Thrombophilia: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>Robert Badgett
imported>Robert Badgett
Line 33: Line 33:
[[Habitual abortion]], the occurrence of three or more [[spontaneous abortion]]s may be due to thrombophilia.<ref name="pmid12648968">{{cite journal| author=Rey E, Kahn SR, David M, Shrier I| title=Thrombophilic disorders and fetal loss: a meta-analysis. | journal=Lancet | year= 2003 | volume= 361 | issue= 9361 | pages= 901-8 | pmid=12648968  
[[Habitual abortion]], the occurrence of three or more [[spontaneous abortion]]s may be due to thrombophilia.<ref name="pmid12648968">{{cite journal| author=Rey E, Kahn SR, David M, Shrier I| title=Thrombophilic disorders and fetal loss: a meta-analysis. | journal=Lancet | year= 2003 | volume= 361 | issue= 9361 | pages= 901-8 | pmid=12648968  
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=12648968 | doi=10.1016/S0140-6736(03)12771-7 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=12648968 | doi=10.1016/S0140-6736(03)12771-7 }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>
The benefit of treatment with [[low molecular weight heparin]] is not clear.<ref name="pmid19208560">{{cite journal| author=Laskin CA, Spitzer KA, Clark CA, Crowther MR, Ginsberg JS, Hawker GA et al.| title=Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial. | journal=J Rheumatol | year= 2009 | volume= 36 | issue= 2 | pages= 279-87 | pmid=19208560
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=19208560 | doi=10.3899/jrheum.080763) }} <!--Formatted by http://sumsearch.uthscsa.edu/cite/--></ref>


==References==
==References==
<references/>
<references/>

Revision as of 10:31, 1 November 2009

In hematology, thrombophilia, also called hypercoagulability, is "a disorder of hemostasis in which there is a tendency for the occurrence of thrombosis."[1]

Clinical

Recurrent embolism and thrombosis

For more information, see: Embolism and thrombosis.


Habitual abortion

Thrombophilia and habitual abortion.[2]
  Odds ratio
Early pregnancy loss
(before 13 weeks)
Late pregnancy loss
Factor V Leiden 2.01 (95% CI 1.13-3.58) 7.83 (95% CI 2.83-21.67)
Prothrombin G20210A 2.56 (95% CI 1.04-.29) 2.30 (95% CI 1.09-4.87)
(non-recurrent)
Protein C deficiency No association
Activated protein C resistance 3.48 (95% CI 1.58-7.69)
Protein S deficiency   7.39 (95% CI 1.28-42.63)
(nonrecurrent)
Methylenetetrahydrofolate mutation No association
Antithrombin deficiencies No association

Thrombophilia have an increased risk of fetal loss, especially stillbirth after 28 weeks of gestation as opposed to miscarriage (spontaneous abortion) before 28 weeks of gestation[3]

Habitual abortion, the occurrence of three or more spontaneous abortions may be due to thrombophilia.[2]

The benefit of treatment with low molecular weight heparin is not clear.[4]

References

  1. Anonymous (2024), Thrombophilia (English). Medical Subject Headings. U.S. National Library of Medicine.
  2. 2.0 2.1 Rey E, Kahn SR, David M, Shrier I (2003). "Thrombophilic disorders and fetal loss: a meta-analysis.". Lancet 361 (9361): 901-8. DOI:10.1016/S0140-6736(03)12771-7. PMID 12648968. Research Blogging.
  3. Preston FE, Rosendaal FR, Walker ID, Briët E, Berntorp E, Conard J et al. (1996). "Increased fetal loss in women with heritable thrombophilia.". Lancet 348 (9032): 913-6. PMID 8843809.
  4. Laskin CA, Spitzer KA, Clark CA, Crowther MR, Ginsberg JS, Hawker GA et al. (2009). "Low molecular weight heparin and aspirin for recurrent pregnancy loss: results from the randomized, controlled HepASA Trial.". J Rheumatol 36 (2): 279-87. DOI:10.3899/jrheum.080763). PMID 19208560. Research Blogging.