D-dimer: Difference between revisions

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(New page: In medicine, '''D-dimer''' is a fibrin degradation product. ==Using D-dimer to determine duration of anticoagulation treatment== An abnormal D-dimer level at the end of treatment ...)
 
imported>Robert Badgett
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==Using D-dimer to determine duration of anticoagulation treatment==
==Using D-dimer to determine duration of anticoagulation treatment==
An abnormal [[D-dimer]] level at the end of treatment might signal the need for continued [[anticoagulation]] with [[warfarin]] among patients with [[embolism and thrombosis]] such as a first unprovoked [[pulmonary embolus]]. If the [[D-dimer]] is abnormal, anticoaguation should be continued, if the D-dimer is normal, the duration of treatment is uncertain.<ref name="pmid17065639">{{cite journal |author=Palareti G, Cosmi B, Legnani C, ''et al'' |title=D-dimer testing to determine the duration of anticoagulation therapy |journal=N. Engl. J. Med. |volume=355 |issue=17 |pages=1780-9 |year=2006 |pmid=17065639 |doi=10.1056/NEJMoa054444}}</ref> In an observation study that collected the[D-dimer before stopping anticoagulation, the D-dimer was not as predictive.<ref>Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. [Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy http://www.cmaj.ca/cgi/content/full/179/5/417]. CMAJ. 2008 Aug 26;179(5):417-426.</ref>
An abnormal D-dimer level at the end of treatment might signal the need for continued [[anticoagulation]] with [[warfarin]] among patients with [[embolism and thrombosis]] such as a first unprovoked [[pulmonary embolus]]. If the D-dimer is abnormal, anticoaguation should be continued, if the D-dimer is normal, the duration of treatment is uncertain.<ref name="pmid17065639">{{cite journal |author=Palareti G, Cosmi B, Legnani C, ''et al'' |title=D-dimer testing to determine the duration of anticoagulation therapy |journal=N. Engl. J. Med. |volume=355 |issue=17 |pages=1780-9 |year=2006 |pmid=17065639 |doi=10.1056/NEJMoa054444}}</ref> In an observation study that collected the D-dimer before stopping anticoagulation, the D-dimer was not as predictive.<ref>Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. [Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy http://www.cmaj.ca/cgi/content/full/179/5/417]. CMAJ. 2008 Aug 26;179(5):417-426.</ref>


==References==
==References==
<references/>
<references/>

Revision as of 13:53, 30 January 2009

In medicine, D-dimer is a fibrin degradation product.

Using D-dimer to determine duration of anticoagulation treatment

An abnormal D-dimer level at the end of treatment might signal the need for continued anticoagulation with warfarin among patients with embolism and thrombosis such as a first unprovoked pulmonary embolus. If the D-dimer is abnormal, anticoaguation should be continued, if the D-dimer is normal, the duration of treatment is uncertain.[1] In an observation study that collected the D-dimer before stopping anticoagulation, the D-dimer was not as predictive.[2]

References

  1. Palareti G, Cosmi B, Legnani C, et al (2006). "D-dimer testing to determine the duration of anticoagulation therapy". N. Engl. J. Med. 355 (17): 1780-9. DOI:10.1056/NEJMoa054444. PMID 17065639. Research Blogging.
  2. Rodger MA, Kahn SR, Wells PS, Anderson DA, Chagnon I, Le Gal G, et al. [Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy http://www.cmaj.ca/cgi/content/full/179/5/417]. CMAJ. 2008 Aug 26;179(5):417-426.