)

At one time, it was indeed appropriate to compare allopathy and homeopathy. While some dictionary definitions still use allopathy as a synonym for conventional medicine, I find the modern usage to be more often by CAM practitioners, as that-which-we-do-not-do. (For the record, I happen to find some complementary medicine useful, or at least worthy of trial in non-critical situations.)
As far as a "modern" comparison, however, I cannot do better than William Osler:

A new school of practitioners has arisen which cares nothing for homeopathy and still less for so-called allopathy. It seeks to study, rationally and scientifically, the action of drugs, old and new."(Flexner report, page 162)

Unquestionably, there was once a competition between something one could legitimately call allopathy, as a "doctrine of opposites", and homeopathy as a "doctrine of similars". Homeopaths often selectively quote Osler as saying that the homeopathic remedies were safer than most allopathic remedies of his era (i.e., late 19th-early 20th century). You'll note that there was insistence on keeping the 1905 quote from von Behring.
It ain't the 20th century any more, and conventional physicians don't prescribe based on opposites, nohow. Yes, there are political residues, but there's now a lot more in the way of evidence-based medicine...and protecting turf. Howard C. Berkowitz 19:37, 12 March 2010 (UTC)
My favorite quote from Paul Starr's book is: “Because homeopathy was simultaneously philosophical and experimental, it seemed to many people to be more rather than less scientific than orthodox medicine.” Dana Ullman 05:37, 7 May 2010 (UTC)

The memory of sugar

is being discussed here and provides a nice illustration of the topic. --Daniel Mietchen 21:56, 3 March 2010 (UTC)

I thought the "memory of sugar" tended to go either to the abdomen or buttocks, depending on genetics? :-)
Seriously, the discussion at that link is what I'd suggest is an expectation. It is possible to be neutral, I think, and mention, in the lede, that homeopathy is not generally accepted. We still do not have a way of dealing with the situation where homeopathy supporters will support a lede that doesn't consider it reasonably credible. Of course, in no other workgroup do we have an equivalent to the health sciences/healing art splits. Should Religion be joined by Atheism? Alternatively, is it possible to have a reasonable Atheism article in Religion? Howard C. Berkowitz 22:46, 3 March 2010 (UTC)
The problem just isn't there with religion and atheism. If you, say, are interested in philosophy of religion, you can get a degree in it regardless of whether you are an atheist or a theist (or something else entirely). I say this from experience - I have a BA in Philosophy, Religion and Ethics from a Catholic college but am an atheist. There are some - I guess the polite way of saying it is 'non-mainstream' - ways of getting a doctorate in religion. You could become a "Doctor of Scientology" (D.Scn) - I read today that Ron DeWolf - Hubbard's son - had been given one, and stated in court that he wasn't sure whether they gave him the Doctorate before or after he'd been given the Bachelors! Or you could get a phony Ph.D from a diploma mill - as quite a lot of the creationists have. The problem with Healing Arts is that you can quite feasibly become a Healing Arts editor with a degree from a non-mainstream parallel academic institution. When mainstream academia isn't bending over backwards to certify degrees in quackery (as two universities in Britain shamefully have), the quacks create their own academic institutions.
"Dr" Gillian McKeith "PhD" has a degree from a place called Clayton College of Natural Health in Birmingham, Alabama. Said college is not accredited by any accrediting body recognized by the Department of Education, and a number of states in the U.S. list it as unaccredited on their websites for student loans (etc.). This does not stop McKeith claiming to have a PhD on her website, nor did it stop Channel 4 television or her publisher from touting this to promote her books and TV programme. She also likes to mention how she is a member of the American Association of Nutritional Consultants. You too can be a member of the American Association of Nutritional Consultants if you send them $60! McKeith has pushed notorious nonsense like the idea that green vegetables are good for you because the green shows they have chlorophyll (true), and the chlorophyll will oxidate your blood (how? Human beings are not plants. They tend to get their oxygen through respiration rather than photosynthesis. And even if they were getting their oxygen through photosynthesis, even your local tanning salon lamps aren't quite powerful enough to penetrate your small intestines).
Another graduate of the Clayton College of Natural Health is cancer quack Hulda Clark who sells a whole variety of magic 'zapping' toys that make funny noises and shine lights and do little more to cure cancer than extract money from punters - I mean, cancer sufferers.
Take any philosopher of religion or even most theologians - they'll certainly be able to say something useful on an article about atheism in the Religion WG. Same for the non-believers within the same fields. The problem with Healing Arts is it lets people with completely bonkers views about reality approve articles on their favourite pseudoscience. If the claims of the homeopaths were true (and, blimey, even our politicians can tell what a big pile of nothing the evidence of two hundred years of homeopathy has amounted to), then most of the articles in the Biology and Chemistry workgroup need rewriting.
I'll repeat myself again: we need to fix the Healing Arts bug. It is nothing more than a bug. It is a bug that is bringing down the great work done by other WGs. It says to anyone who has spent years of their life working on getting a PhD in physics or literature or psychology or whatever that you can get a fake degree from a non-accredited university and also be considered an expert on the same level. How can I, in good conscience, tell the experts in my field to contribute given this significant vulnerability in the Editorship system? –Tom Morris 01:21, 4 March 2010 (UTC)
Religion seemed the obvious parallel, but we could, I suppose, have an Absolute Pacifism workgroup with Military -- not that quite a few professional soldiers don't hate war. Why can Engineering debunk a hoax theory but Health Sciences cannot? Howard C. Berkowitz 02:15, 4 March 2010 (UTC)
Howard, you're one of the eight Charterists. Are you a loud and strong voice therein trying to *remove* Healing Arts as a Workgroup, so that some of this nonsense could then be addressed in the future in a rational way? Hayford Peirce 02:49, 4 March 2010 (UTC)
Compromise in the Charter Committee, I believe, means that the Workgroup and some other details will be passed, without detailed guidance, to the Editorial Council. Personally, I am urging the draft to go to discussion and markup, so we can proceed to the next steps after ratification. While this is an especially galling problem, there are less egregious workgroup structure problems that also need addressing and can't happen at the Charter level. --Howard C. Berkowitz 03:21, 4 March 2010 (UTC)
Even with Pacifism and the Military, there is an implicit understanding that most of the facts are the same. The Pacifist will agree with the General that the U.S. dropped the bomb on Hiroshima or that Nelson died in 1805. They have different opinions, but they do not care out their own facts in quite the same way as the Healing Arts gang. –Tom Morris 07:32, 4 March 2010 (UTC)
No, the analogy may hold. There are those that will insist that any enemy can be defeated through passive resistance and good thoughts, just as some of the healing arts believe that it is utterly wrong to immunize against an infectious organism or use an antibiotic against one. Howard C. Berkowitz 07:43, 4 March 2010 (UTC)
Tom mentions non-mainstream ways of getting doctorates in religion. In fact the Archbishop of Canterbury still has the legal power to award them, which might explain why Church of England bishops always seem to be Dr. Peter Jackson 14:29, 12 March 2010 (UTC)

How well does it work?

We use double-blind studies to tell how well a particular medicine works. The person handout out the medicine does not know whether it's a "real medicine" just a sugar pill. In the case of pain relievers, the potency of an analgesic is rated in terms of how much more effective it is than a placebo.

If I recall correctly, as much as 75% to 90% of the effective pain relief you get from the pills comes from the placebo effect: you take your aspirin or ibuprofen or (without knowing it) your sugar pill, and your headache starts going away within an hour no matter what. The real stuff is only slightly better.

Given all that, how would we design a study to compare homeopathic treatment with conventional treatment? Is it possible to conduct a blind study, if the way the healer deals with the patient is a key ingredient of the therapeutic effect?

For that matter, how can we compare Freudian psychoanalysis to Berne's transactional analysis or modern rational-emotive therapy or to a frank chat with a trusted friend or mentor (like Father O'Malley down at the local Catholic church)?

  • I daresay one result of a careful attempt to measure outcomes could be that "bedside manner" is much more important than we've allowed ourselves to realize.

But I ask again, how do we study and quantify it? --Ed Poor 02:04, 28 March 2010 (UTC)

If one were to review the entire body of experiments that Thomas Edison conducted on electricity, one would have to say that the vast majority of his experiments were failures...and one might fall into a trap by saying that he was a failure. Of course, we KNOW that this is not true. Just because some studies have shown that homeopathic medicines don't work, there is a greater body of research to show that it does. The trick is to know WHEN homeopathic medicines work...and when they don't.
If anyone here wants to review a body of homeopathic research on a specific group of diseases (respiratory allergies) that have primarily been published in high impact conventional journals, such as the Lancet and the BMJ, you might consider reading this review of research I co-authored in a peer-review journal: http://www.ncbi.nlm.nih.gov/pubmed/20359268 -- you can read the entire article online at: www.altmedrev.com (It is in the Spring, 2010, issue, article #6). Dana Ullman 05:43, 7 May 2010 (UTC)

Unsupported assertions

The current text has "Even in Europe, homeopathy is practiced by many conventional physicians, including 30-40% of French doctors and 20% of German doctors." and in the next paragraph "Some medical doctors, particularly in Germany, France, and several other European countries prescribe homeopathic medicines for wide variety of both self-limiting conditions and serious diseases with a high rate of patient satisfaction." There are no supporting citations.

This is obviously redundant; we need at most one of these statements. However, neither strikes me as believable without support, so I am inclined to delete both. Anyone care to comment before I edit? Sandy Harris 15:29, 26 June 2010 (UTC)

Your point about unsupported assertions has come up before, and the current text, in my opinion, is significantly misleading. "homeopathy is practiced by many conventional physicians" does not, as much as some may want it to do so, imply that conventional positions endorse all of homeopathy. By definition, if they are conventional physicians, they are not practicing homeopathy as alternative medicine, but are using some complementary techniques from homeopathy. When I was last in my internist's office, I banged my shoulder against a piece of equipment. He rubbed it a bit. Does that mean he practices massage therapy?
"Patient satisfaction" is a purely subjective assessment and is in no way evidence of efficacy. I could take the sentence starting "Some medical doctors..." and substitute "chemically pure water that has not been exposed to a simillium" and demonstrate high patient satisfaction.
I agree with deleting both. Even if citations are offered, they must be of a quality that indicates that homeopathic methods are a significant part of the practice of these physicians and they are not using it with the intent of creating placebo effects. --Howard C. Berkowitz 17:05, 26 June 2010 (UTC)
It is a fact that at universities in Germany and Austria there are chairs and lectures on homeopathy (in Vienna also at the veterinary university). There are doctors who practice both. --Peter Schmitt 23:10, 26 June 2010 (UTC)
I have no problem if the two sentences ar combined. I think we've gone over this several times on the talk pages. As Peter points out, there are obviously well established 'conventional' medical professionals that use homeopathy for treatment of medical conditions. This is pretty much common knowledge at this point, so I don't see the need for citing a source for the mere fact that some medical physicians use homeopathy in their practices. However, when we add specific numbers such as 30-40%, it does seem to beg for a reference. It shouldn't be hard to find such a reference if it is out there. Otherwise, removing the numbers and just stating the fact shouldn't be a problem.
I don't think we will be able to find any scientific sources that conclude that they use it only on undereducated healthy people as a placebo. In fact, I think the opposite is more likely the case. D. Matt Innis 01:22, 29 June 2010 (UTC)

Would someone who has access care to correct the glaring English mistake in the first paragraph of this approved article? Ro Thorpe 00:16, 2 July 2010 (UTC)

I'm sorry, Ro, I must have a blind spot that is preventing me from seeing this glaring error. Could you be so kind as to point it out? D. Matt Innis 01:42, 2 July 2010 (UTC)
Oh, so go ahead and shoot me! I found it (after reading your request for Hayford to repair it :) D. Matt Innis 01:46, 2 July 2010 (UTC)
Bang, bang - but you've removed it! Many thanks! Ro Thorpe 12:16, 2 July 2010 (UTC)

I provide many solid references to the use of homeopathic medicines by physicians in Europe in an article I wrote at: http://www.huffingtonpost.com/dana-ullman/homeopathic-medicine-euro_b_402490.html (It is NOT my intent for anyone to reference this article in OUR article at this website. Instead, we can use many of the references provided. This article also has many references throughout the article showing that people who use homeopathic medicines tend to have more education than those who don't.)

