3-hydroxy-3-methyl-glutaryl CoA: Difference between revisions
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[[Image:Mevalonate synthesis.jpg|right|thumb|250px|{{#ifexist:Template:Mevalonate synthesis.jpg/credit|{{Mevalonate synthesis.jpg/credit}}<br/>|}}Biosynthesis of mevalonate from HMG CoA.]] | [[Image:Mevalonate synthesis.jpg|right|thumb|250px|{{#ifexist:Template:Mevalonate synthesis.jpg/credit|{{Mevalonate synthesis.jpg/credit}}<br/>|}}Biosynthesis of mevalonate from HMG CoA.]] | ||
The biochemical '''3-hydroxy-3-methyl-glutaryl CoA''' '''(HMG CoA)''', is a chemical precursor of [[mevalonate]], which is a key metabolite in the synthesis of [[cholesterol]]. The cholesterol-lowering statins, such as [[Lipitor]] and [[Crestor]], among others, are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]] which block the synthesis of mevalonate from HMG CoA. | The biochemical '''3-hydroxy-3-methyl-glutaryl CoA''' '''(HMG CoA)''', is a chemical precursor of [[mevalonate]], which is a key metabolite in the synthesis of [[cholesterol]]. The cholesterol-lowering statins, such as [[Lipitor]] and [[Crestor]], among others, are [[Hydroxymethylglutaryl-coenzyme A reductase inhibitor|HMG-CoA reductase inhibitor]]s which block the synthesis of mevalonate from HMG CoA. | ||
Revision as of 13:30, 24 January 2008
The biochemical 3-hydroxy-3-methyl-glutaryl CoA (HMG CoA), is a chemical precursor of mevalonate, which is a key metabolite in the synthesis of cholesterol. The cholesterol-lowering statins, such as Lipitor and Crestor, among others, are HMG-CoA reductase inhibitors which block the synthesis of mevalonate from HMG CoA.