United Kingdom Prospective Diabetes Study: Difference between revisions

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In [[health care]], the '''United Kingdom Prospective Diabetes Study''' ('''UKPDS''') is a [[randomized controlled trial]] of the treatment of [[diabetes mellitus type 2]].<ref name="pmid9742976">{{cite journal |author= |title=Intensive  blood-glucose control with sulphonylureas or insulin compared with  conventional treatment and risk of complications in patients with type 2  diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group |journal=Lancet |volume=352 |issue=9131 |pages=837–53 |year=1998 |pmid=9742976 |doi=10.1016/S0140-6736(98)07019-6}} [http://www.acpjc.org/Content/130/1/ISSUE/ACPJC-1999-130-1-002.htm Review by ACP Journal Club]</ref><ref name="pmid9742977">{{cite journal|  author=| title=Effect of intensive blood-glucose control with metformin  on complications in overweight patients with type 2 diabetes (UKPDS  34). UK Prospective Diabetes Study (UKPDS) Group. | journal=Lancet |  year= 1998 | volume= 352 | issue= 9131 | pages= 854-65 | pmid=9742977  
In [[health care]], the '''United Kingdom Prospective Diabetes Study''' ('''UKPDS''') is a [[randomized controlled trial]] of the treatment of [[diabetes mellitus type 2]].<ref name="pmid9742976">{{cite journal |author= |title=Intensive  blood-glucose control with sulphonylureas or insulin compared with  conventional treatment and risk of complications in patients with type 2  diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group |journal=Lancet |volume=352 |issue=9131 |pages=837–53 |year=1998 |pmid=9742976 |doi=10.1016/S0140-6736(98)07019-6}} [http://www.acpjc.org/Content/130/1/ISSUE/ACPJC-1999-130-1-002.htm Review by ACP Journal Club]</ref><ref name="pmid9742977">{{cite journal|  author=| title=Effect of intensive blood-glucose control with metformin  on complications in overweight patients with type 2 diabetes (UKPDS  34). UK Prospective Diabetes Study (UKPDS) Group. | journal=Lancet |  year= 1998 | volume= 352 | issue= 9131 | pages= 854-65 | pmid=9742977  
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=9742977 }}</ref> Long term follow-up after 10 years is available.<ref name="pmid18784090">{{cite journal| author=Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA| title=10-year follow-up of intensive glucose control in type 2 diabetes. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 15 | pages= 1577-89 | pmid=18784090 | doi=10.1056/NEJMoa0806470 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18784090  }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19071870 Review in: ACP J Club. 2008 Dec 16;149(6):4]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19103832 Review in: Evid Based Nurs. 2009 Jan;12(1):14]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19181941 Review in: Evid Based Med. 2009 Feb;14(1):9-10] </ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=9742977 }}</ref> Long term follow-up after 10 years is available.<ref name="pmid18784090">{{cite journal| author=Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA| title=10-year follow-up of intensive glucose control in type 2 diabetes. | journal=N Engl J Med | year= 2008 | volume= 359 | issue= 15 | pages= 1577-89 | pmid=18784090 | doi=10.1056/NEJMoa0806470 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18784090  }}  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19071870 Review in: ACP J Club. 2008 Dec 16;149(6):4]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19103832 Review in: Evid Based Nurs. 2009 Jan;12(1):14]  [http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19181941 Review in: Evid Based Med. 2009 Feb;14(1):9-10] </ref>

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In health care, the United Kingdom Prospective Diabetes Study (UKPDS) is a randomized controlled trial of the treatment of diabetes mellitus type 2.[1][2] Long term follow-up after 10 years is available.[3]

Trial design of the UKPDS 33.
Trial design of the UKPDS 34.

The UKPDS has created a clinical prediction rule.[4][5]

The study's website is at http://www.dtu.ox.ac.uk/ukpds_trial/.

References

  1. ↑ (1998) "Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group". Lancet 352 (9131): 837–53. DOI:10.1016/S0140-6736(98)07019-6. PMID 9742976. Research Blogging. Review by ACP Journal Club
  2. ↑ (1998) "Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group.". Lancet 352 (9131): 854-65. PMID 9742977.
  3. ↑ Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA (2008). "10-year follow-up of intensive glucose control in type 2 diabetes.". N Engl J Med 359 (15): 1577-89. DOI:10.1056/NEJMoa0806470. PMID 18784090. Research Blogging. Review in: ACP J Club. 2008 Dec 16;149(6):4 Review in: Evid Based Nurs. 2009 Jan;12(1):14 Review in: Evid Based Med. 2009 Feb;14(1):9-10
  4. ↑ Stevens RJ, Kothari V, Adler AI, Stratton IM, United Kingdom Prospective Diabetes Study (UKPDS) Group (2001). "The UKPDS risk engine: a model for the risk of coronary heart disease in Type II diabetes (UKPDS 56).". Clin Sci (Lond) 101 (6): 671-9. PMID 11724655. [e]
  5. ↑ UKPDS Risk Engine
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