Cinoxacin

(CC) Image: David E. Volk
Cinoxacin

Cinoxacin (Cinobac®) is an antibiotic drug use to treat urinary tract infections caused by many aerobic, gram-negative bacteria. It is active against susceptible strains of E. coli, Proteus mirabilis, Proteus vulgaris, Klebsiella pneumoniae, and Enterobacter species.

Mechanism of action

Cinoxacin binds to DNA and interferes with the synthesis of viral RNA and therefore inhibits the production of viral proteins.

Chemistry

Cinoxacin's IUPAC chemical name is 1-ethyl-4-oxo-[1,3]dioxolo[4,5-g]cinnoline-3-carboxylic acid and its chemical formula is C₁₂H₁₀N₂O₅ (MW=262.2182 g/mol). It is related to oxolinic acid and nalidixic acid and it is active over the entire urinary pH range.

External links

The most up-to-date information about Cinoxacin and other drugs can be found at the following sites.

• Cinoxacin - FDA approved drug information (drug label) from DailyMed (U.S. National Library of Medicine).
• Cinoxacin - Drug information for consumers from MedlinePlus (U.S. National Library of Medicine).
• Cinoxacin - Detailed information from DrugBank.