Hypothyroidism: Difference between revisions
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In [[medicine]], '''hypothyroidism''' is "a syndrome that results from abnormally low secretion of [[thyroid hormone]]s from the [[thyroid gland]], leading to a decrease in [[basal metabolic rate]]. In its most severe form, there is accumulation of mucopolysaccharides in the skin and edema, known as [[myxedema]]."<ref>{{MeSH}}</ref> | In [[medicine]], '''hypothyroidism''' is "a syndrome that results from abnormally low secretion of [[thyroid hormone]]s from the [[thyroid gland]], leading to a decrease in [[basal metabolic rate]]. In its most severe form, there is accumulation of mucopolysaccharides in the skin and edema, known as [[myxedema]]."<ref>{{MeSH}}</ref> | ||
Thyroid stimulating hormone levels of less than 10 may not be important.<ref name="pmid20858880">{{cite journal| author=Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP et al.| title=Subclinical hypothyroidism and the risk of coronary heart disease and mortality. | journal=JAMA | year= 2010 | volume= 304 | issue= 12 | pages= 1365-74 | pmid=20858880 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20858880 | doi=10.1001/jama.2010.1361 }} </ref> | Thyroid stimulating hormone levels of less than 10 may not be important.<ref name="pmid20858880">{{cite journal| author=Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP et al.| title=Subclinical hypothyroidism and the risk of coronary heart disease and mortality. | journal=JAMA | year= 2010 | volume= 304 | issue= 12 | pages= 1365-74 | pmid=20858880 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20858880 | doi=10.1001/jama.2010.1361 }} </ref><ref name="pmid9294788">{{cite journal| author=Canaris GJ, Steiner JF, Ridgway EC| title=Do traditional symptoms of hypothyroidism correlate with biochemical disease? | journal=J Gen Intern Med | year= 1997 | volume= 12 | issue= 9 | pages= 544-50 | pmid=9294788 | doi=10.1046/j.1525-1497.1997.07109.x | pmc=PMC1497160 | url=http://www.springerlink.com/content/3x64358412w63473/ }} </ref> | ||
==Diagnosis== | |||
===Symptoms=== | |||
Symptoms may not be accurate.<ref name="pmid10695693">{{cite journal| author=Canaris GJ, Manowitz NR, Mayor G, Ridgway EC| title=The Colorado thyroid disease prevalence study. | journal=Arch Intern Med | year= 2000 | volume= 160 | issue= 4 | pages= 526-34 | pmid=10695693 | doi= | pmc= | url=http://archinte.ama-assn.org/cgi/content/full/160/4/526 }} </ref> | |||
==Treatment== | ==Treatment== | ||
Forty percent of patients taking thyroid hormone replacement may not have appropriate values of [[thyroid stimulating hormone]] (TSH).<ref name="pmid10695693">{{cite journal| author=Canaris GJ, Manowitz NR, Mayor G, Ridgway EC| title=The Colorado thyroid disease prevalence study. | journal=Arch Intern Med | year= 2000 | volume= 160 | issue= 4 | pages= 526-34 | pmid=10695693 | doi= | pmc= | url=http://archinte.ama-assn.org/cgi/content/full/160/4/526 }} </ref> | |||
Taking replacement hormone at night may be better.<ref name="pmid21149757">{{cite journal| author=Bolk N, Visser TJ, Nijman J, Jongste IJ, Tijssen JG, Berghout A| title=Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial. | journal=Arch Intern Med | year= 2010 | volume= 170 | issue= 22 | pages= 1996-2003 | pmid=21149757 | doi=10.1001/archinternmed.2010.436 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21149757 }} </ref> | Taking replacement hormone at night may be better.<ref name="pmid21149757">{{cite journal| author=Bolk N, Visser TJ, Nijman J, Jongste IJ, Tijssen JG, Berghout A| title=Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial. | journal=Arch Intern Med | year= 2010 | volume= 170 | issue= 22 | pages= 1996-2003 | pmid=21149757 | doi=10.1001/archinternmed.2010.436 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21149757 }} </ref> | ||
==References== | ==References== | ||
<references/> | <references/> | ||
Revision as of 15:17, 27 July 2011
In medicine, hypothyroidism is "a syndrome that results from abnormally low secretion of thyroid hormones from the thyroid gland, leading to a decrease in basal metabolic rate. In its most severe form, there is accumulation of mucopolysaccharides in the skin and edema, known as myxedema."[1]
Thyroid stimulating hormone levels of less than 10 may not be important.[2][3]
Diagnosis
Symptoms
Symptoms may not be accurate.[4]
Treatment
Forty percent of patients taking thyroid hormone replacement may not have appropriate values of thyroid stimulating hormone (TSH).[4]
Taking replacement hormone at night may be better.[5]
References
- ↑ Anonymous (2024), Hypothyroidism (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Rodondi N, den Elzen WP, Bauer DC, Cappola AR, Razvi S, Walsh JP et al. (2010). "Subclinical hypothyroidism and the risk of coronary heart disease and mortality.". JAMA 304 (12): 1365-74. DOI:10.1001/jama.2010.1361. PMID 20858880. Research Blogging.
- ↑ Canaris GJ, Steiner JF, Ridgway EC (1997). "Do traditional symptoms of hypothyroidism correlate with biochemical disease?". J Gen Intern Med 12 (9): 544-50. DOI:10.1046/j.1525-1497.1997.07109.x. PMID 9294788. PMC PMC1497160. Research Blogging.
- ↑ 4.0 4.1 Canaris GJ, Manowitz NR, Mayor G, Ridgway EC (2000). "The Colorado thyroid disease prevalence study.". Arch Intern Med 160 (4): 526-34. PMID 10695693. [e]
- ↑ Bolk N, Visser TJ, Nijman J, Jongste IJ, Tijssen JG, Berghout A (2010). "Effects of evening vs morning levothyroxine intake: a randomized double-blind crossover trial.". Arch Intern Med 170 (22): 1996-2003. DOI:10.1001/archinternmed.2010.436. PMID 21149757. Research Blogging.