Beta-2 adrenergic receptor: Difference between revisions
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In [[medicine]] and [[physiology]], '''beta-2 adrenergic receptors''', or '''β-2 adrenergic receptors''', are [[ | {{subpages}} | ||
In [[medicine]] and [[physiology]], '''beta-2 adrenergic receptors''', or '''β-2 adrenergic receptors''', are [[cell surface receptor]]s of the [[G-protein-coupled receptor]] type that are in the [[sympathetic nervous system]]. Beta-2 adrenergic receptors are a "subclass of beta-[[adrenergic receptor]]s (receptors, adrenergic, beta). Beta-2 Adrenergic receptors are more sensitive to [[epinephrine]] than to [[norepinephrine]] and have a high affinity for the agonist [[terbutaline]]. They are widespread, with clinically important roles in skeletal muscle, liver, and vascular, bronchial, gastrointestinal, and genitourinary smooth muscle."<ref name="MeSH-Beta-2">{{MeSH}}</ref> Their functions include ''vasodilation''. | |||
[[Adrenergic | After binding, [[signal transduction]] activates the [[second messenger system]]s adenyl cyclase-[[cyclic AMP]] primarily and also [[cyclic GMP]] which then activates [[protein kinase]]s. | ||
[[Adrenergic beta-agonist]]s, such as [[terbutaline]], are used to treat [[asthma]] by preventing bronchoconstriction. [[Adrenergic beta-antagonist]]s, such as [[atenolol]] or [[metoprolol]] are used to treat cardiac diseases. | |||
==References== | ==References== | ||
{{reflist}} | |||
Latest revision as of 06:58, 14 September 2013
In medicine and physiology, beta-2 adrenergic receptors, or β-2 adrenergic receptors, are cell surface receptors of the G-protein-coupled receptor type that are in the sympathetic nervous system. Beta-2 adrenergic receptors are a "subclass of beta-adrenergic receptors (receptors, adrenergic, beta). Beta-2 Adrenergic receptors are more sensitive to epinephrine than to norepinephrine and have a high affinity for the agonist terbutaline. They are widespread, with clinically important roles in skeletal muscle, liver, and vascular, bronchial, gastrointestinal, and genitourinary smooth muscle."[1] Their functions include vasodilation.
After binding, signal transduction activates the second messenger systems adenyl cyclase-cyclic AMP primarily and also cyclic GMP which then activates protein kinases.
Adrenergic beta-agonists, such as terbutaline, are used to treat asthma by preventing bronchoconstriction. Adrenergic beta-antagonists, such as atenolol or metoprolol are used to treat cardiac diseases.
References
- ↑ Anonymous (2024), Beta-2 adrenergic receptor (English). Medical Subject Headings. U.S. National Library of Medicine.