Penicillin V: Difference between revisions

From Citizendium
Jump to navigation Jump to search
imported>David E. Volk
imported>Jeffrey Scott Bernstein
m ("it" was missing)
Line 2: Line 2:
[[Image:Penicillin V structure.jpg|right|thumb|250px|{{#ifexist:Template:Penicillin V structure.jpg/credit|{{Penicillin V structure.jpg/credit}}<br/>|}}Penicillin V]]  
[[Image:Penicillin V structure.jpg|right|thumb|250px|{{#ifexist:Template:Penicillin V structure.jpg/credit|{{Penicillin V structure.jpg/credit}}<br/>|}}Penicillin V]]  


'''Penicillin V''', or '''phenoxymethyl penicillin''', is a broad-spectrum, beta-[[lactam]]-based [[antibiotic]] used to treat mild to severe infections due to gram-positive bacteria.  Is used to treat dental, hear, middle ear, respiratory tract and skin infections, and can also treat [[rheumatic fever|rheumatic]] and [[scarlet fever]]s.
'''Penicillin V''', or '''phenoxymethyl penicillin''', is a broad-spectrum, beta-[[lactam]]-based [[antibiotic]] used to treat mild to severe infections due to gram-positive bacteria.  It is used to treat dental, hear, middle ear, respiratory tract and skin infections, and can also treat [[rheumatic fever|rheumatic]] and [[scarlet fever]]s.


== Mechanism of action ==
== Mechanism of action ==

Revision as of 10:39, 10 March 2008

This article is developing and not approved.
Main Article
Discussion
Related Articles  [?]
Bibliography  [?]
External Links  [?]
Citable Version  [?]
 
This editable Main Article is under development and subject to a disclaimer.
(CC) Image: David E. Volk
Penicillin V

Penicillin V, or phenoxymethyl penicillin, is a broad-spectrum, beta-lactam-based antibiotic used to treat mild to severe infections due to gram-positive bacteria. It is used to treat dental, hear, middle ear, respiratory tract and skin infections, and can also treat rheumatic and scarlet fevers.

Mechanism of action

Like other penicillin-like drugs, penicillin V works by binding to specific penicillin-binding proteins in bacterial cell walls and blocking the final cross-linking step in the synthesis of bacterial cell walls. This induces autolysis of the bactertial cells by autolysins.

Chemistry

Penicillin V is stable against degradation by beta-lactamases, including penicillinases, and cephalosporinases. Its IUPAC chemical name is (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[[2-(phenoxy)acetyl]amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid and it has molecular formula C16H18N2O5S (MM = 350.3895 g/mol).

Drug interactions

Tetracycline and its derivatives demeclocycline, doxycycline, methacycline, minocycline, oxytetracycline, rolitetracycline, and tetracycline are antagonists of penicillins. The effects of oral contraceptives, including [[ethinyl estradiol] and mestranol are decreased when using penicillin. Penicillins increases the effect and toxicity of methotrexate.[1]


Synonyms and brand names

synonyms

  • Fenossimetilpenicillina
  • Fenoximetilpenicilina
  • Penicillin Phenoxymethyl
  • Penicillin V Potassium
  • Phenoxymethylpenicillinic Acid
  • Phenoxymethylpenicillinic Acid Potassium Salt
  • Phenoxymethylpenicillin Potassium
  • Phenoxymethylenepenicillinic Acid
  • Phenoxymethyl Penicillin
  • Phenoximethylpenicillinum

Brand names

  1. Acipen V®
  2. Apopen®
  3. Beepen-Vk®
  4. Beromycin®
  5. Betapen-Vk®
  6. Calcipen®
  7. Compocillin V®
  8. Crystapen V®
  9. Distaquaine V®
  10. Eskacillian V®
  11. Eskacillin V®
  12. Fenacilin®
  13. Fenospen®
  14. Fenoxypen®
  15. Ledercillin Vk®
  16. Meropenin®
  17. Oracillin®
  18. Oratren®
  19. Ospen®
  20. Pen-Oral®
  21. Pen-V®
  22. Pen-Vee®
  23. Pen-Vee K®
  24. Penapar-Vk®
  25. Penicillin Vk®
  26. Penicillin-Vk®
  27. Pfizerpen Vk®
  28. Phenocillin®
  29. Phenomycilline®
  30. Phenopenicillin®
  31. Robicillin®
  32. Rocilin®
  33. Stabicillin®
  34. Uticillin Vk®
  35. V-Cil®
  36. V-Cillin®
  37. V-Cillin K®
  38. V-Cylina®
  39. V-Cyline®
  40. V-Tablopen®
  41. Vebecillin®
  42. Veetids®
  43. Veetids '125'®
  44. Veetids '250'®
  45. Veetids '500'®

External links