Lymphocyte count: Difference between revisions
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In [[medicine]], the '''lymphocyte count''' is "the number of [[lymphocyte]]s per unit volume of blood."<ref>{{MeSH}}</ref> | {{subpages}} | ||
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In [[medicine]], the '''lymphocyte count''' is "the number of [[lymphocyte]]s per unit volume of blood."<ref>{{MeSH}}</ref> It may further be divided by lymphocyte type, such as B-cell or T-cell, and then T-CD4+ or T-CD8+. | |||
==Clinical uses== | ==Clinical uses== | ||
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===Measure of immune status=== | ===Measure of immune status=== | ||
In predicting a CD4+ T-cell of less than 200:<ref name="pmid8093628">{{cite journal| author=Blatt SP, Lucey CR, Butzin CA, Hendrix CW, Lucey DR| title=Total lymphocyte count as a predictor of absolute CD4+ count and CD4+ percentage in HIV-infected persons. | journal=JAMA | year= 1993 | volume= 269 | issue= 5 | pages= 622-6 | pmid=8093628 | "A CD4 count of <200 × 10(6) cells/μL is very likely if the ED ALC is <950 × 10(6) cells/μL and less likely if the ALC is >1,700 × 10(6) cells/μL".<ref name="pmid21496141">{{cite journal| author=Napoli AM, Fischer CM, Pines JM, Soe-lin H, Goyal M, Milzman D| title=Absolute lymphocyte count in the emergency department predicts a low CD4 count in admitted HIV-positive patients. | journal=Acad Emerg Med | year= 2011 | volume= 18 | issue= 4 | pages= 385-9 | pmid=21496141 | doi=10.1111/j.1553-2712.2011.01031.x | pmc= | url= }} </ref> | ||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8093628 }} | |||
In a second study of predicting a CD4+ T-cell of less than 200:<ref name="pmid8093628">{{cite journal| author=Blatt SP, Lucey CR, Butzin CA, Hendrix CW, Lucey DR| title=Total lymphocyte count as a predictor of absolute CD4+ count and CD4+ percentage in HIV-infected persons. | journal=JAMA | year= 1993 | volume= 269 | issue= 5 | pages= 622-6 | pmid=8093628 | |||
| url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&retmode=ref&cmd=prlinks&id=8093628 }}</ref> | |||
* Total lymphocyte count of more than 2000 has [[sensitivity and specificity|sensitivity]] or 95% | * Total lymphocyte count of more than 2000 has [[sensitivity and specificity|sensitivity]] or 95% | ||
* Total lymphocyte count of less than 1200 has [[sensitivity and specificity|specificity]] of 95% | * Total lymphocyte count of less than 1200 has [[sensitivity and specificity|specificity]] of 95% | ||
Latest revision as of 21:03, 3 June 2011
In medicine, the lymphocyte count is "the number of lymphocytes per unit volume of blood."[1] It may further be divided by lymphocyte type, such as B-cell or T-cell, and then T-CD4+ or T-CD8+.
Clinical uses
Measure of nutritional status
A total lymphocyte count less than 2100 is a marker (although a weak marker) of poor nutrition.[2]
Measure of immune status
"A CD4 count of <200 × 10(6) cells/μL is very likely if the ED ALC is <950 × 10(6) cells/μL and less likely if the ALC is >1,700 × 10(6) cells/μL".[3]
In a second study of predicting a CD4+ T-cell of less than 200:[4]
- Total lymphocyte count of more than 2000 has sensitivity or 95%
- Total lymphocyte count of less than 1200 has specificity of 95%
References
- ↑ Anonymous (2024), Lymphocyte count (English). Medical Subject Headings. U.S. National Library of Medicine.
- ↑ Braga M, Gianotti L, Radaelli G, Cristallo M, Baccari P, Dal Cin S et al. (1991 Nov-Dec) Evaluation of the predictive performance of nutritional indicators by receiver-operating characteristic curve analysis. JPEN J Parenter Enteral Nutr 15 (6):619-24. PMID: 1766051
- ↑ Napoli AM, Fischer CM, Pines JM, Soe-lin H, Goyal M, Milzman D (2011). "Absolute lymphocyte count in the emergency department predicts a low CD4 count in admitted HIV-positive patients.". Acad Emerg Med 18 (4): 385-9. DOI:10.1111/j.1553-2712.2011.01031.x. PMID 21496141. Research Blogging.
- ↑ Blatt SP, Lucey CR, Butzin CA, Hendrix CW, Lucey DR (1993). "Total lymphocyte count as a predictor of absolute CD4+ count and CD4+ percentage in HIV-infected persons.". JAMA 269 (5): 622-6. PMID 8093628.