I urge us to be very careful in significant changing this article because a lot of time and thought went into it previously. Dana Ullman 18:05, 14 July 2010 (UTC)

Review by a sceptical layman (i.e. me)

I'm reviewing the draft. Here is a rough summary of my changes and concerns:

  • I rewrote the paragraph in the lede section about the "long safety record". The reason homeopathy has a long safety record is the very same reason that not travelling has a long safety record: if something is inert and chemically indistinguishable from the delivery mechanism, it will be safe. Safety and efficacy is a balancing act. The reason homeopathy is safe is precisely because it isn't efficacious.
  • I'm not wild about long, windy footnotes about Romanization. I've thus split off the Romanization note about the word "qi" on to a separate page.
  • The section that is disputed about the number of practitioners in France and Germany is in the wrong place. The way in which homeopathy is prescribed or accessed doesn't seem to be to be a principle of homeopathy - homeopathy is homepathy whether it is prescribed by a homeopath or bought over the counter. I've thus moved it into the section which used to be titled "Professional homeopaths: who are they?" which I have retitled "Homeopathy in practice". This section seems to be the place to discuss provision, prescription, education, regulation and the like.
  • The paragraph starting "Homeopathic remedies can be prescribed by professional homeopaths" seems to be a tricky one. Depending on the country and the regulatory regime, homeopathy can be prescribed by a wide variety of people. Sadly (in my opinion), in Britain, quacks of all sorts can have their merry way with the public. Pretty much anyone can set themselves up as an alternative practitioner, so long as they don't make their claims too specific. But in other countries, this varies. It seems the important distinction that needs to be made is that homeopathy - unlike, for want of a better description, real medicine - can be prescribed by anyone.
  • The rest of the section on "A typical homeopathic visit" seems to have some glaring problems. The homeopath is supposed to have EMT training in order to be "adequately trained"? (Heh. Surely, if heart attacks are the problem, what you need to do is to dilute high-fructose corn syrup into non-existence and it'll clear right up? I thought they believed in the law of similars. What's a defibrilator doing in the homeopath's office?) But anyway, this adequate training is according to who? According to government regulations? According to the homeopathic groups? According to us? According to some third-party regulator like the CNHC?
  • The article describes "classical homeopathy" at length, but I haven't seen any discussion of what the alternatives are to classical.
  • There is a lot of repetition of parts of the article. The 'Principles' section is repeated in the section on 'The claims for homeopathy'.
  • No criticism seems to be made of the "treating the whole person" idea. I'm not even sure that this is a desirable thing. If I break my arm, I want my arm fixed, not someone to waffle about my "disturbance in the overall homeostasis of the overall being". In fact, when I broke my arm as a child, I'm very glad that I had access to a surgeon to fix it. This kind of rhetoric seems to be just an evasion tactic - if the studies don't show that homeopathy actually fixes anything (and, well, it wasn't going to put the bones in my elbow back together), then they can justify this kind of thing by pointing out that the person feels vaguely better in some holistic sense.
  • The paragraph about corticosteroids seems to be totally out of place. Oh, it sort of makes sense - it is a follow on from the last paragraph about homeopathy and asthma.

I've got a more radical suggestion. This article obviously needs a fairly ground-up rewrite. Here's what I reckon we should do. The current article seems to have been put together in a rather piecemeal way. Instead, I think the best way is to see if we can come together and work out a list of the fundamental questions that a good article on homeopathy should answer - then build a simple structure around those questions, and fill them in. We may be able to repurpose some of the text from the existing article.

I'd suggest the following list of questions:

  1. What is homeopathy?
  2. Is there any known mechanism for homeopathy?
  3. Is homeopathy clinically effective?
  4. What are the main issues of contention regarding homeopathy?
  5. Why have there been campaigns against homeopathy like the 10:23 campaign?
  6. What is the history of homeopathy? Who is Samuel Hahnemann?
  7. How is homeopathic care provisioned and regulated in different countries?

Before formulating a structure for any potential rewrite, I'm interested in seeing if anyone has any other questions that they'd want to add. –Tom Morris 12:30, 4 July 2010 (UTC)

Tom, I only have a few minutes right now, but let me share a thought or two. My greatest unanswered question is "what is the cognitive process of a homeopath in a patient interaction?" In other words, homeopaths say that every remedy is individualized. Whenever I posed this question to Dana, it was brushed aside, saying that one had to be a trained homeopath to understand.
Odd, but I have written quite a few articles on differential diagnosis in medicine, and some of my most interesting professional work is in expert systems to "individualize" (e.g., what dosage forms are most convenient for the patient and are most likely to be taken on schedule? What other diseases are present -- are there synergistic as well as problem interactions? Are there patient preferences? Are certain side effects more or less likely? Somehow, I manage to muddle through this sort of thing, yet I keep being told there are Inner Secrets to Homeopathy that prevent a straightforward explanation. Now, I'm not a classic layman in conventional medicine, but I can't think of a field where I don't have a basic understanding and the ability to quickly get a much deeper understanding -- and also know what I don't know. In the last six months or so, I've had to do the research to do peer interactions, on the specific diseases of people (two- and four-legged) for whom I'm an advocate and case manager -- involving human iron metabolism, feline squamous cell carcinoma, and peripheral nerve myelin protein 22 and inflammatory polyneuropathy. But I can't begin to understand how a homeopath thinks?
In fairness, I'm not sure how much time I'm willing to expend on homeopathy, at least unless I get comparable collaboration on less controversial, and possibly useful to more people, health science articles (to say nothing of other fields). Howard C. Berkowitz 13:26, 4 July 2010 (UTC)

Luc Montagnier

French virologist Luc Montagnier has said at a prestigious international conference when he presented a new method for detecting viral infections that it bore close parallels to the basic tenets of homeopathy. This has been published in the 'Sunday Times' (London), as well as 'The Australian' - here's a link to the article: http://www.theaustralian.com.au/news/health-science/nobel-laureate-gives-homeopathy-a-boost/story-e6frg8y6-1225887772305

I hope one of you (at least Dana) make time (I don't have the time) to insert this matter into this article.—Ramanand Jhingade 16:26, 5 July 2010 (UTC)

Here's another link: http://epaper.timesofindia.com/Archive/skins/pastissues2/navigator.asp?login=default&AW=1279125246109Ramanand Jhingade 16:37, 14 July 2010 (UTC)

I certainly have no intention of amending the article with newspaper articles, especially those that indicate nothing but a "close parallel." Has Dr. Montagnier's proposal been discussed in mainstream journals?
The first article, in The Australian, mentions a "memory of water" type argument, and cites rejection by other scientists. I'd note that his Nobel was for virology, not physical chemistry. The second is behind a paywall. Howard C. Berkowitz 16:58, 14 July 2010 (UTC)
Hi friends! Actually, I got sent this link to a recent issue of the "New Scientists" by none other than Nobelist Brian Josephson: <http://www.newscientist.com/article/mg20727682.300-60-seconds.html>
"Clear as a Nobel"
Luc Montagnier, the French virologist who won a Nobel prize in 2008 for linking HIV with AIDS, last week made controversial claims that highly dilute solutions of harmful viruses and bacteria emit low-frequency radio waves, allegedly from watery nanostructures formed around the pathogens. Similar claims have been made for homeopathic remedies." Dana Ullman 17:40, 14 July 2010 (UTC)
That link goes to the daily news summary, not anything on homeopathy. As quoted, though, they are "controversial claims". No details. Howard C. Berkowitz 17:57, 14 July 2010 (UTC)
It is necessary to have that link in this article to show that homeopathic remedies are not 'placebos', as some people allege.—Ramanand Jhingade 15:40, 16 July 2010 (UTC)
It is another piece in the puzzle. It is primary research, but it is by a Nobel Prize winner, so it is news about homeopathy. We shouldn't treat it as scientific fact, but it is a fact that a prominent scientist has made the statement that involves a quality of water. It is in no way scientific consensus, an in fact may lead to this guys ruin for whatever reason. We have included news about the British Medical Association's recent position statement concerning homeopathy and this article specifically mentions that statement as well. This is the draft, so I won't categorically remove something that is written comprehensively, neutrally, and objectively about the subject. D. Matt Innis 12:59, 17 July 2010 (UTC)

(undent) Matt, you give it a perfectly good context--as news. It doesn't show, or not show, anything about homeopathic remedies being placebos, or effective, or ineffective, or any particular clinical correlation. As far as I understand, he's made an observation in physical chemistry and RF fields interacting with water, nothing else. I sincerely hope he's not hurt, as he was incredibly dignified while there were attempts to discredit his initial discovery and characterization of HIV -- his Nobel was very deserved. Howard C. Berkowitz 19:42, 17 July 2010 (UTC)

My point in providing the link to the NEW SCIENTIST is to verify that this research is "notable," and as such, a short note is worthy here. Dana Ullman 05:35, 21 July 2010 (UTC)


Matt, you are wonderfully reasonable. Howard is not accurate when he says that Montagnier has "made an observation". Montagnier conducted RESEARCH, and he wrote about it in a peer-review journal. He spoke about it to a group of fellow Nobel Prize winners. And ALL of this was so notable that the "New Scientist" commented about it...and linked it directly to homeopathy. I have no problem if we choose to have the word "controversial" used in describing this new work. The fact of the matter is that this new work discusses "electromagnetic signaling" which may help explain how homeopathic medicines may work. Dana Ullman 18:29, 9 September 2010 (UTC)
Then why isn't the peer-reviewed journal cited, rather than Wired and The Australian? Further, one may write (e.g., an editorial) in a peer-reviewed journal, but not have one's work peer-reviewed by that journal. The peer review process becomes more credible if another independent researcher reproduces of these results. Please provide citations of these events if you want me to believe this is substantive.
Nobel Prize winners, rather by definition, tend to be specialists. One might speak on medicine to a group of Chemistry laureates, and have no special critical review.
It's interesting that we are still arguing how homeopathic medicines "may" work, when it's rather routine to understand the molecular pharmacology of conventional medicines. Sorry, this still comes across as hand-waving for something with a trivial base of evidence.
Have I fired five or six rounds? Howard C. Berkowitz 18:38, 9 September 2010 (UTC)

Evidence that homeopathy works

I hope one of you (at least Dana) can insert sentences that read something like, "there is scientific evidence for homeopathy", using the PDF for "Scientific framework of homeopathy: evidence-based homeopathy" available at http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/286/354 wherever appropriate. I haven't seen anyone object to it here anyway.—Ramanand Jhingade 15:15, 21 July 2010 (UTC)

the word "skeptic"

Wasn't it decided a long time ago that aside from the two existing examples in the article that pro-homeopathy advocates (and anyone else) could NOT use the word "skeptic" in future edits? Just want to make sure. Hayford Peirce 21:50, 5 August 2010 (UTC)

I remember that as a specific ruling by Larry. In my experience, it's almost always used by advocates of a position; the neutrality policy wouldn't be hurt if it were banned. Howard C. Berkowitz 22:41, 5 August 2010 (UTC)
But what about people who are skeptics? Are we not allowed to say that Michael Shermer - who runs the Skeptic's Society and publishes Skeptic magazine - is a skeptic? –Tom Morris 23:02, 5 August 2010 (UTC)
As a direct quote or a self-identification, sure. As condescension to disbelievers, no. Howard C. Berkowitz 23:04, 5 August 2010 (UTC)
Ah, but is it? I consider 'skeptic' to be much less of an insult than 'homeopath'! –Tom Morris 23:06, 5 August 2010 (UTC)
I think it is -- it comes up repeatedly in fringe articles, be they moon landing hoax, UFO, etc. -- anything not a true believer. Howard C. Berkowitz 23:13, 5 August 2010 (UTC)
If *I* use the word, Tom, it's a compliment. If Dana uses it, it's pejorative. That's why Larry (or someone) banned it from this article, if I recall correctly. (I have 20 years' of Skeptical Inquirer on my bookshelf.) Hayford Peirce 23:21, 5 August 2010 (UTC)

What the...?

Homeopaths respond to these concerns by noting that using homeopathic medicines can delay or reduce the use of conventional medicines that are ineffective and dangerous.

If this were The Other Wiki, that'd be an instant "citation needed"! I know homeopaths like to bang on about the evil 'allopaths', but do they honestly respond to the opportunity cost argument with a reversed opportunity cost argument? That's so... indescribably crazy. I certainly would like some verification on that. –Tom Morris 00:42, 6 August 2010 (UTC)

Remember our motto: be bold -- remove it, and let whoever put it there back it up with some facts if they want to restore it. Hayford Peirce 01:42, 6 August 2010 (UTC)
Oh, now we're bold, haha. It's a response to the use of homeopathy for use with things like childhood ear infections, a commonly self limiting condition that is often treated with antibiotics which have unwanted and sometimes dangerous side effects. It probably could be explained a little better when it's all cleaned up. After all, that is the homeopath response. D. Matt Innis 21:50, 7 August 2010 (UTC)
On the other hand, I can point to many medical studies advising against antibiotics in uncomplicated otitis media. Going back to Osler at the turn of the 20th century, he correctly pointed out that "allopathic" drugs were often harmful -- but he then said both homeopathy and (classically defined) allopathy were "cults" that needed to be replaced. One doesn't need to turn to homeopathy to find best practices that avoid both overprescribing and underprescribing. Howard C. Berkowitz 21:59, 7 August 2010 (UTC)
Yup, absolutely agree. D. Matt Innis 01:10, 8 August 2010 (UTC)

principle of infintesimals

I'm thinking that principle needs defining. I'm thinking that the 'principle of infintesimals' is the concept that is controversial. Perhaps one of our homeopaths could explain? D. Matt Innis 12:32, 12 August 2010 (UTC)

Throughout this article, the infinitesimal dose and law of similars have been used interchangeably, but they aren't the same. http://www.similima.com/org20.html has given a brief description of the "infinitesimal dose". The law of similars is just, "using the most similar remedy" - to put it plainly. I don't have the time to check and insert those changes, but I hope you Matt, or may be Dana can do so. The infinitesimal dose can also be defended with the "memory of water" and Monsieur Montagnier's research (see Dana's post above).-Ramanand Jhingade 13:49, 13 August 2010 (UTC)
Certainly using them interchangeably is not accurate. D. Matt Innis 15:05, 13 August 2010 (UTC)
I think the term "interchangeably" was wrong to use - what I meant was that the term "law of similars" is used in the article and draft article, when it's supposed to be "the infinitesimal dose", in some places.—Ramanand Jhingade 15:50, 13 August 2010 (UTC)
So it seems to me that infinitesimal dose needs to be defined. The law of similars can obviously involve large doses of products. Obviously Homeopaths use more than infinitesimal doses in their treatments; otherwise we wouldn't have side effects from a nasal product that has zinc in it. We are not getting this point across. D. Matt Innis 17:47, 13 August 2010 (UTC)
I don't think it's worth the time, since that will also be criticized here (maybe you can use the web-site I mentioned above to do that). The nasal product, "Zicam" wasn't a homeopathic product at all, because it had milligram doses of zinc, which is against homeopathic principles. Homeopathic remedies start with mother tinctures and can go up to higher potencies (more dilute) from there.Ramanand Jhingade 09:50, 23 August 2010 (UTC)
Zicam was marketed as homeopathic, and licensed under special regulations applying to homeopathic products. Sorry, for legal purposes in the US, it was a homeopathic product. Howard C. Berkowitz 15:49, 24 August 2010 (UTC)
I know it was, but it was against homeopathic principles.—Ramanand Jhingade 15:39, 25 August 2010 (UTC)

(undent) Please do not use color for emphasis.

In the context of the United States, your simple statment that it "was against homeopathic principles" is legally irrelevant, as the FDA makes the decision if something is to be regulated as a homeopathic preparation (or food supplement), exempt from a good deal of the regulation of other drugs, or if it is a conventional regulated substance. The FDA determined Zircam was homeopathic, and, while I suppose you might argue, in an article about homeopathy and the FDA, such an argument is irrelevant here. If you reject the argument that a governmental organization cannot make such decisions for a country, then I can argue that homeopathy can't be accepted as a national means of practice in India.

With all things that it approves, the FDA depends on the manufacturer's application. More is accepted is fact in a homeopathic New Drug Application that isn't required to undergo controlled trials. Howard C. Berkowitz 16:57, 5 September 2010 (UTC)

Answer to an "unanswered question": Popularity is no metric of efficacy

Sorry, but the addition "The simple reason for homeopathy's growing popularity is because it works." is completely unacceptable without overwhelming evidence that it does work. Were this to be accepted without sourcing, the logic could be applied to popularity of politicians, especially not in office, supporting the premises their programs work.

I propose to delete this. Popularity is relevant to marketing but not efficacy. Howard C. Berkowitz 15:48, 24 August 2010 (UTC)

Those questions were begging for an answer. If you delete my answer, you must delete the questions preceding my statement as well!—Ramanand Jhingade 15:45, 25 August 2010 (UTC)
Your statement, unsourced, was not an answer. It was purely your opinion, phrased as informal commentary. Also, it is a rather sweeping opinion that goes to the heart of the article, with no evidence behind it. Howard C. Berkowitz 16:45, 25 August 2010 (UTC)
While Howard is right in saying that "popularity" is not a metric of efficacy, popularity is (by definition) its own metric, and statistics about homeopathy's popularity now and in the past has a place in an encyclopedia. Further, I give reference to a half-dozen

surveys that further verify that people who tend to receive homeopathic care tend to be more educated than those who don't.

The following link to an article that I authored provides references to this information (please know that I am not suggesting that we link to this article but only to use the references in this article in our encyclopedia listing: http://www.huffingtonpost.com/dana-ullman/homeopathic-medicine-euro_b_402490.html Dana Ullman 19:14, 9 September 2010 (UTC)
Post hoc, ergo prompter hoc? I can give even more studies that verify more people who drink milk become heroin addicts. Popularity is a principally a metric of efficacy -- of marketing. If it is significant here, Lady Gaga should be even more expert than Dana, and probably has a better figure. Howard C. Berkowitz 19:20, 9 September 2010 (UTC)

Allopathy

"Today, "allopathy" is used by practitioners of alternative and complementary medicine, like homeopaths, osteopaths, naturopaths, chiropractors and so on to refer to conventional, western medicine."

Since practitioners of conventional, western medicine rarely use the term, however, there's no good argument to insist on calling them allopaths. Yes, there are a few historical references, especially when talking of osteopathic vs. allopathic medical schools, but the term used by conventional western physicians tends to be...conventional western physicians.

Ramanand, if I refused to call you anything other than Jean-Paul, would that change your name? Howard C. Berkowitz 16:57, 24 August 2010 (UTC)

Practitioners of alternative and complementary medicine, like homeopaths, osteopaths, naturopaths, chiropractors and so on refer to conventional, western medicine as "allopathy" even today. If you don't like it, you can add something like, "conventional, western physicians do not refer to themselves as allopaths".—Ramanand Jhingade 15:50, 25 August 2010 (UTC)
Each profession defines what it calls itself. That is not the role of other professions. Would you accept the specific words "practitioners of conventional western medicine call homeopaths frauds?" No? Then why do you have the right to define a name, regarded by many as either historically inaccurate -- they don't use the principle of opposites -- or a sneering attack?. I wouldn't have the slightest objection if homeopaths called themselves Similarists, Hahnemannists, etc. -- but that is how they characterize themselves, not how they characterize others. Howard C. Berkowitz 16:44, 25 August 2010 (UTC)

Ruling needed

Mr. Jhingade reinserted "although osteopaths, homeopaths, naturopaths and other alternative medicine practitioners continue to call it allopathy." I will remove this unless an Editor says otherwise, as I believe it has been ruled that one discipline is not permitted to define a name for another. Shall I say "although biologically-oriented scientists consider homeopaths to be quacks? (noise made by the simillium of Oscillococcinum, of course)" At best, this might go in the allopathy article.

Osler deprecated both allopathy and homeopathy by the time of the Flexner report, although, somewhat earlier, he had attacked some of the drugs used by self-descibed allopaths. I'd note the latter was 19th century.

Be very careful, incidentally, in using "osteopath" versus "osteopathic physician". The latter, in the US, does use "allopath" but in a very narrow context dealing with the history of schools. Undergraduate and graduate medical education from traditionally "osteopathic" or "allopathic" education is largely identical, although some additional manipulative techniques may be taught in some historically osteopathic programs -- or by qualified faculty in historically "allopathic" programs. Assuming equal certification, with many boards merging, the scope of practice of DO's and MD's are identical. U.S. osteopathic physicians do not use the term allopathy in regular practice. Indeed, I know a few that don't use manipulation or any special osteopathic methods. As an aside, in the state of Virginia, to perform acupuncture, one must be licensed as a physician; the two I used were, respectively an MD with a OMD degree from Vietnam and a OB/GYN certification from FACOG; the other was an DO internist board-certified in internal medicine.

In the UK -- I can't speak authoritatively for the rest of Europe -- osteopathy is indeed a CAM discipline and its practitioners' scope of practice is not the same as a physician.

I would add that the opinions of naturopaths are irrelevant to this article.

Could we please stop refighting this revert battle? My impression is that rulings have been made.Howard C. Berkowitz 17:30, 5 September 2010 (UTC)

Practitioners of alt. med. still call it allopathy (Look at the American Association of Osteopathic Physicians web-site, the National Center for Homeopathy web-site and so on). I'm sure Dana will support me on this one. I'm looking forward to a ruling too and I believe such a ruling will support the homeopaths' viewpoint, because this article is titled Homeopathy and not, "Criticism of Homeopathy".—Ramanand Jhingade 08:44, 6 September 2010 (UTC)
If you are arguing from the perspective of the American Association of Osteopathic Physicians, you are either ignorant of the historical reason they do that, or deliberately making a false argument that American osteopathic physicians, as distinct from osteopaths in Europe, are in any way "alternative". DOs pass the same undergraduate and graduate certifications as MDs. I suppose I'll have to remind one of my DO friends, a world authority on field and disaster medicine, that he's "alt" and the surgeons shouldn't listen to him. If nothing else, there is a distinction between alternate and complementary.
As far as the National Center for Homeopathy website, what part of "one discipline doesn't specify what another calls itself" do you fail to grasp? I'm sure I can find medical sites that call homeopaths frauds and quacks; would you accept that designation? I'd have to go back into the archives, but I seem to recall that Larry ruled on this a long, long time ago. Dana does not have any editorial authority over what non-alternative practitioners call themselves.
If you think these comments are "attack on homeopathy", I refer you to the commentary of Dirty Harry Callaghan regarding the .44 Magnum. Howard C. Berkowitz 01:46, 7 September 2010 (UTC)

Matt's reversions

Matt, I see you have already reverted what I had added. I don't want to indulge in any "edit warring", so please restore what I had added. I have mentioned the reasons in the sections preceding this.—Ramanand Jhingade 16:20, 25 August 2010 (UTC)

Since you merely identify this a "Matt's reversions", it's difficult to what you specifically have in mind. Did Matt move the questionable material here for discussion? If he did, then it's appropriate to discuss it here, within policy limits, before it goes back.
If he deleted without making it clear what he was deleting, or why he was making a Healing Arts Editor decision to delete it, he needs to put it here. Otherwise, you cannot simply demand that it be put back without consensus or an Editor ruling. Howard C. Berkowitz 16:51, 5 September 2010 (UTC)
I'm in a hurry, but will make a quick reply. I hope Matt brings things here for discussion in future.—Ramanand Jhingade 08:38, 6 September 2010 (UTC)

"Attack piece"

The statement "Some other researchers claim that there is scientific evidence that homeopathy helps in many problems and diseases[3]" was added with the edit note that "the lede can't be an attack piece."

The lede also cannot be a place where non-substantive opinion can be used to "neutralize" the main thrust of expert opinion. Again and again, it's been pointed out that CZ's current neutrality policy does not mean that equal emphasis must be given to each position.

I recommend deletion of the above statement as far too general, and, for that matter, worded in a manner that really doesn't counter but says "well, yes but..." There's an old medical story about a radiologist who crawls, bloody and battered, into his emergency room. Asked what happened, he said it was "consistent with being mugged." Things in the lede need a bit more substance than "consistent with." Howard C. Berkowitz 17:19, 5 September 2010 (UTC)

I don't see any probs with that ref and I'm sure Dana, the only other Homeopath here will support me on that.—Ramanand Jhingade 08:34, 6 September 2010 (UTC)

Similars and "allopathic drugs"

First, I contend there is no such thing, in modern terms, as an allopathic drug. Got any references, such as Goodman and Gilman, that use the term? No, homeopathic texts don't get to define practices in general medicine. Taking a recent addition that I believe must be either radically changed or updated, I quote:

"Recent research has shown that some conventional drugs, which are normally used to do something, can do the opposite also - a rebound effect, similar to homeopathy's law of similars.[1][2]

[3][4]. [5][6] [7][8]. [9][10]"

First, it's impossible to respond to this deluge of citations without any details. Second, for these to be "allopathic" drugs, based on the "principle of opposites", the papers must include that language. Do they?

Second, it's a leap to equate a rebound phenomenon to allopathy; the dose-over-time, molecular control mechanisms, etc., are much more than "opposites". One of the classic examples of rebound, nasally applied vasoconstrictors, doesn't take place when the dose and duration are properly controlled. In general, if the vasoconstrictor is needed for long enough to cause rebound, use of antiinflammatories, such as corticosteroids, cromolyns, or antihistamines should be under active consideration to replace the direct vasoconstrictor.

It was with considerable restraint that I didn't immediately move this to the talk page. Ironically, there are very pleasant, collaborative discussions going on in a number of military and history articles. Maybe getting to kill people makes for more restrained discussion. Howard C. Berkowitz 19:04, 5 September 2010 (UTC)

The rebound effect is well documented and accepted in medical circles, so please don't delete that sentence or the refs I inserted (I've improved on the way it used to read, so pls take a look).—Ramanand Jhingade 08:31, 6 September 2010 (UTC)
Well documented? "Rebound effect' doesn't appear in the index of the standard textbook, Goodman and Gilman's The Pharmacologic Basis of Therapeutics (9th Edition). Now, as I have mentioned, the term "rebound" is indeed used in very specific contexts, such as the response of nasal mucosa to topical vasoconstrictors.
"can lead to the opposite effect, when stopped - a rebound effect, which means they are following homeopathy's law of similars." is not especially an improvement. Of course there are drugs that have adverse effects when stopped inappropriately. Corticosteroids, selective neurotransmitter uptake inhibitors and opioids all come to mind. "Similars" have nothing to do with it, in the sense that a corticosteroid, in a Proving, would be inflammatory. Instead, the adrenal cortex has reduced its production of endogenous steroids because it has sensed a certain blood level.
It's vaguely amusing to hear you comment about people ignorant of homeopathy, when there seem to be so many opportunities to be unaware of molecular pharmacology. But, there are different tastes -- where's the eye of newt and blood of bat when you need them? Howard C. Berkowitz 01:18, 7 September 2010 (UTC)

Dead link

http://www.medscape.com/viewarticle/511604 Reference 102 about the value of talking to patients. Howard C. Berkowitz 19:08, 5 September 2010 (UTC)

Then I suggest we remove the sentence attributed to Vandenbroucke.—Ramanand Jhingade 13:56, 6 September 2010 (UTC)

Thankless CZ

Editing CZ is a thankless job. I'm sure the people who are ignorant about a subject (like Homeopathy) can move on to Facebook, Orkut, Linked in, Twitter or some other networking site/s and make a lot of friends and get to know them really well - we hardly know anything about each other here. Howard, you're probably a nice guy I can get to know better and probably dine with. Sandy, Im sure I can make an interesting 'date'. Why don't y'all look for me on Facebook?—Ramanand Jhingade 13:56, 6 September 2010 (UTC)

I have nothing against friendship, and I do think I've found a number of good friends here. Nevertheless, the essence of what I see as appropriate writing at CZ depends on courtesy, but above all, logic -- western if you will -- and evidence. I have a LinkedIn account, but not Facebook, Twitter, etc. -- and don't want them. On the other hand, I am very active on an assortment of professional mailing lists. Howard C. Berkowitz 18:50, 6 September 2010 (UTC)
First off, I greatly doubt either of us would enjoy a date. 'Sandy' is a short form of 'Alexander', and I'm neither unattached nor gay.
Second, some of your other apparent assumptions are just as bogus. People generally aren't here for social networking, but to contribute toward building an encyclopedia. Nor does not being an expert on homeopathy preclude contributing.
I'm resisting the urge to write a more pointed reply because it would violate CZ:Professionalism#What_behaviors_are_unprofessional.3F. Sandy Harris 23:47, 6 September 2010 (UTC)

Confusing deletions

It's somewhat difficult to tell why things are deleted when the only reasons given are in edit notes, which aren't always easily accessible if, for example, minor edits follow them in the log.

This was deleted, possibly due a claim that it was unsourced -- yet it is sourced. It's a reasonable statement and belongs in the article.

This does not mean that that people treated with homeopathy do feel better as a result - the clinical literature clearly shows this, but Vandenbroucke suggested that this could be because its practitioners treatments spend more time with people than doctors do. "Even if people give you the wrong explanation about what you seek treatment for, the fact that they spend a long time speaking with you might help," Vandenbroucke suggests.[11]

"Homeopaths contend that flawed trials cannot be used to show that homeopathic treatment is ineffective (please read the previous paragraph for information about the positive trials)." This new sentence, especially the underlined words, is argumentative rather than informative. --Howard C. Berkowitz 18:50, 6 September 2010 (UTC)

I didn't do the above editing, though I support it. Just because Vandenbroucke says that statement does not mean it is true, especially when there is at present no data to support it. This idea borders on the preposterous that the "extra" time that homeopaths spend with their patients leads to the therapeutic benefits that homeopathic patients experience. If THAT were the case, then, psychologists would be our finest healers (and sadly, they are not). Although the first interview with a homeopath is typically an hour, the follow-up visits are usually 10-30 minutes, just a little longer than a conventional MD.
As for "flawed" trials, see my longer message in the next section where I talk about the importance of "internal validity" in trials AND "external validity." Dana Ullman 01:09, 14 September 2010 (UTC)

Dana Ullman's thoughts on this article to date

Sorry to be away from the article for so long...

I am very concerned about this present “draft” of the homeopathy article. I feel that it has lost its “encyclopedic” tone, and instead, it is a mixture of encyclopedic information along with strong “point of view” skepticism. Although I do not have a problem with proper skepticism, it is the tone of it AND where it is placed in the article that is critical.

For instance, in the very top portion of this article are paragraphs #3 and #4 which are not encyclopedic in tone or content.

I will try to avoid doing “editing” the article myself. Instead, I will propose here in the TALK section my ideas for what should be said, and I hope that those people who want to maintain a high-quality objective and encyclopedic article will make appropriate changes to the Draft. Needless to say, I will not sign my name, as a Healing Arts Editor, to anything that does not maintain a certain objective tone. And by “objective tone,” I obviously do not mean that this article should just a promo for homeopathy.

My sincere thanx for whoever re-formating my contribution so that we can communicate about them in bit-sizeable chunks. Good work! Dana Ullman 15:37, 14 September 2010 (UTC)

Dana on 3rd paragraph

Ultimately, I recommend some changes in the 3rd paragraph…here’s what I suggest for replacement for this paragraph.

While many medical practitioners prescribe some homeopathic remedies, a significant majority of the scientific and conventional medical community (including a number of national medical representative bodies like the British Medical Association), consider homeopathy to be unfounded and pseudoscientific.[1] Skeptics of homeopathy insist that there is no plausible mechanism to explain how the remedies might work, given that many of them are so dilute that they contain not a single molecule of the active ingredient. However, homeopaths and scientists from varied specialties, including Nobel Prize winning virologist Luc Montagnier, assert that there are viable theories about how homeopathic medicines may act, though as yet, no one explanation has been verified. Advocates assert that the homeopathic “principle of similars” is, in part, the basis for modern day immunizations, allergy treatments, and select other conventional treatments (ie, the use of Ritalin and other amphetamine-like drugs used to treat hyperactive children), while critics have compared it to sympathetic magic.
I wrote the current text. To me it seems accurate and encyclopedic, much better than either what it replaced or your suggestion.
My "While the founder of modern homeopathy was a medical doctor, some modern medical practitioners do prescribe some homeopathic remedies, and some governments do recognise homeopathy as legitimate treatment" instead of your "While many medical practitioners prescribe some homeopathic remedies" gives more arguments favorable to homeopathy, but states them more carefully, your "many" seems dubious to me.
My "the consensus of medical and scientific opinion is that homeopathy is unfounded." seems to me a simple statement of fact.
I removed the claim that it is "pseudoscientific", which seems to me true but unnecessary here. Criticism is fine; gratuitous insults are not.
I do not think the British Medical Association or your "However, ..." or "Advocates assert ..." belong in the lede. The lede needs to be a simple summary of key points. The BMA, Montaignier and Ritalin might all be discussed later, but they do not belong here. Sandy Harris 03:34, 14 September 2010 (UTC)

Greetings, Sandy...we've not interacted yet...let's work together. First, the claim in the present draft that "There is no plausible mechanism..." is false and has no place here. There ARE plausible explanations, though simply none that have been confirmed. Dana Ullman 15:20, 14 September 2010 (UTC)

It depends on the interpretation of the word "plausible". Certainly there are explanations, but I'd say none are plausible. Sandy Harris 02:31, 15 September 2010 (UTC)
Sandy suggests above that my reference to "many physicians" prescribing homeopathic medicines "seems dubious." Perhaps it would help if he re-read our article here where in the "Homeopathy in Practice" section gives some specific figures: "In Europe homeopathy is practiced by many conventional physicians, including 30-40% of French doctors and 20% of German doctors. Some homeopathic treatment is partly covered by some European public health services, including in France and Denmark. In France, 35% of the costs of homeopathic medicine prescribed by a medical doctor are reimbursed from health insurance."...Clearly, the term "many" is not dubious. Dana Ullman 15:48, 14 September 2010 (UTC)
See the discussion under "unsupported assertions" above. Those claims do belong somewhere in the article, if they can be supported, but the lede as it stands seems to me a good summary. Sandy Harris 23:21, 14 September 2010 (UTC)
I have a question for Sandy and Howard and other skeptics. At present, in this lede, there is the sentence: "To a skeptic, the 'principle of similars' is merely an appeal to sympathetic magic." Out of curiosity, do you believe that there is a certain wisdom of the body? Do you believe that the human organism tries to adapt to infection and/or stress by creating symptoms in order to survive? If you answer YES or MAYBE to EITHER of these questions, then using drugs that mimic the body's defenses make sense, and as such, we HAVE to delete or change this ill-founded sentence. Please also remember that the "high potencies" is only a part of homeopathy and that most homeopathic medicines sold in health food stores and pharmacies today are in small, material doses. It is inappropriate (and inaccurate) to assume that ALL homeopathic medicines are in doses beyond Avogadro's number. Dana Ullman 16:34, 14 September 2010 (UTC)
That sentence is fine. What we believe is not at issue. The paragraph is trying to summarise the position about homeopathy of skeptics and critics. I'd say that, if anything, it understates their revulsion. Granted, other parts of the article should give a much more favorable view, but the negative views should be there as well. Sandy Harris 23:21, 14 September 2010 (UTC)
Individual belief is outside the scope of the article, but no, I don't think there is a "wisdom of the body", and, using the medical definition of symptom, the body doesn't create any symptoms -- the mind does. Symptoms are subjective, and signs are objective. A sign may be evidence of a defense mechanism, but it's far more likely to be evidence of a disease process.
The great fallacy I see here is the assumption that proving-based drug mimic the actual defenses. The body's direct defenses against Clostridium tetani exotoxin in tetanus are immunologic. Those defenses are supported by administering synthetic tetanus immune globulin -- we learned to avoid the horse serum preparation as too risky -- to give initial passive immunity, and tetanus toxoid to build active immunity. These don't "mimic" the defenses; they are the defenses. The body really doesn't have defenses against the neurologic effects of the toxin, but benzodiazepines, neuromuscular blocking agents, baclofen and dantrolene provide what, I suppose, could be called "symptomatic" relief. Without getting into all the receptors, we have a pretty decent idea how these drugs reduce the spasticity; we don't need to go the route of finding similars.
I'm not opposed to using unusual explanations when there are no better ones. "Wisdom of the body" sounds like something for a Religion Editor. I do use complementary methods when I have some reason to believe in a favorable risk-benefit. As soon as I hear that something is risk free, alarm bells go off. There are always tradeoffs. I'm facing a terrible one now, as the American Veterinary Medical Association described euthanasia as a means of comfort care that has the side effect of death -- yet I have a beloved cat who has a greater will to live than any human I've ever encountered. Howard C. Berkowitz 23:56, 14 September 2010 (UTC)

The text you are questioning is "There is no plausible mechanism to explain how the remedies might work, given that many of them are so dilute that they contain not a single molecule of the active ingredient. To a skeptic, the "principle of similars" is merely an appeal to sympathetic magic." I think that is OK as it stands.

It could be replaced with something that both states the skeptical position better and mentions that not everyone is skeptical:

To a skeptic, there is neither any solid evidence that homeopathy is effective nor any plausible explanation of why it should be, and the "principle of similars" is merely an appeal to sympathetic magic. Homeopaths, however, believe that they have good answers to these criticisms.
Close. Let me urge that sympathetic magic show as a wikilink, as it is not just a throwaway pejorative, but an anthropological term that shows up across many cultures. Consider dropping the "merely". When I wrote the article on sympathetic magic, it wasn't intended to disparage, but to explain a cultural pattern.
Is it necessary to bring up both the Avogadro argument and similars in the lede, purely from a standpoint of complexity? Yes, I understand that potentiation is an argument that can be countered with the Avogadro point, but similars seem more basic than potentiation in understanding the core argument of homeopathy.
I am not trying to be argumentative when I say that arguing that the principle of similars is an equivalent or superior explanation, to a drug that was designed using molecular structure-activity relationships, is inflammatory. It's one thing for the homeopaths to say why their own preparations work, but it's pushing too hard to say that the homeopaths have better explanations for the drugs developed under different paradigms. Howard C. Berkowitz 02:46, 15 September 2010 (UTC)

4th paragraph

I believe that the present 4th paragraph has NO place in the top section. Discussion of the “possible dangers” from the patient or the doctor’s decision to not use conventional treatments has NO place here. If others wish to insert this information under its proper section, I do not have a problem, though we must then acknowledge: Homeopaths respond to the possible dangers from using homeopathic medicines in replacement of conventional medical care by asserting that there are much greater dangers by using conventional medicines as a first method of treatment.

It probably needs mention of the fact that homeopaths retort that conventional medicines may also have large risks. I'm inclined to think it does belong in the lede, since these risks are a basic issue about homeopathy. However, I don't feel remarkably strongly about that and would be interested in hearing other opinions. Sandy Harris 03:44, 14 September 2010 (UTC)
I would prefer to see it go unless the homeopaths present a statistical risk-benefit argument, based on modern medical practices, not 1900, that the hypothesis is true that the clinical outcome is better with homeopathic treatment than medical or no treatment. The risks of most medical treatments are quantifiable, as are the benefits, with the understanding that statistical aggregates do not apply to individuals.
There are any number of times I've chosen something with significant risk, because there was reasonable evidence the risk was greater than the benefit. Obviously, a cardioplegia solution that stopped my beating heart was risky, but the risk of not having the open-heart surgery was greater. There was reliable data for risk at each stage of the procedure.
When other children would chant "your mother wears army boots," I'd point out that they were part of her uniform. The "medical treatment is more dangerous", without substantial data, rings equally relevant to me. Howard C. Berkowitz 04:34, 14 September 2010 (UTC)
"I would prefer to see it go unless ..." is not clear to me. Are you saying that text on homeopathic rejoinders should not be inserted, or that we should follow Dana's suggestion and remove the current 4th paragraph from the lede? Sandy Harris 05:30, 14 September 2010 (UTC)
Unless the homeopathic rejoinder has strong statistical support, it should not be in the article. It's one thing if there is a formal risk-benefit analysis proving a hypothesis, but if it's no more than "well, medical treatments are dangerous," it's irrelevant defense. Howard C. Berkowitz 06:25, 14 September 2010 (UTC)

In due respect, the formal risk-benefit analysis needs to go BOTH ways. What evidence do you have for the "dangers" of receiving homeopathic treatment...and please do not give individual cases. I do have access to numerous cost-effectiveness studies showing significant cost savings to people who utilize homeopathic medicines. Dana Ullman 15:34, 14 September 2010 (UTC)

Bluntly, it does not need to go both ways. Homeopathy is desperately trying to claim a place at the table in the face of enormous evidence that molecular medicine is effective. It seems your position is that homeopathy and medicine are of equal status and that every claim against homeopathy must be counterattacked by one about medicine. If, indeed, homeopathy is so much an alternative to medicine, this is useless.
Incidentally, it would be wise for you to identify your financial interests in the promotion of homeopathy, such as (from http://www.homeopathic.com/main/bio_dana.jsp):
  • Dana Ullman, M.P.H. (Masters in Public Health, U.C. Berkeley) is "homeopathic.com" and is widely recognized as the foremost spokesperson for homeopathic medicine in the U.S.
  • Dana founded Homeopathic Educational Services, America's largest publisher and distributor of homeopathic books, tapes, software, and medicine kits. For 10 years he served as formulator and spokesperson for a line of homeopathic medicine manufactured by Nature's Way, one of America's leading natural products companies.
See Bob Badgett's developing article on conflict of interest. It is one thing for a practitioner to charge for professional services, but it is generally considered unethical for physicians to refer patients to testing facilities, publications, etc., from which they derive income.
You are the one making the claims that medicine is so dangerous. I didn't make claims about ""dangers" of receiving homeopathic treatment", which is a change of subject. I will say, however, that it is dangerous to seek homeopathic treatment in lieu of medical treatments of established efficacy. Now, that seems a backing-off from the dangers of conventional medicine, but there seems a dearth of such studies from sources not vested in homeopathy. Again, these studies need to be overwhelming to dispute the CZ policy of providing the mainstream view.
"NPOV", incidentally, is WP-speak and discouraged here.
Incidentally, apropos of being encyclopedic, how about contributions other than your single subject? Some of us are interested in building an encyclopedia, not fighting a never-ending battle with single-issue advocates or, as Sandy responded to Ramanand, social networking. Howard C. Berkowitz 16:48, 14 September 2010 (UTC)
Wow, Howard, you're now getting disperate...and I'm sorry to see this. First, for your information, I was personally asked by Larry Sanger (the founder of Citizendium) to edit here, and he asked me to become a Healing Arts Editor. I have never hid any fact about my background. In fact, most people appreciate my knowledge and expertise, except those few people who are threatened by facts, research, references to data, and the substantiation of information.
You and Sandy were asking me for "evidence" that conventional medicine has certain risks. While I could have laughed at this seemingly innocent (or naive) request, I simply responded by asking you to provide evidence that there was danger to homeopathic treatment. Instead of providing this evidence, you have chosen a different strategy to get your bias into this article. Let's avoid such tactics...and let's try to work together to write something fair, accurate, verifiable, and encyclopedic. Dana Ullman 22:26, 14 September 2010 (UTC)
No, I don't believe it is possible to collaborate with you to write something that is fair, accurate, and is not far more supportive of the benefits of homeopathy than is supportable by the views recognized by the bulk of medical opinion and data. I believe the best I can do is point out evasions, selective and often inaccurate statements about pharmacology, misquotations (e.g., saying Sandy or I asked for "evidence" medicine has risks), and what I believe to be a significant conflict of interest. I do so in discussion here, to be sure other members of the community see it, rather than jump into revert wars.
I have never suggested that medical treatment does not has risks; medical treatment always has risks. What I find to be hand-waving is the implication that homeopathy has no risks, including the delay of effective treatment.
You will note that I have asked for an Editor ruling on what I consider continued misues of von Behring as an authority that homeopathy works. I find it sad that regardless of what was done to design a treatment, the data-free argument that similars might be an explanation continues to be brought up.
Larry Sanger is not a health professional, and, I suspect, asked you to be a Healing Arts Editor because you are visible in that field. I would be much less antagonistic to your contributions were you to focus on what homeopaths believe and do, rather than the frequent -- and frequent inaccurate -- attacks on medicine, such as your condescending remark that there are no antifungal and antiviral agents of demonstrated efficacy, and, indeed, demonstrated risk. Indeed, the risk of unmodified amphotericin B has led to significant molecular work to reduce toxicity. You give the impression, however, that Hahnemann got it all right in the early 19th century, and medicine continues to get it wrong.
Professional collaboration does not require that participants like one another. It does not help when they are patronizing, and, if they can't take focused criticism without changing the subject, perhaps the kitchen of knowledge is a bit too hot. Howard C. Berkowitz 22:53, 14 September 2010 (UTC)

Howard, my concern about your editing is that you are just fabricating fights. You wrote above that I said "there are no antifungal and antiviral agents of demonstrated efficacy." Where (!) did I say OR simply imply that? Nowhere! I even repeated my point that we all have to be careful in making broad statement such as the "collective weight of evidence". THIS is what I mean by "straw men." You create arguments with yourself by making up what I say.

Where did you imply that? In an unsigned entry following mine of Howard C. Berkowitz 04:25, 14 September 2010 (UTC)
I am surprised and even a bit shocked to hear your assertion that antibiotics are effective for viral and fungal infections,
Obviously, I disagree, because I then listed numerous examples of antimicrobials effective against such infections.
If you want to accuse me of starting fights with myself, I'll simply conclude that one of me will always win. Howard C. Berkowitz 04:38, 15 September 2010 (UTC)


To clarify (again), my point is not that there are no risks to homeopathic treatment. However, IF we wish to highlight that there are certain risks to homeopathic treatment, we also have to acknowledge that it is widely recognized that there are much greater risks from conventional medical treatment. Dana Ullman 03:43, 15 September 2010 (UTC)

Certainly we should say somewhere in the article that there are also risks with other treatments, and that one of the arguments for homeopathy is that many of its remedies are low-risk. However, "it is widely recognized that there are much greater risks from conventional medical treatment" strikes me as something an encyclopedia cannot subscribe to without a lot more evidence.
In any case, I do not think a detailed discussion of risk issues belongs in the lede. I am inclined to thin the lede should raise the question, and in my opinion the current text does that adequately. Sandy Harris 04:12, 15 September 2010 (UTC)
I agree that a detailed discussion is out of place in the lede. If I may, I'll offer a fairly well-established risk of using homeopathic therapy as a first resort: myocardial infarction (heart attack). Assuming there are no contraindications to thrombolytic therapy, the window for optimal benefit from thrombolysis is 3-6 hours after onset, with declining benefit out to 12 hours. Thrombolysis can reverse the damage to the heart muscle if done within the window. I can cite any number of conditions where death can occur in hours or days without definitive therapy--tetanus is one. Of course, the best treatment for tetanus is prevention -- and TDAP and other immunizations are not designed by the principle of similars.
It's one thing to say that homeopathic remedies might be lower-risk in non-emergent situations, but that isn't what is being said. Of course, one could also say "it is widely recognized that there are much greater benefits, in serious conditions, from appropriate conventional therapy." No, appropriate conventional therapy does not, as been charged, extend to antibiotics for uncomplicated otitis media. Howard C. Berkowitz 04:38, 15 September 2010 (UTC)
In due respect, no one (!) has said or suggested that homeopathic medicines should be a treatment of first resort for heart attacks. THIS is what I mean by my concern for your tendency to create fights/arguments. Let's both avoid creating straw men. That said, I agree with Sandy that the lede should not have a detailed discussion of risks issues, though I would think that we might all agree that it is widely recognized that homeopathic medicines themselves are "basically safe." Also, can I ask us all to try to avoid inserting our own comments within the comments of other writers because it makes it challenging for people to determine who is saying what. Thanx. Dana Ullman 16:51, 19 September 2010 (UTC)
If it's alternative medicine, then it is the first resort. If it's complementary medicine, then there should be guidelines for the scope of practice of homeopathy. In the past, however, Ramanand has said homeopathy should be a first reatment for all manner of conditions. There was an extensive argument about acute asthmatic attacks, which, as I remember,
I am not creating a straw man. Please document when homeopathy should not be the treatment of first resort. Otherwise, I'll assume alternative medicine with no limitations.
Let me clarify my position. I would tend to say that homeopathic medications, themselves, are basically safe. I am very concerned that homeopathy, as a system of treatment, can be as deadly dangerous as a non-surgeon trying an advanced surgical procedure. You have yet to give information that documents what limitations homeopaths accept.
Please stop with the straw man accusations. I do not believe that any consensus is possible between alternative (i.e., not complementary) medicine and coventional medicine. Actually, I'd be far more likely to consult a shamanic healer than a homeopath, as there's a fair bit of documentation that shamans have a good understanding of psychosomatic medicine. I don't know what consensus could exist between someone that rejects the idea of treating the pathogens of infectious disease, and someone that has an understanding of modern microbiology. We, sir, are not on the same side and will not be. Howard C. Berkowitz 17:24, 19 September 2010 (UTC)

Rest of article

Further evidence of the strong POV and non-encyclopedic tone of this Draft is:

--under OVERVIEW: The first two sentences are “attack sentence.” It is clearly inappropriate to provide critique of a subject before adequately describing it FIRST. Those sentences must be removed or placed elsewhere.

I'd say at least the entire first paragraph and probably the whole "Overview" section should be deleted. None of it is real overview of the field. Sandy Harris 03:50, 14 September 2010 (UTC)
I agree with Sandy. There is no need for this "Overview" section, though I do believe that we need to place some of this information about the status and popularity of homeopathy in a section "Homeopathy in Practice." Dana Ullman 15:45, 14 September 2010 (UTC)

-- under OVERVIEW: Some sentences here are just confusing, especially this one and especially its last phrase: They are interested too in why some studies appear to have positive outcomes—do these reflect real efficacy, or can they be accounted for by flaws in study design or in statistical analysis, or "publication bias"—the tendency for small studies with chance positive outcomes to be published while studies with negative or inconclusive outcomes are not.

-- under HISTORICAL ORIGINS, it is confusing and surprising how or why Paracelsus was described as an “astrologer.” This field was not a primary area of his contributions. Just as the bio for Isaac Newton does not describe him as an astrologer, even though he actually wrote more on THIS subject than on mechanistic physics, we editors here know that Newton’s primary contributions to the modern-day have nothing to do with astrology. Needless to say, people here who want homeopathy to sound “quackish” tend to provide this biased information.

-- under HISTORICAL ORIGINS: Inaccurate information has been provided about the present status of the word “allopathy.” There is a long AND significant modern-day usage of this term by conventional medical organizations, medical schools, and state and national governments. Evidence for this is at: http://en.wikipedia.org/wiki/Talk:Allopathic_medicine (see “Hopping's huge list of links). Clearly, the term “allopathy” is still in extremely common usage, and it is simply inaccurate to say that it isn’t. In this light, Osler’s quote has no meaning here, though it may have a place in the article on “allopathy.”

-- under THE LAW OF SIMILARS: As much as I like the subject of “hormesis,” I do not associate its application with the law of similars nor do I know any reference to that. As such, the word “hormesis” has no place in THIS section. We could replace this word, hormesis, with the word “pheromones” because these substances are known to have a powerful effect in extremely small doses AND it is widely known that pheromones from one species are only sensed by those of a “similar” species.

-- under CLINICAL TRIALS TESTING THE EFFICACY… There are many sentences and paragraphs here that I could recommend changes, but I will emphasize those that are most important or most incorrect:

I recommend removal of the following short paragraph & its accompanying quote.

While many of these have indicated positive effects, generally, trials that are larger high-quality trials have tended to show little or no statistically significant effects, as was concluded by the authors of the second Lancet study cited above when they re-analyzed these trials.
“There is increasing evidence that more rigorous trials tend to yield less optimistic results than trials with less precautions against bias.”[98]

My explanation: First, the quote does not verify the sentence it is supposed to substantiate. Second, the article it quotes also asserts that it is a general finding in ALL clinical research that the higher quality trials tend to show less positive results. Third, the fact of the matter is that there are many high quality trials published in “high impact” journals that have shown statistically significant effects, including the four trials by Reilly, et al, the four trials on the treatment of influenza using Oscillococcinum, and the three trials on childhood diarrhea by Jacobs, et al.

We need to be careful in our review of research to avoid skewing the facts with “fudge” words. For instance, one could say that the “collective evidence” of the thousands of studies conducted by Thomas Edison was that electricity was not possible (because only ONE experiment in 1,000+ worked).

The challenge that we have in describing the efficacy (or lack of it) using homeopathic medicines is that we have to evaluate internal validity (how “high quality” were the trials?) AND external validity (is the specific medicine tested commonly used by homeopaths to treat people with that specific condition?). Skeptics of homeopathy tend to evaluate the internal validity issues and totally ignore the external validity issues…and BOTH are essential. To ignore external validity is akin to saying that antibiotics do not work for infections because the “collective weight” of studies on viral, fungal, and bacterial infection shows that these drugs do not work for this common group of diseases. Get it?

No. I don't get it, because I can demonstrate, in vivo and in vitro, that antibiotics do work for viral, fungal and bacterial infections. This is hand-waving and hardly encyclopedic.
I have repeatedly challenged you to respond to why homeopaths seem uninterested in the sort of trials used for customized pharmacogenomic medicine, which do have internal and external validity, and never have gotten an answer. Howard C. Berkowitz 04:25, 14 September 2010 (UTC)
I am surprised and even a bit shocked to hear your assertion that antibiotics are effective for viral and fungal infections, but I have no interest in arguing with you about these subjects here, though these strange assertions may influence your credibility with others. I take much more seriously your unfounded assertion that homeopaths are not interested in research that has internal and external validity. What is your evidence here?
Shocked? Now, if you are holding to the generally obsolete assertion that antibiotics are purely natural products, that's one thing. Let's see...viral? Neuraminidase inhibitors for influenza (as well as the older amantadine and rimantidine), ribavirin for Lassa fever and possibly other hemorrhagic fevers, protease inhibitors (as part of HAART) in lowering HIV levels...well, interferons might or might not be considered antibiotics, but have distinct roles in treating viral diseases. Fungal? Amphotericin B (amphotericin B lipid complex, amphotericin B cholesteryl sulfate, and liposomal amphotericin B); the conazole series; griseofulvin; flucytosine -- and that's not considering topical-only agents. Howard C. Berkowitz 17:07, 14 September 2010 (UTC)
Howard, you're missing my point here. My point is that one must be careful using the term "weight of evidence" because such terms group together various disparate treatments for various disparate conditions. Although I used the term "antibiotics," perhaps I should have used a name of a specific antibiotic, thereby showing that it may be effective for one type of infection but not for "all types" of infection. Likewise, testing homeopathic Arnica for one ailment may prove efficacious, but testing it for two other ailments might show that it is ineffective. One should not say that the "weight of evidence" is that Arnica is not effective. Instead, it is more accurate to say that Arnica is effective one condition but ineffective for two others. Get it now? I hope so...
My intention is not to "fight." My intention is for us to work together to provide verifable accuracy. Dana Ullman 22:37, 14 September 2010 (UTC)
Now I am confused. When you challenged fungi and viruses, it seemed you were challenging the existence of antimicrobial agents (a better term than antibiotic) for those organisms. I gave counterexamples.
No person with reasonable competence in infectious disease suggests there exists Panaceamycin, good for everything, any more than, presumably, Arnica is good for everything. Antimicrobial agents have reasonably well defined spectra, but, since they are directed against mutable living organisms, any competent hospital has a table ("antibiotogram") of the preferred agents for community-acquired and hospital-acquired infections in that locality.
Now, does the "weight of evidence" support appropriate antibiotic use? Yes! "Appropriate" does not include using antibiotics for self-limiting conditions unlikely to be affected by any antibiotic. Appropriate means considering the overall clinical picture -- sounds like the argument you make about syndromes -- such as not using penicillin G for exquisitely penicillin-sensitive streptococci, if the culture shows coinfection with Staphylococcus aureus or other penicillinase-secreting organism. One has to consider potential development of resistance, as well as the practical means of administration--if there is no one qualified to inject a parenteral antibiotic in home care, the antibiotic is irrelevant no matter how effective it may be against the organism. If there's a choice in a patient with a hearing loss, you avoid the especially ototoxic aminoglycosides.
Incidentally, I was just scratching the cognitive process in determining how to treat an infection. Howard C. Berkowitz 03:03, 15 September 2010 (UTC)
Just as doing double-blind and placebo controlled research testing surgical procedures have their methodological and ethical challenges, research on homeopathy has to be sensitive to the method itself. You cannot just test a homeopathic medicine and its effects on a bacteria in a petrie dish, nor can I test acupuncture by putting a needle in a petric dish full of bacteria. You've been told this many times in the past, and yet, you repeatedly feign ignorance about homeopathy and homeopathic research. Please...you're a smart guy. Let's discuss research that does exist. Dana Ullman 15:59, 14 September 2010 (UTC)
I repeat: there are usable methods that have been described for pharmacogenetic medicine. Let the clinician diagnose the individual treatment and send orders for it to the pharmacy. The pharmacy breaks the blinding code and dispenses either the ordered individual treatment or the control arm, the latter which may or may not be placebo. The safety committee monitors, and, assuming the study goes to completion, statistically evaluates the hypothesis that the experimental treatment arm is superior to control.
Incidentally, the piece of laboratory glassware is a Petri dish. If, however, you are referring to bacterial sensitivity testing, production tends to be done with radiochemistry, radioimmune reactions, or immunofluorescence. Consider me dumb since I don't know I'm feigning ignorance about homeopathy. Howard C. Berkowitz 17:07, 14 September 2010 (UTC)
"I've been told"...but by someone I find plausible? You have yet to answer my question about the cognitive process of a homeopathic session, claiming that only a homeopath can understand it, yet no medical discipline makes such a claim of inner mysteries. Howard C. Berkowitz 17:07, 14 September 2010 (UTC)
Howard, I am perfectly able to describe the cognitive process of a homeopath, but I don't think THAT has a place here. I've told you this before (many times!), and yet, you repeated request it. I'm writing this again because it seems that you don't want to remember. Sadly, you consistently seem to want to pick a fight, and you make these strange claims about homeopathy and homeopaths without evidence. To me, it just seems that you have a chip on the shoulder. I have no problems with you making verifiable statements or asking questions, but I do have a problem with you creating boogey-men when none exist.
I will say this: homeopaths usually prescribe their medicines for the overall "syndrome" of the patient, not just their "disease." Dana Ullman 22:46, 14 September 2010 (UTC)
I keep repeating it because you keep refusing to answer it, which I remember very well. Apparently, homeopathy is unique among healing arts and health sciences in not addressing cognition in practitioners.
I suppose that if I can't do better than century-old immunology and pronouncements that regardless of the molecular pharmacology that went into developing a drug, our old buddy similars might be the real explanation.
Sadly, you consistently want to pick a fight with anyone who doesn't regard homeopathy as the greatest thing for health. Howard C. Berkowitz 23:14, 14 September 2010 (UTC)

--Under GOVERNMENT AND INSTITUTIONAL… -- If we choose to include reference to the Great Britain’s House of Commons’ Science and Technology’s report on homeopathy, we have to make it clear that this report was voted on by an extremely small minority of its members. Of the 14 members, 10 did not consider this issue worthy of voting. Ultimately, a “majority” of only THREE members voted for this anti-homeopathy report. Of these 3 votes, two members were so new to the Committee that they did not attend a single hearing on the subject of homeopathy. The third vote for the “report” came from Evan Harris, a vitriolic antagonist to homeopathy who was not re-elected this year, losing to a 20-something year old political neophyte. Finally, because this report was “advisory” only in nature, the health minister overruled it and didn’t accept its conclusions. If anyone wants to make reference to THIS report, we have to add these important facts. I personally suggest that we do not cover this complicated and inconclusive decisions.

It should also be noted that whoever wrote the above was obviously also aware of these facts and choose not to present them. This type of biased reporting should not have a voice here. Let’s strive for more encyclopedic objectivity. Dana Ullman 01:21, 14 September 2010 (UTC)

Repeated defenses of homeopathy, with nothing more than supposition and coincidences, don't belong here either. In my opinion, Mr. Ullman, you will not regard anything short of an article that gives homeopathy as much credibility as conventional medicine as acceptable -- and that, sir, is a promo. Howard C. Berkowitz 04:25, 14 September 2010 (UTC)

Logical fallacies

Take the proposed statement "Advocates assert that the homeopathic “principle of similars” is, in part, the basis for modern day immunizations, allergy treatments, and select other conventional treatments (ie, the use of Ritalin and other amphetamine-like drugs used to treat hyperactive children), while critics have compared it to sympathetic magic. "

If anyone used the principle of similars to plan these treatments, there might be a case. I sincerely doubt, however, that this was ever done; the advocates making after-the-fact, observational rather than molecular, correlations that are extremely dubious. Take a modern immunization, especially an acellular one -- it is designed on a molecular basis to produce desired immunoglobulins and other specific substances; similars were not involved in the design. It's rather hard to say that "similars" is a better explanation than what the molecular pharmacologists intended, and can demonstrate.

Are there homeopathic provings that demonstrate that large doses of cromolyns cause basophil and mast cell degranulation? If not, the molecular explanation that they desensitize the granules, and in turn block the release of histamine and other inflammatory messengers, is a much better shave with Occam's Razor.

I hope we do not have as lengthy a debate on the Tooth Fairy, especially from advocates that are America's leading spokesman for tooth fairies and thus have a financial conflict of interest. Howard C. Berkowitz 01:57, 14 September 2010 (UTC)

Just to throw yet another bit of reality, the use of amphetamine-like drugs, as well as non-amphetamine drugs such as Strattera, for attention deficit disorder — not limited to children — and not discussing other psychotropic drugs is, to put it mildly, showing selection bias. There's as much evidence of neurotransmitter effects than of "similars". Further, if one were to generalize to other psychotropic drugs, one couldn't use the principles of similars to produce hypomania in a normal control. It has repeatedly been demonstrated that lithium carbonate, for example, is not euphoriant. In high doses, it's a depressant -- remarkably so, since the subject will be dead. Howard C. Berkowitz 04:25, 14 September 2010 (UTC)
We cite in this article a quote from Emil Adolph von Behring (the "father of immunology") who asserts, "In spite of all scientific speculations and experiments regarding smallpox vaccination, Jenner’s discovery remained an erratic blocking medicine, till the biochemically thinking Pasteur, devoid of all medical classroom knowledge, traced the origin of this therapeutic block to a principle which cannot better be characterized than by Hahnemann’s word: homeopathic." Whether physicians today (or yesterday) refuse to believe that the "principle of similars" is utilized in medicine, it still can be asserted that they are consciously or subconsciously utilizing it. This is NOT to say that ALL drugs are prescribed by this principle (Howard creates a straw man argument with his reference to lithium carbonate). Further, just because there are other explanations for how or why Ritalin works does not take away the fact that the "similars" principle may also be at play. Dana Ullman 16:14, 14 September 2010 (UTC)
Ah yes. von Behring. 1901 Nobel Prize for 19th century work. Got some authoritative immunology less than a century old? Maybe someone that knew about immunoglobulins?
"It can be asserted" and "just because there are other explanations" doesn't support similars, any more than the Illuminati might be responsible for all evil in international relations. "Might" isn't encyclopedic.
Actually, I prefer the wicker man to the straw man.
I'm disgusted, but I will not give up because the integrity of CZ means something to me. To stop responding to handwaving would be to give in to the stamina of homeopathic advocates.
You were the one that brought up various drugs. I added lithium carbonate as one example. How is it a straw man? In therapeutic doses, it has no effect on non-hypomanic patients. Easy to call things straw men when you don't like them, and drop back to "it can be asserted." The capability of assertion does not make for encyclopedic quality. Howard C. Berkowitz 17:16, 14 September 2010 (UTC)

Regarding 'point of view'

No "point-of-view" disparagement required for conclusions/inferences drawn from science. Any such disparagement itself reflects "point-of-view". The lede as it reads now reflects medical science's judgment of homeopathy. Personally, as a scientist, I consider an open mind a virtue, but I try not to have it so open my skeptical inquirer falls out. Anthony.Sebastian 03:16, 14 September 2010 (UTC)

As I've suggested, we have to face the issue that the two advocates appear not to want the general judgment to appear, unless it is immediately accompanied by a Seinfeld-like "but that's OK, and homeopathy works." Howard C. Berkowitz 04:25, 14 September 2010 (UTC)

Biology-Health Sciences Editor ruling needed

Immunology clearly falls into these fields, not Healing Arts. I contend that it is ludicrous for this article to be using von Behring as a source of authority. It's fair enough to mention a 1901 Nobel Prize winner in a historic context, but a ruling is needed if his statements on homeopathy and immunotherapy can be used as substantiation for plausible modes of immune response. Immunology has progressed a bit in over a century.

It's futile to argue this with Mr. Ullman, and I believe we have enough relevant Editors to settle this point. Howard C. Berkowitz 18:35, 14 September 2010 (UTC)

Agreed (sorry for butting in). (Chunbum Park 09:56, 15 September 2010 (UTC))
Don't feel sorry, Chunbum, your particpation and opinion is a valued part of the decision process.
This appears to be a bigger issue than homeopathy. It appears that you are asking to limit an editor on an article. We don't have a mechanism for that. We've really left that to the devices of other editors to challenge unusual statements by other editors. I would expect that even Dana would appreciate a immunologist's input, but regardless, they'd both still need resources to cite. I'm not sure that a Health Sciences Editor can overrule a Healing Arts editor on an article, but he can certainly challenge anything that counters his beliefs. I would think the EC or EiC would have to rule on something like that. Of course, that would be the Managing Editor should the new charter take effect. D. Matt Innis 12:59, 15 September 2010 (UTC)
That's much what I was thinking. To take a parallel example relevant to Howard, the article on the Iraq War might, and in my view should, discuss the question of its legality. But I don't suppose the article is affiliated to the Law Workgroup. So what happens with a hypothetical conflict between, say, Howard and a law editor on that question? I think the new EC has to think about the whole system here, not just leave it to the ME to invent precedents. Peter Jackson 15:03, 15 September 2010 (UTC)
Perfect example, Peter. The new charter should allow the new ME to make a decision on the fly based on ample input from everyone (especially editors) and then the EC can take its time to review the ME decision and either overrule it or support it. Hopefully, that will develop a sort of "case law" that eventually develop into policy based on a democratically expert debated concepts rather than customary consensus. Meanwhile, authors will be able to move on to different content while the decision is reached elsewhere. D. Matt Innis

(undent) All of you make good points, but the specific may be a little easier. If I were to state the problem in EC terms, it is that different disciplines acquire knowledge at different rates. Were this, for example, a Literature article, Oscar Wilde or G. B. Shaw's comments would be relevant. If this were aviation engineering, however, I think it is relatively obvious that Orville and Wilbur Wright's commentary would not be very relevant to an Airbus (most recent model) or Boeing 787 Dreamliner. While I've often wondered how a classic military genius such as Belisarius would do with airmobile forces, he'd have a bit of catching up.

Von Behring, and indeed Hahnemann, were giants in their time. Today, however, von Behring wouldn't know how to find his way to the protein sequencer or the molecular visualization workstation.

The policy, therefore, might say that to cite an authority as more than a historic point, that authority has to be reasonably familiar with current concepts. It may be even faster now, but, a few years ago, based on MEDLINE growth, the amount of information in health sciences doubled every seven years. Some fields, such as molecular pharmacology, went from nonexistent to major disciplines. There's not going to be a citation that "Von Behring is obsolete", but that's a reasonable inference.

Peter, I would be absolutely delighted to have an article on the legality of the Iraq War. The article is not now affiliated with law, or several other relevant workgroups, due to the three workgroup limit. In doing the main draft of these articles, I had quite enough to do with the "what" and "how" without getting into the just war theory or international law. I would be happy, over an appropriate beverage, to discuss what I personally consider to be vague language in the UN Charter.

Unquestionably, Matt, workgroups need to be revised. I have been doing some experimentation with subgroups, but they are not a sole answer. Howard C. Berkowitz 17:19, 15 September 2010 (UTC)

I think the word "ruling" in the section title is an error. Certainly comment, or even contributions, from those editors would be useful and (I assume) welcomed by all concerned, but I do not think they have the authority to rule here.
The paragraph quoting von Behrig starts "Scientists and medical doctors today do not think that the principle of similars is generally true or useful, and they explain the efficacy of vaccination without referring to it. Physicians of the 19th century however did consider that the principle could be valuable." That strikes me as fair. Given that context-creating text, I see no objection to the von B quote.
As I see it, there are serious issues with this article, and Howard is right about most of them. However, on this particular point, I see him as tilting at a windmill. Sandy Harris 02:52, 16 September 2010 (UTC)
One never knows...the windmills might be giants. Seriously, I really don't have a problem with historical quotes in historical contexts. Such contexts, though, would include both Osler's preference for 19th century homeopathy over 19th century allopathy, and his later statement that both allopathy (as used at the time) and homeopathy were both "cults" that needed to be replaced by scientific medicine.
Recent comments on this talk page, however:

Whether physicians today (or yesterday) refuse to believe that the "principle of similars" is utilized in medicine, it still can be asserted that they are consciously or subconsciously utilizing it. This is NOT to say that ALL drugs are prescribed by this principle (Howard creates a straw man argument with his reference to lithium carbonate). Further, just because there are other explanations for how or why Ritalin works does not take away the fact that the "similars" principle may also be at play. Dana Ullman 16:14, 14 September 2010 (UTC)

made me concerned that advocate(s) wanted to reintroduce the von B quote without the qualifiers, and suggesting that similars are the mechanism of medical immunization. That is not acceptable and is flatly wrong. I suspect that some of the molecular immunologists building acellular vaccines may never have heard of similars and certainly aren't designing with that principle, rather than protein structure-activity.
Lithium carbonate is hardly a straw man, as its activity would not be demonstrated in a proving on a non-hypomanic individual, only toxic effects in high doses. When things demonstate exceptions to basic concepts such as similars and proving, they become significant negative data. "It can be asserted" is hardly encyclopedic, thinking of the classic assertion that if my aunt had testicles, she'd be my uncle.--Howard C. Berkowitz 04:33, 17 September 2010 (UTC)

Howard C. Berkowitz 04:26, 17 September 2010 (UTC)

Followup on Anthony's comment about alternative medicine

While I agree with your addition, I wonder if it goes far enough. Complementary and alternative medicine, while often grouped together, are not the same. Alternative medicine, to use NCCAM's definition, is a substitute for conventional medicine, while complementary medicine can be integrated with conventional medicine. Rather by definition, alternative medicine will not agree with conventional medicine, and never the twain shall meet.

It's not implausible that there could be complementary homeopathy, but I find it interesting that the article really doesn't address it. At best, there are arguments that homeopathy is superior to conventional methods for specific disorders. There's some hand-waving that conventional physicians use homeopathic remedies in their practice, but no discussion of the indications and rationale for doing so. In other articles, there is discussion of the complemntary use of acupuncture, chiropractic, etc.

Whether or not homeopathy is CAM rather than AM, this article overwhelmingly treats it as AM. Howard C. Berkowitz 21:50, 14 September 2010 (UTC)

Howard, I took a long rest from this article, and it seems that you would really benefit from doing so too. I realize that by saying this you may now want to edit more often than ever. My concern is that you are beginning to lash out at me and at this subject in an extremely emotional way. It seems that you are no longer trying to create an encyclopedic article but one that pushes your POV which remain inadequately informed about this subject of homeopathy. Heck, even when Dr. J sought to reach out to Sandy and be friendly, rather than adverserial, Sandy told him that he wasn't interested. That's OK too...and Dr. J didn't seek to connect personally. Let's not make this effort by Dr. J to be as "bad" as you've tried to make it. Dana Ullman 22:54, 14 September 2010 (UTC)
Well, gee. I've been discovered: my whole motivation is attacking homeopathy, and I never, ever contribute to anything else at Citizendium. Obviously, New Delhi metallo-beta-lactamase-1 enzyme is just an attack on homeopathy, as is CZ: Pacific War Subgroup, as is (quite friendly) collaboration on opportunistic encryption.
Why is this in a subsection where I was addressing the complementary and alternative aspects of homeopathy? That was hardly emotional. I neither need nor want your advice or concern on what I should do.
It is adversarial. Deal with it. Mortality & Morbidity conferences, military After-Action Reviews, engineering design reviews, etc., benefit from an adversarial approach.
As far as I can tell, your definition of "adequately informed" is to accept homeopathy. The Ormus article hurt Citizendium, and I am convinced that homeopathy does as well. I do know that I have had people refuse to join CZ specifically due to the homeopathy article. I'll believe you want to be encyclopedic when I see you contribute to things other than a single issue.
If I get extremely emotional about something, I tend to be more quiet, and perhaps smile a lot. Howard C. Berkowitz 23:07, 14 September 2010 (UTC)

Encyclopedia Britannica Online: Homeopathy lede

Possibly of interest:

"Homeopathy"

"a system of therapeutics, notably popular in the 19th century, which was founded on the stated principle that “like cures like,” similia similibus curantur, and which prescribed for patients drugs or other treatments that would produce in healthy persons symptoms of the diseases being treated."

"This system of therapeutics based upon the “law of similars” was introduced in 1796 by the German physician Samuel Hahnemann. He claimed that a large dose of quinine, which had been widely used for the successful treatment of malaria, produced in him effects similar to the symptoms of malaria patients. He thus concluded that all diseases were best treated by drugs that produced in healthy persons effects similar to the symptoms of those diseases. He also undertook experiments with a variety of drugs in an effort to prove this. Hahnemann believed that large doses of drugs aggravate illness and that the efficacy of medicines thus increases with dilution. Accordingly, most homeopathists believed in the action of minute doses of medicine."

"To many patients and some physicians, homeopathy was a mild, welcome alternative to bleeding, purging, polypharmacy, and other heavy-handed therapies of the day. In the 20th century, however, homeopathy has been viewed with little favour and has been criticized for focusing on the symptoms rather than on the underlying causes of disease. Homeopathy still has some adherents, and there are a number of national and international societies, including the International Homoeopathic Medical League, headquartered in Bloemendaal, Neth."

http://www.britannica.com/EBchecked/topic/270182/homeopathy

Anthony.Sebastian 03:27, 16 September 2010 (UTC)

The first two paragraphs, I hope, are not controversial. The talk page controversy, however, has significantly involved both homeopathic attempts to claim medical logic, as well as a broader assumption, by the homeopathy advocates, that homeopathy needs to be regarded as having equal credibility to conventional medicine. Attempts to claim that the principle of similars is the underlying mechanism for medical treatments developed, or validated, using methods of molecular pharmacology fall under my first point. Closely coupled is the homeopathic argument that homeopathy mimics body defenses manifested as symptoms, when the actual defense is quite different than the symptom producing factor -- tetanus is a good example, where the defenses are immunoglobins that have no particular symptom-producing quality, but the symptoms of spasticity and convulsions are caused ("indirectly") by the exotoxin of Clostridium tetani and can be lethal. The defenses neutralize the toxin, and, coupled with antibiotics and surgery, eradicate the source of the toxin.
In other words, there's a refutation of molecular medical arguments, but no molecular explanation of how similars affect the body. Hand-waving about memory of water isn't on the same level as immune reactions that can be demonstrated in vitro and in vivo, or structure-activity interactions with cellular receptors. --Howard C. Berkowitz 23:12, 16 September 2010 (UTC)

"Alternative Medicine and the Laws of Physics"

Of possible interest:

Alternative Medicine and the Laws of Physics

Robert L. Park

Skeptical Inquirer, Volume 21.5, September / October 1997

http://www.csicop.org/si/show/alternative_medicine_and_the_laws_of_physics/

Anthony.Sebastian 03:59, 16 September 2010 (UTC)

Having read the article I feel a neutral way of presenting homeopathy would be something like "it is a type of medicine supported by neither scientific reasoning nor data. that being said this is what homeopaths think: 1, 2, 3." (Chunbum Park 05:40, 16 September 2010 (UTC))
I think that overstates the case. Homeopathy is based on a system that includes reasoning which is at least pseudo-scientific. There is data, though much of it is of dubious quality; in particular, "data" is not the plural of "anecdote". I don't think your text above is neutral in any sense I'd recognise.
The current draft includes "the consensus of medical and scientific opinion is that homeopathy is unfounded." I think that is accurate, neutrally stated, and sufficiently direct.
That said, I do think we should link to highly critical articles such as that one, possibly the rational wiki page, and certainly the lovely cartoon they use. Sandy Harris 07:40, 16 September 2010 (UTC)
See rational wiki's article "Citizendium" first. Anthony.Sebastian 03:57, 17 September 2010 (UTC)

Suggest ending Main Article draft at end of lede

Let reader use Biblio to get further information. Concentrate on thorough Biblio subpage. 06:39, 17 September 2010 (UTC)

I don't think that is an adequate approach for an encyclopedia. We want a reasonably detailed explanation here. That said, the article could likely be shortened significantly without losing anything valuable. Sandy Harris 12:14, 17 September 2010 (UTC)
At home much resource cost that could be going into even copy edit of other articles, articles that deal with topics that are likely to have more serious users? I'd wager that a good part of the hit count on this article is due to people at other wikis looking for controversy.
That being said, I'm not sure how feasible it is under present policy. Assume three Health Sciences and Biology Editors are willing to nominate the truncated approach for Approval. Healing Arts Editors say it is not Approvable. It would be one thing for a Mathematics Editor to question approval for a cryptographic topic written by a computers person, but we've gotten through effective collaboration among, say, Computers, Mathematics, and Military. Health Sciences and Healing Arts, among the workgroups, are the only case where we have different workgroups for fundamentally different views on the same subject area. It's a bug, not a feature; we don't have separate-but-equal Religion and Atheism workgroups. Howard C. Berkowitz 15:53, 17 September 2010 (UTC)

Definition

The current definition reads "System of alternative medicine that asserts — contrary to scientific evidence — that substances known to cause specific syndromes of symptoms can also, in very low and specially prepared doses, help to cure people who are ill with a similar syndrome of symptoms." I think that is a moderately awful definition. The problems I see are:

The "contrary to scientific evidence" bit, or similar text, has been added at least twice and reverted at least once. I don't think it belongs in the definition.
"syndrome of symptoms" is used twice. That's ghastly stylistically, "syndrome" is a technical medical term that may not belong here, and in any case, I suspect "syndrome of symptoms" is redundant. What else could you have a syndrome of? Or does a syndrome include more than just symptoms?

My version would be: A system of alternate medicine based on the idea that substances known to cause particular combinations of symptoms can, in very low and specially prepared doses, help to cure people who are ill with similar symptoms. (sig added later Sandy Harris 23:14, 17 September 2010 (UTC))

""Syndrome of sympoms", indeed, is ghastly. Unfortunately, it touches on a difference between homeopathic and current medical thinking that is as important as similars. Modern physicians look first for an etiological diagnosis: what is the cause of the patient's distress? (Note here that "symptom" is being used in a lay sense here -- there are differences of theory as well). Homeopaths consider that the "disease model", not patient-centric, and often reject a causality-based approach. Their focus is on the products of the cause (in medical thinking) or the body wisdom expressing its defenses.

A better wording would be welcome, but the rejection of etiologic thinking, and the focus on similars as a means of reducing symptoms, is fundamental. Howard C. Berkowitz 15:53, 17 September 2010 (UTC)

Sandy's version:

  • A system of alternate medicine based on the idea that substances known to cause particular combinations of symptoms can, in very low and specially prepared doses, help to cure people who are ill with similar symptoms.


My understanding:

  • A system of alternate medicine based on the idea that large dosages of substances known to cause particular combinations of symptoms in healthy individuals can, in very low and specially prepared doses, help to cure a person whose illness causes similar symptoms.

D. Matt Innis 21:49, 17 September 2010 (UTC)

I am quite willing to be corrected here, but I think the idea of an illness that creates similar symptoms is still too close to an etiologic model of disease to be accepted by homeopaths. While I don't have better words, my sense is they would say the symptoms are produced by the "wisdom of the body" as "defenses" and the remedies strengthen the defenses. --Howard C. Berkowitz 23:59, 17 September 2010 (UTC)


That could be the next sentence.


  • A system of alternate medicine based on the idea that large dosages of substances known to cause particular combinations of symptoms in healthy individuals can, in very low and specially prepared doses, help to cure a person whose illness causes similar symptoms. In essence, they believe that symptoms are produced by the "wisdom of the body" as "defenses" and homeopathic remedies are designed to strengthen those defenses.
D. Matt Innis 03:22, 18 September 2010 (UTC)
Add: They do not use the disease model of conventional medicine, in which there is a disease rather than an individual set of symptoms, and treatment directed at a cause of that disease as it presents in multiple patients. Howard C. Berkowitz 03:29, 18 September 2010 (UTC)
More work:
  • This contrasts with conventional medicine's "disease model" of treatment that looks to treat the disease process and therefore relieve the symptoms.
I'm not sure that's totally true, though. Many conventional treatments are directed at relieving symptoms, too.
D. Matt Innis 03:54, 18 September 2010 (UTC)

(edit conflict) (undent) There's a different philosophy in symptomatic treatment. If I sprained my ankle badly enough to need surgical repair, the cause would be relevant to a conventional orthopedist who needs to work on the damaged structures. Otherwise, the exact ligament stretch might be known, but it's not of therapeutic benefit. Symptomatic pain relief is the first consideration -- yes, rehabilitation may focus on exact etiology, but, for the sake of argument, assume it's self-limiting.

Sometimes, as with uncomplicated childhood otitis media, even if it is bacterial, antibiotic therapy may not be justified. Presumably, though, the child can still get acetaminophen.

In both of the cases above, there was awareness of an etiology, but a choice to treat only symptoms. Palliative care is often largely but not exclusively symptomatic -- still, an etiology would be necessary for chemotherapy or radiotherapy to slow the growth of an incurable tumor. Pain management, though, is symptomatic and even more important. Where does nursing care fit?

The homeopaths, however, appear to exclude the idea of treatment based on etiology, as opposed to symptom relief when the cause is either self-limiting or not treatable. I spend hours daily giving comfort care to my cat buddy, relatively little of which is directed at the cancer itself, but much more in nutrition, emotional support and wound care. Indeed, I am using some complementary medicine along with a lot more conventional things. Homeopathic ideas of symptom-oriented remedies don't enter into it. --Howard C. Berkowitz 04:28, 18 September 2010 (UTC)

I don't think either that long definitions are a good idea in general, or that the proposed "next sentences" are needed in this definition. In the article, certainly; in the lede, probably. However, the definition needs to be short and direct. In particular, it needs to be short enough to look reasonable when cited on a related articles page. Sandy Harris 04:46, 18 September 2010 (UTC)
If the definition is to be short, then, I believe the rejection of etiology is far, far more significant to homeopathy than the better-known issues of small doses. It appears to me that Hahnemann's insight dealt with symptoms being the essential manifestation of health or not-health, and only then did he go to the idea of provings and similars. My understanding is that his using provings for malaria had to do with the symptom production of quinine.
Absolutely, I forgot that we were working on the definition! You're right, Sandy. D. Matt Innis 21:27, 18 September 2010 (UTC)
I believe there's a comment on this page, from a homeopath, that homeopathic remedies are not always administered in homeopathic femtodoses.
The rejection of etiology is also key to much of the dispute with medicine, as I mentioned in terms of clinical trials. It is also, however, central to the medical rejection of some homeopathic approaches, such as the principal treatment for malaria being based on reducing Plasmodium parasites in the blood. Quinine remains a third-line drug for malaria, but its action in reducing fever and chills is due to its ability to suppress the parasites, not (in a medical view) what effects are caused by high doses of quinine. Howard C. Berkowitz 04:56, 18 September 2010 (UTC)
Quinine remains a third-line drug for malaria, but its action in reducing fever and chills is due to its ability to suppress the parasites, not (in a medical view) what effects are caused by high doses of quinine.
I think that's the point; it's not that homeopath's don't care about etiology, they just don't concern themselves with it. If it causes the same symptoms in a normal person, then it's used to treat the person that has those same symptoms, regardless of the cause. As you say, they might contend that the plasmodium is not what causes the symptoms, rather the symptoms are the body's response to plasmodium. To them it doesn't matter. D. Matt Innis 21:28, 18 September 2010 (UTC)
As my grandmother might have said, ah-HAH! Admittedly, I'm taking the example of the worst form of malaria, but a patient presenting with the cerebral form of Plasmodium falciparum malaria may well die in 18 hours. In general, the standard of medical care would be artemisinin-based combination therapy, with critical care support for effects such as acute respiratory distress syndrome or disseminated intravascular coagulation.
Quinine, in substantial doses and in combination with doxycycline, tetracycline, or clindamycin, be lifesaving. If I were the patient, however, and someone offered me homeopathic oral doses of oral quinine, I'd prefer a lethal dose of barbiturates, or a large-caliber bullet to the back of the neck (messy but fast).
Now, I'd have every respect for a complementary homeopath that suspected severe falciparum malaria, and immediately transferred the patient to medical care. Assuming such care were available, I'd regard an alternative practitioner as having, as the lawyers put it, depraved indifference for human life.. Howard C. Berkowitz 22:02, 18 September 2010 (UTC)
I suspect the cerebral form would have different symptoms, therefore different remedies as well. A bullet is probably not one of them. ;-) D. Matt Innis 23:40, 19 September 2010 (UTC)
Are you doubting the efficacy of a .45 caliber ACP 254-grain round, which is lead in a hardly homeopathic dose? Nevertheless, if I had cerebral P. falciparum malaria, I know that active medical treatment is still very iffy. Seriously, we have the problem of any validation here; I cannot imagine an ethics review board that would approve any treatment for such a life-threatening disease without overwhelming laboratory evidence for the control arm. Howard C. Berkowitz 22:21, 20 September 2010 (UTC)

Sandy's edit to the definition

...specifically "help to cure or prevent illnesses involving similar symptoms." While a homeopath will have to review this, I don't think "illnesses involving similar symptoms" is really a homeopathic concept. They certainly object to "diseases with similar symptoms", and tend to reject "disease" as a medical conceit. The symptoms are signals of the body's defenses to be strengthened, not the effects of a causative factor. Howard C. Berkowitz 04:59, 18 September 2010 (UTC)

I think you're splitting hairs, but, yes, let's hear from a homeopath on this. D. Matt Innis 21:27, 18 September 2010 (UTC)
Sandy's new definition is definitely an improvement. D. Matt Innis 21:32, 18 September 2010 (UTC)
Li'l hard pressed for time. I'm happy with Alexander's definition, but if you guys feel it needs to be simpler, I have a 'simpler definition', which would read:-

(Homeopathy is) an alternative system of medicine, which stimulates the natural healing processes of the body (with the help of sub-physiological doses of a remedy, by using its rebound effect), to restore health (homeostasis) in a sick person.

The matter in brackets is optional.—Ramanand Jhingade 07:36, 19 September 2010 (UTC)
Note that it is alternative medicine and not alternate medicine.—Ramanand Jhingade 07:44, 19 September 2010 (UTC)
Unfortunately, "rebound effect" is not a well-defined term, certainly in medicine, so should not be used in a definition unless it is well defined in an article of its own. The alternate definition depends heavily on homeopathic terminology, such as "natural healing processes", as well as using homeostasis is far broader a context than is used in the biological sciences -- to say nothing amout emerging concepts such as allostasis.
The proposed new definition also overemphasizes the aspect of small doses and does not address the apparent rejection, by homeopathy, of the idea of "disease". Instead, it speaks of "restoring health", without addressing the meaning of the state of non-health.
Please confirm or correct the statement that homeopaths do not believe in the concept of disease, in the sense that disease has an etiologic cause and the cause needs to be corrected. Howard C. Berkowitz 08:30, 19 September 2010 (UTC)
I agree with Howard here, Ramanand, that your version introduces too many vague terms to be considered for use as a one sentence definition. D. Matt Innis 23:44, 19 September 2010 (UTC)

What about

A system of alternative medicine based on the idea of stimulating the body's natural healing processes by administering tiny doses of substances which, when given in large doses to healthy individuals, cause similar combinations of symptoms.

I agree that Ramanand's definition has some problems, and I think the full version is too long, but it seems to me the point about stimulating natural defenses is central. Sandy Harris 03:07, 20 September 2010 (UTC)

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